{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.phosphatidylcholine","code":"thing-q650187","url":"https://ver.cy/models/thing/q650187/","name":"phosphatidylcholine","alternateNames":["PC(15:0/22:5(4Z,7Z,10Z,13Z,16Z))","PC(15:0/20:3(5Z,8Z,11Z))","16:0/12-Hete PC","16:0/5-Hete-PC","3-(Hexadecanoyloxy)-2-{[8-(3-octyloxiran-2-yl)octanoyl]oxy}propyl 2-(trimethylazaniumyl)ethyl phosphate","PC(22:4(7Z,10Z,13Z,16Z)/22:5(4Z,7Z,10Z,13Z,16Z))","1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholin","(2-{[3-(hexadecanoyloxy)-2-(octadec-9-enoyloxy)propyl phosphonato]oxy}ethyl)trimethylazanium","[(2R)-2-henicosanoyloxy-3-octadecanoyloxypropyl] 2-(trimethylazaniumyl)ethyl phosphate","[(2R)-3-decanoyloxy-2-tetradecanoyloxypropyl] 2-(trimethylazaniumyl)ethyl phosphate","[(2R)-3-pentadecanoyloxy-2-tridecanoyloxypropyl] 2-(trimethylazaniumyl)ethyl phosphate","[(2R)-2-[(8Z,11Z)-icosa-8,11-dienoyl]oxy-3-octadecanoyloxypropyl] 2-(trimethylazaniumyl)ethyl phosphate"],"kind":"thing","status":"research-draft","version":"0.2.0-wave.3","language":"en","classifiers":{"family":"Thing Registry","category":"Physical world and living systems","entryKind":"thing","plane":"PHY","domain":["PHY.MAT"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"A class of glycerophospholipids with a choline head group, the most abundant phospholipid in animal cell membranes and in egg yolk and soy lecithin, existing as many molecular species that differ in their two fatty acid chains, including oxidised forms such as HETE-containing species and hundreds of species catalogued in lipid databases; phosphatidylcholine forms membrane bilayers, is a source of choline and signalling lipids, and is used as an emulsifier and in liposomes.","purpose":"Let an agent explain phosphatidylcholine and its molecular species, relay structure, biosynthesis and functions from biochemistry references, describe uses in food and pharmaceuticals, and distinguish it from other phospholipids and from lecithin as a mixture.","scope":{"in":[],"out":[],"boundaries":[]},"distinguishingFeatures":["Choline head group","Bilayer-forming","Vast species diversity","Food and drug uses"],"structure":{"bundles":[{"id":"understand","name":"Understand","description":"What phosphatidylcholine is.","layers":[{"id":"structure","name":"Structure","description":"Structure and species.","findings":[{"id":"structure-finding","name":"Structure","description":"Structure.","questions":[{"text":"What is the structure of phosphatidylcholine, and how do molecular species differ?","kind":"definition"},{"text":"Is the question about phosphatidylcholine, lecithin or another phospholipid?","kind":"boundary"}]}]},{"id":"nomenclature","name":"Nomenclature","description":"Nomenclature.","findings":[{"id":"nomenclature-finding","name":"Nomenclature","description":"Nomenclature.","questions":[{"text":"How are species named in shorthand such as PC 16:0/18:1, and how are they catalogued?","kind":"definition"},{"text":"Which entry fits the specific species?","kind":"action"}]}]}]},{"id":"biology","name":"Biology","description":"Biology.","layers":[{"id":"synthesis","name":"Synthesis","description":"Biosynthesis.","findings":[{"id":"synthesis-finding","name":"Synthesis","description":"Synthesis.","questions":[{"text":"How is phosphatidylcholine made by the Kennedy pathway and methylation?","kind":"provenance"},{"text":"Which entry fits phospholipid biosynthesis?","kind":"action"}]}]},{"id":"functions","name":"Functions","description":"Functions.","findings":[{"id":"functions-finding","name":"Functions","description":"Functions.","questions":[{"text":"What roles does it play in membranes, lipoproteins, bile and signalling, including oxidised species in inflammation?","kind":"provenance"},{"text":"Which references are standard?","kind":"provenance"}]}]}]},{"id":"use","name":"Use","description":"Uses and health.","layers":[{"id":"uses","name":"Uses","description":"Food and pharma uses.","findings":[{"id":"uses-finding","name":"Uses","description":"Uses.","questions":[{"text":"How is phosphatidylcholine used as an emulsifier, in liposomes and drug delivery?","kind":"provenance"},{"text":"Which entry fits liposome?","kind":"action"}]}]},{"id":"health","name":"Health","description":"Health and supplements.","findings":[{"id":"health-finding","name":"Health","description":"Health.","questions":[{"text":"What