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oleandomycin

vr.tr.oleandomycin · thing-q1076248

Enable an agent to identify oleandomycin, assess the identity, quality and activity of a particular sample, and determine its suitability for a specified use.

Thing Registry Physical world and living systems PHY.MAT

Bundle → Layer → Finding → Questions Filled

6 bundles · 11 layers · 16 findings · 26 questions

Oleandomycin identity Recognize the specific chemical entity and resolve ambiguous names or identifiers.

Parent structure

Anchor recognition in molecular connectivity and stereochemistry.

Structure match

Record whether the claimed entity and analytical evidence match the reference oleandomycin structure.

  1. Does the candidate structure match the reference oleandomycin connectivity and all specified stereocenters? definition
  2. Which reference-standard comparison or orthogonal analytical evidence supports the sample's identity? measurement

Identifier boundaries

Separate parent identifiers from salt, derivative and product records.

Name resolution

Require structure-aware reconciliation before accepting a name or identifier as equivalent.

  1. Which source establishes that each CAS, PubChem, EC or supplier identifier refers to this exact chemical entity? provenance
  2. Does a record labelled oleandomycin phosphate describe a counterion-containing salt or covalent phosphorylation, and what structural evidence resolves it? boundary
Oleandomycin sample composition Describe how much oleandomycin a sample contains and what accompanies it.

Form and content

Establish material form and the basis of quantitative claims.

Parent-equivalent content

Tie concentration calculations to counterion, water, solvent and assay information.

  1. What neutral, salt, hydrated, solvated or mixed form was actually supplied? definition
  2. How much oleandomycin parent equivalent is present per gram, and is the result reported as received or on a corrected basis? measurement

Purity and grade

Relate impurity evidence and declared grade to a specific application.

Sample acceptance

Evaluate the lot using documented limits rather than a standalone purity percentage.

  1. Which methods quantify oleandomycin, related compounds, water and residual solvents, and what remains unresolved? measurement
  2. Does the lot meet the documented specification for its proposed use, including any required microbiological quality? action
Oleandomycin physical state and stability Assess the supplied material and prepared solutions under recorded conditions.

Phase and dissolution

Record physical behavior with material-form and measurement context.

Usable solution state

Establish whether the intended concentration is dissolved and supported by applicable property evidence.

  1. What solubility has been measured for this oleandomycin form in the intended solvent at the specified pH and temperature? measurement
  2. Do thermal data describe melting, decomposition or another event, and which sample form and method produced them? provenance

Storage and degradation

Link elapsed time and environmental exposure to retained content and activity.

Remaining suitability

Use stability evidence to decide whether stored solid or solution remains qualified.

  1. What data establish acceptable time, temperature, light, moisture and solution-pH conditions for this preparation? provenance
  2. After the recorded storage history or excursion, do content, impurity and activity results justify use or require retesting? action
Oleandomycin antibacterial performance Represent biological activity as evidence tied to a defined experimental system.

Target and assay context

Separate mechanistic evidence from growth-inhibition observations.

Activity evidence

NCATS associates oleandomycin with bacterial 50S ribosomal inhibition; individual results still require their own experimental context. [NCATS](https://drugs.ncats.io/substance/P8ZQ646136)

  1. Does the cited experiment measure ribosomal effects, protein synthesis, growth inhibition or killing? definition
  2. Which organism, strain, medium, inoculum and exposure conditions support the reported oleandomycin effect? provenance

Potency and susceptibility

Make potency and susceptibility comparisons conditional on compatible evidence.

Interpretable performance

Keep potency, MIC and susceptibility interpretation distinct, with explicit standards and uncertainty.

  1. What MIC or potency was measured, with what replicates, uncertainty, reference standard and parent-equivalent concentration? measurement
  2. Is an applicable oleandomycin-specific interpretive criterion available, or must the result remain an uninterpreted experimental measurement? boundary
Oleandomycin handling and use Connect the particular material and intended activity to applicable handling and authorization evidence.

Handling and disposal

Resolve controls for the actual solid, solution or mixture being handled.

Documented controls

Record supported hazard classifications and waste procedures, retaining missing information explicitly.

  1. Which current SDS and classification source cover this oleandomycin form, concentration and jurisdiction, and do they identify an applicable exposure limit? provenance
  2. What documented containment and disposal procedure applies to oleandomycin-containing stock, assay liquid and contaminated materials? action

Application eligibility

Distinguish material qualification from authorization of a product or use.

