{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.wm-liv-021","code":"wm-liv-021-disease-biological-condition","url":"https://ver.cy/models/wm-liv-021-disease-biological-condition/","name":"Disease / Biological Condition","alternateNames":[],"kind":"world-model","status":"published","version":"0.3.0-research.1","language":"en","classifiers":{"family":"World Models","category":"Physical world and living systems","entryKind":"aggregate","plane":"","domain":["PHY.LIV.HLT"],"industry":["Cross-industry"],"navPath":"NAV.PHY.LIV.HLT","tags":["disease","biological","condition","phy.liv.hlt"],"facets":{}},"whatItIs":"Owns condition occurrence identity, subject reference, occurrence boundary and mastership; release-pinned disease concept bindings; pathological class, site, morphology, mechanism and direct behavior; independent clinical, verification and record statuses; onset, manifestation, recognition, diagnosis, recording, remission, relapse, recurrence and resolution clocks; severity, stage, grade, course, functional impact and prognosis assertions; etiology, risk, susceptibility, triggers, criteria, evidence and differential relationships; manifestation, complication, comorbidity, sequela, care and outcome links; provenance, quality, lifecycle, access, retention and loss-aware projections. Disease terminology, organisms, people, specimens, encounters, care plans, observations, tests, phenotypes, genes, variants, pathogens, interventions, outcomes, evidence documents and decisions remain external.","purpose":"Represent one governed biological condition occurrence concerning an organism plus immutable source-qualified assertions about its identity, course, evidence and relationships.","scope":{"in":["Condition occurrence identity, subject, disease concept bindings and direct pathological properties","Independent statuses, course clocks, severity, stage, etiology, evidence, differential and related-condition assertions","Provenance, quality, correction, access, retention and loss-aware interoperability"],"out":["Owning disease terminology, organism, person, specimen, encounter, care plan, observation, test, phenotype, gene, variant, pathogen, intervention, outcome, evidence-document or decision lifecycles","Inferring diagnosis, causation, cure, prognosis, treatment or public-health case status without source-qualified authority and evidence","Protected disclosure, clinical decision, external-system mutation, identity merge or irreversible deletion without authority"],"boundaries":[{"neighbor":"WM-LIV-002 Organism Individual","distinction":"The registered parent is retained as the subject reference. The organism owns biological identity and lifecycle; this model owns only the condition occurrence and its assertions."},{"neighbor":"Disease concept and classification","distinction":"ICD, SNOMED CT, Mondo, Disease Ontology, Orphanet and NCI terminology concepts define categories and mappings. They are not the real condition occurrence affecting one organism."},{"neighbor":"Diagnosis and clinical impression","distinction":"A diagnosis is an attributable epistemic assertion with verification state, criteria, evidence and uncertainty. It can be revised without rewriting the underlying condition occurrence."},{"neighbor":"Observation, phenotype and specimen","distinction":"Signs, symptoms, measurements, tests and phenotypic abnormalities are evidence or manifestations linked to a condition. Their subjects, methods, values and lifecycle remain external."},{"neighbor":"WM-ACT-049 Care Plan / Episode","distinction":"A care plan or episode may target a condition, but encounters, goals, interventions, medications, procedures and care outcomes keep independent mastership."},{"neighbor":"Public-health surveillance case","distinction":"A surveillance case applies jurisdictional criteria for counting and reporting and is explicitly not a substitute for individual clinical diagnosis."},{"neighbor":"Cause, prognosis and outcome","distinction":"Causal attribution and prognosis are qualified assertions; actual outcomes are external events or states. Association, susceptibility, prediction and outcome are never silently treated as intrinsic disease truth."}]},"distinguishingFeatures":["Represents one condition occurrence in one organism, not the disease concept in a terminology.","Clinical status, verification status and record status are independent axes.","Remission is not cure, susceptibility is not disease, and association is not causation.","A diagnosis is an authority-qualified assertion; a single observation or test result is not a diagnosis."],"structure":{"bundles":[{"id":"condition-identity-boundary-and-disease-concept","name":"Condition identity, boundary and disease concept","description":"Groups the governed Resource Consumption concern for condition identity, boundary and disease concept.","layers":[{"id":"condition-occurrence-identity-subject-and-mastership","name":"Condition occurrence identity, subject and mastership","description":"Groups Resource Consumption context for condition occurrence identity, subject and mastership without importing neighboring master lifecycles.","findings":[{"id":"condition-identifier-subject-kind-organism-reference-and-master-system","name":"Condition identifier, subject kind, organism reference and master system","description":"Records condition identifier, subject kind, organism reference and master system as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.","questions":[{"text":"Which condition identity, subject, disease concept, classification release and direct biological properties establish condition identifier, subject kind, organism reference and master system?","id":"condition-identifier-subject-kind-organism-reference-and-master-system-q01","kind":"identity"},{"text":"Which status, clocks, evidence, method, actor and clinical context qualify condition identifier, subject kind, organism reference and master system?","id":"condition-identifier-subject-kind-organism-reference-and-master-system-q02","kind":"authority"},{"text":"Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect condition identifier, subject kind, organism reference and master system?","id":"condition-identifier-subject-kind-organism-reference-and-master-system-q03","kind":"security"}]},{"id":"occurrence-discriminator-episode-boundary-alias-profile-and-record-linkage","name":"Occurrence discriminator, episode boundary, alias, profile and record linkage","description":"Records occurrence discriminator, episode boundary, alias, profile and record linkage as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.","questions":[{"text":"Which