{ "model": { "rank": 12262, "code": "thing-q1077603", "model_id": "vr.tr.mesothelioma", "name": "mesothelioma", "purpose": "Let an agent explain mesothelioma and its link to asbestos, relay classification, diagnosis, treatment and prognosis from oncology guidelines in general terms with attribution, describe the subtypes and stages the registry aliases name, and distinguish mesothelioma from lung cancer and pleural metastases, routing patients to clinicians and legal questions to qualified advisers.", "family": "Thing Registry", "category": "Cross-cutting context", "status": "research-draft", "kind": "thing", "plane": "XCT", "domain": "XCT.QLT", "industry": "", "version": "", "url": "/models/thing/q1077603/", "tier": 2, "score": 40, "payload": { "layer": "wikidata", "aliases": [ "malignant pleural mesothelioma", "lymphohistiocytoid mesothelioma", "recurrent malignant pleural mesothelioma", "advanced malignant pleural mesothelioma", "pleural biphasic mesothelioma", "pleural desmoplastic mesothelioma", "pleural epithelioid mesothelioma", "pleural sarcomatoid mesothelioma", "pericardial mesothelioma", "malignant mesothelioma", "malignant biphasic mesothelioma", "sarcomatoid mesothelioma", "malignant epithelial mesothelioma", "localized malignant mesothelioma", "mesothelioma malignant recurrent" ], "aliasCount": 15, "merged": 17, "knownIn": 40, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q1077603", "url": "https://www.wikidata.org/wiki/Q1077603", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-13T14:57:12Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 4, "engine": "claude" }, "metaModel": { "id": "THING-Q1077603", "registryId": "vr.tr.mesothelioma", "name": "mesothelioma", "version": "0.2.0-wave.4", "entryKind": "thing", "family": "Thing Registry", "domain": [ "XCT.QLT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q1077603/", "model": { "registry_id": "vr.tr.mesothelioma", "name": "mesothelioma", "purpose": "Let an agent explain mesothelioma and its link to asbestos, relay classification, diagnosis, treatment and prognosis from oncology guidelines in general terms with attribution, describe the subtypes and stages the registry aliases name, and distinguish mesothelioma from lung cancer and pleural metastases, routing patients to clinicians and legal questions to qualified advisers.", "definition": "A rare aggressive cancer of the mesothelium, the lining of the lungs, abdomen, heart or testes, most often malignant pleural mesothelioma, strongly linked to asbestos exposure decades earlier, classified by cell type as epithelioid, sarcomatoid or biphasic with rare variants such as desmoplastic and lymphohistiocytoid, staged from early to advanced and recurrent disease; it is a notifiable and compensable occupational disease in many countries. The model gives general information and routes people to clinicians.", "what_it_is_for": "Not applicable; a disease.", "affordances": [ "explain the disease", "relay diagnosis and treatment", "route to clinicians and advisers", "distinguish related conditions" ], "distinguishing_features": [ "Mesothelial origin", "Asbestos related", "Long latency", "Occupational disease" ], "appearance": "Not a visible object; a tumour of the pleura or other lining.", "visual_identification": [ "Cancer of the mesothelium", "Malignant pleural mesothelioma, biphasic, desmoplastic, lymphohistiocytoid, advanced and recurrent disease", "Lung cancer arises in the lung; pleural metastases come from other cancers" ], "physical_properties": [ { "quantity": "asbestos link", "typical_range": "about 80 percent of cases", "unit": "note", "note": "" }, { "quantity": "latency", "typical_range": "20-50", "unit": "years", "note": "" }, { "quantity": "median survival", "typical_range": "about 12-21", "unit": "months", "note": "varies by type and treatment" }, { "quantity": "incidence", "typical_range": "about 30000", "unit": "cases per year", "note": "worldwide, estimates" } ], "families_and_kinds": [ "pleural mesothelioma", "peritoneal mesothelioma", "pericardial and testicular mesothelioma", "epithelioid, sarcomatoid and biphasic types", "rare variants such as desmoplastic and lymphohistiocytoid", "advanced and recurrent disease" ], "related_models": [ { "relation": "is a kind of", "target": "asbestos-related disease", "why": "in registry terms" }, { "relation": "is a kind of", "target": "notifiable disease", "why": "in registry terms" }, { "relation": "is caused by", "target": "asbestos", "why": "in most cases" }, { "relation": "is contrasted with", "target": "lung cancer", "why": "which arises in lung tissue" } ], "identifiers": [ { "scheme": "ICD-10", "value_or_pattern": "C45", "note": "mesothelioma" }, { "scheme": "MeSH", "value_or_pattern": "D008654", "note": "Mesothelioma" } ], "standards_and_regulation": [ "Asbestos bans and occupational exposure limits", "Occupational disease compensation schemes", "Oncology guidelines such as ESMO and NCCN" ], "failure_modes_and_hazards": [ "Agents giving personal medical or legal advice", "Late diagnosis", "Registry aliases mixing subtypes and stages" ], "in_scope": [], "out_of_scope": [], "characteristics": [] }, "sources": [], "structure": { "bundles": [ { "id": "understand", "name": "Understand", "description": "What mesothelioma is.", "rationale": "Clinical.", "layers": [ { "id": "definition", "name": "Definition", "description": "Definition.", "findings": [ { "id": "definition-finding", "name": "Definition", "description": "Definition.", "questions": [ { "text": "What