Dated use evidence

Require current, jurisdiction-specific evidence for any regulated application and link detailed product decisions to the product model.

  1. What dated authority establishes the status of the proposed research, human, veterinary or other application in the relevant jurisdiction? provenance
  2. Does the proposed action require evidence about a specific formulation, product authorization or clinical context beyond this substance model? boundary
Evidence and external alignment What the world already says about this thing, gathered so the model can be checked against it.

Reported evidence

Findings from the breadth pass, kept separate from the structural claims.

Check these first

Recalled without web access and unsourced; every item is a lead to verify.

  1. Which of these check these first hold for the sense of oleandomycin this model covers, and on what evidence? provenance

Identifiers and schemes

Recalled without web access and unsourced; every item is a lead to verify.

  1. Which of these identifiers and schemes hold for the sense of oleandomycin this model covers, and on what evidence? provenance

Real-world use

Recalled without web access and unsourced; every item is a lead to verify.

  1. Which of these real-world use hold for the sense of oleandomycin this model covers, and on what evidence? provenance

Typical measurements

Recalled without web access and unsourced; every item is a lead to verify.

  1. Which of these typical measurements hold for the sense of oleandomycin this model covers, and on what evidence? provenance

Failure modes and hazards

Recalled without web access and unsourced; every item is a lead to verify.

  1. Which of these failure modes and hazards hold for the sense of oleandomycin this model covers, and on what evidence? provenance

Neighbouring kinds and how to tell them apart

Recalled without web access and unsourced; every item is a lead to verify.

  1. Which of these neighbouring kinds and how to tell them apart hold for the sense of oleandomycin this model covers, and on what evidence? provenance

Classifiers Filled

Family
Thing Registry
Category
Physical world and living systems
Entry kind
thing
Plane
PHY
Domain
PHY.MAT

What it is Filled

Oleandomycin is a macrolide antibiotic produced by Streptomyces antibioticus, with a 14-membered lactone ring bearing sugar residues, that inhibits bacterial protein synthesis through interaction with the 50S ribosomal subunit.

In scope

  • Oleandomycin molecular identity, stereochemistry and identifier reconciliation.
  • Sample composition, purity, grade and oleandomycin content on a stated basis.
  • Physical form, solution conditions and evidence of stability or degradation.
  • Measured antibacterial activity with organism, assay and reference-standard context.
  • Substance-specific handling evidence and jurisdiction-specific restrictions relevant to a proposed use.

Out of scope

  • Finished medicines, combination products, packaging and their complete formulations.
  • Patient diagnosis, prescribing, dosing and treatment selection.
  • Standalone models of troleandomycin, erythromycin and covalently modified oleandomycin derivatives.
  • Production-organism biology and fermentation-process design.
  • Complete models of bacterial species, infections and resistance mechanisms.

Why it exists Filled

Enable an agent to identify oleandomycin, assess the identity, quality and activity of a particular sample, and determine its suitability for a specified use.

Distinguishing features Filled

  • Require a stereochemical structure match to InChIKey RZPAKFUAFGMUPI-QESOVKLGSA-N; the neutral formula C35H61NO12 alone does not establish identity. [ChEBI](https://www.ebi.ac.uk/chebi/CHEBI:16869)
  • Distinguish the neutral substance from protonated oleandomycin and counterion-containing material by charge, counterion identification and composition. ChEBI separately identifies its conjugate acid. [ChEBI](https://www.ebi.ac.uk/chebi/CHEBI:16869)
  • Reject automatic synonym merging with troleandomycin or oleandomycin 2'-O-phosphate: ChEBI records them as related derivatives. [ChEBI](https://www.ebi.ac.uk/chebi/CHEBI:16869)
  • Require an oleandomycin reference comparison to distinguish it from erythromycin; membership in the macrolide antibiotic class is insufficient. [NCATS](https://drugs.ncats.io/substance/P8ZQ646136)
  • Inspect composition before mapping historical product names to the pure substance: NCATS describes Sigmamycin as a combination containing oleandomycin and tetracycline. [NCATS](https://drugs.ncats.io/substance/P8ZQ646136)

What robots and AI may and may not do Filled

Must not

  • Recommend it or a dose for a person or animal.
  • Advise its use as a growth promoter in livestock where that is banned.
  • Supply it outside the regulated medicines chain.