condition identity, subject, disease concept, classification release and direct biological properties establish occurrence discriminator, episode boundary, alias, profile and record linkage?","id":"occurrence-discriminator-episode-boundary-alias-profile-and-record-linkage-q01","kind":"classification"},{"text":"Which status, clocks, evidence, method, actor and clinical context qualify occurrence discriminator, episode boundary, alias, profile and record linkage?","id":"occurrence-discriminator-episode-boundary-alias-profile-and-record-linkage-q02","kind":"requirement"},{"text":"Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect occurrence discriminator, episode boundary, alias, profile and record linkage?","id":"occurrence-discriminator-episode-boundary-alias-profile-and-record-linkage-q03","kind":"privacy"}]}]},{"id":"disease-concept-code-definition-and-classification","name":"Disease concept, code, definition and classification","description":"Groups Resource Consumption context for disease concept, code, definition and classification without importing neighboring master lifecycles.","findings":[{"id":"disease-concept-code-system-release-display-definition-and-synonym","name":"Disease concept, code system, release, display, definition and synonym","description":"Records disease concept, code system, release, display, definition and synonym as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.","questions":[{"text":"Which condition identity, subject, disease concept, classification release and direct biological properties establish disease concept, code system, release, display, definition and synonym?","id":"disease-concept-code-system-release-display-definition-and-synonym-q01","kind":"classification"},{"text":"Which status, clocks, evidence, method, actor and clinical context qualify disease concept, code system, release, display, definition and synonym?","id":"disease-concept-code-system-release-display-definition-and-synonym-q02","kind":"constraint"},{"text":"Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect disease concept, code system, release, display, definition and synonym?","id":"disease-concept-code-system-release-display-definition-and-synonym-q03","kind":"retention"}]},{"id":"category-hierarchy-postcoordination-rare-disease-and-species-profile","name":"Category, hierarchy, postcoordination, rare-disease and species profile","description":"Records category, hierarchy, postcoordination, rare-disease and species profile as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.","questions":[{"text":"Which condition identity, subject, disease concept, classification release and direct biological properties establish category, hierarchy, postcoordination, rare-disease and species profile?","id":"category-hierarchy-postcoordination-rare-disease-and-species-profile-q01","kind":"interoperability"},{"text":"Which status, clocks, evidence, method, actor and clinical context qualify category, hierarchy, postcoordination, rare-disease and species profile?","id":"category-hierarchy-postcoordination-rare-disease-and-species-profile-q02","kind":"process"},{"text":"Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect category, hierarchy, postcoordination, rare-disease and species profile?","id":"category-hierarchy-postcoordination-rare-disease-and-species-profile-q03","kind":"access"}]}]}]},{"id":"pathology-anatomy-and-direct-properties","name":"Pathology, anatomy and direct properties","description":"Groups the governed Resource Consumption concern for pathology, anatomy and direct properties.","layers":[{"id":"pathological-class-site-morphology-and-mechanism","name":"Pathological class, site, morphology and mechanism","description":"Groups Resource Consumption context for pathological class, site, morphology and mechanism without importing neighboring master lifecycles.","findings":[{"id":"disorder-disease-syndrome-injury-infection-anomaly-and-finding-profile","name":"Disorder, disease, syndrome, injury, infection, anomaly and finding profile","description":"Records disorder, disease, syndrome, injury, infection, anomaly and finding profile as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.","questions":[{"text":"Which condition identity, subject, disease concept, classification release and direct biological properties establish disorder, disease, syndrome, injury, infection, anomaly and finding profile?","id":"disorder-disease-syndrome-injury-infection-anomaly-and-finding-profile-q01","kind":"classification"},{"text":"Which status, clocks, evidence, method, actor and clinical context qualify disorder, disease, syndrome, injury, infection, anomaly and finding profile?","id":"disorder-disease-syndrome-injury-infection-anomaly-and-finding-profile-q02","kind":"event"},{"text":"Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect disorder, disease, syndrome, injury, infection, anomaly and finding profile?","id":"disorder-disease-syndrome-injury-infection-anomaly-and-finding-profile-q03","kind":"exception"}]},{"id":"body-site-laterality-morphology-pathological-process-mechanism-and-extent","name":"Body site, laterality, morphology, pathological process, mechanism and extent","description":"Records body site, laterality, morphology, pathological process, mechanism and extent as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.","questions":[{"text":"Which condition identity, subject, disease concept, classification release and direct biological properties establish body site, laterality, morphology, pathological process, mechanism and extent?","id":"body-site-laterality-morphology-pathological-process-mechanism-and-extent-q01","kind":"spatial"},{"text":"Which status, clocks, evidence, method, actor and clinical context qualify body site, laterality, morphology, pathological process, mechanism and extent?","id":"body-site-laterality-morphology-pathological-process-mechanism-and-extent-q02","kind":"measurement"},{"text":"Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect body site, laterality, morphology, pathological process, mechanism and extent?","id":"body-site-laterality-morphology-pathological-process-mechanism-and-extent-q03","kind":"interoperability"}]}]},{"id":"intrinsic-behavior-capability-and-distinguishing-characteristics","name":"Intrinsic behavior, capability and distinguishing characteristics","description":"Groups Resource Consumption context for intrinsic behavior, capability and distinguishing characteristics without importing neighboring master lifecycles.","findings":[{"id":"progression-persistence-transmission-damage-reversibility-and-instability","name":"Progression, persistence, transmission, damage, reversibility