{ "model": { "rank": 5297, "code": "thing-hormone", "model_id": "vr.tr.hormone", "name": "hormone", "purpose": "the secretion of an endocrine gland that is transmitted by the blood to the tissue on which it has a specific effect", "family": "Thing Registry", "category": "Physical world and living systems", "status": "research-draft", "kind": "thing", "plane": "PHY", "domain": "PHY.LIV", "industry": "", "version": "", "url": "/models/thing/hormone/", "tier": 2, "score": 68, "payload": { "layer": "wordnet", "aliases": [ "endocrine", "internal secretion", "noradrenaline", "norepinephrine", "adrenocorticotropic hormone", "adrenocorticotrophic hormone", "ACTH", "adrenocorticotropin", "adrenocorticotrophin", "corticotropin", "corticotrophin", "gastrointestinal hormone", "GI hormones", "gastrin", "cholecystokinin", "secretin", "ghrelin", "motilin", "glucagon", "gonadotropin", "gonadotrophin", "gonadotropic hormone", "gonadotrophic hormone", "insulin", "recombinant human insulin", "Humulin", "melatonin", "neurohormone", "oxytocin", "Pitocin", "parathyroid hormone", "parathormone", "relaxin", "releasing hormone", "RH", "releasing factor", "hypothalamic releasing hormone", "hypothalamic releasing factor", "somatotropin", "somatotrophin" ], "aliasCount": 161, "merged": 68, "knownIn": 0, "facets": { "substance": "living", "origin": "natural", "agency": "inert", "mobility": "not-applicable", "scale": "not-applicable", "affordances": [ "observable" ] }, "markers": [], "lexicalClass": "noun.body", "senseRank": 0, "alsoRegisteredAs": null, "source": { "dataset": "oewn:2024", "synset": "oewn-05414462-n", "ili": "i65385", "license": "CC BY 4.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-09T22:04:59Z", "providers": [ "Codex" ], "breadth": "recalled by Codex without web access - no source was read", "missingProviders": [], "pass": 2, "cost": { "grok": { "seconds": 25.3, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a08833-0d80-7f30-8a5f-048afef20ce9\n--------\nuser\nDescribe what is already known about one registered thing. Answer as JSON only, no prose around it.\n\nThing: hormone\nSense to describe: the secretion of an endocrine gland that is transmitted by the blood to the tissue on which it has a specific effect\nDomain c", "usd": 0, "recall": true }, "codex": { "seconds": 57.1, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a08833-0d8d-7f30-a5cc-e9244997399e\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: hormone\nRegistry id: vr.tr.hormone\nPlane / domain: PHY / PHY.LIV\nRegistry definition: the secretion of an endocrine gland that is transmitted by the " } } }, "metaModel": { "id": "THING-HORMONE", "registryId": "vr.tr.hormone", "name": "hormone", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.LIV" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/hormone/", "model": { "registry_id": "vr.tr.hormone", "name": "hormone", "purpose": "Enable an agent to recognise a hormone, record its endocrine signalling context, interpret observations and identify what evidence is needed before acting on them.", "definition": "A hormone, in the classical endocrine sense, is a chemical messenger secreted by an endocrine gland into the blood that alters the activity of distant target cells possessing the appropriate receptors.", "scope_statement": "This model owns hormone identity and its role as an endocrine secretion carried through blood to responsive tissue, following the scope of registry entry vr.tr.hormone in PHY / PHY.LIV.", "in_scope": [ "Hormone identity, molecular form and distinctions between precursors, active forms and metabolites", "Endocrine source, secretion conditions and regulation", "Blood transport, availability and clearance", "Target receptors, tissue responsiveness and physiological effects", "Contextual measurement and evidence supporting interpretation" ], "out_of_scope": [ "Endocrine glands and target organs as complete anatomical entities", "Whole organisms, species taxonomy and population conservation", "Local paracrine or autocrine signalling considered independently of blood-borne endocrine action", "Endocrine diseases as diagnostic and treatment models", "Hormone medicines as manufactured products with prescribing and administration requirements" ], "distinguishing_features": [ "Establish an endocrine secretory source and a blood-borne route to responsive tissue; presence in blood alone does not establish hormone status.", "Identify receptor-mediated signalling evidence rather than classifying a substance as a hormone solely because it changes tissue function.", "Distinguish the secreted hormone from its precursor, inactive metabolite and laboratory measurement surrogate.", "Separate a molecule's endocrine role from local signalling roles it may also perform.", "Distinguish endogenous secretion from administered material even when their molecular identities match." ], "characteristics": [ { "name": "Molecular identity and form", "kind": "category", "unit_or_values": "Established name, molecular identifier, chemical class and