{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.caffeine","code":"thing-q60235","url":"https://ver.cy/models/thing/q60235/","name":"caffeine","alternateNames":["Buckfast Tonic Wine","Caffeine-13C3 solution","1,7-Dimethyl-3-(¹³C)methyl-3,7-dihydro-1H-purine-2,6-dione","(14-C)Caffeine"],"kind":"thing","status":"published","version":"0.1.0-research.1","language":"en","classifiers":{"family":"Thing Registry","category":"Physical world and living systems","entryKind":"thing","plane":"PHY","domain":["PHY.MAT"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"Caffeine is the xanthine alkaloid 1,3,7-trimethylxanthine, a competitive antagonist at adenosine A1 and A2A receptors, that occurs in Coffea, Camellia, Theobroma, Paullinia, Ilex and related plants and is isolated or synthesised as an anhydrous crystalline solid for use as a food flavour, CNS stimulant, analgesic adjuvant and neonatal respiratory stimulant.","purpose":"Enable an AI agent to recognise caffeine, assess the identity and condition of a particular quantity, and determine which handling, formulation or transfer actions are supported by evidence.","scope":{"in":["Chemical identity and evidence distinguishing caffeine from related methylxanthines","Physical form and composition of an identified caffeine sample or lot","Caffeine quantity, concentration and the basis of each measurement","Source, processing history and evidence supporting grade or purity claims","Condition and constraints governing storage, handling, formulation and transfer"],"out":["Complete composition and quality of coffee, tea, energy drinks and other caffeine-containing products","Cultivation and biology of plants that produce caffeine","Individual consumption histories, metabolism, symptoms and clinical treatment","Manufacturing equipment and complete extraction or synthesis processes","Commercial orders, inventory accounting and transport operations","Legal rules themselves, which belong to jurisdictional models referenced for a particular use"],"boundaries":[]},"distinguishingFeatures":["Require identity evidence consistent with 1,3,7-trimethylxanthine; a methylxanthine-family label alone does not distinguish caffeine from theobromine or theophylline.","Use molecular formula C8H10N4O2 as a consistency check, while requiring structural or analytical evidence because formula alone does not establish identity.","Distinguish caffeine substance from a caffeine-containing extract or beverage by recording the surrounding matrix and measured caffeine fraction.","Distinguish anhydrous caffeine, hydrated material and caffeine-containing preparations through declared composition and suitable analytical evidence; do not treat their gross masses as interchangeable caffeine masses."],"structure":{"bundles":[{"id":"caffeine-identity-and-boundaries","name":"Caffeine identity and boundaries","description":"Establishes that the represented substance is caffeine and identifies the material boundary around it.","layers":[{"id":"molecular-identification","name":"Molecular identification","description":"Records the chemical assignment and the evidence needed to discriminate caffeine.","findings":[{"id":"caffeine-identity-evidence","name":"Caffeine identity evidence","description":"Capture the declared identity, reference material and analytical evidence, preserving the distinction between declaration and confirmation.","questions":[{"text":"What evidence identifies this material as 1,3,7-trimethylxanthine rather than another methylxanthine?","id":"caffeine-identity-evidence-q01","kind":"definition"},{"text":"Which method and reference support the identity assignment, and what interfering compounds can that method distinguish?","id":"caffeine-identity-evidence-q02","kind":"measurement"}]}]},{"id":"substance-and-preparation-boundary","name":"Substance and preparation boundary","description":"Separates caffeine from its host matrix and from preparations whose names include caffeine.","findings":[{"id":"represented-caffeine-entity","name":"Represented caffeine entity","description":"Specify whether the record concerns isolated caffeine or the caffeine constituent of a larger material.","questions":[{"text":"Does this record represent isolated caffeine, caffeine in a solution, or caffeine within a botanical or formulated mixture?","id":"represented-caffeine-entity-q01","kind":"boundary"},{"text":"If the preparation includes water or other components, which mass and composition belong to caffeine and which belong to the preparation model?","id":"represented-caffeine-entity-q02","kind":"boundary"}]}]}]},{"id":"caffeine-form-and-condition","name":"Caffeine form and condition","description":"Records the physical state relevant to measuring and using a caffeine material.","layers":[{"id":"solid-form-and-moisture","name":"Solid form and moisture","description":"Captures the declared and observed state of solid caffeine.","findings":[{"id":"solid-state-basis","name":"Solid state basis","description":"Record hydration, moisture and powder condition without inferring them from appearance alone.","questions":[{"text":"What evidence establishes the caffeine material's hydration or solid form, and what remains uncharacterised?","id":"solid-state-basis-q01","kind":"measurement"},{"text":"What moisture measurement or observed clumping requires reassessment of sampling, weighing or the assay basis?","id":"solid-state-basis-q02","kind":"action"}]}]},{"id":"dissolved-state","name":"Dissolved state","description":"Describes