{ "model": { "rank": 2128, "code": "thing-q11078", "model_id": "vr.tr.endocrine-system", "name": "endocrine system", "purpose": "Enable an AI agent to recognise an endocrine system, assess the evidence for its regulatory state, and identify justified observations, referrals, or authorised interventions.", "family": "Thing Registry", "category": "Physical world and living systems", "status": "research-draft", "kind": "thing", "plane": "PHY", "domain": "PHY.OBJ", "industry": "", "version": "", "url": "/models/thing/q11078/", "tier": 2, "score": 114, "payload": { "layer": "wikidata", "aliases": [ "chromaffin system", "renin–angiotensin system" ], "aliasCount": 2, "merged": 2, "knownIn": 114, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q11078", "url": "https://www.wikidata.org/wiki/Q11078", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-07T09:58:27Z", "providers": [ "Codex", "Grok" ], "missingProviders": [], "pass": 2, "cost": { "grok": { "usd": 0.00392326, "turns": 1, "seconds": 56.4, "error": null }, "codex": { "seconds": 75.4, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.3\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a07b4c-e58c-7b10-9c38-f0d3df9e08db\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: endocrine system\nRegistry id: vr.tr.endocrine-system\nPlane / domain: PHY / PHY.OBJ\nRegistry definition: (none recorded)\nNames folded into this entry:" } } }, "metaModel": { "id": "THING-Q11078", "registryId": "vr.tr.endocrine-system", "name": "endocrine system", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.OBJ" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q11078/", "model": { "registry_id": "vr.tr.endocrine-system", "name": "endocrine system", "purpose": "Enable an AI agent to recognise an endocrine system, assess the evidence for its regulatory state, and identify justified observations, referrals, or authorised interventions.", "definition": "The endocrine system is the set of ductless glands, dispersed endocrine cells, and circulating hormones that coordinate distant target-cell activity by chemical signalling through the bloodstream (and locally by paracrine/autocrine routes), distinct from neural transmission and from exocrine secretion.", "scope_statement": "This model owns the organism-level system of endocrine hormone production, release, transport, reception, metabolism, and feedback, including relationships among distributed endocrine tissues and their target tissues; species and life stage must be explicit.", "in_scope": [ "Endocrine glands, distributed endocrine cells, and their participation in hormone signalling", "Hormone production, secretion, circulation, availability, and clearance", "Endocrine axes, feedback relationships, and target-tissue responsiveness", "Temporal regulation and changes associated with development and physiological context", "Evidence of endocrine function, dysfunction, and effects of interventions" ], "out_of_scope": [ "Whole-organ anatomy and non-endocrine functions owned by individual organ models", "Exocrine secretion through ducts and its digestive or surface functions", "Neural signalling except where it regulates or receives endocrine signals", "Complete reproductive, metabolic, immune, or skeletal systems beyond their endocrine interfaces", "Disease-specific diagnostic criteria and treatment protocols", "Clinical encounter management, prescribing authority, and consent records" ], "distinguishing_features": [ "Determine whether the referent is an organism-level hormone-regulatory system rather than one gland, one hormone, or one endocrine disorder.", "Distinguish internal hormone release and target signalling from exocrine delivery through ducts; a mixed-function organ can participate in both.", "Identify hormone-producing tissue, a signalling route, and responsive targets; anatomical proximity alone does not establish endocrine participation.", "Distinguish endocrine participation from exclusively local paracrine or autocrine signalling, while permitting a molecule or tissue to participate in multiple signalling modes.", "Identify endocrine feedback or coordinated regulation rather than treating an isolated hormone concentration as the state of the whole system." ], "characteristics": [ { "name": "Organism and physiological context", "kind": "category", "unit_or_values": "Species, developmental stage, reproductive context, and relevant physiological conditions", "why_it_matters": "Determines which structures, axes, rhythms, and reference comparisons are applicable." }, { "name": "Endocrine tissue participation", "kind": "relation", "unit_or_values": "Tissue or cell population → hormone product → endocrine role; evidence status attached", "why_it_matters": "Recognises distributed endocrine activity without equating the system with a fixed list of glands." }, { "name": "Regulatory connections", "kind": "relation", "unit_or_values": "Source, target, signal, stimulatory or inhibitory effect, feedback direction, and supported context", "why_it_matters": "Supports interpretation of coordinated and discordant observations across an endocrine axis." }, { "name": "Hormone concentration", "kind": "measurement", "unit_or_values": "Analyte-specific units with specimen, collection time, assay, and total or free fraction", "why_it_matters": "Makes