{ "model": { "rank": 3902, "code": "thing-q11088", "model_id": "vr.tr.celiac-disease", "name": "celiac disease", "purpose": "Enable an agent to recognise celiac disease, assess the evidence and activity attributed to it, and identify appropriate next steps while preserving diagnostic uncertainty.", "family": "Thing Registry", "category": "Information and virtual systems", "status": "research-draft", "kind": "thing", "plane": "INF", "domain": "INF.KNW", "industry": "", "version": "", "url": "/models/thing/q11088/", "tier": 2, "score": 80, "payload": { "layer": "wikidata", "aliases": [ "refractory celiac disease", "celiac disease, susceptibility to, 1" ], "aliasCount": 2, "merged": 2, "knownIn": 80, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": "vr.tr.celiac-disease", "source": { "dataset": "wikidata", "item": "Q11088", "url": "https://www.wikidata.org/wiki/Q11088", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-09T19:02:02Z", "providers": [ "Codex" ], "breadth": "recalled by Codex without web access - no source was read", "missingProviders": [], "pass": 2, "cost": { "grok": { "seconds": 30.5, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a0878b-5b01-79e1-9906-a85cb3f33fec\n--------\nuser\nDescribe what is already known about one registered thing. Answer as JSON only, no prose around it.\n\nThing: celiac disease\nSense to describe: (none recorded)\nDomain code: XCT.STA\nAlso known as: (none)\n\n\nContext for this batch of 695 things:\n# Batch 004: 1001 r", "usd": 0, "recall": true }, "codex": { "seconds": 71, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a0878b-5b0b-7132-a8f9-6283c83d2c59\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: celiac disease\nRegistry id: vr.tr.celiac-disease\nPlane / domain: XCT / XCT.STA\nRegistry definition: (none recorded)\nNames folded into this entry: (no" } } }, "metaModel": { "id": "THING-Q11088", "registryId": "vr.tr.celiac-disease", "name": "celiac disease", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "XCT.STA" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q11088/", "model": { "registry_id": "vr.tr.celiac-disease", "name": "celiac disease", "purpose": "Enable an agent to recognise celiac disease, assess the evidence and activity attributed to it, and identify appropriate next steps while preserving diagnostic uncertainty.", "definition": "Celiac disease is a chronic, immune-mediated systemic disorder in genetically susceptible individuals, triggered by dietary gluten from wheat, barley and rye and characterized by gluten-dependent small-intestinal injury and associated autoantibodies.", "scope_statement": "This model owns the disease concept registered as vr.tr.celiac-disease in XCT / XCT.STA, including its gluten-related immune mechanism, diagnostic boundaries, manifestations, course and management constraints; it distinguishes the condition from a person's diagnosis and episodes of care.", "in_scope": [ "Celiac disease identity, terminology and versioned classification mappings", "Gluten exposure, genetic susceptibility and immune-mediated small-intestinal injury", "Diagnostic evidence, testing conditions and guideline-specific confirmation pathways", "Intestinal and extraintestinal manifestations, disease activity and complications", "Disease-specific dietary management, response assessment and unresolved symptoms" ], "out_of_scope": [ "The patient's complete health record and unrelated conditions", "Appointments, referrals and other episodes of care", "Wheat allergy and non-celiac gluten sensitivity as independent conditions", "Food product composition, certification and manufacturing processes", "Laboratory assay operation and endoscopy procedure specifications", "Population-wide nutrition policy and general dietary planning" ], "distinguishing_features": [ "Distinguish celiac disease from wheat allergy by the disease mechanism and diagnostic evidence; a wheat-associated reaction alone does not identify celiac disease.", "Distinguish celiac disease from non-celiac gluten sensitivity by evaluating celiac-specific serology and intestinal evidence through an applicable diagnostic pathway; symptom improvement after gluten avoidance alone is insufficient.", "Distinguish genetic susceptibility from established disease: a compatible HLA result supports susceptibility but does not independently establish celiac disease.", "Distinguish celiac enteropathy from other causes of villous injury by combining histology with serology, exposure history and assessment of alternative explanations.", "Distinguish controlled celiac disease from absence of disease: improvement during gluten avoidance does not by itself invalidate an established diagnosis." ], "characteristics": [ { "name": "Diagnostic assertion status", "kind": "state", "unit_or_values": "suspected | confirmed under a named pathway | unresolved | excluded under stated conditions | historical diagnosis requiring