{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.aporphine-alkaloids","code":"thing-q56296907","url":"https://ver.cy/models/thing/q56296907/","name":"aporphine alkaloids","alternateNames":["(6aR)-3-[[2-(4-hydroxyphenyl)ethylamino]methyl]-1-methoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-2-ol","laurotetanine","4,15,16-trimethoxy-10-azatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadeca-1,3,6,9(17),11,13,15-heptaene-5,8-dione","18-Hydroxy-3,5-dioxa-11-azapentacyclo[10.7.1.02,6.08,20.014,19]icosa-1(20),2(6),7,9,11,14(19),15,17-octaen-13-one","5-Hydroxy-4,15,16-trimethoxy-10,10-dimethyl-10-azatetracyclo[7.7.1.0^{2,7}.0^{13,17}]heptadeca-1(16),2(7),3,5,13(17),14-hexaen-10-ium","Luteanine","N-methylputerine","Menispermine","l-N-Acetylanonaine","Thalictrucarpine","Thaliporphine","(+)-Launobine"],"kind":"thing","status":"published","version":"0.2.0-wave.2","language":"en","classifiers":{"family":"Thing Registry","category":"Physical world and living systems","entryKind":"thing","plane":"PHY","domain":["PHY.MAT"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"A class of isoquinoline alkaloids with a tetracyclic aporphine skeleton, found in plants of families such as Annonaceae, Lauraceae, Magnoliaceae and Papaveraceae, including compounds such as laurotetanine, luteanine, glaucine, boldine and nuciferine; aporphine alkaloids show diverse biological activities studied in pharmacology and natural products chemistry, some are used in traditional medicine and a few in licensed medicines, and this entry gives general information only.","purpose":"Let an agent explain aporphine alkaloids as a chemical class, describe their plant sources and biosynthesis, summarise documented biological activities with attribution, and route medicinal questions to professionals.","scope":{"in":[],"out":[],"boundaries":[]},"distinguishingFeatures":["Aporphine skeleton","Plant origin","Diverse activities","Research interest"],"structure":{"bundles":[{"id":"understand","name":"Understand","description":"The chemical class.","layers":[{"id":"structure","name":"Structure","description":"Skeleton and subclasses.","findings":[{"id":"structure-finding","name":"Structure","description":"Structure.","questions":[{"text":"What is the aporphine skeleton, and how do simple, oxo, dehydro and dimeric aporphines differ?","kind":"definition"},{"text":"Which entry fits a specific compound?","kind":"action"}]}]},{"id":"sources","name":"Sources","description":"Plant sources and biosynthesis.","findings":[{"id":"sources-finding","name":"Sources","description":"Sources.","questions":[{"text":"Which plants produce aporphine alkaloids, and how are they biosynthesised from benzylisoquinoline precursors?","kind":"provenance"},{"text":"Which entry fits a specific plant?","kind":"action"}]}]}]},{"id":"activity","name":"Activity","description":"Biological activity.","layers":[{"id":"pharmacology","name":"Pharmacology","description":"Documented activities.","findings":[{"id":"pharmacology-finding","name":"Pharmacology","description":"Pharmacology.","questions":[{"text":"What biological activities of aporphine alkaloids are documented in research, and how strong is the evidence?","kind":"provenance"},{"text":"Which findings are preliminary?","kind":"boundary"}]}]},{"id":"medicine","name":"Medicine","description":"Medicinal use.","findings":[{"id":"medicine-finding","name":"Medicine","description":"Medicine.","questions":[{"text":"Which aporphines are used in licensed or traditional medicines, and what do regulators say?","kind":"provenance"},{"text":"Is the user asking about their own use of a herbal product, which needs a professional?","kind":"boundary"}]}]}]},{"id":"analyse","name":"Analyse","description":"Analysis and research.","layers":[{"id":"methods","name":"Methods","description":"Analytical methods.","findings":[{"id":"methods-finding","name":"Methods","description":"Methods.","questions":[{"text":"How are aporphine alkaloids isolated, identified and quantified?","kind":"provenance"},{"text":"Which databases document them?","kind":"provenance"}]}]},{"id":"toxicity","name":"Toxicity","description":"Toxicity.","findings":[{"id":"toxicity-finding","name":"Toxicity","description":"Toxicity.","questions":[{"text":"Which aporphine alkaloids are toxic, and what safety data exist?","kind":"provenance"},{"text":"Is a poisoning emergency present, requiring a