{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.methsuximide","code":"thing-q906414","url":"https://ver.cy/models/thing/q906414/","name":"methsuximide","alternateNames":["(3S)-1,3-Dimethyl-3-phenylpyrrolidine-2,5-dione"],"kind":"thing","status":"published","version":"0.1.0-research.1","language":"en","classifiers":{"family":"Thing Registry","category":"Physical world and living systems","entryKind":"thing","plane":"PHY","domain":["PHY.MAT"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"Methsuximide is a synthetic succinimide anticonvulsant whose antiseizure activity is substantially mediated by its active metabolite, N-desmethylmethsuximide, and which is used for absence seizures resistant to other medicines.","purpose":"Enable an agent to recognise methsuximide, assess the identity and fitness of a material sample, and determine which handling or pharmaceutical-use decisions its evidence supports.","scope":{"in":["Molecular identity and authoritative substance identifiers for methsuximide","Sample grade, assay, impurities and analytical identity evidence","Physical form, measured properties and storage-dependent condition","Relationships to methsuximide-containing medicines and metabolic products","Substance handling hazards and jurisdiction-specific constraints"],"out":["Finished capsule formulations, excipients, packaging and product authorisations","Patient diagnosis, prescribing, dose adjustment and individual treatment outcomes","Independent models of N-desmethylmethsuximide and other succinimides","Manufacturing equipment and complete synthesis procedures","General models of epilepsy and absence seizures"],"boundaries":[]},"distinguishingFeatures":["Require molecular connectivity consistent with N,2-dimethyl-2-phenylsuccinimide; a succinimide class label alone cannot establish identity. [DailyMed label](https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=64a6ee88-c6b1-4e13-8208-b6772ef65a74)","Check the formula C12H13NO2 and PubChem CID 6476 together with a structure-specific analytical result; formula alone cannot distinguish isomers. [PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/Methsuximide)","Distinguish the parent compound from N-desmethylmethsuximide when assigning analytical results; the label explicitly distinguishes this metabolite in poisoning assessment. [DailyMed label](https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=64a6ee88-c6b1-4e13-8208-b6772ef65a74)","Treat Celontin as a linked medicine containing methsuximide, rather than identifying the capsule and its excipients as the pure substance. [DailyMed label](https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=64a6ee88-c6b1-4e13-8208-b6772ef65a74)"],"structure":{"bundles":[{"id":"methsuximide-identity","name":"Methsuximide identity","description":"Establishes which chemical entity the registry entry denotes.","layers":[{"id":"molecular-boundary","name":"Molecular boundary","description":"Defines the parent structure and separates neighbouring chemical entities.","findings":[{"id":"parent-structure-match","name":"Parent structure match","description":"Record structural identity evidence and the reference against which the candidate material was compared.","questions":[{"text":"Which authoritative structure defines methsuximide, including any specified stereochemical composition?","id":"parent-structure-match-q01","kind":"definition"},{"text":"Which analytical observations distinguish this sample from other succinimides and the N-desmethyl derivative?","id":"parent-structure-match-q02","kind":"measurement"}]}]},{"id":"identifier-reconciliation","name":"Identifier reconciliation","description":"Connects the registered substance to external chemical records without importing product identity.","findings":[{"id":"authority-linked-identifiers","name":"Authority-linked identifiers","description":"Maintain verified identifiers and candidate synonyms with their source and identity scope.","questions":[{"text":"Which CAS, PubChem, UNII and applicable EC records resolve to the same methsuximide structure?","id":"authority-linked-identifiers-q01","kind":"provenance"},{"text":"Does each encountered name denote methsuximide itself, a containing medicine or a different chemical entity?","id":"authority-linked-identifiers-q02","kind":"boundary"}]}]}]},{"id":"methsuximide-material-quality","name":"Methsuximide material quality","description":"Describes the composition and qualification of a particular methsuximide lot.","layers":[{"id":"assay-and-related-substances","name":"Assay and related substances","description":"Separates parent content from impurities and other sample components.","findings":[{"id":"selective-composition-evidence","name":"Selective composition evidence","description":"Require methods that quantify methsuximide with demonstrated selectivity for relevant accompanying compounds.","questions":[{"text":"What is the methsuximide mass fraction, on what reporting basis, and with what measurement uncertainty?","id":"selective-composition-evidence-q01","kind":"measurement"},{"text":"Which related substances, residual solvents