verification", "why_it_matters": "Prevents symptoms, susceptibility or an undocumented historical label from being treated as confirmed disease." }, { "name": "Diagnostic framework", "kind": "relation", "unit_or_values": "Issuing body, guideline title, version or year, jurisdiction and applicable age group", "why_it_matters": "Confirmation requirements and eligibility for pathways without biopsy depend on the framework applied." }, { "name": "Gluten exposure at evaluation", "kind": "state", "unit_or_values": "usual gluten-containing diet | reduced intake | gluten avoidance | supervised challenge | unknown; include duration and estimated intake when available", "why_it_matters": "Exposure conditions affect interpretation of diagnostic and follow-up evidence." }, { "name": "Celiac-related serology", "kind": "measurement", "unit_or_values": "Assay identity, immunoglobulin class, result, laboratory unit, upper limit of normal, date and concurrent total IgA where relevant", "why_it_matters": "Supports interpretation of antibody findings without assuming that assays or numerical thresholds are interchangeable." }, { "name": "Duodenal histological evidence", "kind": "category", "unit_or_values": "Sampling sites and adequacy, reported mucosal findings, grading system and version, examination date, or not obtained", "why_it_matters": "Makes intestinal evidence interpretable and distinguishes absent sampling from normal findings." }, { "name": "HLA susceptibility evidence", "kind": "category", "unit_or_values": "Reported celiac-associated HLA findings, test coverage, interpretation source, or not tested", "why_it_matters": "Keeps susceptibility evidence separate from proof of disease and makes negative results interpretable." }, { "name": "Clinical presentation", "kind": "category", "unit_or_values": "Intestinal manifestations | extraintestinal manifestations | mixed presentation | no recognised symptoms; specify individual findings", "why_it_matters": "Avoids requiring gastrointestinal symptoms for recognition." }, { "name": "Disease activity and response", "kind": "state", "unit_or_values": "Separate dated assessments of symptoms, serology, nutritional status and mucosal findings; unknown where unassessed", "why_it_matters": "Prevents improvement in one domain from being treated as evidence that every domain has recovered." }, { "name": "Population frequency estimate", "kind": "measurement", "unit_or_values": "Percentage or cases per stated denominator, with population, geography, observation period, ascertainment method and source", "why_it_matters": "Separates screening positivity, confirmed disease and recorded diagnoses when comparing prevalence." } ], "affordances": [ "Assess whether recorded evidence supports a celiac disease assertion under a named diagnostic framework.", "Identify missing evidence and testing conditions that limit interpretation.", "Distinguish celiac disease from relevant alternative explanations and record unresolved overlap.", "Track symptoms, serology, nutritional consequences and intestinal recovery as separate outcomes.", "Identify when persistent symptoms or suspected complications warrant clinician reassessment.", "Link disease-specific management constraints to dietary support and care plans without equating those plans with the disease." ] }, "sources": [], "structure": { "bundles": [ { "id": "celiac-identity-and-boundaries", "name": "Celiac identity and boundaries", "description": "Establishes what disease concept an assertion refers to and how it differs from adjacent gluten-related conditions.", "rationale": "Gluten-associated symptoms, genetic susceptibility and established celiac disease must not collapse into a single label.", "layers": [ { "id": "terminology-and-classification", "name": "Terminology and classification", "description": "Connects the registry concept to sourced definitions and versioned clinical terminology.", "findings": [ { "id": "versioned-disease-identity", "name": "Versioned disease identity", "description": "Record the definition and classification mapping used, including whether a code denotes the disease, a manifestation or a diagnostic context.", "questions": [ { "text": "Which authoritative definition establishes the intended meaning of celiac disease for vr.tr.celiac-disease?", "kind": "definition", "id": "versioned-disease-identity-q01" }, { "text": "Which ICD-10 variant, ICD-11 release and SNOMED CT edition supply verified mappings, and what is each mapping's scope?", "kind": "provenance", "id": "versioned-disease-identity-q02" } ] } ] }, { "id": "adjacent-condition-boundaries", "name": "Adjacent condition boundaries", "description": "Separates the disease from similar presentations and from records asserting that it exists.", "findings": [ { "id": "disease-versus-associated-labels", "name": "Disease versus associated labels", "description": "Distinguish celiac disease from wheat allergy, non-celiac gluten