and instability","description":"Records progression, persistence, transmission, damage, reversibility and instability as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.","questions":[{"text":"Which condition identity, subject, disease concept, classification release and direct biological properties establish progression, persistence, transmission, damage, reversibility and instability?","id":"progression-persistence-transmission-damage-reversibility-and-instability-q01","kind":"state"},{"text":"Which status, clocks, evidence, method, actor and clinical context qualify progression, persistence, transmission, damage, reversibility and instability?","id":"progression-persistence-transmission-damage-reversibility-and-instability-q02","kind":"evidence"},{"text":"Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect progression, persistence, transmission, damage, reversibility and instability?","id":"progression-persistence-transmission-damage-reversibility-and-instability-q03","kind":"decision"}]},{"id":"recognition-features-discriminators-confounders-and-condition-affordances","name":"Recognition features, discriminators, confounders and condition affordances","description":"Records recognition features, discriminators, confounders and condition affordances as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.","questions":[{"text":"Which condition identity, subject, disease concept, classification release and direct biological properties establish recognition features, discriminators, confounders and condition affordances?","id":"recognition-features-discriminators-confounders-and-condition-affordances-q01","kind":"evidence"},{"text":"Which status, clocks, evidence, method, actor and clinical context qualify recognition features, discriminators, confounders and condition affordances?","id":"recognition-features-discriminators-confounders-and-condition-affordances-q02","kind":"quality"},{"text":"Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect recognition features, discriminators, confounders and condition affordances?","id":"recognition-features-discriminators-confounders-and-condition-affordances-q03","kind":"identity"}]}]}]},{"id":"independent-status-time-and-clinical-course","name":"Independent status, time and clinical course","description":"Groups the governed Resource Consumption concern for independent status, time and clinical course.","layers":[{"id":"clinical-verification-record-and-assertion-status","name":"Clinical, verification, record and assertion status","description":"Groups Resource Consumption context for clinical, verification, record and assertion status without importing neighboring master lifecycles.","findings":[{"id":"clinical-active-inactive-remission-relapse-recurrence-resolved-and-unknown","name":"Clinical active, inactive, remission, relapse, recurrence, resolved and unknown","description":"Records clinical active, inactive, remission, relapse, recurrence, resolved and unknown as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.","questions":[{"text":"Which condition identity, subject, disease concept, classification release and direct biological properties establish clinical active, inactive, remission, relapse, recurrence, resolved and unknown?","id":"clinical-active-inactive-remission-relapse-recurrence-resolved-and-unknown-q01","kind":"state"},{"text":"Which status, clocks, evidence, method, actor and clinical context qualify clinical active, inactive, remission, relapse, recurrence, resolved and unknown?","id":"clinical-active-inactive-remission-relapse-recurrence-resolved-and-unknown-q02","kind":"validation"},{"text":"Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect clinical active, inactive, remission, relapse, recurrence, resolved and unknown?","id":"clinical-active-inactive-remission-relapse-recurrence-resolved-and-unknown-q03","kind":"classification"}]},{"id":"unconfirmed-provisional-differential-confirmed-refuted-excluded-and-record-status","name":"Unconfirmed, provisional, differential, confirmed, refuted, excluded and record status","description":"Records unconfirmed, provisional, differential, confirmed, refuted, excluded and record status as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.","questions":[{"text":"Which condition identity, subject, disease concept, classification release and direct biological properties establish unconfirmed, provisional, differential, confirmed, refuted, excluded and record status?","id":"unconfirmed-provisional-differential-confirmed-refuted-excluded-and-record-status-q01","kind":"validation"},{"text":"Which status, clocks, evidence, method, actor and clinical context qualify unconfirmed, provisional, differential, confirmed, refuted, excluded and record status?","id":"unconfirmed-provisional-differential-confirmed-refuted-excluded-and-record-status-q02","kind":"security"},{"text":"Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect unconfirmed, provisional, differential, confirmed, refuted, excluded and record status?","id":"unconfirmed-provisional-differential-confirmed-refuted-excluded-and-record-status-q03","kind":"composition"}]}]},{"id":"onset-manifestation-diagnosis-and-course-clocks","name":"Onset, manifestation, diagnosis and course clocks","description":"Groups Resource Consumption context for onset, manifestation, diagnosis and course clocks without importing neighboring master lifecycles.","findings":[{"id":"onset-manifestation-recognition-diagnosis-recording-and-effective-time","name":"Onset, manifestation, recognition, diagnosis, recording and effective time","description":"Records onset, manifestation, recognition, diagnosis, recording and effective time as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.","questions":[{"text":"Which condition identity, subject, disease concept, classification release and direct biological properties establish onset, manifestation, recognition, diagnosis, recording and effective time?","id":"onset-manifestation-recognition-diagnosis-recording-and-effective-time-q01","kind":"temporal"},{"text":"Which status, clocks, evidence, method, actor and clinical context qualify onset, manifestation, recognition, diagnosis, recording and effective time?","id":"onset-manifestation-recognition-diagnosis-recording-and-effective-time-q02","kind":"privacy"},{"text":"Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect onset, manifestation, recognition, diagnosis, recording and effective