{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.enzyme","code":"thing-q8047","url":"https://ver.cy/models/thing/q8047/","name":"enzyme","alternateNames":[],"kind":"thing","status":"published","version":"0.2.0-wave.2","language":"en","classifiers":{"family":"Thing Registry","category":"Physical world and living systems","entryKind":"thing","plane":"PHY","domain":["PHY.MAT"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"A protein, or occasionally RNA, that catalyses a biochemical reaction by lowering its activation energy without being consumed, with high specificity for substrates; enzymes drive metabolism, digestion, DNA replication and repair, and are used in industry, medicine and diagnostics, and are classified by the reactions they catalyse.","purpose":"Let an agent explain enzymes, their kinetics and classification, support research and industrial questions, and address enzyme-related health topics at a general level.","scope":{"in":[],"out":[],"boundaries":[]},"distinguishingFeatures":["Biological catalysts","Substrate specificity","Regulated activity","Classified by reaction"],"structure":{"bundles":[{"id":"mechanism","name":"Mechanism","description":"How enzymes work.","layers":[{"id":"catalysis","name":"Catalysis","description":"Lowering activation energy.","findings":[{"id":"catalysis-finding","name":"Catalysis","description":"Catalysis.","questions":[{"text":"How does this enzyme catalyse its reaction, and what is its active site?","kind":"definition"},{"text":"Which cofactors does it need?","kind":"provenance"}]}]},{"id":"kinetics","name":"Kinetics","description":"Rates.","findings":[{"id":"kinetics-finding","name":"Kinetics","description":"Kinetics.","questions":[{"text":"What are the Km and Vmax of this enzyme, and what do they mean?","kind":"measurement"},{"text":"How do inhibitors affect the rate?","kind":"definition"}]}]}]},{"id":"classify","name":"Classify","description":"Nomenclature.","layers":[{"id":"ec","name":"EC","description":"EC classification.","findings":[{"id":"ec-finding","name":"EC","description":"Classification.","questions":[{"text":"What is the EC number of this enzyme, and what does each part mean?","kind":"provenance"},{"text":"Which database records it?","kind":"provenance"}]}]},{"id":"regulation","name":"Regulation","description":"Control of activity.","findings":[{"id":"regulation-finding","name":"Regulation","description":"Regulation.","questions":[{"text":"How is this enzyme regulated, by allostery, modification or expression?","kind":"provenance"},{"text":"What conditions affect its activity?","kind":"definition"}]}]}]},{"id":"uses","name":"Uses","description":"Applications.","layers":[{"id":"industry","name":"Industry","description":"Industrial enzymes.","findings":[{"id":"industry-finding","name":"Industry","description":"Industry.","questions":[{"text":"How are enzymes used in food, detergents, textiles and biofuels?","kind":"provenance"},{"text":"Which safety rules apply to workers?","kind":"provenance"}]}]},{"id":"medicine","name":"Medicine","description":"Diagnostics and therapy.","findings":[{"id":"medicine-finding","name":"Medicine","description":"Medicine.","questions":[{"text":"How are enzymes used in diagnostics and as therapies, in general terms?","kind":"provenance"},{"text":"Is the user asking about their own enzyme test results?","kind":"boundary"}]}]}]},{"id":"learn","name":"Learn","description":"Study.","layers":[{"id":"deficiency","name":"Deficiency","description":"Enzyme deficiencies.","findings":[{"id":"deficiency-finding","name":"Deficiency","description":"Deficiencies.","questions":[{"text":"What is known about this enzyme deficiency, according to medical sources?","kind":"provenance"},{"text":"Which specialist should be consulted?","kind":"provenance"}]}]},{"id":"teach","name":"Teach","description":"Teaching.","findings":[{"id":"teach-finding","name":"Teach","description":"Teaching.","questions":[{"text":"How can enzyme action be demonstrated safely in class?","kind":"action"},{"text":"Which misconceptions arise?","kind":"provenance"}]}]}]}]},"agentConduct":{"may":["Explain how enzymes work, their classification and uses, citing sources.","Look up enzyme data in curated databases and report it with its source."],"mustNot":["Help produce or enhance biological toxins or agents to harm people, whoever is asking.","Advise taking enzyme supplements to treat a disease without evidence.","Present enzymes in products as safe for people with allergies when they are not."],"requiresHuman":["Medical decisions on enzyme replacement therapy.","Releasing engineered enzymes or organisms outside contained use."]},"ethics":{"considerations":["Enzyme deficiencies cause serious disease; access to treatment is unequal.","Industrial enzymes can cause occupational allergy and asthma."],"affectedParties":["Patients with enzyme disorders","Industrial workers","Consumers"]},"owners":{"steward":"Nobody: a natural molecule; the Enzyme Commission system names them.","roles":[],"masterSystems":["Curated enzyme databases"]},"relations":[{"target":"Q426799","type":"parent","note":"registry parent class"},{"target":"Q8054","type":"parent","note":"registry parent class"},{"target":"protein","type":"related","note":"category"},{"target":"biocatalysts","type":"related","note":"category"},{"target":"metabolic pathway","type":"related","note":"reactions"},{"target":"restriction enzyme","type":"related","note":"example class"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.enzyme","Wikidata: Q8047 (https://www.wikidata.org/wiki/Q8047)","EC number: Enzyme Commission classification nomenclature"]},"properties":{"applicability":"required","items":["Molecular mass:  kilodaltons - Molecular mass is determined from molecular composition or measured by mass spectrometry, with subunit and assembled complex values distinguished.","Hydrodynamic radius:  nanometers - Hydrodynamic radius is measured in solution by diffusion or light scattering methods under specified conditions.","Solubility:  milligrams per milliliter - Solubility is measured in a specified solvent at a stated temperature, pH and ionic strength."]},"recognition":{"applicability":"required","items":["Named with the suffix -ase","Classified by EC numbers","Hormones signal rather than catalyse","Not visible; proteins in cells and laboratory preparations."]},"capabilities":{"applicability":"required","items":["explain enzyme mechanism and kinetics","classify enzymes by EC number","describe industrial and medical uses","explain enzyme deficiencies in general terms"]},"hazards":{"applicability":"required","items":["Enzyme allergies in industry","Agents giving medical advice on enzyme deficiencies","Misinterpreting kinetics"]},"interfaces":{"applicability":"required","items":["IUBMB enzyme nomenclature","Regulations on enzymes in food and industry","Medicines regulation for enzyme therapies"]},"context":{"applicability":"required","items":["Biochemistry, biotechnology and medicine.","oxidoreductases","transferases","hydrolases","lyases, isomerases, ligases and translocases","ribozymes"]}},"sources":[{"title":"Wikidata item Q8047: enzyme","url":"https://www.wikidata.org/wiki/Q8047","note":"identity and sense of the item"},{"title":"Wikipedia: Enzyme","url":"https://en.wikipedia.org/wiki/Enzyme","note":"general description of the item"}],"openQuestions":["Should each enzyme class be a separate entry?","How should enzyme databases be linked?","How should clinical guidance be linked?"],"resources":{"spec":"/models/things/publications/thing-q8047/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q8047/spec.json"],"providers":["Claude"],"researchStatus":"unreviewed","generatedAt":"2026-09-11T19:32:26Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"filled","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-07T10:10:32+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass"},"score":1.0}}