sensitivity, susceptibility and the diagnosis event.", "questions": [ { "text": "What evidence distinguishes this assertion from wheat allergy or non-celiac gluten sensitivity?", "kind": "boundary", "id": "disease-versus-associated-labels-q01" }, { "text": "Does the record describe the disease, a provisional diagnostic assertion, genetic susceptibility or an episode of care?", "kind": "boundary", "id": "disease-versus-associated-labels-q02" } ] } ] } ] }, { "id": "gluten-susceptibility-and-injury", "name": "Gluten, susceptibility and injury", "description": "Represents the relationship between relevant exposure, host susceptibility and intestinal immune injury.", "rationale": "Exposure and susceptibility explain disease context but must remain distinct from evidence confirming the condition.", "layers": [ { "id": "gluten-exposure-context", "name": "Gluten exposure context", "description": "Records exposure information needed to interpret manifestations and testing.", "findings": [ { "id": "exposure-relative-to-evidence", "name": "Exposure relative to evidence", "description": "Anchor reported gluten intake or avoidance to the dates of symptoms, serology and biopsy.", "questions": [ { "text": "What gluten exposure or avoidance was reported before each diagnostic sample, and over what period?", "kind": "measurement", "id": "exposure-relative-to-evidence-q01" }, { "text": "If intake was reduced before testing, what clinician-directed reassessment does the applicable guideline support?", "kind": "action", "id": "exposure-relative-to-evidence-q02" } ] } ] }, { "id": "susceptibility-and-enteropathy", "name": "Susceptibility and enteropathy", "description": "Distinguishes inherited susceptibility from observed immune and mucosal abnormalities.", "findings": [ { "id": "mechanism-evidence-separation", "name": "Mechanism and evidence separation", "description": "Represent HLA findings, immune markers and intestinal injury as related but non-interchangeable evidence.", "questions": [ { "text": "Which reported findings concern susceptibility, which concern immune activity, and which demonstrate mucosal injury?", "kind": "definition", "id": "mechanism-evidence-separation-q01" }, { "text": "What alternative causes could explain the observed intestinal injury, and which have been evaluated?", "kind": "boundary", "id": "mechanism-evidence-separation-q02" } ] } ] } ] }, { "id": "diagnostic-evidence-and-confirmation", "name": "Diagnostic evidence and confirmation", "description": "Organises interpretable test results and the rules used to reach or defer a diagnosis.", "rationale": "Diagnostic confidence depends on assay context, sampling and eligibility for a specific confirmation pathway.", "layers": [ { "id": "serology-interpretation", "name": "Serology interpretation", "description": "Preserves assay details and factors that affect the meaning of antibody results.", "findings": [ { "id": "interpretable-antibody-evidence", "name": "Interpretable antibody evidence", "description": "Record antibody results with reference limits, immunoglobulin context and contemporaneous exposure.", "questions": [ { "text": "Which assays were used, what were their results and upper limits of normal, and was total IgA assessed?", "kind": "measurement", "id": "interpretable-antibody-evidence-q01" }, { "text": "How do IgA deficiency, reduced gluten intake or discordant results affect interpretation under the cited guideline?", "kind": "boundary", "id": "interpretable-antibody-evidence-q02" } ] } ] }, { "id": "confirmation-pathway", "name": "Confirmation pathway", "description": "Connects diagnostic conclusions to biopsy evidence or documented eligibility for another accepted pathway.", "findings": [ { "id": "criteria-supported-conclusion", "name": "Criteria-supported conclusion", "description": "Retain the applicable criteria, evidence satisfying them and unresolved reasons to defer confirmation.", "questions": [ { "text": "Which issuing body and guideline version govern this conclusion, and are its age and pathway eligibility requirements met?", "kind": "provenance", "id": "criteria-supported-conclusion-q01" }, { "text": "What biopsy sampling and histology support confirmation, or which documented criteria justify a pathway without biopsy?", "kind": "measurement", "id": "criteria-supported-conclusion-q02" }, { "text": "What further evaluation is indicated when serology, histology and clinical context disagree?", "kind": "action", "id": "criteria-supported-conclusion-q03" } ] } ] } ] }, { "id": "presentation-course-and-burden", "name": "Presentation, course and burden", "description": "Describes manifestations, affected populations and changes in disease expression over time.", "rationale": "Celiac disease can be recognised through different manifestations, and symptoms alone do not capture its activity or burden.", "layers": [ { "id": "manifestations-and-populations", "name": "Manifestations and