time?","id":"onset-manifestation-recognition-diagnosis-recording-and-effective-time-q03","kind":"relationship"}]},{"id":"remission-relapse-recurrence-abatement-resolution-death-and-new-occurrence","name":"Remission, relapse, recurrence, abatement, resolution, death and new occurrence","description":"Records remission, relapse, recurrence, abatement, resolution, death and new occurrence as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.","questions":[{"text":"Which condition identity, subject, disease concept, classification release and direct biological properties establish remission, relapse, recurrence, abatement, resolution, death and new occurrence?","id":"remission-relapse-recurrence-abatement-resolution-death-and-new-occurrence-q01","kind":"lifecycle"},{"text":"Which status, clocks, evidence, method, actor and clinical context qualify remission, relapse, recurrence, abatement, resolution, death and new occurrence?","id":"remission-relapse-recurrence-abatement-resolution-death-and-new-occurrence-q02","kind":"retention"},{"text":"Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect remission, relapse, recurrence, abatement, resolution, death and new occurrence?","id":"remission-relapse-recurrence-abatement-resolution-death-and-new-occurrence-q03","kind":"state"}]}]}]},{"id":"severity-stage-grade-course-and-impact","name":"Severity, stage, grade, course and impact","description":"Groups the governed Resource Consumption concern for severity, stage, grade, course and impact.","layers":[{"id":"severity-stage-grade-extent-and-course-assessment","name":"Severity, stage, grade, extent and course assessment","description":"Groups Resource Consumption context for severity, stage, grade, extent and course assessment without importing neighboring master lifecycles.","findings":[{"id":"severity-value-scale-method-threshold-assessor-time-and-confidence","name":"Severity value, scale, method, threshold, assessor, time and confidence","description":"Records severity value, scale, method, threshold, assessor, time and confidence as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.","questions":[{"text":"Which condition identity, subject, disease concept, classification release and direct biological properties establish severity value, scale, method, threshold, assessor, time and confidence?","id":"severity-value-scale-method-threshold-assessor-time-and-confidence-q01","kind":"measurement"},{"text":"Which status, clocks, evidence, method, actor and clinical context qualify severity value, scale, method, threshold, assessor, time and confidence?","id":"severity-value-scale-method-threshold-assessor-time-and-confidence-q02","kind":"access"},{"text":"Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect severity value, scale, method, threshold, assessor, time and confidence?","id":"severity-value-scale-method-threshold-assessor-time-and-confidence-q03","kind":"lifecycle"}]},{"id":"stage-grade-extent-acute-chronic-episodic-progressive-remitting-and-terminal","name":"Stage, grade, extent, acute, chronic, episodic, progressive, remitting and terminal","description":"Records stage, grade, extent, acute, chronic, episodic, progressive, remitting and terminal as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.","questions":[{"text":"Which condition identity, subject, disease concept, classification release and direct biological properties establish stage, grade, extent, acute, chronic, episodic, progressive, remitting and terminal?","id":"stage-grade-extent-acute-chronic-episodic-progressive-remitting-and-terminal-q01","kind":"classification"},{"text":"Which status, clocks, evidence, method, actor and clinical context qualify stage, grade, extent, acute, chronic, episodic, progressive, remitting and terminal?","id":"stage-grade-extent-acute-chronic-episodic-progressive-remitting-and-terminal-q02","kind":"exception"},{"text":"Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect stage, grade, extent, acute, chronic, episodic, progressive, remitting and terminal?","id":"stage-grade-extent-acute-chronic-episodic-progressive-remitting-and-terminal-q03","kind":"temporal"}]}]},{"id":"functional-impact-prognosis-hazard-and-possible-actions","name":"Functional impact, prognosis, hazard and possible actions","description":"Groups Resource Consumption context for functional impact, prognosis, hazard and possible actions without importing neighboring master lifecycles.","findings":[{"id":"impairment-activity-participation-burden-quality-of-life-and-context","name":"Impairment, activity, participation, burden, quality of life and context","description":"Records impairment, activity, participation, burden, quality of life and context as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.","questions":[{"text":"Which condition identity, subject, disease concept, classification release and direct biological properties establish impairment, activity, participation, burden, quality of life and context?","id":"impairment-activity-participation-burden-quality-of-life-and-context-q01","kind":"relationship"},{"text":"Which status, clocks, evidence, method, actor and clinical context qualify impairment, activity, participation, burden, quality of life and context?","id":"impairment-activity-participation-burden-quality-of-life-and-context-q02","kind":"interoperability"},{"text":"Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect impairment, activity, participation, burden, quality of life and context?","id":"impairment-activity-participation-burden-quality-of-life-and-context-q03","kind":"spatial"}]},{"id":"prognosis-risk-urgency-observe-monitor-diagnose-treat-control-and-prevent","name":"Prognosis, risk, urgency, observe, monitor, diagnose, treat, control and prevent","description":"Records prognosis, risk, urgency, observe, monitor, diagnose, treat, control and prevent as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.","questions":[{"text":"Which condition identity, subject, disease concept, classification release and direct biological properties establish prognosis, risk, urgency, observe, monitor, diagnose, treat, control and prevent?","id":"prognosis-risk-urgency-observe-monitor-diagnose-treat-control-and-prevent-q01","kind":"decision"},{"text":"Which status, clocks, evidence, method, actor and clinical context qualify prognosis, risk, urgency, observe, monitor, diagnose, treat, control and prevent?","id":"prognosis-risk-urgency-observe-monitor-diagnose-treat-control-and-prevent-q02","kind":"decision"},{"text":"Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect prognosis, risk, urgency, observe, monitor, diagnose, treat, control and