a measured result interpretable and comparable without confusing concentration with secretion rate." }, { "name": "Hormone availability and disposition", "kind": "state", "unit_or_values": "Binding, activation, inactivation, and clearance status; measured, inferred, or unknown", "why_it_matters": "Separates hormone production from the amount and form available to target tissues." }, { "name": "Target responsiveness", "kind": "state", "unit_or_values": "Preserved, reduced, increased, mixed, or unknown; qualified by hormone, tissue, and evidence", "why_it_matters": "Allows circulating hormone levels and biological response to be assessed separately." }, { "name": "Secretory timing", "kind": "measurement", "unit_or_values": "Sampling times, pulse intervals, rhythm phase, amplitude, and observation duration where established", "why_it_matters": "Prevents a single sample from being mistaken for sustained endocrine behaviour." }, { "name": "Axis functional assessment", "kind": "state", "unit_or_values": "Adequate, deficient, excessive, dysregulated, indeterminate, or unassessed; axis and context specified", "why_it_matters": "Records a bounded interpretation with uncertainty instead of declaring the entire system normal or abnormal." } ], "affordances": [ "Map documented endocrine tissues, hormones, targets, and feedback relationships for the organism.", "Record and contextualise hormone measurements alongside physiological responses.", "Compare longitudinal or paired observations within an endocrine axis and flag unexplained discordance.", "Identify missing observations needed to distinguish secretion, transport, clearance, and target-response explanations.", "Track endocrine effects of documented exposures and authorised interventions.", "Route findings for qualified review using applicable protocols while preserving uncertainty and action authority." ] }, "sources": [ { "id": "src-nih-endocrine", "title": "Endocrine Glands", "url": "https://www.ncbi.nlm.nih.gov/books/NBK279407/", "what_it_supports": "Anatomical definition of ductless glands, hormone transport in blood, and the classical gland list (pituitary, thyroid, parathyroid, adrenal, pineal, plus gonads and pancreatic islets as mixed organs).", "url_status": "live" }, { "id": "src-wiki-endocrine", "title": "Endocrine system", "url": "https://en.wikipedia.org/wiki/Endocrine_system", "what_it_supports": "System-level definition, distinction from exocrine glands, hypothalamic control, diffuse neuroendocrine cells, and neighbouring concepts (nervous system, exocrine system).", "url_status": "live" }, { "id": "src-who-icd11", "title": "ICD-11 - Endocrine, nutritional or metabolic diseases (chapter 05)", "url": "https://icd.who.int/browse/2025-01/mms/en#334423054", "what_it_supports": "Clinical classification of endocrine diseases as a governed diagnostic domain (WHO ICD-11), including gland-specific disease blocks used in practice.", "url_status": "live" }, { "id": "src-mesh-endocrine", "title": "MeSH - Endocrine System (D004703)", "url": "https://meshb.nlm.nih.gov/record/ui?ui=D004703", "what_it_supports": "Controlled vocabulary identifier and scope: the system of glands that release chemical substances into the blood, covering glands and circulating hormones as catalogued by NLM.", "url_status": "live" } ], "structure": { "bundles": [ { "id": "endocrine-membership", "name": "Endocrine membership", "description": "Establishes which tissues and signalling activities constitute this organism's endocrine system.", "rationale": "The system includes distributed endocrine activity and cannot be recognised solely by naming classical glands.", "layers": [ { "id": "organism-specific-composition", "name": "Organism-specific composition", "description": "Locates endocrine participation within the organism and its life stage.", "findings": [ { "id": "documented-hormone-producing-tissues", "name": "Documented hormone-producing tissues", "description": "Record participating glands and cell populations, their hormone products, and the basis for including them.", "questions": [ { "text": "Which species and life stage define the endocrine system being modelled?", "kind": "definition", "id": "documented-hormone-producing-tissues-q01" }, { "text": "What evidence establishes hormone production and endocrine participation for each included tissue or cell population?", "kind": "provenance", "id": "documented-hormone-producing-tissues-q02" } ] } ] }, { "id": "signalling-boundaries", "name": "Signalling boundaries", "description": "Separates endocrine roles from adjacent functions without splitting mixed-function organs.", "findings": [ { "id": "endocrine-role-boundary", "name": "Endocrine role boundary", "description": "Record which activities belong to endocrine signalling and which remain owned by neighbouring models.", "questions": [ { "text": "For each included signal, what release route and target relationship justify treating it as endocrine?", "kind": "boundary", "id": "endocrine-role-boundary-q01" }, { "text": "Which exocrine, neural, paracrine, or autocrine activities share these tissues but require separate representation?", "kind": "boundary", "id": "endocrine-role-boundary-q02" } ] } ] } ] }, { "id": "hormone-availability", "name": "Hormone availability", "description": "Represents