poison centre?","kind":"boundary"}]}]}]},{"id":"learn","name":"Learn","description":"History and teaching.","layers":[{"id":"history","name":"History","description":"History.","findings":[{"id":"history-finding","name":"History","description":"History.","questions":[{"text":"How were aporphine alkaloids discovered and characterised?","kind":"provenance"},{"text":"Which references are standard?","kind":"provenance"}]}]},{"id":"teach","name":"Teach","description":"Teaching.","findings":[{"id":"teach-finding","name":"Teach","description":"Teaching.","questions":[{"text":"How can alkaloid classes be taught in natural products chemistry?","kind":"action"},{"text":"Which misconceptions arise?","kind":"provenance"}]}]}]}]},"agentConduct":{"may":["Describe the aporphine class, its plant sources and representative compounds at reference level.","Distinguish aporphines from other isoquinoline alkaloid classes."],"mustNot":["Recommend aporphine-containing plants or compounds as remedies.","Advise on dosing or preparing any compound in the class.","Repeat unproven medicinal claims as established."],"requiresHuman":["Any decision to use a compound from this class on a person or animal."]},"ethics":{"considerations":["Some aporphines are toxic or psychoactive; unproven claims put people at risk."],"affectedParties":["People using herbal products","Researchers"]},"owners":{"steward":"Nobody owns the class; medicine regulators control compounds approved as drugs.","roles":[],"masterSystems":[]},"relations":[{"target":"Q73266145","type":"parent","note":"registry parent class"},{"target":"isoquinoline alkaloid","type":"related","note":"category"},{"target":"morphinan alkaloid","type":"related","note":"another isoquinoline-derived class"},{"target":"alternative medicine","type":"related","note":"traditional uses"},{"target":"gene expression","type":"related","note":"biosynthetic regulation"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.aporphine-alkaloids","Wikidata: Q56296907 (https://www.wikidata.org/wiki/Q56296907)"]},"properties":{"applicability":"required","items":["Molar mass:  g/mol - Calculate the value from the molecular formula of the identified compound, specifying any salt or solvate form.","Melting temperature:  degrees Celsius - Measure the identified solid using capillary melting analysis or differential scanning calorimetry, recording decomposition where observed.","Solubility:  g/L - Measure the dissolved concentration at equilibrium while specifying the compound form, solvent, temperature and pH."]},"recognition":{"applicability":"required","items":["Tetracyclic aporphine skeleton","Isoquinoline origin","Morphinan alkaloids have a different skeleton","Not physical as a class; crystalline compounds in the laboratory."]},"capabilities":{"applicability":"required","items":["explain the chemical class","describe sources and biosynthesis","summarise activities with attribution","route medicinal questions"]},"hazards":{"applicability":"required","items":["Toxicity of some compounds","Unproven medicinal claims","Confusing alkaloid classes"]},"interfaces":{"applicability":"required","items":["Pharmacopoeial standards for compounds used in medicines","Herbal medicine regulation","Chemical nomenclature conventions"]},"context":{"applicability":"required","items":["Alkaloids with the aporphine skeleton.","simple aporphines such as nuciferine","oxoaporphines","dehydroaporphines and proaporphines","dimeric aporphines","aporphines used in medicines such as glaucine"]}},"sources":[{"title":"Wikidata item Q56296907: aporphine alkaloids","url":"https://www.wikidata.org/wiki/Q56296907","note":"identity and sense of the item"},{"title":"Wikipedia: Aporphine alkaloids","url":"https://en.wikipedia.org/wiki/Aporphine_alkaloids","note":"general description of the item"}],"openQuestions":["Should each compound be a separate entry?","How should natural product databases be linked?","How should herbal regulation be linked?"],"resources":{"spec":"/models/things/publications/thing-q56296907/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q56296907/spec.json"],"providers":["Claude"],"researchStatus":"unreviewed","generatedAt":"2026-09-12T00:23:59Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"filled","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-07T10:10:31+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass"},"score":1.0}}