{ "model": { "rank": 13509, "code": "thing-q1138580", "model_id": "vr.tr.ewing-sarcoma", "name": "Ewing sarcoma", "purpose": "Let an agent explain Ewing sarcoma, relay biology, diagnosis, treatment and prognosis from oncology sources in general terms with attribution, describe the forms the registry aliases name, and distinguish Ewing sarcoma from osteosarcoma, other small round cell tumours and benign bone lesions, supporting patients and families compassionately and routing to specialists.", "family": "Thing Registry", "category": "Cross-cutting context", "status": "research-draft", "kind": "thing", "plane": "XCT", "domain": "XCT.STA", "industry": "", "version": "", "url": "/models/thing/q1138580/", "tier": 2, "score": 37, "payload": { "layer": "wikidata", "aliases": [ "metastatic Ewing's sarcoma", "metastatic extra-osseous Ewing's sarcoma", "Askin's tumor", "bone Ewing's sarcoma", "extraosseous Ewing's sarcoma", "Ewing's family recurrent tumor", "recurrent Ewing's sarcoma", "localized Askin's tumor", "soft tissue peripheral neuroepithelioma", "extraosseous Ewings sarcoma-primitive neuroepithelial tumor", "nonmetastatic extra-osseous Ewing's sarcoma" ], "aliasCount": 11, "merged": 11, "knownIn": 37, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q1138580", "url": "https://www.wikidata.org/wiki/Q1138580", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-13T18:46:32Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 4, "engine": "claude" }, "metaModel": { "id": "THING-Q1138580", "registryId": "vr.tr.ewing-sarcoma", "name": "Ewing sarcoma", "version": "0.2.0-wave.4", "entryKind": "thing", "family": "Thing Registry", "domain": [ "XCT.STA" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q1138580/", "model": { "registry_id": "vr.tr.ewing-sarcoma", "name": "Ewing sarcoma", "purpose": "Let an agent explain Ewing sarcoma, relay biology, diagnosis, treatment and prognosis from oncology sources in general terms with attribution, describe the forms the registry aliases name, and distinguish Ewing sarcoma from osteosarcoma, other small round cell tumours and benign bone lesions, supporting patients and families compassionately and routing to specialists.", "definition": "A rare malignant tumour of bone or soft tissue, most common in children, teenagers and young adults, driven by a chromosomal translocation typically fusing the EWSR1 and FLI1 genes, occurring in bone, in extraosseous sites and as the chest wall Askin tumour, and presenting as localised, metastatic or recurrent disease within the Ewing family of tumours; treatment combines chemotherapy with surgery and radiotherapy under specialist paediatric and sarcoma teams. The model gives general information and routes people to clinicians.", "what_it_is_for": "Not applicable; a cancer.", "affordances": [ "explain the disease", "relay treatment and prognosis in general terms", "route to specialists and support", "distinguish related tumours" ], "distinguishing_features": [ "Young patients", "Fusion gene driven", "Bone or soft tissue", "Multimodal treatment" ], "appearance": "Not a visible object; a bone or soft tissue tumour.", "visual_identification": [ "Small round cell sarcoma of bone or soft tissue", "Bone and extraosseous Ewing sarcoma, Askin tumour, metastatic and recurrent disease", "Osteosarcoma forms bone matrix; other small round cell tumours have different genetics; benign lesions are not cancer" ], "physical_properties": [ { "quantity": "incidence", "typical_range": "about 1 per million", "unit": "per year", "note": "overall, higher in adolescents" }, { "quantity": "typical fusion", "typical_range": "EWSR1-FLI1", "unit": "note", "note": "" }, { "quantity": "described", "typical_range": "1921", "unit": "year", "note": "James Ewing" }, { "quantity": "5-year survival, localised", "typical_range": "about 70-80", "unit": "percent", "note": "varies" } ], "families_and_kinds": [ "bone Ewing sarcoma", "extraosseous Ewing sarcoma", "Askin tumour of the chest wall", "metastatic Ewing sarcoma", "recurrent Ewing family tumours", "Ewing-like sarcomas with other fusions" ], "related_models": [ { "relation": "is a kind of", "target": "bone sarcoma", "why": "in registry terms" }, { "relation": "is part of", "target": "paediatric oncology", "why": "in registry terms" }, { "relation": "is driven by", "target": "EWSR1", "why": "gene fusions" }, { "relation": "is contrasted with", "target": "osteosarcoma", "why": "" } ], "identifiers": [ { "scheme": "ICD-O", "value_or_pattern": "9260/3", "note": "Ewing sarcoma" }, { "scheme": "MeSH", "value_or_pattern": "D012512", "note": "Sarcoma, Ewing" } ], "standards_and_regulation": [ "Paediatric and sarcoma oncology guidelines", "Clinical trial regulations" ], "failure_modes_and_hazards": [ "Agents giving personal medical advice", "Delayed diagnosis of bone pain in young people", "Insensitive framing of prognosis" ], "in_scope": [], "out_of_scope": [], "characteristics": [] }, "sources": [], "structure": { "bundles": [ { "id": "understand", "name": "Understand", "description": "What Ewing sarcoma is.", "rationale": "Clinical.", "layers": [ { "id": "definition", "name": "Definition", "description": "Definition.", "findings": [ { "id": "definition-finding", "name": "Definition", "description": "Definition.", "questions": [ { "text": "What is Ewing sarcoma, and how does it differ from osteosarcoma, other small round cell tumours