how hormone production becomes an available signal at a target.", "rationale": "A circulating concentration alone cannot identify whether a difference originates in secretion, binding, conversion, or clearance.", "layers": [ { "id": "production-and-release", "name": "Production and release", "description": "Connects hormone products to producing tissues and documented release conditions.", "findings": [ { "id": "secretory-capacity-and-drive", "name": "Secretory capacity and drive", "description": "Record evidence about hormone production and release, distinguishing direct observations from inferred capacity.", "questions": [ { "text": "Which observations support the tissue's ability to produce and release this hormone?", "kind": "provenance", "id": "secretory-capacity-and-drive-q01" }, { "text": "Which measured stimuli or suppressive conditions accompanied the observed hormone level?", "kind": "measurement", "id": "secretory-capacity-and-drive-q02" } ] } ] }, { "id": "transport-conversion-and-clearance", "name": "Transport, conversion, and clearance", "description": "Tracks processes between release and target exposure.", "findings": [ { "id": "available-hormone-form", "name": "Available hormone form", "description": "Record relevant circulating fractions, molecular forms, and evidence of altered disposition.", "questions": [ { "text": "Does the observation measure total hormone, free hormone, a precursor, or a metabolite, and in which specimen?", "kind": "measurement", "id": "available-hormone-form-q01" }, { "text": "What evidence supports a contribution from binding, conversion, or clearance to the observed level?", "kind": "provenance", "id": "available-hormone-form-q02" } ] } ] } ] }, { "id": "axes-feedback-and-response", "name": "Axes, feedback, and response", "description": "Represents coordinated endocrine regulation and the response of target tissues.", "rationale": "Endocrine state depends on relationships among signals and responses, including feedback and sensitivity.", "layers": [ { "id": "regulatory-axis-organisation", "name": "Regulatory axis organisation", "description": "Maps upstream regulators, downstream signals, and feedback connections.", "findings": [ { "id": "supported-feedback-relationships", "name": "Supported feedback relationships", "description": "Record the direction, context, and evidential basis of endocrine regulatory connections.", "questions": [ { "text": "Which upstream signals, endocrine tissues, downstream hormones, and feedback targets define each represented axis?", "kind": "definition", "id": "supported-feedback-relationships-q01" }, { "text": "Which source supports each stimulatory or inhibitory relationship in this species and physiological context?", "kind": "provenance", "id": "supported-feedback-relationships-q02" } ] } ] }, { "id": "target-tissue-response", "name": "Target-tissue response", "description": "Connects hormone exposure to tissue sensitivity and observed physiological effects.", "findings": [ { "id": "signal-response-concordance", "name": "Signal-response concordance", "description": "Record whether observed target responses align with hormone exposure, preserving alternative explanations.", "questions": [ { "text": "Which tissue-specific response measurements accompany the hormone observations, and over what interval?", "kind": "measurement", "id": "signal-response-concordance-q01" }, { "text": "What evidence distinguishes altered target responsiveness from altered hormone availability or a non-endocrine cause?", "kind": "provenance", "id": "signal-response-concordance-q02" } ] } ] } ] }, { "id": "endocrine-observation-context", "name": "Endocrine observation context", "description": "Makes endocrine observations interpretable across sampling conditions, rhythms, and physiological transitions.", "rationale": "Sampling time, assay properties, and physiological context can materially change the meaning of an endocrine result.", "layers": [ { "id": "sampling-and-assay-interpretation", "name": "Sampling and assay interpretation", "description": "Captures the conditions and analytical limitations of hormone measurements.", "findings": [ { "id": "interpretable-hormone-observation", "name": "Interpretable hormone observation", "description": "Record sufficient analytical and contextual information to judge whether a result supports comparison or inference.", "questions": [ { "text": "What specimen, collection time, units, assay method, and relevant collection conditions accompany this result?", "kind": "measurement", "id": "interpretable-hormone-observation-q01" }, { "text": "What source supports the chosen reference interval or decision threshold, and does it apply to this organism and context?", "kind": "provenance", "id": "interpretable-hormone-observation-q02" }, { "text": "Which documented assay interference or specimen limitation could affect interpretation?", "kind": "measurement", "id": "interpretable-hormone-observation-q03" } ] } ] }, { "id": "rhythms-and-physiological-transitions", "name": "Rhythms and physiological transitions", "description": "Places observations within endocrine timing and changes in physiological demand.", "findings": [ { "id": "time-dependent-endocrine-pattern", "name": "Time-dependent endocrine pattern", "description": "Record temporal