{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.quinolizidine-alkaloid","code":"thing-q76515995","url":"https://ver.cy/models/thing/q76515995/","name":"quinolizidine alkaloid","alternateNames":["11-[(16-Hydroxy-5,7,11,19-tetraoxapentacyclo[10.8.0.02,10.04,8.013,18]icosa-2,4(8),9,13(18),14,16-hexaen-17-yl)methyl]-7,11-diazatricyclo[7.3.1.02,7]trideca-2,4-dien-6-one","11-[(16-Hydroxy-5,7,11,19-tetraoxapentacyclo[10.8.0.02,10.04,8.013,18]icosa-2,4(8),9,13(18),14,16-hexaen-15-yl)methyl]-7,11-diazatricyclo[7.3.1.02,7]trideca-2,4-dien-6-one","Feruloyllupinine","octahydro-1H-quinolizin-1-ylmethyl 3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate","2,3,4,6,7,8,9,9a-octahydro-1H-quinolizin-1-ylmethyl 3-[3-methoxy-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyphenyl]prop-2-enoate","2,3,4,6,7,8,9,9a-octahydro-1H-quinolizin-1-ylmethyl 3-[3-methoxy-4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]prop-2-enoate","Nupharolutine","[(3R,6S,9R,9aS)-6-(furan-3-yl)-9-methyl-2,3,4,6,7,8,9,9a-octahydro-1H-quinolizin-3-yl]methanol","(3R,9S,9aR)-6-(furan-3-yl)-3,9-dimethyl-2,3,4,8,9,9a-hexahydro-1H-quinolizine","(16-oxo-7,15-diazatetracyclo[7.7.1.02,7.010,15]heptadecan-4-yl) 1H-pyrrole-2-carboxylate","[(1S,2S,9aR)-2-hydroxy-2,3,4,6,7,8,9,9a-octahydro-1H-quinolizin-1-yl]methyl 1H-pyrrole-2-carboxylate","[(1S,2S,4S,9S,10R,12R,13S)-12,13-dihydroxy-14-oxo-7,15-diazatetracyclo[7.7.1.02,7.010,15]heptadecan-4-yl] 1H-pyrrole-2-carboxylate"],"kind":"thing","status":"published","version":"0.2.0-wave.5","language":"en","classifiers":{"family":"Thing Registry","category":"Physical world and living systems","entryKind":"thing","plane":"PHY","domain":["PHY.MAT"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"A class of alkaloids containing a quinolizidine ring system, found mainly in legumes of the family Fabaceae, especially lupins (Lupinus) and related genera; examples include lupinine, sparteine, lupanine and cytisine.","purpose":"Let an agent describe quinolizidine alkaloids, their sources, structures and toxicity in general terms, and point to food safety guidance, without giving medical advice.","scope":{"in":[],"out":[],"boundaries":[]},"distinguishingFeatures":["Bitter lupins contain high levels; sweet lupin varieties have low levels.","Cytisine is used as a smoking cessation medicine in some countries.","Debittering is needed before eating bitter lupin seeds."],"structure":{"bundles":[{"id":"compound","name":"Compound","description":"Which alkaloid.","layers":[{"id":"identity","name":"Identity","description":"Name and identifiers.","findings":[{"id":"compound","name":"Compound","description":"Name and IDs.","questions":[{"text":"Which compound?","kind":"provenance"},{"text":"What are its identifiers?","kind":"provenance"}]}]},{"id":"structure","name":"Structure","description":"Skeleton type.","findings":[{"id":"structure","name":"Structure","description":"Type.","questions":[{"text":"Which structural type?","kind":"provenance"},{"text":"How many rings?","kind":"measurement"}]}]}]},{"id":"occurrence","name":"Occurrence","description":"Sources.","layers":[{"id":"plants","name":"Plants","description":"Species.","findings":[{"id":"plant-source","name":"Plant source","description":"Species and part.","questions":[{"text":"Which plants contain it?","kind":"provenance"},{"text":"At what levels?","kind":"measurement"}]}]},{"id":"foods","name":"Foods","description":"Lupin products.","findings":[{"id":"food-content","name":"Food content","description":"Measured alkaloids, method, units, fresh weight or dry matter, and the survey or source.","questions":[{"text":"What levels occur in foods?","kind":"measurement"},{"text":"From which survey?","kind":"provenance"}]}]}]},{"id":"toxicology","name":"Toxicology","description":"Effects.","layers":[{"id":"effects","name":"Effects","description":"Mechanism.","findings":[{"id":"toxic-effect","name":"Toxic effect","description":"Effect and source.","questions":[{"text":"What effects are reported?","kind":"provenance"},{"text":"At what exposure?","kind":"measurement"}]}]},{"id":"guidance","name":"Guidance","description":"Limits.","findings":[{"id":"guidance-value","name":"Guidance value","description":"Value and body.","questions":[{"text":"Which guidance values exist?","kind":"provenance"},{"text":"From which assessment?","kind":"provenance"}]}]}]},{"id":"uses","name":"Uses","description":"Pharmacology.","layers":[{"id":"medicines","name":"Medicines","description":"Approved