specified molecular form", "why_it_matters": "Prevents precursors, metabolites and related molecules from being treated as interchangeable." }, { "name": "Endocrine source", "kind": "relation", "unit_or_values": "Secreting cell type, tissue or gland, with organism and life-stage context", "why_it_matters": "Connects hormone identity to its biological source without assuming a single source in every context." }, { "name": "Secretion pattern", "kind": "state", "unit_or_values": "Observed basal, pulsatile, rhythmic or stimulus-linked secretion, with timing and evidence", "why_it_matters": "A sampled concentration may not represent secretion across time." }, { "name": "Circulating concentration", "kind": "measurement", "unit_or_values": "Assay-reported amount or mass per volume, such as pmol/L or ng/mL, with specimen and sampling time", "why_it_matters": "Supports comparison only when analyte, units, method and sampling context are compatible." }, { "name": "Transport and binding", "kind": "relation", "unit_or_values": "Carrier identity where applicable; free, bound or total fraction measured", "why_it_matters": "Changes in binding can change the relationship between measured concentration and tissue exposure." }, { "name": "Target receptor and tissue", "kind": "relation", "unit_or_values": "Receptor identity, responding cell or tissue and supporting evidence", "why_it_matters": "Makes the claimed specificity of action explicit." }, { "name": "Biological response", "kind": "state", "unit_or_values": "Specified endpoint, response direction, magnitude where measured and observation interval", "why_it_matters": "Separates hormone detection from demonstrated biological effect." }, { "name": "Clearance or circulating half-life", "kind": "measurement", "unit_or_values": "Clearance in volume/time or half-life in time units, with organism and experimental conditions", "why_it_matters": "Helps distinguish altered removal from altered secretion." }, { "name": "Feedback participation", "kind": "relation", "unit_or_values": "Regulated variable, upstream signal, feedback direction and physiological context", "why_it_matters": "Supports interpretation of linked signals rather than an isolated hormone value." } ], "affordances": [ "Match a named substance or measured analyte to a specified hormone form.", "Trace evidence from endocrine source through blood transport to responsive tissue.", "Compare measurements after checking units, assays, fractions and sampling context.", "Identify competing explanations involving secretion, transport, clearance or responsiveness.", "Flag missing evidence and route diagnostic or treatment decisions to the relevant clinical model." ] }, "sources": [], "structure": { "bundles": [ { "id": "hormone-identity-and-boundary", "name": "Hormone identity and boundary", "description": "Establish which molecular entity and endocrine role the record describes.", "rationale": "Hormone names can conceal differences between molecular forms, biological roles and measured analytes.", "layers": [ { "id": "molecular-form", "name": "Molecular form", "description": "Resolve names to the specific substance under consideration.", "findings": [ { "id": "active-form-and-related-molecules", "name": "Active form and related molecules", "description": "Record the identified form and its relationship to precursors, processed products and metabolites.", "questions": [ { "text": "Which molecular form does this hormone name designate in this record?", "kind": "definition", "id": "active-form-and-related-molecules-q01" }, { "text": "Which precursors, metabolites or related forms must be distinguished from it?", "kind": "boundary", "id": "active-form-and-related-molecules-q02" } ] } ] }, { "id": "endocrine-role", "name": "Endocrine role", "description": "Test inclusion against the registry's blood-borne endocrine definition.", "findings": [ { "id": "source-route-target-evidence", "name": "Source, route and target evidence", "description": "Capture evidence for endocrine secretion, blood transport and a specific effect in responsive tissue.", "questions": [ { "text": "What evidence establishes an endocrine source, circulation through blood and a responsive target?", "kind": "provenance", "id": "source-route-target-evidence-q01" }, { "text": "Does this observation concern endocrine action, local signalling or administered material?", "kind": "boundary", "id": "source-route-target-evidence-q02" } ] } ] } ] }, { "id": "production-and-secretion", "name": "Production and secretion", "description": "Describe where the hormone is produced and how release changes with physiological context.", "rationale": "Source and release dynamics are necessary to interpret circulating hormone observations.", "layers": [ { "id": "secretory-source", "name": "Secretory source", "description": "Connect hormone production and release to identified endocrine cells.", "findings": [ { "id": "production-processing-release", "name": "Production, processing and release", "description": "Distinguish synthesis, any