prevent?","id":"prognosis-risk-urgency-observe-monitor-diagnose-treat-control-and-prevent-q03","kind":"provenance"}]}]}]},{"id":"etiology-evidence-differential-and-related-conditions","name":"Etiology, evidence, differential and related conditions","description":"Groups the governed Resource Consumption concern for etiology, evidence, differential and related conditions.","layers":[{"id":"cause-risk-susceptibility-trigger-and-association","name":"Cause, risk, susceptibility, trigger and association","description":"Groups Resource Consumption context for cause, risk, susceptibility, trigger and association without importing neighboring master lifecycles.","findings":[{"id":"causative-agent-mechanism-inheritance-gene-variant-pathogen-and-exposure","name":"Causative agent, mechanism, inheritance, gene, variant, pathogen and exposure","description":"Records causative agent, mechanism, inheritance, gene, variant, pathogen and exposure as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.","questions":[{"text":"Which condition identity, subject, disease concept, classification release and direct biological properties establish causative agent, mechanism, inheritance, gene, variant, pathogen and exposure?","id":"causative-agent-mechanism-inheritance-gene-variant-pathogen-and-exposure-q01","kind":"relationship"},{"text":"Which status, clocks, evidence, method, actor and clinical context qualify causative agent, mechanism, inheritance, gene, variant, pathogen and exposure?","id":"causative-agent-mechanism-inheritance-gene-variant-pathogen-and-exposure-q02","kind":"identity"},{"text":"Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect causative agent, mechanism, inheritance, gene, variant, pathogen and exposure?","id":"causative-agent-mechanism-inheritance-gene-variant-pathogen-and-exposure-q03","kind":"ownership"}]},{"id":"risk-factor-susceptibility-trigger-protective-factor-association-and-causality","name":"Risk factor, susceptibility, trigger, protective factor, association and causality","description":"Records risk factor, susceptibility, trigger, protective factor, association and causality as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.","questions":[{"text":"Which condition identity, subject, disease concept, classification release and direct biological properties establish risk factor, susceptibility, trigger, protective factor, association and causality?","id":"risk-factor-susceptibility-trigger-protective-factor-association-and-causality-q01","kind":"evidence"},{"text":"Which status, clocks, evidence, method, actor and clinical context qualify risk factor, susceptibility, trigger, protective factor, association and causality?","id":"risk-factor-susceptibility-trigger-protective-factor-association-and-causality-q02","kind":"classification"},{"text":"Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect risk factor, susceptibility, trigger, protective factor, association and causality?","id":"risk-factor-susceptibility-trigger-protective-factor-association-and-causality-q03","kind":"authority"}]}]},{"id":"criteria-observation-phenotype-evidence-and-differential","name":"Criteria, observation, phenotype, evidence and differential","description":"Groups Resource Consumption context for criteria, observation, phenotype, evidence and differential without importing neighboring master lifecycles.","findings":[{"id":"diagnostic-rule-case-definition-observation-test-phenotype-and-evidence","name":"Diagnostic rule, case definition, observation, test, phenotype and evidence","description":"Records diagnostic rule, case definition, observation, test, phenotype and evidence as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.","questions":[{"text":"Which condition identity, subject, disease concept, classification release and direct biological properties establish diagnostic rule, case definition, observation, test, phenotype and evidence?","id":"diagnostic-rule-case-definition-observation-test-phenotype-and-evidence-q01","kind":"validation"},{"text":"Which status, clocks, evidence, method, actor and clinical context qualify diagnostic rule, case definition, observation, test, phenotype and evidence?","id":"diagnostic-rule-case-definition-observation-test-phenotype-and-evidence-q02","kind":"composition"},{"text":"Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect diagnostic rule, case definition, observation, test, phenotype and evidence?","id":"diagnostic-rule-case-definition-observation-test-phenotype-and-evidence-q03","kind":"requirement"}]},{"id":"differential-competing-alternative-refuted-excluded-uncertain-and-conflict","name":"Differential, competing, alternative, refuted, excluded, uncertain and conflict","description":"Records differential, competing, alternative, refuted, excluded, uncertain and conflict as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.","questions":[{"text":"Which condition identity, subject, disease concept, classification release and direct biological properties establish differential, competing, alternative, refuted, excluded, uncertain and conflict?","id":"differential-competing-alternative-refuted-excluded-uncertain-and-conflict-q01","kind":"decision"},{"text":"Which status, clocks, evidence, method, actor and clinical context qualify differential, competing, alternative, refuted, excluded, uncertain and conflict?","id":"differential-competing-alternative-refuted-excluded-uncertain-and-conflict-q02","kind":"relationship"},{"text":"Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect differential, competing, alternative, refuted, excluded, uncertain and conflict?","id":"differential-competing-alternative-refuted-excluded-uncertain-and-conflict-q03","kind":"constraint"}]}]}]},{"id":"relationships-governance-provenance-and-exchange","name":"Relationships, governance, provenance and exchange","description":"Groups the governed Resource Consumption concern for relationships, governance, provenance and exchange.","layers":[{"id":"manifestation-complication-comorbidity-care-and-outcome-links","name":"Manifestation, complication, comorbidity, care and outcome links","description":"Groups Resource Consumption context for manifestation, complication, comorbidity, care and outcome links without importing neighboring master lifecycles.","findings":[{"id":"sign-symptom-observation-phenotype-complication-comorbidity-and-sequela","name":"Sign, symptom, observation, phenotype, complication, comorbidity and sequela","description":"Records sign, symptom, observation, phenotype, complication, comorbidity and sequela as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.","questions":[{"text":"Which condition identity, subject, disease