{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.epithelial-to-mesenchymal-transition","code":"thing-q74419","url":"https://ver.cy/models/thing/q74419/","name":"epithelial to mesenchymal transition","alternateNames":["cardiac epithelial to mesenchymal transition","epicardial cell to mesenchymal cell transition","mesodermal to mesenchymal transition involved in gastrulation","neural crest formation","clearance of cells from fusion plate by epithelial to mesenchymal transition"],"kind":"thing","status":"published","version":"0.2.0-wave.4","language":"en","classifiers":{"family":"Thing Registry","category":"Activities and processes","entryKind":"thing","plane":"ACT","domain":["ACT.PRC"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"A biological process in which epithelial cells, which normally stick together in sheets, lose their adhesion and take on the mobile, migratory character of mesenchymal cells; it is essential to normal embryonic development and wound healing, and a related process contributes to how some cancers spread. The registry aliases name specific developmental instances such as neural crest formation and cardiac and gastrulation transitions. This is a scientific topic described at a general level.","purpose":"Let an agent explain epithelial to mesenchymal transition, relay its role in development, healing and disease from biology sources at a general level, describe the specific instances its aliases name, and distinguish it from the reverse transition.","scope":{"in":[],"out":[],"boundaries":[]},"distinguishingFeatures":["Loss of cell adhesion","Gain of migratory character","Key in development","Linked to cancer spread"],"structure":{"bundles":[{"id":"understand","name":"Understand","description":"What the transition is.","layers":[{"id":"definition","name":"Definition","description":"Definition.","findings":[{"id":"definition-finding","name":"Definition","description":"Definition.","questions":[{"text":"What is epithelial to mesenchymal transition, and how does it differ from the reverse process?","kind":"definition"},{"text":"Is the question about a specific developmental instance?","kind":"boundary"}]}]},{"id":"instances","name":"Instances","description":"Named instances.","findings":[{"id":"instances-finding","name":"Instances","description":"Instances.","questions":[{"text":"What are neural crest formation and cardiac and gastrulation transitions?","kind":"definition"},{"text":"Which entry fits the specific instance?","kind":"action"}]}]}]},{"id":"development","name":"Development","description":"Development.","layers":[{"id":"embryo","name":"Embryo","description":"Embryonic role.","findings":[{"id":"embryo-finding","name":"Embryo","description":"Embryo.","questions":[{"text":"How does the transition shape embryonic development?","kind":"provenance"},{"text":"Which references are standard?","kind":"provenance"}]}]},{"id":"healing","name":"Healing","description":"Wound healing.","findings":[{"id":"healing-finding","name":"Healing","description":"Healing.","questions":[{"text":"How does the transition support wound healing?","kind":"provenance"},{"text":"Which sources are cited?","kind":"provenance"}]}]}]},{"id":"disease","name":"Disease","description":"Disease.","layers":[{"id":"cancer","name":"Cancer","description":"Cancer link.","findings":[{"id":"cancer-finding","name":"Cancer","description":"Cancer.","questions":[{"text":"How is a related transition linked to how cancers spread, as sources describe?","kind":"provenance"},{"text":"Is the link stated at a general level?","kind":"boundary"}]}]},{"id":"fibrosis","name":"Fibrosis","description":"Fibrosis.","findings":[{"id":"fibrosis-finding","name":"Fibrosis","description":"Fibrosis.","questions":[{"text":"How is the transition associated with fibrosis?","kind":"provenance"},{"text":"Which sources are cited?","kind":"provenance"}]}]}]},{"id":"context","name":"Context","description":"Mechanism.","layers":[{"id":"mechanism","name":"Mechanism","description":"Mechanism.","findings":[{"id":"mechanism-finding","name":"Mechanism","description":"Mechanism.","questions":[{"text":"What molecular signals drive the transition, in general terms?","kind":"provenance"},{"text":"Which sources are cited?","kind":"provenance"}]}]},{"id":"reverse","name":"Reverse","description":"Reverse process.","findings":[{"id":"reverse-finding","name":"Reverse","description":"Reverse.","questions":[{"text":"What is the reverse mesenchymal to epithelial transition?","kind":"provenance"},{"text":"Which entry fits the reverse process?","kind":"action"}]}]}]}]},"agentConduct":{"may":["Explain epithelial to mesenchymal transition and its roles in development, healing and disease.","Distinguish it from the reverse transition.","Cite research findings with sources."],"mustNot":["Overstate its link to cancer or claim it as a cure target.","Give personal medical advice based on research findings.","Present preliminary laboratory results as established.","Promote unproven treatments claiming to block it."],"requiresHuman":["Using research on it in a clinical decision."]},"ethics":{"considerations":["Cancer patients are vulnerable to hype and false hope.","Accurate science communication protects trust."],"affectedParties":["Patients","Researchers","Readers of health news"]},"owners":{"steward":"Nobody: a biological process; researchers study it.","roles":[],"masterSystems":[]},"relations":[{"target":"Q14883191","type":"parent","note":"registry parent class"},{"target":"cell differentiation","type":"related","note":"related"},{"target":"mesenchymal to epithelial transition","type":"related"},{"target":"embryonic development","type":"related"},{"target":"wound healing","type":"related"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.epithelial-to-mesenchymal-transition","Wikidata: Q74419 (https://www.wikidata.org/wiki/Q74419)"]},"properties":{"applicability":"not-applicable","items":["starting cells: epithelial cells note","resulting cells: mesenchymal cells note","registry parent: mesenchymal cell differentiation note"]},"recognition":{"applicability":"optional","items":["Epithelial cells becoming migratory mesenchymal cells","Neural crest formation, cardiac and gastrulation transitions","The reverse mesenchymal to epithelial transition restores adhesion","Not a visible object; a cellular change observed under the microscope as cells detach and migrate."]},"capabilities":{"applicability":"required","items":["explain the process","relay its role in development","relay its role in disease generally","distinguish it from the reverse process"]},"hazards":{"applicability":"required","items":["Overstating the cancer link","Confusing with the reverse transition","Conflating developmental instances"]},"interfaces":{"applicability":"required","items":["Scientific consensus in cell biology"]},"context":{"applicability":"required","items":["Converting adherent epithelial cells into migratory mesenchymal cells.","developmental transition","wound-healing transition","cancer-associated transition"]}},"sources":[{"title":"Wikidata item Q74419: epithelial to mesenchymal transition","url":"https://www.wikidata.org/wiki/Q74419","note":"identity and sense of the item"},{"title":"Wikipedia: Epithelial–mesenchymal transition","url":"https://en.wikipedia.org/wiki/Epithelial%E2%80%93mesenchymal_transition","note":"general description of the item"}],"openQuestions":["Should developmental instances be separate entries?","How should the cancer link be qualified?","How should the reverse process be linked?"],"resources":{"spec":"/models/things/publications/thing-q74419/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q74419/spec.json"],"providers":["Claude"],"researchStatus":"unreviewed","generatedAt":"2026-09-14T03:25:52Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"not-applicable","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-06T19:52:01+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass","interaction.properties":"Plane ACT: no invented physical properties."},"score":1.0}}