and benign lesions?", "kind": "definition" }, { "text": "Is the user or a family facing a diagnosis, needing their specialist team and support services?", "kind": "boundary" } ] } ] }, { "id": "forms", "name": "Forms", "description": "Forms.", "findings": [ { "id": "forms-finding", "name": "Forms", "description": "Forms.", "questions": [ { "text": "What are bone and extraosseous Ewing sarcoma, the Askin tumour and metastatic and recurrent disease?", "kind": "definition" }, { "text": "Which entry fits the specific form?", "kind": "action" } ] } ] } ] }, { "id": "biology", "name": "Biology", "description": "Biology and diagnosis.", "rationale": "Science.", "layers": [ { "id": "genetics", "name": "Genetics", "description": "Genetics.", "findings": [ { "id": "genetics-finding", "name": "Genetics", "description": "Genetics.", "questions": [ { "text": "How do EWSR1 fusions drive Ewing sarcoma?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "diagnosis", "name": "Diagnosis", "description": "Diagnosis.", "findings": [ { "id": "diagnosis-finding", "name": "Diagnosis", "description": "Diagnosis.", "questions": [ { "text": "How is Ewing sarcoma diagnosed with imaging, biopsy and molecular testing, in general terms?", "kind": "provenance" }, { "text": "Which sources are cited?", "kind": "provenance" } ] } ] } ] }, { "id": "care", "name": "Care", "description": "Treatment.", "rationale": "Clinical.", "layers": [ { "id": "treatment", "name": "Treatment", "description": "Treatment.", "findings": [ { "id": "treatment-finding", "name": "Treatment", "description": "Treatment.", "questions": [ { "text": "What general treatment approaches do guidelines describe?", "kind": "provenance" }, { "text": "Which entry fits sarcoma treatment?", "kind": "action" } ] } ] }, { "id": "research", "name": "Research", "description": "Research and trials.", "findings": [ { "id": "research-finding", "name": "Research", "description": "Research.", "questions": [ { "text": "What research and trials are underway, as reported?", "kind": "provenance" }, { "text": "Which entry fits clinical trial registries?", "kind": "action" } ] } ] } ] }, { "id": "context", "name": "Context", "description": "Support and history.", "rationale": "Context.", "layers": [ { "id": "support", "name": "Support", "description": "Support.", "findings": [ { "id": "support-finding", "name": "Support", "description": "Support.", "questions": [ { "text": "What support exists for young patients, families and survivors?", "kind": "provenance" }, { "text": "Which entry fits childhood cancer support organisations?", "kind": "action" } ] } ] }, { "id": "history", "name": "History", "description": "History.", "findings": [ { "id": "history-finding", "name": "History", "description": "History.", "questions": [ { "text": "How did James Ewing describe the tumour, and how did understanding change?", "kind": "provenance" }, { "text": "Which entry fits James Ewing?", "kind": "action" } ] } ] } ] } ] }, "openQuestions": [ "Should Askin tumour and extraosseous Ewing sarcoma be separate primary entries?", "How should oncology sources be linked?", "The registry entry has merged aliases naming sites and stages; should they be split off?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "abstract concept", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a Ewing sarcoma, record what state it is in, and decide what may be done with it.", "whatItIs": "Let an agent explain Ewing sarcoma, relay biology, diagnosis, treatment and prognosis from oncology sources in general terms with attribution, describe the forms the registry aliases name, and distinguish Ewing sarcoma from osteosarcoma, other small round cell tumours and benign bone lesions, supporting patients and families compassionately and routing to specialists.", "characteristics": { "substance": "abstract", "origin": "conceptual", "agency": "inert" }, "whatYouCanDoWithIt": [ "observed and measured" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: metastatic Ewing's sarcoma, metastatic extra-osseous Ewing's sarcoma, Askin's tumor, bone Ewing's sarcoma, extraosseous Ewing's sarcoma, Ewing's family recurrent tumor, recurrent Ewing's sarcoma, localized Askin's tumor, soft tissue peripheral neuroepithelioma, extraosseous Ewings sarcoma-primitive neuroepithelial tumor, nonmetastatic extra-osseous Ewing's sarcoma.", "11 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 37 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a Ewing sarcoma, and on what evidence are they told apart?" ], "whatItIsMadeOf": "an abstraction with no physical instance", "physicalCharacter": [ "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state" ], "howItIsRecognised": [ "Nothing to see. What is recognised is an instance of it, and which instances count is exactly what is argued about." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "metastatic Ewing's sarcoma", "metastatic extra-osseous Ewing's sarcoma", "Askin's tumor", "bone Ewing's sarcoma", "extraosseous Ewing's sarcoma", "Ewing's family recurrent tumor", "recurrent Ewing's sarcoma", "localized Askin's tumor", "soft tissue peripheral neuroepithelioma", "extraosseous Ewings sarcoma-primitive neuroepithelial tumor", "nonmetastatic extra-osseous Ewing's sarcoma" ] } ], "standing": "Described in 37 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 11 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one Ewing sarcoma from another, and a Ewing sarcoma from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a Ewing sarcoma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a Ewing sarcoma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a Ewing sarcoma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a Ewing sarcoma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a Ewing sarcoma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a Ewing sarcoma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a Ewing sarcoma sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a Ewing sarcoma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a Ewing sarcoma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a Ewing sarcoma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a Ewing sarcoma from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a Ewing sarcoma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a Ewing sarcoma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a Ewing sarcoma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a Ewing sarcoma passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a Ewing sarcoma between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a Ewing sarcoma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a Ewing sarcoma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a Ewing sarcoma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a Ewing sarcoma, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a Ewing sarcoma is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a Ewing sarcoma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a Ewing sarcoma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a Ewing sarcoma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "definitions-in-contest", "name": "Definitions and who holds them", "description": "What Ewing sarcoma is taken to mean, and by whom.", "rationale": "When a field disagrees about a concept, the disagreement is the content. A model that picks one definition silently destroys the information.", "layers": [ { "id": "competing-definitions", "name": "Competing definitions", "description": "The main readings and the traditions behind them.", "findings": [ { "id": "definition-map", "name": "Definitions and their holders", "description": "Each definition with the school or body that holds it.", "questions": [ { "id": "definition-map-q01", "text": "Which definitions of Ewing sarcoma are in use, and which tradition or body holds each?", "kind": "definition" }, { "id": "definition-map-q02", "text": "What turns on the difference between them in practice?", "kind": "boundary" } ] } ] }, { "id": "operationalisation", "name": "Operationalisation", "description": "How it is measured or applied when it has to be.", "findings": [ { "id": "operational-record", "name": "Measures and proxies", "description": "Instruments and indicators used to stand in for it.", "questions": [ { "id": "operational-record-q01", "text": "How is Ewing sarcoma operationalised or measured in practice, and by what instrument?", "kind": "measurement" }, { "id": "operational-record-q02", "text": "What does that operationalisation leave out, and when does that matter?", "kind": "boundary" } ] } ] } ] }, { "id": "instances-and-use", "name": "Instances, use and consequence", "description": "What counts as an instance of Ewing sarcoma and what follows from calling something that.", "rationale": "Applying a concept is an act with consequences, so a model must say what the label licenses and what it does not.", "layers": [ { "id": "instances", "name": "What counts as an instance", "description": "Clear cases, borderline cases and non-cases.", "findings": [ { "id": "instance-tests", "name": "Tests for an instance", "description": "What would settle whether something falls under it.", "questions": [ { "id": "instance-tests-q01", "text": "What would settle whether something is an instance of Ewing sarcoma?", "kind": "boundary" }, { "id": "instance-tests-q02", "text": "Which borderline cases are argued about, and on what grounds?", "kind": "definition" } ] } ] }, { "id": "consequence", "name": "Consequence of application", "description": "Rights, duties or decisions that follow from the label.", "findings": [ { "id": "consequence-record", "name": "What the label licenses", "description": "What an agent may do once something is classified this way.", "questions": [ { "id": "consequence-record-q01", "text": "What follows practically once something is treated as Ewing sarcoma?", "kind": "action" }, { "id": "consequence-record-q02", "text": "What must an agent not infer from the label alone?", "kind": "action" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a Ewing sarcoma came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a Ewing sarcoma and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a Ewing sarcoma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a Ewing sarcoma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a Ewing sarcoma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a Ewing sarcoma is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a Ewing sarcoma, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a Ewing sarcoma, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a Ewing sarcoma is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 5, "layers": 10, "findings": 12, "questions": 32 } } } }