patterns and relevant developmental or physiological transitions without assuming one sample represents a stable state.", "questions": [ { "text": "How do sampling times relate to relevant sleep, feeding, pulse, daily, or reproductive timing?", "kind": "measurement", "id": "time-dependent-endocrine-pattern-q01" }, { "text": "Which longitudinal observations distinguish a persistent change from a transient response or physiological transition?", "kind": "measurement", "id": "time-dependent-endocrine-pattern-q02" } ] } ] } ] }, { "id": "endocrine-state-and-action", "name": "Endocrine state and action", "description": "Connects bounded functional assessments to exposures, review needs, and authorised action.", "rationale": "An agent must distinguish observed endocrine evidence from causal interpretation and from permission to intervene.", "layers": [ { "id": "functional-state-and-causal-uncertainty", "name": "Functional state and causal uncertainty", "description": "Records axis-specific assessments and competing explanations.", "findings": [ { "id": "bounded-endocrine-assessment", "name": "Bounded endocrine assessment", "description": "Record the supported functional interpretation, its time window, confidence, and unresolved causes.", "questions": [ { "text": "Which paired hormone and physiological observations support the stated functional assessment of this axis?", "kind": "measurement", "id": "bounded-endocrine-assessment-q01" }, { "text": "What remains unresolved among altered gland function, upstream regulation, hormone disposition, target response, and measurement error?", "kind": "boundary", "id": "bounded-endocrine-assessment-q02" } ] } ] }, { "id": "exposures-and-authorised-interventions", "name": "Exposures and authorised interventions", "description": "Tracks endocrine perturbations and the basis for subsequent observation or action.", "findings": [ { "id": "endocrine-action-basis", "name": "Endocrine action basis", "description": "Record relevant exposures and interventions, their temporal relationship to findings, and the authority and evidence for next steps.", "questions": [ { "text": "Which exogenous hormones, medicines, procedures, or other documented exposures preceded the endocrine changes?", "kind": "provenance", "id": "endocrine-action-basis-q01" }, { "text": "Which applicable protocol and authorised decision-maker determine whether further sampling, dynamic testing, specialist review, or intervention is appropriate?", "kind": "action", "id": "endocrine-action-basis-q02" }, { "text": "Which endocrine signals and target responses should be followed to assess the outcome of an authorised intervention?", "kind": "action", "id": "endocrine-action-basis-q03" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-kinds", "name": "Kinds and varieties", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "classical ductless endocrine glands (pituitary, thyroid, parathyroid, adrenal, pineal)", "hypothalamic neuroendocrine control (releasing and inhibiting hormones, posterior pituitary peptides)", "gonadal endocrine tissue (ovary, testis)", "pancreatic islets (islets of Langerhans)", "diffuse neuroendocrine system / APUD cells (gut, lung, other mucosae)", "adipose and other non-classical endocrine organs (adipokines, myokines, osteokines)", "placental endocrine function (in pregnancy)", "ectopic and tumour-associated hormone production" ], "questions": [ { "id": "evidence-kinds-q01", "text": "Which of these kinds and varieties hold for the sense of endocrine system this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-identifiers", "name": "Identifiers and schemes", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ { "scheme": "Wikidata", "value_or_pattern": "Q11078", "note": "item 'endocrine system'" }, { "scheme": "MeSH", "value_or_pattern": "D004703", "note": "descriptor 'Endocrine System'" }, { "scheme": "UBERON", "value_or_pattern": "UBERON:0000949", "note": "anatomical entity 'endocrine system'" }, { "scheme": "FMA", "value_or_pattern": "FMA:9668", "note": "Foundational Model of Anatomy 'Endocrine system'" }, { "scheme": "ICD-11", "value_or_pattern": "chapter 05 (5A00-5D46 range in MMS)", "note": "WHO classification of endocrine, nutritional or metabolic diseases; not an identifier of the healthy system itself" } ], "questions": [ { "id": "evidence-identifiers-q01", "text": "Which of these identifiers and schemes hold for the sense of endocrine system this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-standards-and-regulation", "name": "Standards and regulation", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "WHO ICD-11 chapter 05 - classification of endocrine, nutritional or metabolic diseases (World Health Organization)", "IUPAC / IFCC recommendations on nomenclature of peptide hormones and immunoassay reporting (International Union of Pure and Applied Chemistry; International Federation of Clinical Chemistry and Laboratory Medicine)", "ISO 15189 - requirements for quality and competence of medical laboratories performing hormone assays (International Organization for Standardization)", "CLIA (US) and IVDR (EU 2017/746) - legal frameworks governing clinical endocrine laboratory testing and in-vitro diagnostic devices (CMS/FDA; European Union)", "Endocrine Society / European Society of