{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.bone-marrow","code":"thing-q546523","url":"https://ver.cy/models/thing/q546523/","name":"bone marrow","alternateNames":["bone marrow as food","cattle bone marrow","femur bone marrow","humerus bone marrow","myeloid tissue","human bone marrow","yellow bone marrow","red bone marrow","gelatinous bone marrow"],"kind":"thing","status":"published","version":"0.2.0-wave.3","language":"en","classifiers":{"family":"Thing Registry","category":"Physical world and living systems","entryKind":"thing","plane":"PHY","domain":["PHY.LIV"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"The soft tissue inside bones, consisting of red marrow that produces blood cells and yellow marrow rich in fat, found in the cavities of long bones such as the femur and humerus and in the spongy bone of the pelvis, ribs and vertebrae; bone marrow is the site of haematopoiesis, is sampled to diagnose blood disorders, is transplanted to treat leukaemia and other diseases, and is eaten as food in many cuisines.","purpose":"Let an agent explain bone marrow and its functions, relay clinical information on marrow sampling, disorders and transplantation from clinical sources, describe culinary use, and route personal questions to clinicians.","scope":{"in":[],"out":[],"boundaries":[]},"distinguishingFeatures":["Haematopoietic tissue","Red and yellow types","Transplantable","Site of blood cancers"],"structure":{"bundles":[{"id":"biology","name":"Biology","description":"Structure and function.","layers":[{"id":"structure","name":"Structure","description":"Structure.","findings":[{"id":"structure-finding","name":"Structure","description":"Structure.","questions":[{"text":"What are red and yellow marrow, and where are they found?","kind":"definition"},{"text":"Is the question about marrow, bone or the spinal cord?","kind":"boundary"}]}]},{"id":"function","name":"Function","description":"Haematopoiesis.","findings":[{"id":"function-finding","name":"Function","description":"Function.","questions":[{"text":"How does marrow produce blood cells?","kind":"definition"},{"text":"Which entry fits haematopoiesis?","kind":"action"}]}]}]},{"id":"clinical","name":"Clinical","description":"Disorders and sampling.","layers":[{"id":"disorders","name":"Disorders","description":"Disorders.","findings":[{"id":"disorders-finding","name":"Disorders","description":"Disorders.","questions":[{"text":"Which disorders affect the marrow, from leukaemia to aplastic anaemia, in general terms?","kind":"provenance"},{"text":"Is the user asking about their own condition, which needs a clinician?","kind":"boundary"}]}]},{"id":"sampling","name":"Sampling","description":"Biopsy and tests.","findings":[{"id":"sampling-finding","name":"Sampling","description":"Sampling.","questions":[{"text":"How and why is marrow sampled, per clinical sources?","kind":"provenance"},{"text":"Which references are standard?","kind":"provenance"}]}]}]},{"id":"transplant","name":"Transplant","description":"Transplantation and donation.","layers":[{"id":"transplant","name":"Transplant","description":"Transplantation.","findings":[{"id":"transplant-finding","name":"Transplant","description":"Transplant.","questions":[{"text":"How do marrow and stem cell transplants work, and what do they treat?","kind":"provenance"},{"text":"Which entry fits stem cell transplantation?","kind":"action"}]}]},{"id":"donation","name":"Donation","description":"Donation.","findings":[{"id":"donation-finding","name":"Donation","description":"Donation.","questions":[{"text":"How do donor registries work, and what does donation involve?","kind":"provenance"},{"text":"Which entry fits a specific donor registry?","kind":"action"}]}]}]},{"id":"context","name":"Context","description":"Food and history.","layers":[{"id":"food","name":"Food","description":"Marrow as food.","findings":[{"id":"food-finding","name":"Food","description":"Food.","questions":[{"text":"How is bone marrow used in cuisines, and what safety rules apply?","kind":"provenance"},{"text":"Which entry fits offal?","kind":"action"}]}]},{"id":"history","name":"History","description":"History.","findings":[{"id":"history-finding","name":"History","description":"History.","questions":[{"text":"How