populations", "description": "Records intestinal and extraintestinal findings and the context of population estimates.", "findings": [ { "id": "presentation-and-ascertainment", "name": "Presentation and ascertainment", "description": "Separate observed manifestations from attributed consequences and distinguish routes of disease detection.", "questions": [ { "text": "Which gastrointestinal, nutritional, growth, skin or other extraintestinal findings are documented, and how is their attribution supported?", "kind": "measurement", "id": "presentation-and-ascertainment-q01" }, { "text": "For a prevalence claim, what population, observation year and diagnostic ascertainment method produced the estimate?", "kind": "provenance", "id": "presentation-and-ascertainment-q02" } ] } ] }, { "id": "longitudinal-disease-state", "name": "Longitudinal disease state", "description": "Tracks changes across clinical, biochemical and intestinal evidence without forcing a single stage label.", "findings": [ { "id": "activity-and-consequences-over-time", "name": "Activity and consequences over time", "description": "Preserve separate trajectories for symptoms, antibody results, nutritional consequences and mucosal findings.", "questions": [ { "text": "How have symptoms, serology, nutritional status and any repeat histology changed relative to management and exposure?", "kind": "measurement", "id": "activity-and-consequences-over-time-q01" }, { "text": "Which complications are confirmed, suspected or unassessed, and what evidence supports each status?", "kind": "boundary", "id": "activity-and-consequences-over-time-q02" } ] } ] } ] }, { "id": "dietary-management-and-reassessment", "name": "Dietary management and reassessment", "description": "Represents disease-specific management requirements and evaluation of incomplete response.", "rationale": "An agent must distinguish an intended gluten-free diet, actual exposure, recovery and persistent disease before suggesting next steps.", "layers": [ { "id": "gluten-free-management", "name": "Gluten-free management", "description": "Connects dietary treatment to feasible support, exposure assessment and nutritional adequacy.", "findings": [ { "id": "management-feasibility-and-follow-up", "name": "Management feasibility and follow-up", "description": "Record the prescribed approach, access barriers and evidence used to assess implementation and response.", "questions": [ { "text": "What dietary guidance and specialist nutritional support have been provided, and what barriers affect implementation?", "kind": "action", "id": "management-feasibility-and-follow-up-q01" }, { "text": "How are inadvertent gluten exposure, nutritional adequacy and treatment response assessed without relying solely on reported symptoms?", "kind": "measurement", "id": "management-feasibility-and-follow-up-q02" } ] } ] }, { "id": "persistent-symptoms-and-injury", "name": "Persistent symptoms and injury", "description": "Structures reassessment when expected improvement is incomplete or new problems arise.", "findings": [ { "id": "nonresponse-differentiation", "name": "Nonresponse differentiation", "description": "Distinguish ongoing exposure, an uncertain original diagnosis, alternative conditions and suspected refractory disease.", "questions": [ { "text": "Which explanations for persistent symptoms or intestinal injury have been evaluated, and what remains unresolved?", "kind": "boundary", "id": "nonresponse-differentiation-q01" }, { "text": "Which criteria and specialist assessment are required before applying a refractory celiac disease label?", "kind": "provenance", "id": "nonresponse-differentiation-q02" }, { "text": "What documented findings warrant specialist reassessment or investigation of complications?", "kind": "action", "id": "nonresponse-differentiation-q03" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-confidence-notes", "name": "Check these first", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "This is a recall-based description; no sources or terminology releases were consulted.", "Check current guideline revisions and jurisdiction-specific labeling requirements before operational use; pediatric and adult diagnostic criteria are not interchangeable.", "Potential disease and refractory subtypes require precise specialist definitions; prevalence estimates should specify population, year and ascertainment method." ], "questions": [ { "id": "evidence-confidence-notes-q01", "text": "Which of these check these first hold for the sense of celiac disease this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-kinds", "name": "Kinds and varieties", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Classical celiac disease, presenting with malabsorption", "Nonclassical celiac disease, presenting without overt malabsorption", "Asymptomatic celiac disease", "Potential celiac disease, with compatible serology but no villous atrophy", "Refractory celiac disease