Endocrinology clinical practice guidelines - disease-specific standards of care, not a statute (professional societies)" ], "questions": [ { "id": "evidence-standards-and-regulation-q01", "text": "Which of these standards and regulation hold for the sense of endocrine system this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "Clinical endocrinology: diagnosis and long-term management of diabetes, thyroid disease, adrenal failure, pituitary tumours, and reproductive-hormone disorders via blood hormone panels and imaging.", "Pharmacotherapy: replacement (levothyroxine, insulin, hydrocortisone, sex steroids), suppression (antithyroid drugs, somatostatin analogues), and receptor modulation (SERMs, GLP-1 receptor agonists).", "Occupational and environmental health: biomonitoring of endocrine-disrupting chemicals (bisphenols, phthalates, persistent organic pollutants) against hormone-axis endpoints.", "Veterinary and livestock practice: reproductive synchronisation, growth-promoting hormone regulation, and companion-animal endocrine disease (hyperthyroidism, Cushing, diabetes).", "Research and drug development: use of the HPA, HPG and HPT axes as endpoints in toxicology, oncology (hormone-dependent cancers), and metabolic trials." ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of endocrine system this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-measurements", "name": "Typical measurements", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ { "quantity": "circulating thyrotropin (TSH)", "typical_range": "about 0.4-4.0 in many adult reference intervals (method- and lab-specific)", "unit": "mIU/L" }, { "quantity": "free thyroxine (FT4)", "typical_range": "roughly 9-25 (assay-dependent adult interval)", "unit": "pmol/L" }, { "quantity": "morning serum cortisol", "typical_range": "approximately 140-690 (clock-time and assay dependent)", "unit": "nmol/L" }, { "quantity": "HbA1c (glycated haemoglobin, diabetes/endocrine metabolic control)", "typical_range": "non-diabetic typically <42; treatment targets often around 48-53", "unit": "mmol/mol (IFCC) or %" }, { "quantity": "plasma glucose (fasting)", "typical_range": "normoglycaemia commonly 3.9-5.6", "unit": "mmol/L" }, { "quantity": "serum 25-hydroxyvitamin D (steroid-hormone metabolite often reported with endocrine panels)", "typical_range": "deficiency commonly defined <30; sufficiency often 50-125", "unit": "nmol/L" }, { "quantity": "number of classical endocrine glands commonly enumerated in human anatomy teaching", "typical_range": "8-10 named glands depending on whether pineal, thymus, and gonads are counted", "unit": "count" } ], "questions": [ { "id": "evidence-measurements-q01", "text": "Which of these typical measurements hold for the sense of endocrine system this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "Hyposecretion: primary gland failure (Addison disease, primary hypothyroidism, type 1 diabetes, hypogonadism) or secondary/tertiary failure from pituitary or hypothalamic disease.", "Hypersecretion and autonomy: Graves disease, Cushing disease/syndrome, primary hyperparathyroidism, acromegaly, insulinoma and other functioning tumours.", "Receptor or post-receptor resistance: type 2 diabetes, androgen-insensitivity syndromes, thyroid-hormone resistance.", "Iatrogenic disruption: exogenous glucocorticoids, immune-checkpoint inhibitor hypophysitis/thyroiditis, abrupt withdrawal of replacement therapy (adrenal crisis).", "Endocrine-disrupting chemical exposure altering development, fertility, or thyroid economy.", "Oncologic hazard: hormone-dependent cancers (breast, prostate, endometrium) and mass-effect/invasion from pituitary or adrenal tumours.", "Life-threatening acute crises: diabetic ketoacidosis, myxoedema coma, thyroid storm, adrenal crisis, severe hyponatraemia from SIADH or cortisol deficiency." ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of endocrine system this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-regional-variation", "name": "Regional variation", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "Iodine nutrition and thyroid disease pattern: iodine-deficient regions still show more goitre and some hyperthyroidism patterns; iodine-replete populations have more autoimmune thyroid disease (WHO/IGN iodine-status maps).", "Diabetes classification and screening thresholds vary slightly across ADA, WHO, and national programmes; gestational-diabetes criteria are not globally uniform.", "Legal status of hormone therapies (gender-affirming hormones, anabolic steroids, growth hormone) differs by jurisdiction.", "Naming: 'endocrine system' vs older 'ductless gland system'; some languages and curricula still treat the pancreas or gonads as primarily exocrine/reproductive rather than endocrine organs.", "Vitamin D cut-offs, units (nmol/L vs ng/mL), and screening policy differ between Endocrine Society, IOM/NAM, and national laboratories." ], "questions": [ { "id": "evidence-regional-variation-q01", "text": "Which of these regional variation hold for the sense of endocrine system this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ { "name": "nervous system / neuroendocrine signalling", "difference": "Neural transmission uses synapses and milliseconds; endocrine signalling uses blood-borne (or tissue-fluid) hormones