concept, classification release and direct biological properties establish sign, symptom, observation, phenotype, complication, comorbidity and sequela?","id":"sign-symptom-observation-phenotype-complication-comorbidity-and-sequela-q01","kind":"relationship"},{"text":"Which status, clocks, evidence, method, actor and clinical context qualify sign, symptom, observation, phenotype, complication, comorbidity and sequela?","id":"sign-symptom-observation-phenotype-complication-comorbidity-and-sequela-q02","kind":"state"},{"text":"Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect sign, symptom, observation, phenotype, complication, comorbidity and sequela?","id":"sign-symptom-observation-phenotype-complication-comorbidity-and-sequela-q03","kind":"process"}]},{"id":"encounter-care-plan-intervention-medication-procedure-outcome-and-decision","name":"Encounter, care plan, intervention, medication, procedure, outcome and decision","description":"Records encounter, care plan, intervention, medication, procedure, outcome and decision as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.","questions":[{"text":"Which condition identity, subject, disease concept, classification release and direct biological properties establish encounter, care plan, intervention, medication, procedure, outcome and decision?","id":"encounter-care-plan-intervention-medication-procedure-outcome-and-decision-q01","kind":"relationship"},{"text":"Which status, clocks, evidence, method, actor and clinical context qualify encounter, care plan, intervention, medication, procedure, outcome and decision?","id":"encounter-care-plan-intervention-medication-procedure-outcome-and-decision-q02","kind":"lifecycle"},{"text":"Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect encounter, care plan, intervention, medication, procedure, outcome and decision?","id":"encounter-care-plan-intervention-medication-procedure-outcome-and-decision-q03","kind":"event"}]}]},{"id":"provenance-lifecycle-access-quality-and-interoperability","name":"Provenance, lifecycle, access, quality and interoperability","description":"Groups Resource Consumption context for provenance, lifecycle, access, quality and interoperability without importing neighboring master lifecycles.","findings":[{"id":"asserter-recorder-source-method-review-correction-merge-split-and-audit","name":"Asserter, recorder, source, method, review, correction, merge, split and audit","description":"Records asserter, recorder, source, method, review, correction, merge, split and audit as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.","questions":[{"text":"Which condition identity, subject, disease concept, classification release and direct biological properties establish asserter, recorder, source, method, review, correction, merge, split and audit?","id":"asserter-recorder-source-method-review-correction-merge-split-and-audit-q01","kind":"provenance"},{"text":"Which status, clocks, evidence, method, actor and clinical context qualify asserter, recorder, source, method, review, correction, merge, split and audit?","id":"asserter-recorder-source-method-review-correction-merge-split-and-audit-q02","kind":"temporal"},{"text":"Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect asserter, recorder, source, method, review, correction, merge, split and audit?","id":"asserter-recorder-source-method-review-correction-merge-split-and-audit-q03","kind":"measurement"}]},{"id":"sensitivity-consent-purpose-retention-quality-and-standards-projection","name":"Sensitivity, consent, purpose, retention, quality and standards projection","description":"Records sensitivity, consent, purpose, retention, quality and standards projection as a source-qualified Disease / Biological Condition assertion while terminology, observations, specimens, encounters, care plans and decisions retain external mastership.","questions":[{"text":"Which condition identity, subject, disease concept, classification release and direct biological properties establish sensitivity, consent, purpose, retention, quality and standards projection?","id":"sensitivity-consent-purpose-retention-quality-and-standards-projection-q01","kind":"privacy"},{"text":"Which status, clocks, evidence, method, actor and clinical context qualify sensitivity, consent, purpose, retention, quality and standards projection?","id":"sensitivity-consent-purpose-retention-quality-and-standards-projection-q02","kind":"spatial"},{"text":"Which relationships, lifecycle changes, access controls, quality checks and interoperability losses affect sensitivity, consent, purpose, retention, quality and standards projection?","id":"sensitivity-consent-purpose-retention-quality-and-standards-projection-q03","kind":"evidence"}]}]}]}]},"agentConduct":{"may":["Record a condition with a release-pinned terminology code and source.","Validate codes against the declared terminology release.","Detect probable duplicate condition records for review.","Summarise the course, stage and severity history from recorded assertions."],"mustNot":["Make or confirm a diagnosis.","Infer a condition from one observation or from genetic susceptibility.","Disclose a condition outside the authorised purpose.","Merge or delete condition records without authority.","Report a public-health case without the responsible authority."],"requiresHuman":["Diagnosis and verification of a condition.","Disclosure of a condition to third parties.","Notification to public-health authorities."]},"ethics":{"considerations":["Health conditions are sensitive data; disclosure can cause stigma, discrimination and loss of work or insurance.","Wrong or outdated diagnoses can lead to harmful treatment.","Public-health reporting must balance community protection against individual privacy.","Animal conditions also matter for welfare and for diseases shared with people."],"affectedParties":["Patients","Animals and their keepers","Clinicians and veterinarians","Communities affected by public-health decisions"]},"owners":{"steward":"Declare Dimension owner, condition and organism masters, terminology stewards, diagnostic authorities, data stewards, access approvers and auditors.","roles":[{"name":"Dimension owner","responsibilities":["Own namespace, mastership, delegation, access, retention and federation rules."]},{"name":"Condition registry steward","responsibilities":["Own occurrence identity, deduplication, lifecycle, quality and terminology bindings."]},{"name":"Terminology authority or curator","responsibilities":["Own concept systems, releases, definitions, mappings and classification profiles."]