{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.blood-coagulation-disease","code":"thing-q890200","url":"https://ver.cy/models/thing/q890200/","name":"blood coagulation disease","alternateNames":["coagulation protein disease","haemorrhagic disease of the newborn","hereditary combined deficiency of vitamin K-dependent clotting factors","consumption coagulopathy","inherited blood coagulation disease","coagulation factor deficiency","vascular hemorrhagic disorder","intravascular coagulation","blood platelet disease","factor XII deficiency","reduced prothrombin activity","fibrinogen abnormality"],"kind":"thing","status":"published","version":"0.2.0-wave.4","language":"en","classifiers":{"family":"Thing Registry","category":"Information and virtual systems","entryKind":"thing","plane":"INF","domain":["INF.KNW"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"A condition in which the blood's ability to coagulate and form clots is impaired, including inherited coagulation factor deficiencies such as haemophilia A and B and von Willebrand disease, the rare hereditary combined deficiency of vitamin K-dependent factors, acquired conditions such as vitamin K deficiency bleeding of the newborn, liver disease and consumption coagulopathy, and drug-induced disorders; serious bleeding is an emergency and these conditions are managed by haematologists.","purpose":"Let an agent explain blood coagulation diseases and their kinds, relay mechanisms, diagnosis and treatment from haematology references in general terms, route people with bleeding or a diagnosis to clinicians and emergency services, and distinguish coagulation disorders from platelet disorders, vascular bleeding and thrombophilia.","scope":{"in":[],"out":[],"boundaries":[]},"distinguishingFeatures":["Blood clot formation is impaired.","Conditions may be inherited or acquired.","Impaired coagulation creates a bleeding tendency.","These conditions require specialist care."],"structure":{"bundles":[{"id":"emergency","name":"Emergency","description":"Serious bleeding.","layers":[{"id":"act","name":"Act","description":"Act now.","findings":[{"id":"act-finding","name":"Act","description":"Act.","questions":[{"text":"Does the user describe heavy or uncontrolled bleeding, head injury or bleeding in a known disorder, which needs emergency care?","kind":"boundary"},{"text":"Has the agent directed the user to emergency services or their haemophilia centre before anything else?","kind":"action"}]}]},{"id":"signs","name":"Signs","description":"Warning signs.","findings":[{"id":"signs-finding","name":"Signs","description":"Signs.","questions":[{"text":"What signs suggest a bleeding disorder, as authorities list them?","kind":"definition"},{"text":"Which entry fits emergency medical services?","kind":"action"}]}]}]},{"id":"understand","name":"Understand","description":"What these diseases are.","layers":[{"id":"definition","name":"Definition","description":"Definition and kinds.","findings":[{"id":"definition-finding","name":"Definition","description":"Definition.","questions":[{"text":"What are blood coagulation diseases, and how do inherited, acquired, newborn and consumption forms differ?","kind":"definition"},{"text":"Is the question about the group or a personal case needing a clinician?","kind":"boundary"}]}]},{"id":"mechanism","name":"Mechanism","description":"Mechanism.","findings":[{"id":"mechanism-finding","name":"Mechanism","description":"Mechanism.","questions":[{"text":"How does the coagulation cascade work, and how do factor deficiencies and vitamin K affect it?","kind":"provenance"},{"text":"Which entry fits the specific disorder?","kind":"action"}]}]}]},{"id":"care","name":"Care","description":"Diagnosis and treatment.","layers":[{"id":"diagnosis","name":"Diagnosis","description":"Diagnosis.","findings":[{"id":"diagnosis-finding","name":"Diagnosis","description":"Diagnosis.","questions":[{"text":"How are coagulation disorders diagnosed with clotting times, factor assays and genetics, in general terms?","kind":"provenance"},{"text":"Which references are standard?","kind":"provenance"}]}]},{"id":"treatment","name":"Treatment","description":"Treatment.","findings":[{"id":"treatment-finding","name":"Treatment","description":"Treatment.","questions":[{"text":"What treatments exist, from factor replacement and gene therapy to vitamin K and management of DIC, as guidelines state?","kind":"provenance"},{"text":"Which sources are cited?","kind":"provenance"}]}]}]},{"id":"context","name":"Context","description":"Living and history.","layers":[{"id":"living","name":"Living","description":"Living with a disorder.","findings":[{"id":"living-finding","name":"Living","description":"Living.","questions":[{"text":"How do people with bleeding disorders manage daily life, and where are support organisations?","kind":"action"},{"text":"Which