over seconds to days. Shared hypothalamic neurons that secrete into the portal or systemic circulation are classified as neuroendocrine, not purely neural." }, { "name": "exocrine system (glands with ducts)", "difference": "Exocrine products leave via ducts to an epithelial surface (sweat, saliva, pancreatic enzymes, bile); endocrine products enter interstitial fluid and blood. Mixed organs (pancreas, gonads, liver) are separated by which product and route is meant." }, { "name": "paracrine / autocrine local signalling", "difference": "Same chemical classes may act locally without a physiologically relevant circulating concentration; endocrine status is assigned when the mediator acts at a distance via blood (or is measured as a circulating hormone in clinical practice)." }, { "name": "immune cytokine network", "difference": "Cytokines can circulate and affect distant organs, but immunology catalogues them as immune mediators; endocrine catalogues restrict to hormones of dedicated glands and recognised endocrine cells unless a cytokine is used as an endocrine biomarker (e.g. adipokines)." }, { "name": "metabolic / nutritional disease chapter without a primary gland lesion", "difference": "ICD-11 groups endocrine, nutritional and metabolic diseases together; a primary nutritional deficiency or inborn error of metabolism is not a failure of an endocrine gland even when hormone levels shift secondarily." } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of endocrine system this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Does the registry intend a human endocrine system, vertebrate endocrine systems, or a broader comparative scope requiring different anatomical and signalling structures?", "Which distributed endocrine tissues and signals should be mandatory for recognition, and which should be included only when relevant to the organism or task?", "What evidence standard should establish endocrine participation when the same molecule also acts through paracrine, autocrine, or neural routes?", "Which species-specific sources should govern axis relationships, physiological timing, assay interpretation, and functional assessment?", "Which existing Vercy models own overlapping endocrine concepts, disease protocols, and action authority, and should this entry link to an existing world model?" ], "statistics": { "bundles": 6, "layers": 11, "findings": 18, "questions": 30 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "device, machine or tool", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a endocrine system, record what state it is in, and decide what may be done with it.", "whatItIs": "Enable an AI agent to recognise an endocrine system, assess the evidence for its regulatory state, and identify justified observations, referrals, or authorised interventions.", "characteristics": { "substance": "material", "origin": "manufactured", "agency": "inert", "mobility": "varies" }, "whatYouCanDoWithIt": [ "observed and measured" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: chromaffin system, renin–angiotensin system.", "2 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 114 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a endocrine system, and on what evidence are they told apart?" ], "whatItIsMadeOf": "matter you can touch", "physicalCharacter": [ "Mobility varies between examples.", "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state" ], "howItIsRecognised": [ "Recognised by form, by the arrangement of its controls, and by markings - a plate, a model number, a certification mark. Form alone rarely separates two models that do very different things." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "chromaffin system", "renin–angiotensin system" ] } ], "standing": "Described in 114 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 2 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one endocrine system from another, and a endocrine system from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a endocrine system, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a endocrine system, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a endocrine system is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a endocrine system, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a endocrine system, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a endocrine system is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a endocrine system sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a endocrine system, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a endocrine system, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a endocrine system is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a endocrine system from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a endocrine system, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a endocrine system, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a endocrine system is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "form-and-composition", "name": "Form, composition and condition", "description": "What a endocrine system is made of, what shape and size it takes, and what state it is in.", "rationale": "A physical thing can be measured, and a model that cannot record its measurements cannot support