does evidence say about phosphatidylcholine supplements and choline nutrition, with findings attributed?","kind":"provenance"},{"text":"Is the user asking for personal supplement advice, which needs a professional?","kind":"boundary"}]}]}]},{"id":"context","name":"Context","description":"Methods and history.","layers":[{"id":"methods","name":"Methods","description":"Lipidomics.","findings":[{"id":"methods-finding","name":"Methods","description":"Methods.","questions":[{"text":"How are phosphatidylcholine species measured by mass spectrometry in lipidomics?","kind":"provenance"},{"text":"Which sources are cited?","kind":"provenance"}]}]},{"id":"history","name":"History","description":"History.","findings":[{"id":"history-finding","name":"History","description":"History.","questions":[{"text":"How was lecithin discovered by Gobley, and how did phospholipid science develop?","kind":"provenance"},{"text":"Which entry fits the history of biochemistry?","kind":"action"}]}]}]}]},"agentConduct":{"may":["explain structure and species","relay biosynthesis and functions","describe uses","distinguish from related lipids"],"mustNot":[],"requiresHuman":[]},"ethics":{"considerations":[],"affectedParties":[]},"owners":{"steward":"","roles":[],"masterSystems":[]},"relations":[{"target":"Q407595","type":"parent","note":"registry parent class"},{"target":"Q420004","type":"parent","note":"registry parent class"},{"target":"glycerophospholipid","type":"related","note":"in registry terms"},{"target":"metabolite","type":"related","note":"in registry terms"},{"target":"cell membrane","type":"related","note":"as the main phospholipid"},{"target":"lecithin","type":"related","note":"the commercial mixture"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.phosphatidylcholine","Wikidata: Q650187 (https://www.wikidata.org/wiki/Q650187)","LIPID MAPS: GP01 glycerophosphocholines","ChEBI: CHEBI:49183 phosphatidylcholine"]},"properties":{"applicability":"required","items":["share of membrane phospholipid: about 40-50 percent - mammalian cells"]},"recognition":{"applicability":"required","items":["Choline-headed glycerophospholipid","Many species by fatty acid composition, including oxidised forms","Phosphatidylethanolamine and sphingomyelin are other membrane lipids; lecithin is a mixture rich in phosphatidylcholine","Not visible; a waxy or oily lipid in bulk."]},"capabilities":{"applicability":"required","items":["explain structure and species","relay biosynthesis and functions","describe uses","distinguish from related lipids"]},"hazards":{"applicability":"required","items":["Confusing species and nomenclature","Overstating health supplement claims","Oxidation in storage"]},"interfaces":{"applicability":"required","items":["Food additive rules for lecithin (E322)","Pharmacopoeial standards for phospholipid excipients","Lipid nomenclature conventions"]},"context":{"applicability":"required","items":["Membrane structure, choline source and emulsification.","phosphatidylcholine species by fatty acid chains, such as PC 16:0/18:1","polyunsaturated species with arachidonic and docosapentaenoic acids","oxidised phosphatidylcholines including HETE-containing species","lysophosphatidylcholine","lecithin as a natural mixture","synthetic phosphatidylcholines for liposomes"]}},"sources":[],"openQuestions":["Should lecithin and lysophosphatidylcholine be separate entries?","How should lipid databases be linked?","The registry entry has merged aliases naming specific molecular species; should they be split off?","Which entry fits the specific species?","Which entry fits phospholipid biosynthesis?","Which entry fits liposome?"],"resources":{"spec":"/models/things/publications/thing-q650187/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q650187/spec.json"],"providers":["Claude"],"researchStatus":"unreviewed","generatedAt":"2026-09-13T01:44:01Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"derived","ethics":"missing","owners":"missing","relations":"filled","interaction.identity":"filled","interaction.properties":"filled","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"missing"},"notes":{"agentConduct":"Affordances listed as what may be done; prohibitions collected from the text.","sources":"Written from model knowledge without web access; claims are unverified."},"score":0.794}}