uses.","findings":[{"id":"medicine","name":"Medicine","description":"Compound and approval.","questions":[{"text":"Which compounds are medicines?","kind":"provenance"},{"text":"Where approved?","kind":"provenance"}]}]},{"id":"agriculture","name":"Agriculture","description":"Breeding.","findings":[{"id":"breeding","name":"Breeding","description":"Varieties.","questions":[{"text":"How are low-alkaloid varieties bred?","kind":"provenance"},{"text":"Which varieties?","kind":"provenance"}]}]}]}]},"agentConduct":{"may":["describe chemistry and point to food safety guidance"],"mustNot":["give dosing advice","advise eating raw bitter lupins"],"requiresHuman":["suspected poisoning, which goes to poison centres"]},"ethics":{"considerations":["food safety"],"affectedParties":["consumers","farmers"]},"owners":{"steward":"nobody; a compound class","roles":[],"masterSystems":["ChEBI","PubChem"]},"relations":[{"target":"Q70702","type":"parent","note":"registry parent class"},{"target":"Q76516005","type":"parent","note":"registry parent class"},{"target":"alkaloid","type":"related","note":"chemistry"},{"target":"lupin","type":"related","note":"plant source"},{"target":"lupin poisoning","type":"related","note":"toxicity"},{"target":"quinolizidine ring","type":"contains","note":"structure"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.quinolizidine-alkaloid","Wikidata: Q76515995 (https://www.wikidata.org/wiki/Q76515995)","ChEBI: CHEBI:26515 quinolizidine alkaloid class","ChEBI or PubChem: per compound individual alkaloids"]},"properties":{"applicability":"not-applicable","items":[]},"recognition":{"applicability":"required","items":["Appearance cannot establish identity or concentration; chromatography and mass spectrometry are used","Pure compounds are typically crystalline solids or oils."]},"capabilities":{"applicability":"required","items":["describe structures and examples","describe occurrence in lupins","explain food safety limits in general terms","point to toxicology sources"]},"hazards":{"applicability":"required","items":["Anticholinergic poisoning from improperly debittered lupins","Livestock poisoning"]},"interfaces":{"applicability":"required","items":["Food safety assessments of lupin alkaloids, such as the EFSA opinion (2019)","National limits for alkaloids in lupin foods where set"]},"context":{"applicability":"required","items":["Plant defence compounds; relevant to food safety of lupin products and to pharmacology.","lupinine type","sparteine and lupanine types","cytisine type","matrine type"]}},"sources":[{"title":"Q76515995","url":"https://www.wikidata.org/wiki/Q76515995","note":"identity of the registry item, labels and sitelinks"},{"title":"Quinolizidine alkaloids","url":"","note":"class description"},{"title":"Quinolizidine alkaloid - CHEBI:26515","url":"https://www.ebi.ac.uk/chebi/CHEBI:26515","note":"Chemical class identity and class-level identifier."},{"title":"Scientific opinion on quinolizidine alkaloids in feed and food, particularly lupins and lupin-derived products","url":"https://www.efsa.europa.eu/en/efsajournal/pub/5860","note":"2019 assessment, structures, occurrence, analytical methods, bitter and sweet lupins, human and animal toxicity."},{"title":"Alkaloids and allergies: current data on health risks from lupin seeds in food","url":"https://www.bfr.bund.de/en/opinions/alkaloids-and-allergies-current-data-on-health-risks-from-lupin-seeds-in-food/","note":"Variable alkaloid profiles and concentrations, analytical limitations and food-safety context."},{"title":"Cytisinicline (cytisine)","url":"https://awttc.nhs.wales/accessing-medicines/medicine-recommendations/cytisinicline-cytisine/","note":"Cytisine's medicinal use for smoking cessation and its alternative name cytisinicline."}],"openQuestions":["The registry merges individual compounds named by systematic names; they should be separate entries."],"resources":{"spec":"/models/things/publications/thing-q76515995/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q76515995/spec.json"],"providers":["Claude"],"researchStatus":"unreviewed","generatedAt":"2026-10-22T10:42:11Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"not-applicable","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-22T10:47:00+00:00: completeness 1.00; sense: Wikidata description; 4 live sources; review by codex: pass","interaction.properties":"A compound class: properties belong to each compound."},"score":1.0}}