and water measurements are required by the applicable specification?","id":"selective-composition-evidence-q02","kind":"definition"},{"text":"Can the assay resolve methsuximide from the impurities actually encountered in this lot?","id":"selective-composition-evidence-q03","kind":"measurement"}]}]},{"id":"grade-and-lot-disposition","name":"Grade and lot disposition","description":"Connects lot evidence to a qualified material use.","findings":[{"id":"supported-grade-claim","name":"Supported grade claim","description":"Treat grade and release status as documented conclusions rather than consequences of a supplier's substance name.","questions":[{"text":"Which dated specification and certificate support this lot's claimed methsuximide grade?","id":"supported-grade-claim-q01","kind":"provenance"},{"text":"Does the evidence permit the proposed analytical or manufacturing use, or require quarantine or retesting?","id":"supported-grade-claim-q02","kind":"action"}]}]}]},{"id":"methsuximide-physical-condition","name":"Methsuximide physical condition","description":"Records condition-dependent properties and changes during storage or preparation.","layers":[{"id":"phase-and-preparation-properties","name":"Phase and preparation properties","description":"Qualifies thermal and solubility observations with their experimental conditions.","findings":[{"id":"qualified-property-measurements","name":"Qualified property measurements","description":"Record measured methsuximide properties with sample composition, methods and conditions.","questions":[{"text":"What phase and melting interval does the qualified methsuximide sample exhibit, and is decomposition observed?","id":"qualified-property-measurements-q01","kind":"measurement"},{"text":"What solubility is demonstrated in the intended preparation medium at the stated temperature and pH?","id":"qualified-property-measurements-q02","kind":"measurement"},{"text":"Is any reported boiling point experimental, estimated or invalidated by decomposition?","id":"qualified-property-measurements-q03","kind":"provenance"}]}]},{"id":"storage-and-change","name":"Storage and change","description":"Tracks whether handling history compromises the lot's qualified condition.","findings":[{"id":"stability-supported-disposition","name":"Stability-supported disposition","description":"Base storage limits and retest decisions on evidence applicable to the actual methsuximide material and container.","questions":[{"text":"Which stability data support temperature, moisture and light controls for this bulk material or prepared solution?","id":"stability-supported-disposition-q01","kind":"provenance"},{"text":"After an excursion, which methsuximide assay or degradation measurements determine whether the material remains usable?","id":"stability-supported-disposition-q02","kind":"action"}]}]}]},{"id":"methsuximide-pharmaceutical-relations","name":"Methsuximide pharmaceutical relations","description":"Connects the substance to medicines and biological transformation while retaining separate entity boundaries.","layers":[{"id":"ingredient-to-medicine","name":"Ingredient to medicine","description":"Locates therapeutic claims on the appropriate medicine and jurisdiction.","findings":[{"id":"label-scoped-use","name":"Label-scoped use","description":"The cited US Celontin label identifies use for absence seizures refractory to other drugs; represent this as a product-label relationship. [DailyMed label](https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=64a6ee88-c6b1-4e13-8208-b6772ef65a74)","questions":[{"text":"Which dated medicine label supports the indication associated with this methsuximide-containing product?","id":"label-scoped-use-q01","kind":"provenance"},{"text":"Which strength, formulation and use restrictions belong to the linked medicine rather than to bulk methsuximide?","id":"label-scoped-use-q02","kind":"boundary"}]}]},{"id":"parent-and-metabolite-evidence","name":"Parent and metabolite evidence","description":"Separates administered chemical identity from analytes observed after administration.","findings":[{"id":"analyte-specific-interpretation","name":"Analyte-specific interpretation","description":"Attach biological measurements to their exact parent or metabolite analyte, matrix and sampling context.","questions":[{"text":"Does the result quantify methsuximide, N-desmethylmethsuximide or a combined analytical signal?","id":"analyte-specific-interpretation-q01","kind":"definition"},{"text":"What matrix, sampling time, units and assay selectivity qualify the result?","id":"analyte-specific-interpretation-q02","kind":"measurement"},{"text":"Which primary evidence establishes the metabolite's activity and persistence relative to methsuximide?","id":"analyte-specific-interpretation-q03","kind":"provenance"}]}]}]},{"id":"methsuximide-hazards-and-permissions","name":"Methsuximide hazards and permissions","description":"Supports evidence-based handling and distinguishes substance constraints from medicine regulation.","layers":[{"id":"bulk-handling-evidence","name":"Bulk handling evidence","description":"Establishes