any decision that depends on them.", "layers": [ { "id": "form-and-dimensions", "name": "Form and dimensions", "description": "Shape, size, mass and the ranges these take across examples.", "findings": [ { "id": "measurable-dimensions", "name": "Measurable dimensions and their units", "description": "The quantities worth recording and the units they are recorded in.", "questions": [ { "id": "measurable-dimensions-q01", "text": "What identifies and describes the dimensions of a endocrine system, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "measurable-dimensions-q02", "text": "Who or what asserted this about the dimensions of a endocrine system, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "measurable-dimensions-q03", "text": "What may an agent decide or do once the dimensions of a endocrine system is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "material-and-composition", "name": "Material and composition", "description": "Materials, parts and how they are put together.", "findings": [ { "id": "parts-and-materials", "name": "Parts and materials", "description": "What a endocrine system is built from and which parts are replaceable.", "questions": [ { "id": "parts-and-materials-q01", "text": "What identifies and describes the composition of a endocrine system, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "parts-and-materials-q02", "text": "Who or what asserted this about the composition of a endocrine system, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "parts-and-materials-q03", "text": "What may an agent decide or do once the composition of a endocrine system is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "condition-and-integrity", "name": "Condition and integrity", "description": "Wear, damage, health and the difference between working and broken.", "findings": [ { "id": "condition-assessment", "name": "Condition, damage and health", "description": "How the condition of a endocrine system is judged and by whom.", "questions": [ { "id": "condition-assessment-q01", "text": "What identifies and describes the condition of a endocrine system, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "condition-assessment-q02", "text": "Who or what asserted this about the condition of a endocrine system, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "condition-assessment-q03", "text": "What may an agent decide or do once the condition of a endocrine system is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "place-and-movement", "name": "Place and movement", "description": "Where a endocrine system is, how it got there and where it may go (varies).", "rationale": "A thing that can move needs its position recorded with a time, or every later claim about it is about a place it has left.", "layers": [ { "id": "location-and-placement", "name": "Location and placement", "description": "Position, containment and the reference frame the position is given in.", "findings": [ { "id": "position-and-frame", "name": "Position, container and reference frame", "description": "Where a endocrine system is, and what that position is measured against.", "questions": [ { "id": "position-and-frame-q01", "text": "What identifies and describes the location of a endocrine system, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "position-and-frame-q02", "text": "Who or what asserted this about the location of a endocrine system, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "position-and-frame-q03", "text": "What may an agent decide or do once the location of a endocrine system is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "movement-and-transfer", "name": "Movement and transfer", "description": "How a endocrine system is carried, installed or relocated.", "findings": [ { "id": "movement-events", "name": "Movement events and constraints", "description": "What counts as a movement, what records it and what limits it.", "questions": [ { "id": "movement-events-q01", "text": "What identifies and describes the movement of a endocrine system, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "movement-events-q02", "text": "Who or what asserted this about the movement of a endocrine system, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "movement-events-q03", "text": "What may an agent decide or do once the movement of a endocrine system is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a endocrine system passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a endocrine system between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a endocrine system, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a endocrine system, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a endocrine system is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a endocrine system, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a endocrine system is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a endocrine system, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a endocrine system, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a endocrine system is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "function-and-principle", "name": "Function and operating principle", "description": "What endocrine system is for and how it achieves it.", "rationale": "Two devices with the