Only with a human decision

  • Any decision to treat a person or animal with it.

May

  • Describe oleandomycin and its history as a human and veterinary antibiotic.
  • Report its current authorization status, which varies by country.

Moral aspects Filled

  • Antibiotic misuse in people and animals breeds resistance.
  • Residues in food can affect consumers.

Who is affected

  • Patients and animals
  • Consumers
  • The public at risk of resistance

Owners Filled

Steward

The authorization holder; medicines and veterinary regulators control its use.

Master systems

  • Medicines and veterinary product registers

Links to other meta-models Filled

parent

  • Q422687 - registry parent class

What else AI and robots need to interact with it Filled

Identity and identifiers required Filled

  • Vercy registry: vr.tr.oleandomycin
  • Wikidata: Q1076248 (https://www.wikidata.org/wiki/Q1076248)

Direct properties required Filled

  • Chemical identity: CHEBI:16869; CAS 3922-90-5; InChIKey RZPAKFUAFGMUPI-QESOVKLGSA-N
  • Neutral molecular formula and molar mass: C35H61NO12; approximately 687.86 g/mol
  • Material form: Neutral parent, specified salt, specified solvate or hydrate, solution, mixture, unresolved
  • Oleandomycin content: mg/g or mass %, specifying as-received, dry or anhydrous basis and parent-equivalent conversion
  • Related substances and residues: Individual and total impurities in mass % or mg/kg; water and residual solvents reported separately
  • Dissolution and solution condition: Solubility in mg/mL at stated solvent, pH and temperature; prepared concentration in mg/mL or mmol/L
  • Thermal behavior: Melting or decomposition event in °C with method; boiling point only if experimentally meaningful at a stated pressure
  • Antibacterial activity: MIC in µg/mL or validated potency units/mg, with strain, method and reference standard
  • Storage qualification: Within validated conditions, excursion under review, retest required, failed, unknown
  • Applicable hazard and use evidence: Links to form-specific SDS, classification record, exposure-limit source and dated jurisdictional authorization

Recognition required Filled

  • Usually a white powder or tablets; identified by label and analysis.

Capabilities and actions required Filled

  • Resolve a supplier or registry record to oleandomycin using structure and material-form evidence.
  • Calculate oleandomycin-equivalent concentration from verified composition and assay basis.
  • Select identity, content and impurity checks suitable for the intended sample use.
  • Compare antibacterial measurements only when their strain, method and concentration bases are compatible.
  • Assess whether a stored sample requires retesting before use.
  • Identify the handling documentation and current authorization evidence required for a proposed application.

Hazards and failure modes required Filled

  • Can interact with other medicines and cause liver effects.
  • Overuse drives macrolide resistance.

Standards and interfaces required Filled

  • The Anatomical Therapeutic Chemical classification maintained by the WHO Collaborating Centre for Drug Statistics Methodology classifies oleandomycin under J01FA05 among macrolide antibacterials.

Context of use required Filled

  • Oleandomycin is encountered in antibiotic research, pharmaceutical reference collections and analytical work involving macrolide compounds.
  • It may be studied for chemical identity, purity, antibacterial activity and bacterial resistance.
  • Its historical therapeutic role provides context for pharmaceutical literature and records.

Sources Filled

  1. Wikidata item Q1076248: oleandomycin - identity and sense of the item
  2. Wikipedia: Oleandomycin - general description of the item

Open questions

  • Which PubChem CID and EC identifier resolve to the exact stereochemical parent, and how should conflicting or form-specific registry mappings be reconciled?
  • Which authoritative specifications and reference standards establish identity, parent content, potency and impurity limits for each intended grade?
  • What experimentally supported solubility, ionization, thermal and stability data apply separately to the neutral substance, supplied salts and prepared solutions?
  • Which oleandomycin-specific susceptibility methods, interpretive criteria and resistance evidence support present-day interpretation without borrowing criteria from other macrolides?
  • What current form-specific GHS classifications, occupational exposure limits, disposal requirements and jurisdictional use authorizations can be verified?

Machine files

Provenance

thing registry research (pass 2) · unreviewed

Built from: models/things/publications/thing-q1076248/spec.json