controls for the actual methsuximide material and operation.","findings":[{"id":"material-specific-exposure-controls","name":"Material-specific exposure controls","description":"Use applicable hazard records and exposure assessments for weighing, transfer, spills and disposal.","questions":[{"text":"Which dated SDS and jurisdictional GHS assessment apply to this methsuximide grade and physical form?","id":"material-specific-exposure-controls-q01","kind":"provenance"},{"text":"Is there an authoritative occupational exposure limit, or only a supplier or internal control limit?","id":"material-specific-exposure-controls-q02","kind":"definition"},{"text":"Which documented controls govern this quantity and operation, including spill collection and disposal?","id":"material-specific-exposure-controls-q03","kind":"action"}]}]},{"id":"clinical-and-regulatory-boundaries","name":"Clinical and regulatory boundaries","description":"Links restrictions to their source, subject and jurisdiction.","findings":[{"id":"restriction-scope","name":"Restriction scope","description":"The cited label contraindicates use in patients with succinimide hypersensitivity; retain this as a clinical restriction separate from workplace classification. [DailyMed label](https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=64a6ee88-c6b1-4e13-8208-b6772ef65a74)","questions":[{"text":"Which clinical warnings and interaction records should an agent retrieve before passing methsuximide information into a treatment workflow?","id":"restriction-scope-q01","kind":"action"},{"text":"Does a cited restriction govern the chemical substance, a pharmaceutical ingredient lot or a particular marketed medicine?","id":"restriction-scope-q02","kind":"boundary"},{"text":"Which authority and effective date support the applicable supply or use restriction?","id":"restriction-scope-q03","kind":"provenance"}]}]}]},{"id":"evidence-and-external-alignment","name":"Evidence and external alignment","description":"What the world already says about this thing, gathered so the model can be checked against it.","layers":[{"id":"reported-evidence","name":"Reported evidence","description":"Findings from the breadth pass, kept separate from the structural claims.","findings":[{"id":"evidence-confidence-notes","name":"Check these first","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these check these first hold for the sense of methsuximide this model covers, and on what evidence?","id":"evidence-confidence-notes-q01","kind":"provenance"}]},{"id":"evidence-identifiers","name":"Identifiers and schemes","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these identifiers and schemes hold for the sense of methsuximide this model covers, and on what evidence?","id":"evidence-identifiers-q01","kind":"provenance"}]},{"id":"evidence-real-world-use","name":"Real-world use","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these real-world use hold for the sense of methsuximide this model covers, and on what evidence?","id":"evidence-real-world-use-q01","kind":"provenance"}]},{"id":"evidence-measurements","name":"Typical measurements","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these typical measurements hold for the sense of methsuximide this model covers, and on what evidence?","id":"evidence-measurements-q01","kind":"provenance"}]},{"id":"evidence-failure-modes-and-hazards","name":"Failure modes and hazards","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these failure modes and hazards hold for the sense of methsuximide this model covers, and on what evidence?","id":"evidence-failure-modes-and-hazards-q01","kind":"provenance"}]},{"id":"evidence-regional-variation","name":"Regional variation","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these regional variation hold for the sense of methsuximide this model covers, and on what evidence?","id":"evidence-regional-variation-q01","kind":"provenance"}]},{"id":"evidence-neighbours","name":"Neighbouring kinds and how to tell them apart","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these neighbouring kinds and how to tell them apart hold for the sense of methsuximide this model covers, and on what evidence?","id":"evidence-neighbours-q01","kind":"provenance"}]}]}]}]},"agentConduct":{"may":["Describe methsuximide, its use in absence seizures and its warnings from official drug information.","Remind patients to keep taking anticonvulsants as prescribed and to talk to their doctor before changes.","Track stock and expiry in a pharmacy the agent is authorized to manage."],"mustNot":["Recommend, dose or adjust methsuximide for a particular patient.","Advise stopping an anticonvulsant suddenly.","Downplay warnings on mood changes, blood disorders or pregnancy.","Help anyone obtain it without a prescription."],"requiresHuman":["Any decision to start, stop or change an antiseizure medicine."]