required processing and secretion for the specified hormone.", "questions": [ { "text": "Which cells or tissues synthesise and secrete this form in the organism under study?", "kind": "provenance", "id": "production-processing-release-q01" }, { "text": "What processing, if any, separates the synthesised precursor from the released or active form?", "kind": "definition", "id": "production-processing-release-q02" } ] } ] }, { "id": "release-dynamics", "name": "Release dynamics", "description": "Record secretion timing and the conditions that modify it.", "findings": [ { "id": "stimuli-and-temporal-pattern", "name": "Stimuli and temporal pattern", "description": "Characterise supported release patterns without assigning a universal baseline.", "questions": [ { "text": "Which stimuli or upstream signals alter secretion, and in what direction?", "kind": "provenance", "id": "stimuli-and-temporal-pattern-q01" }, { "text": "What sampling interval and physiological context are needed to detect the relevant secretion pattern?", "kind": "measurement", "id": "stimuli-and-temporal-pattern-q02" } ] } ] } ] }, { "id": "circulation-and-clearance", "name": "Circulation and clearance", "description": "Describe transport through blood and processes that determine persistence and availability.", "rationale": "Circulating concentration reflects transport and removal as well as secretion.", "layers": [ { "id": "blood-transport", "name": "Blood transport", "description": "Identify circulating forms and carrier interactions where applicable.", "findings": [ { "id": "free-bound-and-total", "name": "Free, bound and total hormone", "description": "Specify which circulating fraction is observed and how binding affects its interpretation.", "questions": [ { "text": "Does the observation represent free, bound or total hormone, and how was that fraction determined?", "kind": "measurement", "id": "free-bound-and-total-q01" }, { "text": "Which carrier interactions, if any, must be considered when relating this result to tissue exposure?", "kind": "provenance", "id": "free-bound-and-total-q02" } ] } ] }, { "id": "conversion-and-removal", "name": "Conversion and removal", "description": "Track activation, inactivation and elimination relevant to hormone persistence.", "findings": [ { "id": "metabolic-fate", "name": "Metabolic fate", "description": "Separate removal of the measured form from conversion into another biologically relevant form.", "questions": [ { "text": "Which tissues and processes convert, inactivate or eliminate this hormone form?", "kind": "provenance", "id": "metabolic-fate-q01" }, { "text": "Under what conditions were any reported half-life or clearance values measured?", "kind": "measurement", "id": "metabolic-fate-q02" } ] } ] } ] }, { "id": "target-response-and-feedback", "name": "Target response and feedback", "description": "Connect receptor engagement to tissue effects and endocrine regulation.", "rationale": "Hormone availability, tissue responsiveness and feedback must be distinguished to explain an observed effect.", "layers": [ { "id": "receptor-dependent-response", "name": "Receptor-dependent response", "description": "Describe the receptors and tissue conditions supporting a specific response.", "findings": [ { "id": "receptor-and-effect-link", "name": "Receptor and effect link", "description": "Record evidence linking hormone exposure to receptor activity and a defined biological endpoint.", "questions": [ { "text": "Which receptor and responding cell type support the claimed effect?", "kind": "provenance", "id": "receptor-and-effect-link-q01" }, { "text": "What endpoint, exposure level and observation interval demonstrate the response?", "kind": "measurement", "id": "receptor-and-effect-link-q02" } ] } ] }, { "id": "feedback-regulation", "name": "Feedback regulation", "description": "Place the hormone within supported regulatory relationships.", "findings": [ { "id": "regulated-variable-and-loop", "name": "Regulated variable and loop", "description": "Identify what is regulated and how downstream conditions influence upstream secretion.", "questions": [ { "text": "Which regulated variable or downstream signal feeds back on this hormone's release?", "kind": "definition", "id": "regulated-variable-and-loop-q01" }, { "text": "Which linked observations would help distinguish changed secretion from changed target responsiveness?", "kind": "measurement", "id": "regulated-variable-and-loop-q02" } ] } ] } ] }, { "id": "measurement-and-interpretation", "name": "Measurement and interpretation", "description": "Make hormone observations comparable and state the limits of conclusions drawn from them.", "rationale": "An assay result cannot be interpreted reliably without knowing what was measured and under which conditions.", "layers": [ { "id": "analytical-observation", "name": "Analytical observation", "description": "Capture specimen, assay and collection details that affect the reported value.", "findings": [ { "id": "assay-specific-result", "name": "Assay-specific