},{"name":"Clinical or biological asserter","responsibilities":["Own diagnosis, clinical status, severity, stage, course and evidence assertions within delegated scope."]},{"name":"Laboratory or observation steward","responsibilities":["Own specimen, test, observation, phenotype and source evidence outside this model."]},{"name":"Care or public-health authority","responsibilities":["Own care-plan, encounter, surveillance, reporting and intervention decisions outside this model."]},{"name":"Data steward or access authority","responsibilities":["Own consent, purpose, sensitivity, minimum disclosure, retention and access decisions."]},{"name":"Reviewer or auditor","responsibilities":["Review identity, evidence, conflicts, lifecycle, quality and disclosure without rewriting originals."]}],"masterSystems":[]},"relations":[{"target":"WM-LIV-002 Organism Individual","type":"references","note":"Resolve the registered organism subject without importing its identity or lifecycle."},{"target":"WM-ACT-049 Care Plan / Episode","type":"references","note":"Resolve care context, goals and interventions while condition and care-plan mastership remain separate."},{"target":"Specimen, observation, test, phenotype, evidence, intervention, outcome and decision masters","type":"references","note":"Resolve diagnostic and care context without importing neighboring lifecycles."},{"target":"WHO ICD-11 2026 release and ICF","type":"aligned","note":"Project disease classification, coding and functioning context with exact releases and explicit scope."},{"target":"SNOMED CT clinical finding and disorder model","type":"aligned","note":"Project disorder, finding site, morphology, cause, severity, course and occurrence attributes under licensed release pins."},{"target":"HL7 FHIR R5 Condition, ClinicalImpression and Observation","type":"aligned","note":"Project clinical exchange views while preserving resource maturity, status axes and diagnostic boundaries."},{"target":"OMOP CDM 5.4 ConditionOccurrence and ConditionEra","type":"aligned","note":"Project observational analytics records and era derivation without treating analytics rules as biological truth."},{"target":"Mondo, Human Disease Ontology, Orphanet and NCI Thesaurus","type":"aligned","note":"Project disease concepts, definitions, mappings, rare-disease and cancer terminology with exact releases."},{"target":"Human Phenotype Ontology and GA4GH Phenopacket Schema","type":"aligned","note":"Project phenotypic evidence and disease diagnoses while keeping observed features distinct."},{"target":"ClinGen Gene-Disease Validity and CDC surveillance case definitions","type":"aligned","note":"Project evidence-based relationship strength and jurisdictional case classification as separate assertions."},{"target":"W3C PROV-O, DQV and ODRL 2.2","type":"aligned","note":"Project derivation, quality, rights and access constraints."},{"target":"RFC 3339 and RFC 8785","type":"aligned","note":"Project unambiguous clocks and deterministic JSON serialization."},{"target":"WM-LIV-002 Organism Individual","type":"neighbor","note":"The registered parent is retained as the subject reference. The organism owns biological identity and lifecycle; this model owns only the condition occurrence and its assertions."},{"target":"Disease concept and classification","type":"neighbor","note":"ICD, SNOMED CT, Mondo, Disease Ontology, Orphanet and NCI terminology concepts define categories and mappings. They are not the real condition occurrence affecting one organism."},{"target":"Diagnosis and clinical impression","type":"neighbor","note":"A diagnosis is an attributable epistemic assertion with verification state, criteria, evidence and uncertainty. It can be revised without rewriting the underlying condition occurrence."},{"target":"Observation, phenotype and specimen","type":"neighbor","note":"Signs, symptoms, measurements, tests and phenotypic abnormalities are evidence or manifestations linked to a condition. Their subjects, methods, values and lifecycle remain external."},{"target":"WM-ACT-049 Care Plan / Episode","type":"neighbor","note":"A care plan or episode may target a condition, but encounters, goals, interventions, medications, procedures and care outcomes keep independent mastership."},{"target":"Public-health surveillance case","type":"neighbor","note":"A surveillance case applies jurisdictional criteria for counting and reporting and is explicitly not a substitute for individual clinical diagnosis."},{"target":"Cause, prognosis and outcome","type":"neighbor","note":"Causal attribution and prognosis are qualified assertions; actual outcomes are external events or states. Association, susceptibility, prediction and outcome are never silently treated as intrinsic disease truth."},{"target":"WM-LIV-002","type":"parent"}],"interaction":{"identity":{"applicability":"required","items":["Authoritative master-system identifier for the condition occurrence or source clinical record.","Terminology-qualified immutable identifier for a diagnostic, status, evidence or lifecycle assertion.","Adopting-Dimension UUID or ULID when no authoritative external identifier exists."]},"properties":{"applicability":"not-applicable","items":[]},"recognition":{"applicability":"required","items":["A condition record has a subject, a coded concept, clinical and verification status, onset and the asserting authority.","Often confused with a disease concept, an observation, a symptom and a diagnostic test result."]},"capabilities":{"applicability":"required","items":["Register condition occurrence: Create stable occurrence identity for one condition concerning one organism while preserving source record links.","Bind disease concept: Attach a release-pinned disease concept without making the terminology entry the occurrence identity.","Assert diagnosis or hypothesis: Append a source-qualified diagnostic assertion with independent verification status and evidence.","Record independent status: Record clinical activity, verification and record state as separate controlled assertions.","Record course, stage and severity: Append time-bound course, stage, grade, severity and extent assessments with method and scale.","Link cause, risk and evidence: Add typed causal, risk, susceptibility and evidentiary relationships without promoting association to causation.","Link manifestations and impact: Reference signs, symptoms, observations, phenotypes, complications and functioning effects.","Reconcile differential and duplicate: Compare competing diagnoses and duplicate records while preserving every original assertion and decision basis.","Govern condition lifecycle: Append correction, recurrence, relapse, remission, resolution, split, merge or supersession events.","Project authorized view: Produce a minimum-necessary standards projection with purpose, access and semantic-loss controls."]