was the role of marrow in blood formation discovered, and how did transplantation develop?","kind":"provenance"},{"text":"Which sources are cited?","kind":"provenance"}]}]}]}]},"agentConduct":{"may":["Explain the role of bone marrow in making blood cells.","Explain how bone marrow donation and transplantation work in general terms.","Point people to donor registries and qualified clinicians."],"mustNot":["Give a person a diagnosis or treatment plan for a marrow disorder.","Share a person's marrow test results or donor status without consent.","Present donation risks as zero or as frightening beyond the evidence.","Help anyone buy or sell bone marrow for transplant outside lawful systems."],"requiresHuman":["Registering, matching or contacting a donor.","Any decision about marrow biopsy or transplant."]},"ethics":{"considerations":["Donation saves lives and must rest on informed, free consent.","Diagnosis of blood cancers is frightening; information must be accurate and humane."],"affectedParties":["Patients","Donors","Families"]},"owners":{"steward":"The donor and patient for their own tissue; donor registries record volunteers.","roles":[],"masterSystems":["Bone marrow donor registries"]},"relations":[{"target":"Q109173541","type":"parent","note":"registry parent class"},{"target":"Q112826975","type":"parent","note":"registry parent class"},{"target":"Q28841127","type":"parent","note":"registry parent class"},{"target":"Q40397","type":"parent","note":"registry parent class"},{"target":"blood forming organ","type":"related","note":"in registry terms"},{"target":"zone of bone organ","type":"related","note":"in registry terms"},{"target":"blood cell","type":"related","note":"by haematopoiesis"},{"target":"haematopoietic stem cell transplantation","type":"related","note":"for blood diseases"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.bone-marrow","Wikidata: Q546523 (https://www.wikidata.org/wiki/Q546523)","MeSH: D001853 bone marrow","TA2: bone marrow Terminologia Anatomica"]},"properties":{"applicability":"required","items":["share of body mass: about 4 percent - adult","blood cells produced: hundreds of billions per day - adult"]},"recognition":{"applicability":"required","items":["Tissue inside bone cavities","Red marrow makes blood; yellow marrow stores fat","Bone itself and the spinal cord are different tissues","Soft red or yellow tissue inside bones, seen in cut bones and in marrow samples."]},"capabilities":{"applicability":"required","items":["explain structure and function","relay clinical sampling and transplant information","describe culinary use","route personal questions to clinicians"]},"hazards":{"applicability":"required","items":["Marrow failure and blood cancers","Transplant complications such as graft-versus-host disease","Agents giving personal medical advice"]},"interfaces":{"applicability":"required","items":["Transplant and donor registry regulations","Clinical standards for marrow biopsy","Food safety rules for marrow, including BSE-related controls"]},"context":{"applicability":"required","items":["Producing blood cells; also food.","red marrow, myeloid tissue","yellow marrow","marrow by bone: femur, humerus, pelvis, sternum","human and animal marrow, including cattle marrow as food","marrow as a transplant source"]}},"sources":[{"title":"Wikidata item Q546523: bone marrow","url":"https://www.wikidata.org/wiki/Q546523","note":"identity and sense of the item"},{"title":"Wikipedia: Bone marrow","url":"https://en.wikipedia.org/wiki/Bone_marrow","note":"general description of the item"}],"openQuestions":["Should haematopoiesis and transplantation be the linked primary entries?","How should donor registries be linked?","The registry entry has merged aliases naming marrow by bone and as food; should they be split off?"],"resources":{"spec":"/models/things/publications/thing-q546523/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q546523/spec.json"],"providers":["Claude"],"researchStatus":"unreviewed","generatedAt":"2026-09-12T22:24:12Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"filled","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-06T19:52:00+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass"},"score":1.0}}