caffeine's state within a solvent or formulation under recorded conditions.","findings":[{"id":"dissolution-and-precipitation-status","name":"Dissolution and precipitation status","description":"Capture whether the assigned caffeine quantity is dissolved and whether that state supports representative transfer.","questions":[{"text":"For the recorded solvent composition, temperature and caffeine concentration, what evidence shows complete dissolution or remaining solids?","id":"dissolution-and-precipitation-status-q01","kind":"measurement"},{"text":"Has storage or a formulation change produced precipitation that requires mixing, reassay or a revised transfer procedure?","id":"dissolution-and-precipitation-status-q02","kind":"action"}]}]}]},{"id":"caffeine-quantity-and-assay","name":"Caffeine quantity and assay","description":"Makes caffeine amounts interpretable across solids, solutions and mixtures.","layers":[{"id":"amount-and-concentration-basis","name":"Amount and concentration basis","description":"Records quantities with the denominators and corrections needed for calculations.","findings":[{"id":"interpretable-caffeine-quantity","name":"Interpretable caffeine quantity","description":"Attach units, sample boundary, assay basis and uncertainty to each caffeine quantity.","questions":[{"text":"Is the stated quantity gross material mass, caffeine mass or caffeine concentration, and what is its denominator?","id":"interpretable-caffeine-quantity-q01","kind":"measurement"},{"text":"What assay, moisture or preparation-composition correction is required to calculate the caffeine amount available for transfer?","id":"interpretable-caffeine-quantity-q02","kind":"action"}]}]},{"id":"analytical-selectivity-and-sampling","name":"Analytical selectivity and sampling","description":"Establishes what a caffeine measurement demonstrates about the sampled material.","findings":[{"id":"representative-caffeine-assay","name":"Representative caffeine assay","description":"Record method selectivity, calibration and sampling limits before treating a result as representative of a lot or mixture.","questions":[{"text":"How does the assay separate caffeine response from related methylxanthines and matrix interference?","id":"representative-caffeine-assay-q01","kind":"measurement"},{"text":"Which sample, sampling procedure and calibration evidence support applying this caffeine result to the represented material?","id":"representative-caffeine-assay-q02","kind":"provenance"}]}]}]},{"id":"caffeine-origin-and-quality","name":"Caffeine origin and quality","description":"Connects source and processing claims to evidence about the actual caffeine material.","layers":[{"id":"origin-claim-traceability","name":"Origin claim traceability","description":"Preserves the evidence behind extraction, synthesis and source claims.","findings":[{"id":"documented-caffeine-lineage","name":"Documented caffeine lineage","description":"Link the caffeine lot to source and processing records without deriving purity or suitability from an origin label.","questions":[{"text":"Which records support a botanical extraction, synthesis or other origin claim for this caffeine lot?","id":"documented-caffeine-lineage-q01","kind":"provenance"},{"text":"Which purification, blending or repackaging steps connect the supplied lot to the material currently represented?","id":"documented-caffeine-lineage-q02","kind":"provenance"}]}]},{"id":"purity-and-use-specification","name":"Purity and use specification","description":"Tests grade and suitability claims against an identified specification.","findings":[{"id":"supported-caffeine-grade","name":"Supported caffeine grade","description":"Record caffeine assay and relevant impurity results against the requirements of a specific intended use.","questions":[{"text":"Which specification and version define the claimed caffeine grade, and which lot-specific results demonstrate conformity?","id":"supported-caffeine-grade-q01","kind":"provenance"},{"text":"Which related methylxanthines, residual processing substances or matrix contaminants require limits for the proposed use, and which have actually been measured?","id":"supported-caffeine-grade-q02","kind":"measurement"}]}]}]},{"id":"caffeine-handling-and-use-decisions","name":"Caffeine handling and use decisions","description":"Connects caffeine identity, quantity and condition to justified material actions.","layers":[{"id":"material-handling-controls","name":"Material handling controls","description":"Identifies the handling and storage instructions applicable to the actual caffeine preparation.","findings":[{"id":"supported-handling-action","name":"Supported handling action","description":"Associate proposed weighing, transfer and storage actions with current material documentation and operational capability.","questions":[{"text":"Which safety and storage documentation applies to this caffeine material's form, concentration and supplier lot?","id":"supported-handling-action-q01","kind":"provenance"},{"text":"Do the available weighing, containment and labelling procedures support the proposed caffeine quantity and transfer accuracy?","id":"supported-handling-action-q02","kind":"action"}]}]},{"id":"qualification-and-downstream-handoff","name":"Qualification and downstream handoff","description":"Determines whether a proposed use is supported and passes caffeine quantities to neighbouring models.","findings":[{"id":"caffeine-use-decision","name":"Caffeine use