result", "description": "Bind each value to its analyte, method, units and sampling conditions.", "questions": [ { "text": "What specimen, assay, hormone form, units and collection time produced this result?", "kind": "measurement", "id": "assay-specific-result-q01" }, { "text": "What evidence addresses cross-reactivity, interference and specimen handling for this assay?", "kind": "provenance", "id": "assay-specific-result-q02" } ] } ] }, { "id": "contextual-interpretation", "name": "Contextual interpretation", "description": "Constrain comparison and subsequent action to the available physiological and analytical evidence.", "findings": [ { "id": "comparison-and-action-limits", "name": "Comparison and action limits", "description": "Record applicable comparison conditions, unresolved explanations and boundaries on agent action.", "questions": [ { "text": "Which reference interval or comparison series applies to this assay, organism and physiological state?", "kind": "measurement", "id": "comparison-and-action-limits-q01" }, { "text": "What missing context must be resolved before comparison, and which proposed decisions require a clinical or experimental protocol?", "kind": "action", "id": "comparison-and-action-limits-q02" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-confidence-notes", "name": "Check these first", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "This description covers the supplied classical endocrine sense; broader usage also includes hormones produced by dispersed endocrine cells and plant hormones.", "Glycoprotein hormones are a subgroup of protein hormones, so the listed kinds are not mutually exclusive.", "Specific identifiers, reference preparations, assay intervals, and therapeutic rules require substance-level verification; none were researched for this response." ], "questions": [ { "id": "evidence-confidence-notes-q01", "text": "Which of these check these first hold for the sense of hormone this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-kinds", "name": "Kinds and varieties", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Peptide and protein hormones, including insulin and growth hormone", "Glycoprotein hormones, including thyroid-stimulating hormone and follicle-stimulating hormone", "Steroid hormones, including cortisol and aldosterone", "Thyroid hormones, including thyroxine and triiodothyronine", "Catecholamine hormones, including adrenaline and noradrenaline" ], "questions": [ { "id": "evidence-kinds-q01", "text": "Which of these kinds and varieties hold for the sense of hormone this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-identifiers", "name": "Identifiers and schemes", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "scheme": "CAS Registry Number", "value_or_pattern": "Digits in three hyphen-separated groups, with a final check digit", "note": "Identifies particular hormone substances or preparations; hormone as a functional class has no single CAS number." }, { "scheme": "ChEBI", "value_or_pattern": "CHEBI: followed by digits", "note": "Provides identifiers for chemical entities and biological roles relevant to hormones." }, { "scheme": "UniProtKB", "value_or_pattern": "UniProtKB accession", "note": "Relevant to peptide and protein hormone precursors; the accession may describe a precursor containing several processed products rather than only the mature hormone." } ], "questions": [ { "id": "evidence-identifiers-q01", "text": "Which of these identifiers and schemes hold for the sense of hormone this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-standards-and-regulation", "name": "Standards and regulation", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "WHO International Standards provide reference preparations for selected hormones to support assay calibration and, where applicable, assignment of biological activity in international units." ], "questions": [ { "id": "evidence-standards-and-regulation-q01", "text": "Which of these standards and regulation hold for the sense of hormone this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Endogenous regulation of metabolism, growth, reproduction, stress responses, and fluid and electrolyte balance", "Measurement in blood to investigate endocrine gland function and feedback relationships", "Hormone replacement when endogenous production is deficient", "Pharmacological stimulation or suppression of hormone-dependent processes", "Monitoring physiological changes and responses to treatment" ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of hormone this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-measurements", "name": "Typical measurements", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "quantity": "Circulating molar concentration", "typical_range": "Hormone-specific; interpretation depends on sampling time, physiological state, and assay.", "unit": "pmol/L or nmol/L" }, { "quantity": "Circulating mass concentration", "typical_range": "Hormone-specific; total and unbound concentrations can differ substantially.", "unit": "pg/mL