same name can work on different principles, and the principle is what predicts failure and constrains use.", "layers": [ { "id": "intended-function", "name": "Intended function", "description": "The job it does, and the jobs it is used for anyway.", "findings": [ { "id": "function-record", "name": "Function, principle and variants", "description": "What it does, how, and which variants do it differently.", "questions": [ { "id": "function-record-q01", "text": "What function does endocrine system perform, on what operating principle, and which variants differ in that principle?", "kind": "definition" }, { "id": "function-record-q02", "text": "What use falls outside the intended function but happens in practice?", "kind": "boundary" } ] } ] }, { "id": "capacity-and-rating", "name": "Capacity and rating", "description": "The numbers that say what it can do and where it stops.", "findings": [ { "id": "ratings", "name": "Ratings and their conditions", "description": "Rated capacity, power, throughput and the conditions each assumes.", "questions": [ { "id": "ratings-q01", "text": "What ratings characterise endocrine system, in what units, and under what stated conditions?", "kind": "measurement" }, { "id": "ratings-q02", "text": "What happens beyond the rating - degradation, refusal, damage - and how is that detected?", "kind": "action" } ] } ] } ] }, { "id": "operation-and-state", "name": "Operation, controls and state", "description": "How endocrine system is operated and what state it is in right now.", "rationale": "An agent acting on a device needs its current state and the controls that change it, not just its specification.", "layers": [ { "id": "controls-and-modes", "name": "Controls and modes", "description": "What can be set, what that changes, and what is interlocked.", "findings": [ { "id": "control-surface", "name": "Control surface and interlocks", "description": "The settings available and the conditions that block them.", "questions": [ { "id": "control-surface-q01", "text": "What controls and modes does endocrine system have, and what does each change?", "kind": "definition" }, { "id": "control-surface-q02", "text": "Which actions are interlocked or forbidden in which state, and what must be true before acting?", "kind": "action" } ] } ] }, { "id": "condition-and-maintenance", "name": "Condition and maintenance", "description": "Wear, service intervals, consumables and the line between working and broken.", "findings": [ { "id": "service-record", "name": "Condition, service and consumables", "description": "What is consumed, what is serviced, and how condition is judged.", "questions": [ { "id": "service-record-q01", "text": "What consumables and service does endocrine system need, at what interval, and on whose authority?", "kind": "measurement" }, { "id": "service-record-q02", "text": "What evidence separates a unit that is working from one that is out of service?", "kind": "boundary" } ] } ] } ] }, { "id": "kind-model-unit", "name": "Kind, model and unit", "description": "Whether a claim about endocrine system is about the kind, a product line, or one physical unit.", "rationale": "This is the boundary most often got wrong for made things, and getting it wrong mixes a catalogue entry with the machine in the yard.", "layers": [ { "id": "level-of-reference", "name": "Level of reference", "description": "The three levels and what belongs at each.", "findings": [ { "id": "level-rules", "name": "What belongs to kind, model and unit", "description": "Which properties are shared by all of them and which are not.", "questions": [ { "id": "level-rules-q01", "text": "Which facts about endocrine system hold for every one of them, which for a model, and which only for one unit?", "kind": "boundary" }, { "id": "level-rules-q02", "text": "What identifies an individual unit, and what should an agent do when it has only the kind?", "kind": "action" } ] } ] }, { "id": "standards-and-conformity", "name": "Standards and conformity", "description": "The standards a working example must meet and who attests it.", "findings": [ { "id": "conformity", "name": "Standards, marks and attestation", "description": "Which standard applies, who certifies, and what the mark means.", "questions": [ { "id": "conformity-q01", "text": "Which standards govern endocrine system, issued by whom, and what does conformity actually assert?", "kind": "provenance" }, { "id": "conformity-q02", "text": "What may an agent conclude from a certification mark, and what may it not?", "kind": "boundary" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a endocrine system came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a endocrine system and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a endocrine system, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a endocrine system, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a endocrine system is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a endocrine system is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a endocrine system, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a endocrine system, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a endocrine system is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 8, "layers": 17, "findings": 19, "questions": 51 } } } }