decision","description":"Record release, restriction or reassessment decisions for a stated application while delegating product and person-specific judgments.","questions":[{"text":"For the proposed application and jurisdiction, what evidence supports releasing this caffeine material, and what missing result requires holding it?","id":"caffeine-use-decision-q01","kind":"action"},{"text":"Which product or exposure model receives the caffeine amount, uncertainty and preparation basis for downstream assessment?","id":"caffeine-use-decision-q02","kind":"boundary"}]}]}]},{"id":"evidence-and-external-alignment","name":"Evidence and external alignment","description":"What the world already says about this thing, gathered so the model can be checked against it.","layers":[{"id":"reported-evidence","name":"Reported evidence","description":"Findings from the breadth pass, kept separate from the structural claims.","findings":[{"id":"evidence-kinds","name":"Kinds and varieties","description":"Reported by the breadth pass; each item needs checking against its source before it becomes normative.","questions":[{"text":"Which of these kinds and varieties hold for the sense of caffeine this model covers, and on what evidence?","id":"evidence-kinds-q01","kind":"provenance"}]},{"id":"evidence-identifiers","name":"Identifiers and schemes","description":"Reported by the breadth pass; each item needs checking against its source before it becomes normative.","questions":[{"text":"Which of these identifiers and schemes hold for the sense of caffeine this model covers, and on what evidence?","id":"evidence-identifiers-q01","kind":"provenance"}]},{"id":"evidence-standards-and-regulation","name":"Standards and regulation","description":"Reported by the breadth pass; each item needs checking against its source before it becomes normative.","questions":[{"text":"Which of these standards and regulation hold for the sense of caffeine this model covers, and on what evidence?","id":"evidence-standards-and-regulation-q01","kind":"provenance"}]},{"id":"evidence-real-world-use","name":"Real-world use","description":"Reported by the breadth pass; each item needs checking against its source before it becomes normative.","questions":[{"text":"Which of these real-world use hold for the sense of caffeine this model covers, and on what evidence?","id":"evidence-real-world-use-q01","kind":"provenance"}]},{"id":"evidence-measurements","name":"Typical measurements","description":"Reported by the breadth pass; each item needs checking against its source before it becomes normative.","questions":[{"text":"Which of these typical measurements hold for the sense of caffeine this model covers, and on what evidence?","id":"evidence-measurements-q01","kind":"provenance"}]},{"id":"evidence-failure-modes-and-hazards","name":"Failure modes and hazards","description":"Reported by the breadth pass; each item needs checking against its source before it becomes normative.","questions":[{"text":"Which of these failure modes and hazards hold for the sense of caffeine this model covers, and on what evidence?","id":"evidence-failure-modes-and-hazards-q01","kind":"provenance"}]},{"id":"evidence-regional-variation","name":"Regional variation","description":"Reported by the breadth pass; each item needs checking against its source before it becomes normative.","questions":[{"text":"Which of these regional variation hold for the sense of caffeine this model covers, and on what evidence?","id":"evidence-regional-variation-q01","kind":"provenance"}]},{"id":"evidence-neighbours","name":"Neighbouring kinds and how to tell them apart","description":"Reported by the breadth pass; each item needs checking against its source before it becomes normative.","questions":[{"text":"Which of these neighbouring kinds and how to tell them apart hold for the sense of caffeine this model covers, and on what evidence?","id":"evidence-neighbours-q01","kind":"provenance"}]}]}]}]},"agentConduct":{"may":["Describe caffeine, its sources and effects in general terms, citing health guidance.","Report caffeine content from labels and flag high-caffeine products."],"mustNot":["Recommend caffeine doses to a specific person, especially pure powders or tablets.","Promote caffeinated products to children or market energy drinks as safe in unlimited amounts.","Present caffeine as a substitute for sleep in safety-critical work.","Add caffeine to food or drink without the consumer's knowledge."],"requiresHuman":["Advice on caffeine for pregnant people, children or people with heart conditions."]},"ethics":{"considerations":["Concentrated caffeine products have caused deaths by overdose.","Coffee and tea work involves farm labour with known exploitation risks."],"affectedParties":["Children and young people","Pregnant people","People with heart conditions"]},"owners":{"steward":"The producer or seller of each product; food and drug authorities set limits.","roles":[],"masterSystems":["Chemical substance inventories and registration databases"]},"relations":[{"target":"Q3319060","type":"parent","note":"registry parent class"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.caffeine","Wikidata: Q60235 (https://www.wikidata.org/wiki/Q60235)"]},"properties":{"applicability":"required","items":["Identity assignment: Declared caffeine identity, identifiers and supporting analytical evidence","Material presentation: Isolated solid, solution, extract constituent or other specified mixture constituent","Solid form and hydration: Reported solid form, hydration status, method and unknown status","Caffeine amount: mg, g or mol of caffeine with uncertainty and calculation basis","Caffeine concentration: mg/mL, mg/g, mol/L or explicitly defined mass fraction","Assay and impurity profile: Caffeine assay on a stated basis; named impurities and their concentrations or reporting limits","Origin and processing lineage: Links to supplier, lot, extraction or synthesis route, and subsequent processing records","Observed material condition: Recorded observations of moisture, clumping, dissolution, precipitation or contamination, with observation time","Use qualification: Links to an intended use, applicable specification, test results and release decision"]},"recognition":{"applicability":"required","items":["Pure caffeine commonly appears as a white crystalline powder, unlike the visibly colored plant materials and beverages that contain it.","Crystalline caffeine can exhibit a fine needle-like habit, although processing can obscure this appearance and neither color nor crystal shape establishes identity."]},"capabilities":{"applicability":"required","items":["Request or compare identity testing that discriminates caffeine from related methylxanthines.","Calculate caffeine quantities and dilutions from supported assay, concentration and measurement bases.","Select sampling, weighing, dissolution or transfer actions consistent with the material's documented form and handling requirements.","Compare a caffeine lot with the specification required for a proposed formulation or analytical use.","Quarantine or route material for reassessment when identity, concentration, contamination or condition evidence is inadequate.","Link caffeine quantities into product and exposure models while preserving their measurement basis."]},"hazards":{"applicability":"required","items":["High doses, especially from powders, can cause dangerous heart rhythm problems.","Withdrawal causes headaches and fatigue in regular users."]},"interfaces":{"applicability":"required","items":["The United States Pharmacopeia caffeine monograph, issued by the United States Pharmacopeial Convention, specifies quality requirements for caffeine used as a compendial pharmaceutical substance.","The European Pharmacopoeia caffeine monograph, issued by the Council of Europe through the European Directorate for the Quality of Medicines and HealthCare, specifies pharmaceutical quality requirements."]},"context":{"applicability":"required","items":["Caffeine occurs naturally in several plants and is encountered in coffee, tea, cocoa and other foods and beverages.","Isolated caffeine is used in food manufacturing, pharmaceutical formulations and laboratory research.","Assessment distinguishes pure caffeine from mixtures because intended use and material composition determine suitable quality requirements."]}},"sources":[{"title":"PubChem Compound Summary for CID 2519, Caffeine - NCBI/NLM","url":"https://pubchem.ncbi.nlm.nih.gov/compound/2519","note":"Identity (CAS, InChIKey, formula, melting point, solubility) and pharmacological classification as a methylxanthine adenosine-receptor antagonist."},{"title":"Scientific Opinion on the safety of caffeine - EFSA Panel on Dietetic Products, Nutrition and Allergies, EFSA Journal 2015;13(5):4102","url":"https://doi.org/10.2903/j.efsa.2015.4102","note":"Adult, child and pregnancy intake levels considered without safety concern, and characterisation of acute and habitual exposure from foods and drinks."},{"title":"21 CFR 182.1180 Caffeine - U.S. Food and Drug Administration (eCFR)","url":"https://www.ecfr.gov/current/title-21/section-182.1180","note":"U.S. GRAS listing of caffeine in cola-type beverages at not more than 0.02 percent."},{"title":"Regulation (EU) No 1169/2011 on the provision of food information to consumers, Annex III - European Union","url":"https://eur-lex.europa.eu/eli/reg/2011/1169/oj","note":"Mandatory high-caffeine warning on beverages other than tea or coffee with caffeine above 150 mg/L."},{"title":"Caffeine (Q60235) - Wikidata","url":"https://www.wikidata.org/wiki/Q60235","note":"Crosswalk of CAS, UNII, ChEBI, ATC, PubChem and other public identifiers."},{"title":"Wikipedia: Caffeine","url":"https://en.wikipedia.org/wiki/Caffeine","note":"general description of the item"}],"openQuestions":["Does an existing Vercy world model already own caffeine or its chemical-substance identity, requiring this registry entry to link to it?","Which authoritative references and analytical methods should establish caffeine identity and discriminate relevant methylxanthines in each supported matrix?","Which caffeine solid forms and hydration states need explicit representation, and what evidence is sufficient to assign them?","Which specifications, impurity limits and assay conventions govern the intended food, pharmaceutical, laboratory or industrial applications?","What verified storage, dissolution and reassessment criteria apply to the caffeine forms and preparations this model will support?"],"resources":{"spec":"/models/things/publications/thing-q60235/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q60235/spec.json"],"providers":["Codex","Grok"],"researchStatus":"unreviewed","generatedAt":"2026-09-07T11:16:59Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"filled","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-07T10:10:32+00:00: completeness 1.00; sense: Wikidata description; 5 live sources; review by codex: pass"},"score":1.0}}