{ "model": { "rank": 5659, "code": "thing-q12252367", "model_id": "vr.tr.atherosclerosis", "name": "atherosclerosis", "purpose": "Let an agent explain atherosclerosis and its mechanisms in neutral clinical terms, relay risk factors, sites, diagnosis and management in general from cardiology guidelines, describe prevention, and route people with symptoms or risk questions to clinicians.", "family": "Thing Registry", "category": "Cross-cutting context", "status": "research-draft", "kind": "thing", "plane": "XCT", "domain": "XCT.STA", "industry": "", "version": "", "url": "/models/thing/q12252367/", "tier": 2, "score": 65, "payload": { "layer": "wikidata", "aliases": [ "renal artery atheroma", "cerebral atherosclerosis", "aortic atherosclerosis", "generalized atherosclerosis", "obliterating endarteritis" ], "aliasCount": 5, "merged": 5, "knownIn": 65, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q12252367", "url": "https://www.wikidata.org/wiki/Q12252367", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-13T06:32:40Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 3, "engine": "claude" }, "metaModel": { "id": "THING-Q12252367", "registryId": "vr.tr.atherosclerosis", "name": "atherosclerosis", "version": "0.2.0-wave.3", "entryKind": "thing", "family": "Thing Registry", "domain": [ "XCT.STA" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q12252367/", "model": { "registry_id": "vr.tr.atherosclerosis", "name": "atherosclerosis", "purpose": "Let an agent explain atherosclerosis and its mechanisms in neutral clinical terms, relay risk factors, sites, diagnosis and management in general from cardiology guidelines, describe prevention, and route people with symptoms or risk questions to clinicians.", "definition": "A chronic disease of the arteries in which plaques of lipids, inflammatory cells, calcium and fibrous tissue build up in the artery wall, narrowing and stiffening vessels and predisposing to thrombosis, affecting the coronary, cerebral, aortic, renal and peripheral arteries and causing heart attack, stroke, aneurysm, kidney disease and limb ischaemia, driven by high cholesterol, smoking, hypertension, diabetes, age and genetics; atherosclerosis develops over decades and is the leading cause of death worldwide through cardiovascular disease.", "what_it_is_for": "Not applicable; a disease.", "affordances": [ "explain mechanisms and sites", "relay risk factors and management", "describe prevention", "route to clinicians" ], "distinguishing_features": [ "Plaque formation", "Chronic inflammation", "Multiple arterial sites", "Modifiable risk factors" ], "appearance": "Not a visible object; plaques in artery walls seen on imaging.", "visual_identification": [ "Plaque build-up in arteries", "Coronary, cerebral, aortic, renal and generalised atherosclerosis; obliterating endarteritis as a related term", "Arteriosclerosis is the broader stiffening; vasculitis is inflammatory; thrombosis is the clot" ], "physical_properties": [ { "quantity": "cardiovascular deaths", "typical_range": "about 18", "unit": "million per year", "note": "WHO estimates" }, { "quantity": "key lipid", "typical_range": "LDL cholesterol", "unit": "note", "note": "" }, { "quantity": "plaque onset", "typical_range": "childhood fatty streaks", "unit": "note", "note": "" } ], "families_and_kinds": [ "coronary atherosclerosis", "cerebral atherosclerosis", "aortic atherosclerosis and aneurysm", "renal artery atheroma", "peripheral artery disease", "generalised atherosclerosis", "obliterating endarteritis as a historical and related term" ], "related_models": [ { "relation": "is a kind of", "target": "arteriosclerotic cardiovascular disease", "why": "in registry terms" }, { "relation": "is driven by", "target": "low-density lipoprotein", "why": "cholesterol" }, { "relation": "causes", "target": "myocardial infarction", "why": "and stroke" }, { "relation": "is treated with", "target": "statin", "why": "among other measures" } ], "identifiers": [ { "scheme": "ICD-11", "value_or_pattern": "BD40", "note": "atherosclerotic chronic arterial occlusive disease" }, { "scheme": "MeSH", "value_or_pattern": "D050197", "note": "atherosclerosis" } ], "standards_and_regulation": [ "Cardiovascular prevention guidelines from ESC, AHA and national bodies", "Lipid-lowering drug regulation", "Tobacco control and nutrition policies" ], "failure_modes_and_hazards": [ "Agents giving personal medical advice", "Ignoring emergency symptoms of heart attack and stroke", "Confusing atherosclerosis with arteriosclerosis" ], "in_scope": [], "out_of_scope": [], "characteristics": [] }, "sources": [], "structure": { "bundles": [ { "id": "help", "name": "Help", "description": "Emergency first.", "rationale": "Safety.", "layers": [ { "id": "emergency", "name": "Emergency", "description": "Heart