entry fits haemophilia organisations?","kind":"action"}]}]},{"id":"history","name":"History","description":"History.","findings":[{"id":"history-finding","name":"History","description":"History.","questions":[{"text":"How did understanding and treatment of haemophilia develop, including the contaminated blood scandals, as historians describe?","kind":"provenance"},{"text":"Which entry fits the history of haematology?","kind":"action"}]}]}]}]},"agentConduct":{"may":["Explain the kinds of clotting disorders, inherited and acquired, from medical sources.","Point people to haemophilia and bleeding disorder centres.","Distinguish bleeding from clotting tendencies."],"mustNot":["Diagnose a coagulation disorder or interpret a person's clotting tests.","Advise starting, stopping or changing anticoagulants or factor therapy.","Disclose a person's bleeding disorder or carrier status without consent.","Advise a person with a bleeding disorder on surgery or injections without their care team."],"requiresHuman":["Any treatment decision for a person with a bleeding or clotting disorder."]},"ethics":{"considerations":["Wrong advice on blood thinners or clotting factors can cause fatal bleeding or clots.","Carrier status is genetic information that affects whole families."],"affectedParties":["Patients and carriers","Families","Clinicians"]},"owners":{"steward":"Nobody owns the condition; treating haematologists answer for care, and haemophilia centres keep patient registers.","roles":[],"masterSystems":["National haemophilia and bleeding disorder registries"]},"relations":[{"target":"Q102186671","type":"parent","note":"registry parent class"},{"target":"hemic system symptom","type":"related","note":"in registry terms"},{"target":"blood disorder","type":"related","note":"in general terms"},{"target":"haemophilia","type":"related","note":"the best known inherited form"},{"target":"platelet disorder","type":"related","note":"affecting primary haemostasis"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.blood-coagulation-disease","Wikidata: Q890200 (https://www.wikidata.org/wiki/Q890200)","ICD-10: D65-D69 coagulation defects and other haemorrhagic conditions","MeSH: D001778 Blood Coagulation Disorders"]},"properties":{"applicability":"not-applicable","items":["haemophilia A prevalence: about 1 in 5000 male births","von Willebrand disease: most common inherited bleeding disorder note","coagulation factors: 13 numbered count - traditional numbering"]},"recognition":{"applicability":"optional","items":["Disorder of the clotting cascade","Haemophilia, von Willebrand disease, factor deficiencies, vitamin K deficiency bleeding, consumption coagulopathy","Platelet disorders affect primary haemostasis; thrombophilia favours clots; vascular bleeding is vessel weakness","Not a visible object; bruising, prolonged bleeding or clotting."]},"capabilities":{"applicability":"required","items":["route emergencies first","explain kinds and mechanisms","relay diagnosis and treatment","distinguish related disorders"]},"hazards":{"applicability":"required","items":["Delayed treatment of serious bleeding","Agents giving personal medical advice","Confusing coagulation and platelet disorders"]},"interfaces":{"applicability":"required","items":["WFH and national haemophilia guidelines","Newborn vitamin K prophylaxis recommendations","Blood product and factor concentrate regulation"]},"context":{"applicability":"required","items":["Not applicable; a disease group.","inherited factor deficiencies such as haemophilia A and B","von Willebrand disease","rare deficiencies including combined vitamin K-dependent factor deficiency","vitamin K deficiency bleeding of the newborn","acquired coagulopathies from liver disease, anticoagulants and DIC","coagulation protein disorders causing thrombosis"]}},"sources":[{"title":"Wikidata item Q890200: blood coagulation disease","url":"https://www.wikidata.org/wiki/Q890200","note":"identity and sense of the item"},{"title":"Wikipedia: Coagulopathy","url":"https://en.wikipedia.org/wiki/Coagulopathy","note":"general description of the item"}],"openQuestions":["Should haemophilia, von Willebrand disease and DIC be separate primary entries?","How should haematology references be linked?","The registry entry has merged aliases naming distinct disorders; should they be split off?"],"resources":{"spec":"/models/things/publications/thing-q890200/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q890200/spec.json"],"providers":["Claude"],"researchStatus":"unreviewed","generatedAt":"2026-09-13T13:11:03Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"not-applicable","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-07T10:10:33+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass","interaction.properties":"Plane INF: no invented physical properties."},"score":1.0}}