},"ethics":{"considerations":["Stopping antiseizure medicines abruptly can trigger dangerous seizures.","People with epilepsy face stigma and need accurate, respectful information."],"affectedParties":["People with epilepsy","Families and carers","Prescribers"]},"owners":{"steward":"The prescribing clinician answers for each use; medicines regulators authorize the product.","roles":[],"masterSystems":["National medicines registers"]},"relations":[{"target":"Q11173","type":"parent","note":"registry parent class"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.methsuximide","Wikidata: Q906414 (https://www.wikidata.org/wiki/Q906414)"]},"properties":{"applicability":"required","items":["Molecular identity agreement: confirmed | provisional | conflicting | untested; structure and analytical evidence required","Substance identifier mapping: Registry id, CAS number, PubChem CID, UNII and EC number where verified, each linked to its authority","Methsuximide assay: % mass fraction, with as-is or dry basis, method and uncertainty","Related substances and residuals: % or mg/kg by named analyte; method, detection limit and acceptance specification","Material grade: reference standard | research reagent | pharmaceutical ingredient | unspecified; supporting specification","Physical form and thermal behaviour: Observed phase; melting interval in °C; thermal method, pressure and decomposition observation","Solubility under stated conditions: mg/mL or mol/L, with solvent, temperature, pH where relevant and equilibration method","Sample disposition: quarantined | released for specified use | retest required | rejected","Parent-metabolite relationship: Named metabolite, transformation evidence and analyte-specific biological measurements","Applicable hazard and regulatory record: Dated SDS, GHS assessment, exposure-limit authority and jurisdiction-specific ingredient or product record"]},"recognition":{"applicability":"required","items":["A material label naming methsuximide or mesuximide provides a documentary identification cue that requires supporting analytical evidence.","The molecular formula C12H13NO2 on an accompanying label or certificate helps distinguish the stated substance from other succinimide anticonvulsants.","The pure substance is described as a white crystalline powder, an appearance shared by many compounds and insufficient to confirm identity."]},"capabilities":{"applicability":"required","items":["Reconcile a supplier-labelled methsuximide sample with authoritative identity records and reference analyses.","Compare assay and impurity results with the specification required for a proposed use.","Select documented analytical preparation and storage conditions appropriate to the material form.","Link a medicine to its methsuximide ingredient while preserving product-specific strength and excipients.","Separate parent and metabolite evidence when reviewing biological analyses.","Release, quarantine or request retesting of a sample using explicit evidence and decision authority."]},"hazards":{"applicability":"required","items":["Can cause drowsiness, blood disorders and changes in mood or behaviour.","Sudden withdrawal can provoke seizures."]},"interfaces":{"applicability":"required","items":["The Anatomical Therapeutic Chemical classification issued by the WHO Collaborating Centre for Drug Statistics Methodology assigns methsuximide, listed as mesuximide, code N03AD03.","The Federal Food, Drug, and Cosmetic Act, enacted by the United States Congress and administered by the Food and Drug Administration, governs its medicinal products in the United States."]},"context":{"applicability":"required","items":["Methsuximide is encountered as a pharmaceutical active substance and in prescription medicines for absence seizures resistant to other medicines.","It is also encountered in pharmaceutical quality testing and studies of its active metabolite."]}},"sources":[{"title":"Wikidata item Q906414: methsuximide","url":"https://www.wikidata.org/wiki/Q906414","note":"identity and sense of the item"},{"title":"Wikipedia: Mesuximide","url":"https://en.wikipedia.org/wiki/Mesuximide","note":"general description of the item"}],"openQuestions":["Which authoritative records establish the CAS number, applicable EC identifier, accepted synonyms and stereochemical scope of this registry entry?","Which current compendial or validated specifications define methsuximide assay, related-substance limits and pharmaceutical ingredient qualification?","What experimentally supported melting, solubility, thermal decomposition and storage-stability data apply to identified bulk forms and prepared solutions?","Which jurisdiction-specific GHS classifications and occupational exposure limits, if any, are supported for bulk methsuximide?","Which primary studies establish parent-versus-metabolite activity, persistence and analytical interpretation, and where does that evidence remain uncertain?"],"resources":{"spec":"/models/things/publications/thing-q906414/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q906414/spec.json"],"providers":["Codex"],"researchStatus":"unreviewed","generatedAt":"2026-09-12T11:17:37Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"filled","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-07T10:10:33+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass"},"score":1.0}}