type I", "Refractory celiac disease type II" ], "questions": [ { "id": "evidence-kinds-q01", "text": "Which of these kinds and varieties hold for the sense of celiac disease this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-identifiers", "name": "Identifiers and schemes", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "scheme": "ICD-10, World Health Organization", "value_or_pattern": "K90.0", "note": "Coeliac disease; record the classification version and any national modification." }, { "scheme": "SNOMED CT", "value_or_pattern": "396331005", "note": "Celiac disease; verify terminology edition and release before operational use." } ], "questions": [ { "id": "evidence-identifiers-q01", "text": "Which of these identifiers and schemes hold for the sense of celiac disease this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-standards-and-regulation", "name": "Standards and regulation", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "American College of Gastroenterology: 2023 clinical guideline on diagnosis and management of celiac disease.", "European Society for Paediatric Gastroenterology, Hepatology and Nutrition: 2020 pediatric diagnostic guideline, including a defined pathway for diagnosis without biopsy in selected children.", "Codex Alimentarius Commission: CXS 118-1979, Standard for Foods for Special Dietary Use for Persons Intolerant to Gluten.", "United States Food and Drug Administration: gluten-free food-labeling requirements under 21 CFR 101.91.", "European Commission: Implementing Regulation (EU) No 828/2014 on information concerning the absence or reduced presence of gluten in food." ], "questions": [ { "id": "evidence-standards-and-regulation-q01", "text": "Which of these standards and regulation hold for the sense of celiac disease this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Clinical recognition of intestinal and extraintestinal disease, including presentations involving anemia, impaired growth or reduced bone density.", "Diagnostic assessment using celiac serology, total IgA and, where indicated, duodenal biopsies, interpreted in relation to gluten exposure.", "Targeted testing of higher-risk groups, including first-degree relatives and people with associated autoimmune conditions.", "Management through a sustained gluten-free diet, nutritional assessment and follow-up of symptoms, serology and intestinal recovery.", "Clinical documentation and coding that distinguish the underlying disease from a diagnostic investigation or episode of care." ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of celiac disease this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Reducing gluten intake before diagnostic testing can make serology and histology falsely reassuring.", "IgA deficiency can cause false-negative IgA-based serology unless accounted for.", "HLA-DQ2 or HLA-DQ8 positivity indicates susceptibility but does not establish the diagnosis.", "Unrecognized disease or continued gluten exposure can contribute to nutritional deficiencies, anemia, impaired growth and bone disease.", "Persistent symptoms require evaluation for ongoing exposure and alternative conditions; refractory disease, particularly type II, carries increased lymphoma risk." ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of celiac disease this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-regional-variation", "name": "Regional variation", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Diagnostic pathways differ between pediatric and adult guidelines and between healthcare systems, especially regarding diagnosis without biopsy.", "Food-labeling rules and the treatment of oats differ by jurisdiction; contamination with wheat, barley or rye is a practical concern.", "Reported prevalence varies with population, genetic susceptibility, gluten consumption and case-finding methods; diagnosed prevalence differs from screening-detected prevalence." ], "questions": [ { "id": "evidence-regional-variation-q01", "text": "Which of these regional variation hold for the sense of celiac disease this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "name": "Wheat allergy", "difference": "An allergic response to wheat proteins, often assessed through allergy history and IgE testing, rather than the characteristic gluten-dependent autoimmune enteropathy of celiac disease." }, { "name": "Non-celiac gluten sensitivity", "difference": "Symptoms associated with gluten-containing foods after celiac disease and wheat allergy have been excluded; there is no established specific diagnostic biomarker." }, { "name": "Irritable bowel syndrome", "difference": "A disorder of gut-brain interaction that may produce similar symptoms but does not itself explain celiac-specific autoantibodies or villous atrophy." }, { "name": "Dermatitis herpetiformis", "difference": "A cutaneous manifestation of gluten-sensitive disease, distinguished by characteristic skin