or ng/mL" }, { "quantity": "Concentration expressed against a biological reference standard", "typical_range": "Analyte- and reference-standard-specific; no class-wide interval.", "unit": "IU/L or mIU/L" } ], "questions": [ { "id": "evidence-measurements-q01", "text": "Which of these typical measurements hold for the sense of hormone this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Insufficient secretion can impair the functions normally supported by the hormone.", "Excess secretion can overstimulate target tissues and disrupt physiological feedback.", "Receptor defects or downstream signalling defects can cause hormone resistance despite adequate or elevated circulating concentrations.", "Inappropriate exogenous hormone exposure can cause adverse effects and suppress endogenous production through feedback.", "Assay interference, binding-protein changes, and poorly timed sampling can produce misleading laboratory interpretations." ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of hormone this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-regional-variation", "name": "Regional variation", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Laboratories and jurisdictions differ in reporting units, assay methods, and reference intervals.", "Adrenaline and epinephrine are alternative names for the same hormone; noradrenaline and norepinephrine likewise name the same substance." ], "questions": [ { "id": "evidence-regional-variation-q01", "text": "Which of these regional variation hold for the sense of hormone this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "name": "Neurotransmitter", "difference": "A neurotransmitter is released by a neuron to signal across a synaptic junction; a circulating endocrine messenger acts through blood transport. The same molecule can serve both roles." }, { "name": "Paracrine mediator", "difference": "A paracrine mediator acts locally on neighbouring cells rather than reaching distant targets through systemic circulation." }, { "name": "Autocrine signal", "difference": "An autocrine signal acts on the cell that secreted it; classical endocrine signalling acts on distant target cells." }, { "name": "Exocrine secretion", "difference": "An exocrine secretion is delivered through a duct onto an epithelial surface or into a lumen rather than secreted into the blood." }, { "name": "Neurohormone", "difference": "A neurohormone is released into circulation by a neurosecretory neuron; it is a hormone distinguished by its cellular source." }, { "name": "Hormone receptor", "difference": "The receptor is the molecular component that recognizes the hormone and initiates or modifies signalling, rather than the circulating messenger itself." } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of hormone this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Should this entry's endocrine-gland definition include hormones released by dispersed endocrine cells, or should those cases remain explicit boundary questions?", "How should hormones outside blood-circulating animal systems be related to this narrowly defined registry entry?", "Which authoritative nomenclature and identifier sources should govern hormone forms, precursors and metabolites?", "What evidence threshold should establish endocrine action when the same molecule also has local signalling roles?", "Which hormone-specific assay and physiological-context requirements need specialised extensions rather than inclusion in this general model?" ], "statistics": { "bundles": 6, "layers": 11, "findings": 19, "questions": 29 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "organism", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched.", "facetsInferred": false, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a hormone, record what state it is in, and decide what may be done with it.", "whatItIs": "the secretion of an endocrine gland that is transmitted by the blood to the tissue on which it has a specific effect", "characteristics": { "substance": "living", "origin": "natural", "agency": "inert" }, "whatYouCanDoWithIt": [ "observed and measured" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: endocrine, internal secretion, noradrenaline, norepinephrine, adrenocorticotropic hormone, adrenocorticotrophic hormone, ACTH, adrenocorticotropin, adrenocorticotrophin, corticotropin, corticotrophin, gastrointestinal hormone.", "68 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a hormone, and on what evidence are they told apart?" ], "whatItIsMadeOf": "a living thing", "physicalCharacter": [ "Does nothing on its own; everything it does, something else did to it." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state" ], "howItIsRecognised": [ "Recognised by diagnostic characters, and those differ by life stage - the young of many kinds are mistaken for other kinds entirely. A sighting is settled by characters, a photograph and a place, not by a name alone." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "endocrine", "internal secretion", "noradrenaline", "norepinephrine", "adrenocorticotropic hormone", "adrenocorticotrophic hormone", "ACTH", "adrenocorticotropin", "adrenocorticotrophin", "corticotropin", "corticotrophin", "gastrointestinal hormone" ] } ], "standing": "68 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one hormone from another, and a hormone from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a hormone, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a hormone, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a hormone is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a hormone, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a hormone, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a hormone is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a hormone sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a hormone, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a hormone, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a hormone is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a hormone from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a hormone, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a hormone, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a hormone is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "form-and-composition", "name": "Form, composition and condition", "description": "What a hormone is made of, what shape and size it takes, and what state it is in.", "rationale": "A physical thing can be measured, and a model that cannot record its measurements cannot support any decision that depends on them.", "layers": [ { "id": "form-and-dimensions", "name": "Form and dimensions", "description": "Shape, size, mass and the ranges these take across examples.", "findings": [ { "id": "measurable-dimensions", "name": "Measurable dimensions and their units", "description": "The quantities worth recording and the units they are recorded in.", "questions": [ { "id": "measurable-dimensions-q01", "text": "What identifies and describes the dimensions of a hormone, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "measurable-dimensions-q02", "text": "Who or what asserted this about the dimensions of a hormone, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "measurable-dimensions-q03", "text": "What may an agent decide or do once the dimensions of a hormone is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "material-and-composition", "name": "Material and composition", "description": "Anatomy, parts and life stage.", "findings": [ { "id": "parts-and-materials", "name": "Parts and life stages", "description": "The parts of a hormone and the stages it passes through.", "questions": [ { "id": "parts-and-materials-q01", "text": "What identifies and describes the composition of a hormone, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "parts-and-materials-q02", "text": "Who or what asserted this about the composition of a hormone, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "parts-and-materials-q03", "text": "What may an agent decide or do once the composition of a hormone is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "condition-and-integrity", "name": "Condition and integrity", "description": "Wear, damage, health and the difference between working and broken.", "findings": [ { "id": "condition-assessment", "name": "Condition, damage and health", "description": "How the condition of a hormone is judged and by whom.", "questions": [ { "id": "condition-assessment-q01", "text": "What identifies and describes the condition of a hormone, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "condition-assessment-q02", "text": "Who or what asserted this about the condition of a hormone, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "condition-assessment-q03", "text": "What may an agent decide or do once the condition of a hormone is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a hormone passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a hormone between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a hormone, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a hormone, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a hormone is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a hormone, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a hormone is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a hormone, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a hormone, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a hormone is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "taxonomic-placement", "name": "Taxonomic placement and identification", "description": "What hormone is called scientifically, by whose authority, and how a specimen is recognised.", "rationale": "Names change with revisions while the organism does not, so a name without its authority and date cannot be reconciled later.", "layers": [ { "id": "accepted-name", "name": "Accepted name and synonymy", "description": "The current binomial, its author and date, and