},"hazards":{"applicability":"required","items":["Misdiagnosis carried forward in records.","Disclosure of sensitive conditions.","Duplicate or conflicting records for one condition.","Missed or delayed notification of a notifiable disease."]},"interfaces":{"applicability":"required","items":["HL7 FHIR Condition.","WHO ICD-11.","SNOMED CT.","Mondo Disease Ontology.","Human Phenotype Ontology for manifestations."]},"context":{"applicability":"required","items":["Human clinical terminology does not govern every species, research use, public-health regime or jurisdiction.","FHIR Condition and ClinicalImpression are Trial Use and living terminologies require exact maturity and release pins.","Diagnosis, notification, consent, privacy, retention, access and reporting duties vary by jurisdiction and organizational policy."]}},"sources":[{"title":"International Classification of Diseases","url":"https://www.who.int/standards/classifications/classification-of-diseases","note":"World Health Organization"},{"title":"ICD API Documentation","url":"https://icd.who.int/docs/icd-api/APIDoc-Version2/","note":"World Health Organization"},{"title":"ICD API Supported Classifications","url":"https://icd.who.int/docs/icd-api/SupportedClassifications/","note":"World Health Organization"},{"title":"ICD-11 Reference Guide","url":"https://icdcdn.who.int/icd11referenceguide/en/html/index.html","note":"World Health Organization"},{"title":"International Classification of Functioning, Disability and Health","url":"https://www.who.int/standards/classifications/international-classification-of-functioning-disability-and-health","note":"World Health Organization"},{"title":"Clinical finding and disorder","url":"https://docs.snomed.org/snomed-ct-specifications/snomed-ct-editorial-guide/readme/authoring/domain-specific-modeling/clinical-finding-and-disorder","note":"SNOMED International"},{"title":"SNOMED CT Concept Model","url":"https://docs.snomed.org/snomed-ct-practical-guides/snomed-ct-starter-guide/6-snomed-ct-concept-model","note":"SNOMED International"},{"title":"FHIR R5 Condition","url":"https://hl7.org/fhir/R5/condition.html","note":"Health Level Seven International"},{"title":"FHIR R5 ClinicalImpression","url":"https://hl7.org/fhir/R5/clinicalimpression.html","note":"Health Level Seven International"},{"title":"FHIR R5 Observation","url":"https://hl7.org/fhir/R5/observation.html","note":"Health Level Seven International"},{"title":"OMOP Common Data Model 5.4","url":"https://ohdsi.github.io/CommonDataModel/cdm54.html","note":"Observational Health Data Sciences and Informatics"},{"title":"Mondo Disease Ontology","url":"https://mondo.monarchinitiative.org/","note":"Monarch Initiative"},{"title":"Human Disease Ontology","url":"https://www.disease-ontology.org/welcome/","note":"Disease Ontology Project"},{"title":"Orphanet Classifications","url":"https://www.orphadata.com/_classifications/","note":"Orphanet"},{"title":"Human Phenotype Ontology","url":"https://hpo.jax.org/","note":"Monarch Initiative"},{"title":"Phenopacket Schema Disease","url":"https://phenopacket-schema.readthedocs.io/en/latest/disease.html","note":"Global Alliance for Genomics and Health"},{"title":"Gene-Disease Validity Classification","url":"https://www.clinicalgenome.org/docs/gene-disease-validity-classification-information/","note":"Clinical Genome Resource"},{"title":"Surveillance Case Definitions","url":"https://ndc.services.cdc.gov/","note":"Centers for Disease Control and Prevention"},{"title":"NCI Thesaurus","url":"https://www.cancer.gov/about-nci/organization/cbiit/vocabulary","note":"National Cancer Institute"},{"title":"PROV-O: The PROV Ontology","url":"https://www.w3.org/TR/prov-o/","note":"World Wide Web Consortium"},{"title":"Data Quality Vocabulary","url":"https://www.w3.org/TR/vocab-dqv/","note":"World Wide Web Consortium"},{"title":"ODRL Information Model 2.2","url":"https://www.w3.org/TR/odrl-model/","note":"World Wide Web Consortium"},{"title":"Date and Time on the Internet","url":"https://www.rfc-editor.org/rfc/rfc3339.html","note":"Internet Engineering Task Force"},{"title":"JSON Canonicalization Scheme","url":"https://www.rfc-editor.org/rfc/rfc8785.html","note":"Internet Engineering Task Force"}],"openQuestions":["Develop disease-family and species-specific diagnostic, staging, severity, course, treatment, surveillance and safety profiles with domain experts.","Resolve detailed sibling boundaries for organism, specimen, observation, phenotype, encounter, care plan, intervention, outcome, evidence, prediction and decision models.","Pin production crosswalks to exact ICD, SNOMED CT, FHIR, OMOP, Mondo, Disease Ontology, Orphanet, HPO, Phenopacket and NCI releases and execute conformance suites.","Obtain independent clinical, biological, veterinary, terminology, epidemiology, privacy, legal, security and records review.","Disease-specific diagnostic, staging, severity, treatment, surveillance, species, jurisdictional and safety profiles require expert review.","Organisms, people, specimens, encounters, care plans, observations, tests, phenotypes, causes, interventions, outcomes, terminologies, evidence and decisions remain neighboring masters.","Automated diagnosis, prognosis, treatment selection, surveillance reporting and unrestricted protected-health disclosure remain outside scope."],"resources":{"spec":"/models/wm-liv-021-disease-biological-condition/spec.yaml","agents":"/models/wm-liv-021-disease-biological-condition/AGENTS.md","source":"https://github.com/ver-cy/world-models/tree/feat/mega-model-registry/research/runs/wm-liv-021"},"provenance":{"origin":"world-models research","builtFrom":["models/wm-liv-021-disease-biological-condition/spec.yaml","ver-cy/world-models/card-supplements/wm-liv-021-disease-biological-condition.json"],"providers":["Codex"],"researchStatus":"reviewable-draft","generatedAt":"2026-09-07T09:56:59Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"not-applicable","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"interaction.properties":"A condition is a clinical concept; severity and stage are assessments recorded about a person, not physical properties.","_supplement":"Sections authored in card supplement 1.0.0 by Claude (Opus 5.5) (2026-10-05, unreviewed). Written from the published specification and established practice in the field; no new sources were read. Unreviewed."},"score":1.0}}