findings and granular IgA deposition on direct immunofluorescence." }, { "name": "Other causes of villous atrophy", "difference": "Medication effects, infections and immune disorders can mimic intestinal histology; villous atrophy alone does not establish celiac disease." } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of celiac disease this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Does an existing Vercy world model already own this disease concept, requiring the registry entry to link to that publication?", "Which current authoritative diagnostic frameworks should govern the model across adult, paediatric and jurisdiction-specific settings?", "What exact ICD-10, ICD-11 and SNOMED CT mappings apply, including edition, release and distinctions involving manifestations or complications?", "How should potential celiac disease, seronegative presentations and refractory subtypes be represented while preserving this registry entry's granularity?", "Which sourced population estimates and follow-up criteria are sufficiently comparable to support prevalence and recovery assessments?" ], "statistics": { "bundles": 6, "layers": 11, "findings": 18, "questions": 30 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "disease or condition", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a celiac disease, record what state it is in, and decide what may be done with it.", "whatItIs": "Enable an agent to recognise celiac disease, assess the evidence and activity attributed to it, and identify appropriate next steps while preserving diagnostic uncertainty.", "characteristics": { "substance": "information", "origin": "conceptual", "agency": "inert" }, "whatYouCanDoWithIt": [ "read and interpreted" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: refractory celiac disease, celiac disease, susceptibility to, 1.", "2 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 80 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a celiac disease, and on what evidence are they told apart?" ], "whatItIsMadeOf": "content that has to be carried by something else", "physicalCharacter": [ "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "read it and act on what it says" ], "howItIsRecognised": [ "Recognised by criteria applied to signs and findings, not by appearance. Two conditions can look identical and be distinguished only by test." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "refractory celiac disease", "celiac disease, susceptibility to, 1" ] } ], "standing": "Described in 80 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 2 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one celiac disease from another, and a celiac disease from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a celiac disease, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a celiac disease, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a celiac disease is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a celiac disease, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a celiac disease, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a celiac disease is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a celiac disease sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a celiac disease, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a celiac disease, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a celiac disease is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a celiac disease from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a celiac disease, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a celiac disease, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a celiac disease is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a celiac disease passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a celiac disease between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a celiac disease, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a celiac disease, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a celiac disease is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a celiac disease, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a celiac disease is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a celiac disease, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a celiac disease, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a celiac disease is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "content-and-access", "name": "Content, encoding and access", "description": "What a celiac disease says, how it is encoded and who may read it.", "rationale": "An informational thing carries content that can be copied, versioned and withheld, none of which its physical carrier explains.", "layers": [ { "id": "content-and-encoding", "name": "Content and encoding", "description": "The content itself, its format and its language.", "findings": [ { "id": "content-and-format", "name": "Content, format