is mesothelioma, and how does it differ from lung cancer and pleural metastases?", "kind": "definition" }, { "text": "Is the user describing personal symptoms, a diagnosis or a compensation claim, which need clinicians or qualified advisers?", "kind": "boundary" } ] } ] }, { "id": "types", "name": "Types", "description": "Types.", "findings": [ { "id": "types-finding", "name": "Types", "description": "Types.", "questions": [ { "text": "What are pleural, peritoneal, epithelioid, sarcomatoid, biphasic, desmoplastic and lymphohistiocytoid mesothelioma?", "kind": "definition" }, { "text": "Which entry fits the specific type?", "kind": "action" } ] } ] } ] }, { "id": "cause", "name": "Cause", "description": "Cause and prevention.", "rationale": "Regulation.", "layers": [ { "id": "asbestos", "name": "Asbestos", "description": "Asbestos.", "findings": [ { "id": "asbestos-finding", "name": "Asbestos", "description": "Asbestos.", "questions": [ { "text": "How does asbestos cause mesothelioma, and which exposures carry risk?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "prevention", "name": "Prevention", "description": "Prevention and law.", "findings": [ { "id": "prevention-finding", "name": "Prevention", "description": "Prevention.", "questions": [ { "text": "How do bans, exposure limits and compensation schemes address the disease?", "kind": "provenance" }, { "text": "Which sources are cited?", "kind": "provenance" } ] } ] } ] }, { "id": "care", "name": "Care", "description": "Diagnosis and treatment.", "rationale": "Clinical.", "layers": [ { "id": "diagnosis", "name": "Diagnosis", "description": "Diagnosis and staging.", "findings": [ { "id": "diagnosis-finding", "name": "Diagnosis", "description": "Diagnosis.", "questions": [ { "text": "How is mesothelioma diagnosed and staged, as guidelines describe?", "kind": "provenance" }, { "text": "Which entry fits pleural biopsy?", "kind": "action" } ] } ] }, { "id": "treatment", "name": "Treatment", "description": "Treatment.", "findings": [ { "id": "treatment-finding", "name": "Treatment", "description": "Treatment.", "questions": [ { "text": "What are surgery, chemotherapy, immunotherapy and palliative options, in general terms?", "kind": "provenance" }, { "text": "Which entry fits the specific treatment?", "kind": "action" } ] } ] } ] }, { "id": "context", "name": "Context", "description": "Epidemiology and support.", "rationale": "Context.", "layers": [ { "id": "epidemiology", "name": "Epidemiology", "description": "Epidemiology.", "findings": [ { "id": "epidemiology-finding", "name": "Epidemiology", "description": "Epidemiology.", "questions": [ { "text": "How does incidence vary by country and over time with asbestos use?", "kind": "provenance" }, { "text": "Which entry fits occupational disease?", "kind": "action" } ] } ] }, { "id": "support", "name": "Support", "description": "Support.", "findings": [ { "id": "support-finding", "name": "Support", "description": "Support.", "questions": [ { "text": "What patient support and research organisations exist?", "kind": "provenance" }, { "text": "Which entry fits cancer support organisations?", "kind": "action" } ] } ] } ] } ] }, "openQuestions": [ "Should pleural mesothelioma and the histological subtypes be separate primary entries?", "How should oncology and occupational health sources be linked?", "The registry entry has merged aliases naming subtypes and stages; should they be split off?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "abstract concept", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a mesothelioma, record what state it is in, and decide what may be done with it.", "whatItIs": "Let an agent explain mesothelioma and its link to asbestos, relay classification, diagnosis, treatment and prognosis from oncology guidelines in general terms with attribution, describe the subtypes and stages the registry aliases name, and distinguish mesothelioma from lung cancer and pleural metastases, routing patients to clinicians and legal questions to qualified advisers.", "characteristics": { "substance": "abstract", "origin": "conceptual", "agency": "inert" }, "whatYouCanDoWithIt": [ "observed and measured" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: malignant pleural mesothelioma, lymphohistiocytoid mesothelioma, recurrent malignant pleural mesothelioma, advanced malignant pleural mesothelioma, pleural biphasic mesothelioma, pleural desmoplastic mesothelioma, pleural epithelioid mesothelioma, pleural sarcomatoid mesothelioma, pericardial mesothelioma, malignant mesothelioma, malignant biphasic mesothelioma, sarcomatoid mesothelioma.", "17 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 40 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a mesothelioma, and on what evidence are they told apart?" ], "whatItIsMadeOf": "an abstraction with no physical instance", "physicalCharacter": [ "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state" ], "howItIsRecognised": [ "Nothing to see. What is recognised is an instance of it, and which instances count is exactly what is argued about." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "malignant pleural mesothelioma", "lymphohistiocytoid mesothelioma", "recurrent malignant pleural mesothelioma", "advanced malignant pleural mesothelioma", "pleural biphasic mesothelioma", "pleural desmoplastic mesothelioma", "pleural epithelioid mesothelioma", "pleural sarcomatoid mesothelioma", "pericardial mesothelioma", "malignant mesothelioma", "malignant biphasic mesothelioma", "sarcomatoid mesothelioma" ] } ], "standing": "Described in 40 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 17 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one mesothelioma from another, and a mesothelioma from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a mesothelioma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a mesothelioma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a mesothelioma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a mesothelioma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a mesothelioma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a mesothelioma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a mesothelioma sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a mesothelioma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a mesothelioma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a mesothelioma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a mesothelioma from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a mesothelioma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a mesothelioma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a mesothelioma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a mesothelioma passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a mesothelioma between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a mesothelioma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a mesothelioma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a mesothelioma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a mesothelioma, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a mesothelioma is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a mesothelioma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a mesothelioma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a mesothelioma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "definitions-in-contest", "name": "Definitions and who holds them", "description": "What mesothelioma is taken to mean, and by whom.", "rationale": "When a field disagrees about a concept, the disagreement is the content. A model that picks one definition silently destroys the information.", "layers": [ { "id": "competing-definitions", "name": "Competing definitions", "description": "The main readings and the traditions behind them.", "findings": [ { "id": "definition-map", "name": "Definitions and their holders", "description": "Each definition with the school or body that holds it.", "questions": [ { "id": "definition-map-q01", "text": "Which definitions of mesothelioma are in use, and which tradition or body holds each?", "kind": "definition" }, { "id": "definition-map-q02", "text": "What turns on the difference between them in practice?", "kind": "boundary" } ] } ] }, { "id": "operationalisation", "name": "Operationalisation", "description": "How it is measured or applied when it has to be.", "findings": [ { "id": "operational-record", "name": "Measures and proxies", "description": "Instruments and indicators used to stand in for it.", "questions": [ { "id": "operational-record-q01", "text": "How is mesothelioma operationalised or measured in practice, and by what instrument?", "kind": "measurement" }, { "id": "operational-record-q02", "text": "What does that operationalisation leave out, and when does that matter?", "kind": "boundary" } ] } ] } ] }, { "id": "instances-and-use", "name": "Instances, use and consequence", "description": "What counts as an instance of mesothelioma and what follows from calling something that.", "rationale": "Applying a concept is an act with consequences, so a model must say what the label licenses and what it does not.", "layers": [ { "id": "instances", "name": "What counts as an instance", "description": "Clear cases, borderline cases and non-cases.", "findings": [ { "id": "instance-tests", "name": "Tests for an instance", "description": "What would settle whether something falls under it.", "questions": [ { "id": "instance-tests-q01", "text": "What would settle whether something is an instance of mesothelioma?", "kind": "boundary" }, { "id": "instance-tests-q02", "text": "Which borderline cases are argued about, and on what grounds?", "kind": "definition" } ] } ] }, { "id": "consequence", "name": "Consequence of application", "description": "Rights, duties or decisions that follow from the label.", "findings": [ { "id": "consequence-record", "name": "What the label licenses", "description": "What an agent may do once something is classified this way.", "questions": [ { "id": "consequence-record-q01", "text": "What follows practically once something is treated as mesothelioma?", "kind": "action" }, { "id": "consequence-record-q02", "text": "What must an agent not infer from the label alone?", "kind": "action" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a mesothelioma came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a mesothelioma and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a mesothelioma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a mesothelioma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a mesothelioma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a mesothelioma is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a mesothelioma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a mesothelioma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a mesothelioma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 5, "layers": 10, "findings": 12, "questions": 32 } } } }