{ "model": { "rank": 17190, "code": "thing-q1079120", "model_id": "vr.tr.hyperlipidemia", "name": "hyperlipidemia", "purpose": "Let an agent explain hyperlipidemia and its types, relay causes, risk, screening and general management from cardiology and lipid guidelines, describe the forms the registry aliases name, and distinguish hyperlipidemia from dyslipidemia broadly, from atherosclerosis and from normal lipid variation, routing people to clinicians without personal advice.", "family": "Thing Registry", "category": "Cross-cutting context", "status": "research-draft", "kind": "thing", "plane": "XCT", "domain": "XCT.STA", "industry": "", "version": "", "url": "/models/thing/q1079120/", "tier": 2, "score": 31, "payload": { "layer": "wikidata", "aliases": [ "hypertriglyceridemia", "familial hyperlipidemia", "mixed hyperlipidemia", "hyperalphalipoproteinemia", "hypertriglyceridemic waist", "major hypertriglyceridemia" ], "aliasCount": 6, "merged": 6, "knownIn": 31, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q1079120", "url": "https://www.wikidata.org/wiki/Q1079120", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-13T18:31:19Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 4, "engine": "claude" }, "metaModel": { "id": "THING-Q1079120", "registryId": "vr.tr.hyperlipidemia", "name": "hyperlipidemia", "version": "0.2.0-wave.4", "entryKind": "thing", "family": "Thing Registry", "domain": [ "XCT.STA" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q1079120/", "model": { "registry_id": "vr.tr.hyperlipidemia", "name": "hyperlipidemia", "purpose": "Let an agent explain hyperlipidemia and its types, relay causes, risk, screening and general management from cardiology and lipid guidelines, describe the forms the registry aliases name, and distinguish hyperlipidemia from dyslipidemia broadly, from atherosclerosis and from normal lipid variation, routing people to clinicians without personal advice.", "definition": "Abnormally elevated levels of lipids or lipoproteins in the blood, including high LDL cholesterol, hypertriglyceridemia and major hypertriglyceridemia, mixed hyperlipidemia with both raised, familial forms such as familial hypercholesterolaemia and familial combined hyperlipidemia, and hyperalphalipoproteinemia with high HDL; the hypertriglyceridemic waist phenotype combines raised triglycerides with abdominal obesity. Hyperlipidemia is a major risk factor for cardiovascular disease, and very high triglycerides can cause pancreatitis. The model routes people to clinicians.", "what_it_is_for": "Not applicable; a metabolic condition.", "affordances": [ "explain types", "relay risk and management", "route to clinicians", "distinguish related conditions" ], "distinguishing_features": [ "Raised lipids", "Genetic and acquired", "Cardiovascular risk", "Often silent" ], "appearance": "Not a visible object; sometimes xanthomas or corneal arcus.", "visual_identification": [ "Elevated blood lipids or lipoproteins", "Hypertriglyceridemia, familial hyperlipidemia, mixed hyperlipidemia, hyperalphalipoproteinemia, hypertriglyceridemic waist", "Dyslipidemia includes low HDL; atherosclerosis is arterial disease; normal variation is within reference ranges" ], "physical_properties": [ { "quantity": "familial hypercholesterolaemia prevalence", "typical_range": "about 1 in 250", "unit": "note", "note": "heterozygous" }, { "quantity": "severe hypertriglyceridemia threshold", "typical_range": "about 10", "unit": "mmol/L", "note": "about 880 mg/dL, pancreatitis risk" }, { "quantity": "Fredrickson classification", "typical_range": "types I to V", "unit": "note", "note": "1967" } ], "families_and_kinds": [ "hypercholesterolaemia including familial forms", "hypertriglyceridemia and major hypertriglyceridemia", "mixed and familial combined hyperlipidemia", "hyperalphalipoproteinemia", "secondary hyperlipidemia from diabetes, hypothyroidism or drugs", "hypertriglyceridemic waist phenotype" ], "related_models": [ { "relation": "is a kind of", "target": "lipid metabolism disorder", "why": "in registry terms" }, { "relation": "increases risk of", "target": "atherosclerosis", "why": "" }, { "relation": "includes", "target": "familial hypercholesterolemia", "why": "" }, { "relation": "is treated with", "target": "statin", "why": "among other therapies" } ], "identifiers": [ { "scheme": "ICD-10", "value_or_pattern": "E78", "note": "disorders of lipoprotein metabolism" }, { "scheme": "MeSH", "value_or_pattern": "D006949", "note": "Hyperlipidemias" } ], "standards_and_regulation": [ "ESC/EAS and ACC/AHA lipid guidelines", "Screening programmes for familial hypercholesterolaemia" ], "failure_modes_and_hazards": [ "Agents giving personal medical or medication advice", "Missing familial forms in young people", "Pancreatitis from very high triglycerides" ], "in_scope": [], "out_of_scope": [], "characteristics": [] }, "sources": [], "structure": { "bundles": [ { "id": "understand", "name": "Understand", "description": "What hyperlipidemia is.", "rationale": "Clinical.", "layers": [ { "id": "definition", "name": "Definition", "description": "Definition.", "findings": [ { "id": "definition-finding", "name": "Definition", "description": "Definition.", "questions": [ { "text": "What is