and language", "description": "What a celiac disease contains and in what form it is held.", "questions": [ { "id": "content-and-format-q01", "text": "What identifies and describes the content of a celiac disease, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "content-and-format-q02", "text": "Who or what asserted this about the content of a celiac disease, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "content-and-format-q03", "text": "What may an agent decide or do once the content of a celiac disease is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "access-and-rights", "name": "Access, rights and retention", "description": "Who may read, copy or change it, and for how long it is kept.", "findings": [ { "id": "access-rules", "name": "Access rules and retention", "description": "The permissions attached to a celiac disease and the period it survives.", "questions": [ { "id": "access-rules-q01", "text": "What identifies and describes access to a celiac disease, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "access-rules-q02", "text": "Who or what asserted this about access to a celiac disease, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "access-rules-q03", "text": "What may an agent decide or do once access to a celiac disease is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "diagnosis-and-criteria", "name": "Diagnosis, criteria and coding", "description": "What makes a case of celiac disease a case, and under which revision.", "rationale": "Criteria change between revisions, so a diagnosis without its coding revision cannot be compared with a later one.", "layers": [ { "id": "criteria", "name": "Diagnostic criteria", "description": "The criteria in force and who issues them.", "findings": [ { "id": "criteria-record", "name": "Criteria, issuer and revision", "description": "What must be true for a diagnosis, according to whom.", "questions": [ { "id": "criteria-record-q01", "text": "What criteria define celiac disease, issued by which body, in which revision?", "kind": "definition" }, { "id": "criteria-record-q02", "text": "What changed between revisions that would reclassify existing cases?", "kind": "boundary" } ] } ] }, { "id": "coding", "name": "Coding and terminology", "description": "The codes used to record it and their mapping.", "findings": [ { "id": "coding-record", "name": "Codes and mappings", "description": "Which classification codes apply and how they map.", "questions": [ { "id": "coding-record-q01", "text": "Which classification and terminology codes cover celiac disease, and how do they map to each other?", "kind": "definition" }, { "id": "coding-record-q02", "text": "What is lost when a case is mapped from one scheme to another?", "kind": "boundary" } ] } ] } ] }, { "id": "course-and-population", "name": "Course, population and care", "description": "How celiac disease develops, whom it affects, and what is done about it.", "rationale": "The condition, the diagnosis and the episode of care are three different things, and an agent must not merge them.", "layers": [ { "id": "course", "name": "Course and stages", "description": "Onset, progression, remission and outcome.", "findings": [ { "id": "course-record", "name": "Stages and transitions", "description": "The stages recorded and what moves a case between them.", "questions": [ { "id": "course-record-q01", "text": "What course does celiac disease typically take, and what marks each stage?", "kind": "definition" }, { "id": "course-record-q02", "text": "What separates the condition itself from an episode of care for it?", "kind": "boundary" } ] } ] }, { "id": "population", "name": "Affected populations", "description": "Who is affected, how often, and on what evidence.", "findings": [ { "id": "epidemiology", "name": "Prevalence and its basis", "description": "Rates with their population, period and source.", "questions": [ { "id": "epidemiology-q01", "text": "What prevalence or incidence is reported for celiac disease, in which population and period?", "kind": "measurement" }, { "id": "epidemiology-q02", "text": "What may an agent not conclude about an individual from a population rate?", "kind": "action" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a celiac disease came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a celiac disease and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a celiac disease, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a celiac disease, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a celiac disease is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a celiac disease is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a celiac disease, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a celiac disease, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a celiac disease is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 6, "layers": 12, "findings": 14, "questions": 38 } } } }