the names it replaced.", "findings": [ { "id": "name-and-authority", "name": "Accepted name, authority and synonyms", "description": "What to record so a later revision can be applied without losing the old data.", "questions": [ { "id": "name-and-authority-q01", "text": "What is the accepted scientific name of hormone, with its author and year, and which synonyms does it absorb?", "kind": "definition" }, { "id": "name-and-authority-q02", "text": "Which taxonomic authority is being followed, and what would a competing authority say?", "kind": "provenance" } ] } ] }, { "id": "field-identification", "name": "Field identification", "description": "The characters that separate hormone from what it is confused with.", "findings": [ { "id": "diagnostic-characters", "name": "Diagnostic characters and confusable kinds", "description": "Features that settle an identification, and those that only suggest it.", "questions": [ { "id": "diagnostic-characters-q01", "text": "Which observable characters distinguish hormone from its closest look-alikes, and at which life stage are they visible?", "kind": "boundary" }, { "id": "diagnostic-characters-q02", "text": "What evidence is enough to record an identification as confirmed rather than provisional?", "kind": "provenance" } ] } ] } ] }, { "id": "life-cycle-and-condition", "name": "Life stages, condition and behaviour", "description": "What hormone does over its life and how its state is judged.", "rationale": "Stage and condition change what may be done - handled, treated, harvested, left alone - and both are observations with a time.", "layers": [ { "id": "stages-and-reproduction", "name": "Stages and reproduction", "description": "Development from origin to death, including forms that look like different animals.", "findings": [ { "id": "life-stages", "name": "Life stages and their marks", "description": "The stages worth recording and what tells them apart.", "questions": [ { "id": "life-stages-q01", "text": "What stages does hormone pass through, and what observable change marks each transition?", "kind": "definition" }, { "id": "life-stages-q02", "text": "Which stages are so unlike the adult that they are mistaken for another kind?", "kind": "boundary" } ] } ] }, { "id": "health-and-condition", "name": "Health and condition", "description": "How condition is assessed and by whom.", "findings": [ { "id": "condition-assessment", "name": "Condition assessment", "description": "Signs of health, injury and stress, and who is competent to judge them.", "questions": [ { "id": "condition-assessment-q01", "text": "How is the condition of hormone judged, on what scale, and by whom?", "kind": "measurement" }, { "id": "condition-assessment-q02", "text": "What condition obliges an agent to act, and what act is permitted to whom?", "kind": "action" } ] } ] } ] }, { "id": "range-and-status", "name": "Habitat, range and conservation status", "description": "Where hormone lives and how threatened it is.", "rationale": "Range and status govern what is lawful, and both are assessments with an assessor and a year rather than facts of nature.", "layers": [ { "id": "habitat-and-range", "name": "Habitat and range", "description": "Native range, introductions and the habitat it needs.", "findings": [ { "id": "range-record", "name": "Range, introductions and habitat", "description": "What to record about where it is found and how it got there.", "questions": [ { "id": "range-record-q01", "text": "What is the native range of hormone, where has it been introduced, and what habitat does it require?", "kind": "definition" }, { "id": "range-record-q02", "text": "What distinguishes a native record from an introduced or vagrant one?", "kind": "boundary" } ] } ] }, { "id": "protection-status", "name": "Protection and legal status", "description": "Conservation assessments and the rules that follow from them.", "findings": [ { "id": "status-and-rules", "name": "Conservation status and legal consequence", "description": "The assessment, its date, and what it forbids or requires where.", "questions": [ { "id": "status-and-rules-q01", "text": "What conservation status does hormone hold, under which assessment and year?", "kind": "provenance" }, { "id": "status-and-rules-q02", "text": "What does that status forbid or require of an agent, and in which jurisdiction?", "kind": "action" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a hormone came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a hormone and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a hormone, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a hormone, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a hormone is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a hormone is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a hormone, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a hormone, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a hormone is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 7, "layers": 15, "findings": 17, "questions": 45 } } } }