hyperlipidemia, and how does it differ from dyslipidemia, atherosclerosis and normal variation?", "kind": "definition" }, { "text": "Is the user asking about their own lipid results or medication, which needs a clinician?", "kind": "boundary" } ] } ] }, { "id": "types", "name": "Types", "description": "Types.", "findings": [ { "id": "types-finding", "name": "Types", "description": "Types.", "questions": [ { "text": "What are hypertriglyceridemia, familial and mixed hyperlipidemia, hyperalphalipoproteinemia and the hypertriglyceridemic waist?", "kind": "definition" }, { "text": "Which entry fits the specific type?", "kind": "action" } ] } ] } ] }, { "id": "causes", "name": "Causes", "description": "Causes and risk.", "rationale": "Clinical.", "layers": [ { "id": "genetic", "name": "Genetic", "description": "Genetic causes.", "findings": [ { "id": "genetic-finding", "name": "Genetic", "description": "Genetic.", "questions": [ { "text": "Which genes cause familial hyperlipidemias?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "risk", "name": "Risk", "description": "Cardiovascular risk.", "findings": [ { "id": "risk-finding", "name": "Risk", "description": "Risk.", "questions": [ { "text": "How do lipids affect cardiovascular risk, as guidelines describe?", "kind": "provenance" }, { "text": "Which sources are cited?", "kind": "provenance" } ] } ] } ] }, { "id": "care", "name": "Care", "description": "Screening and management.", "rationale": "Clinical.", "layers": [ { "id": "screening", "name": "Screening", "description": "Screening.", "findings": [ { "id": "screening-finding", "name": "Screening", "description": "Screening.", "questions": [ { "text": "How are lipids measured and when is screening recommended?", "kind": "provenance" }, { "text": "Which entry fits lipid profile?", "kind": "action" } ] } ] }, { "id": "management", "name": "Management", "description": "Management.", "findings": [ { "id": "management-finding", "name": "Management", "description": "Management.", "questions": [ { "text": "What general approaches do guidelines describe, from lifestyle to statins and newer drugs?", "kind": "provenance" }, { "text": "Which entry fits statin?", "kind": "action" } ] } ] } ] }, { "id": "context", "name": "Context", "description": "Classification and research.", "rationale": "Context.", "layers": [ { "id": "classification", "name": "Classification", "description": "Classification.", "findings": [ { "id": "classification-finding", "name": "Classification", "description": "Classification.", "questions": [ { "text": "What is the Fredrickson classification?", "kind": "provenance" }, { "text": "Which entry fits Fredrickson classification?", "kind": "action" } ] } ] }, { "id": "research", "name": "Research", "description": "Research.", "findings": [ { "id": "research-finding", "name": "Research", "description": "Research.", "questions": [ { "text": "What therapies are being researched, such as PCSK9 and ANGPTL3 targeting?", "kind": "provenance" }, { "text": "Which entry fits PCSK9 inhibitor?", "kind": "action" } ] } ] } ] } ] }, "openQuestions": [ "Should hypertriglyceridemia and familial hypercholesterolaemia be separate primary entries?", "How should lipid guidelines be linked?", "The registry entry has merged aliases naming lipid patterns and a phenotype; should they be split off?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "abstract concept", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a hyperlipidemia, record what state it is in, and decide what may be done with it.", "whatItIs": "Let an agent explain hyperlipidemia and its types, relay causes, risk, screening and general management from cardiology and lipid guidelines, describe the forms the registry aliases name, and distinguish hyperlipidemia from dyslipidemia broadly, from atherosclerosis and from normal lipid variation, routing people to clinicians without personal advice.", "characteristics": { "substance": "abstract", "origin": "conceptual", "agency": "inert" }, "whatYouCanDoWithIt": [ "observed and measured" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: hypertriglyceridemia, familial hyperlipidemia, mixed hyperlipidemia, hyperalphalipoproteinemia, hypertriglyceridemic waist, major hypertriglyceridemia.", "6 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 31 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a hyperlipidemia, and on what evidence are they told apart?" ], "whatItIsMadeOf": "an abstraction with no physical instance", "physicalCharacter": [ "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state" ], "howItIsRecognised": [ "Nothing to see. What is recognised is an instance of it, and which instances count is exactly what is argued about." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "hypertriglyceridemia", "familial hyperlipidemia", "mixed hyperlipidemia", "hyperalphalipoproteinemia", "hypertriglyceridemic waist", "major hypertriglyceridemia" ] } ], "standing": "Described in 31 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 6 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one hyperlipidemia from another, and a hyperlipidemia from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a hyperlipidemia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a hyperlipidemia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a hyperlipidemia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a hyperlipidemia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a hyperlipidemia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a hyperlipidemia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a hyperlipidemia sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a hyperlipidemia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a hyperlipidemia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a hyperlipidemia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a hyperlipidemia from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a hyperlipidemia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a hyperlipidemia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a hyperlipidemia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a hyperlipidemia passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a hyperlipidemia between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a hyperlipidemia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a hyperlipidemia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a hyperlipidemia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a hyperlipidemia, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a hyperlipidemia is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a hyperlipidemia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a hyperlipidemia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a hyperlipidemia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "definitions-in-contest", "name": "Definitions and who holds them", "description": "What hyperlipidemia is taken to mean, and by whom.", "rationale": "When a field disagrees about a concept, the disagreement is the content. A model that picks one definition silently destroys the information.", "layers": [ { "id": "competing-definitions", "name": "Competing definitions", "description": "The main readings and the traditions behind them.", "findings": [ { "id": "definition-map", "name": "Definitions and their holders", "description": "Each definition with the school or body that holds it.", "questions": [ { "id": "definition-map-q01", "text": "Which definitions of hyperlipidemia are in use, and which tradition or body holds each?", "kind": "definition" }, { "id": "definition-map-q02", "text": "What turns on the difference between them in practice?", "kind": "boundary" } ] } ] }, { "id": "operationalisation", "name": "Operationalisation", "description": "How it is measured or applied when it has to be.", "findings": [ { "id": "operational-record", "name": "Measures and proxies", "description": "Instruments and indicators used to stand in for it.", "questions": [ { "id": "operational-record-q01", "text": "How is hyperlipidemia operationalised or measured in practice, and by what instrument?", "kind": "measurement" }, { "id": "operational-record-q02", "text": "What does that operationalisation leave out, and when does that matter?", "kind": "boundary" } ] } ] } ] }, { "id": "instances-and-use", "name": "Instances, use and consequence", "description": "What counts as an instance of hyperlipidemia and what follows from calling something that.", "rationale": "Applying a concept is an act with consequences, so a model must say what the label licenses and what it does not.", "layers": [ { "id": "instances", "name": "What counts as an instance", "description": "Clear cases, borderline cases and non-cases.", "findings": [ { "id": "instance-tests", "name": "Tests for an instance", "description": "What would settle whether something falls under it.", "questions": [ { "id": "instance-tests-q01", "text": "What would settle whether something is an instance of hyperlipidemia?", "kind": "boundary" }, { "id": "instance-tests-q02", "text": "Which borderline cases are argued about, and on what grounds?", "kind": "definition" } ] } ] }, { "id": "consequence", "name": "Consequence of application", "description": "Rights, duties or decisions that follow from the label.", "findings": [ { "id": "consequence-record", "name": "What the label licenses", "description": "What an agent may do once something is classified this way.", "questions": [ { "id": "consequence-record-q01", "text": "What follows practically once something is treated as hyperlipidemia?", "kind": "action" }, { "id": "consequence-record-q02", "text": "What must an agent not infer from the label alone?", "kind": "action" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a hyperlipidemia came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a hyperlipidemia and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a hyperlipidemia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a hyperlipidemia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a hyperlipidemia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a hyperlipidemia is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a hyperlipidemia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a hyperlipidemia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a hyperlipidemia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 5, "layers": 10, "findings": 12, "questions": 32 } } } }