attack and stroke.", "findings": [ { "id": "emergency-finding", "name": "Emergency", "description": "Emergency.", "questions": [ { "text": "Why do chest pain, sudden weakness, facial drooping, speech difficulty or a cold painful limb need emergency services immediately?", "kind": "action" }, { "text": "Is the user describing these symptoms now, which means calling emergency services?", "kind": "boundary" } ] } ] }, { "id": "risk", "name": "Risk", "description": "Risk assessment.", "findings": [ { "id": "risk-finding", "name": "Risk", "description": "Risk.", "questions": [ { "text": "How do clinicians assess cardiovascular risk, and who should be assessed?", "kind": "provenance" }, { "text": "Is the user asking about their own risk or treatment, which needs a clinician?", "kind": "boundary" } ] } ] } ] }, { "id": "understand", "name": "Understand", "description": "The disease.", "rationale": "Clinical.", "layers": [ { "id": "mechanism", "name": "Mechanism", "description": "Mechanism.", "findings": [ { "id": "mechanism-finding", "name": "Mechanism", "description": "Mechanism.", "questions": [ { "text": "How do plaques form and rupture, and how do lipids and inflammation drive atherosclerosis?", "kind": "definition" }, { "text": "Is the question about atherosclerosis, arteriosclerosis or vasculitis?", "kind": "boundary" } ] } ] }, { "id": "sites", "name": "Sites", "description": "Sites and consequences.", "findings": [ { "id": "sites-finding", "name": "Sites", "description": "Sites.", "questions": [ { "text": "How do coronary, cerebral, aortic, renal and peripheral atherosclerosis present and what do they cause?", "kind": "definition" }, { "text": "Which entry fits the specific site?", "kind": "action" } ] } ] } ] }, { "id": "care", "name": "Care", "description": "Diagnosis and management.", "rationale": "Clinical.", "layers": [ { "id": "diagnosis", "name": "Diagnosis", "description": "Diagnosis.", "findings": [ { "id": "diagnosis-finding", "name": "Diagnosis", "description": "Diagnosis.", "questions": [ { "text": "How is atherosclerosis detected by lipid tests, imaging and functional tests?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "treatment", "name": "Treatment", "description": "Treatment.", "findings": [ { "id": "treatment-finding", "name": "Treatment", "description": "Treatment.", "questions": [ { "text": "How is atherosclerosis managed with lifestyle, statins, antiplatelets and revascularisation, in general terms?", "kind": "provenance" }, { "text": "Which sources are cited?", "kind": "provenance" } ] } ] } ] }, { "id": "context", "name": "Context", "description": "Prevention and research.", "rationale": "Context.", "layers": [ { "id": "prevention", "name": "Prevention", "description": "Prevention.", "findings": [ { "id": "prevention-finding", "name": "Prevention", "description": "Prevention.", "questions": [ { "text": "How do diet, exercise, smoking cessation and blood pressure control prevent atherosclerosis, as guidelines state?", "kind": "provenance" }, { "text": "Which entry fits cardiovascular prevention?", "kind": "action" } ] } ] }, { "id": "research", "name": "Research", "description": "Research.", "findings": [ { "id": "research-finding", "name": "Research", "description": "Research.", "questions": [ { "text": "What research addresses inflammation, new lipid drugs and imaging, with findings attributed?", "kind": "provenance" }, { "text": "Which entry fits cardiovascular research?", "kind": "action" } ] } ] } ] } ] }, "openQuestions": [ "Should coronary artery disease and peripheral artery disease be separate primary entries?", "How should cardiology guidelines be linked?", "The registry entry has merged aliases naming sites and a historical term; should they be split off?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "disease or condition", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a atherosclerosis, record what state it is in, and decide what may be done with it.", "whatItIs": "Let an agent explain atherosclerosis and its mechanisms in neutral clinical terms, relay risk factors, sites, diagnosis and management in general from cardiology guidelines, describe prevention, and route people with symptoms or risk questions to clinicians.", "characteristics": { "substance": "abstract", "origin": "conceptual", "agency": "inert" }, "whatYouCanDoWithIt": [ "observed and measured" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: renal artery atheroma, cerebral atherosclerosis, aortic atherosclerosis, generalized atherosclerosis, obliterating endarteritis.", "5 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 65 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a atherosclerosis, and on what evidence are they told apart?" ], "whatItIsMadeOf": "an abstraction with no physical instance", "physicalCharacter": [ "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state" ], "howItIsRecognised": [ "Recognised by criteria applied to signs and findings, not by appearance. Two conditions can look identical and be distinguished only by test." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "renal artery atheroma", "cerebral atherosclerosis", "aortic atherosclerosis", "generalized atherosclerosis", "obliterating endarteritis" ] } ], "standing": "Described in 65 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 5 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one atherosclerosis from another, and a atherosclerosis from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a atherosclerosis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a atherosclerosis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a atherosclerosis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a atherosclerosis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a atherosclerosis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a atherosclerosis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a atherosclerosis sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a atherosclerosis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a atherosclerosis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a atherosclerosis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a atherosclerosis from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a atherosclerosis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a atherosclerosis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a atherosclerosis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a atherosclerosis passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a atherosclerosis between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a atherosclerosis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a atherosclerosis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a atherosclerosis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a atherosclerosis, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a atherosclerosis is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a atherosclerosis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a atherosclerosis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a atherosclerosis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "diagnosis-and-criteria", "name": "Diagnosis, criteria and coding", "description": "What makes a case of atherosclerosis a case, and under which revision.", "rationale": "Criteria change between revisions, so a diagnosis without its coding revision cannot be compared with a later one.", "layers": [ { "id": "criteria", "name": "Diagnostic criteria", "description": "The criteria in force and who issues them.", "findings": [ { "id": "criteria-record", "name": "Criteria, issuer and revision", "description": "What must be true for a diagnosis, according to whom.", "questions": [ { "id": "criteria-record-q01", "text": "What criteria define atherosclerosis, issued by which body, in which revision?", "kind": "definition" }, { "id": "criteria-record-q02", "text": "What changed between revisions that would reclassify existing cases?", "kind": "boundary" } ] } ] }, { "id": "coding", "name": "Coding and terminology", "description": "The codes used to record it and their mapping.", "findings": [ { "id": "coding-record", "name": "Codes and mappings", "description": "Which classification codes apply and how they map.", "questions": [ { "id": "coding-record-q01", "text": "Which classification and terminology codes cover atherosclerosis, and how do they map to each other?", "kind": "definition" }, { "id": "coding-record-q02", "text": "What is lost when a case is mapped from one scheme to another?", "kind": "boundary" } ] } ] } ] }, { "id": "course-and-population", "name": "Course, population and care", "description": "How atherosclerosis develops, whom it affects, and what is done about it.", "rationale": "The condition, the diagnosis and the episode of care are three different things, and an agent must not merge them.", "layers": [ { "id": "course", "name": "Course and stages", "description": "Onset, progression, remission and outcome.", "findings": [ { "id": "course-record", "name": "Stages and transitions", "description": "The stages recorded and what moves a case between them.", "questions": [ { "id": "course-record-q01", "text": "What course does atherosclerosis typically take, and what marks each stage?", "kind": "definition" }, { "id": "course-record-q02", "text": "What separates the condition itself from an episode of care for it?", "kind": "boundary" } ] } ] }, { "id": "population", "name": "Affected populations", "description": "Who is affected, how often, and on what evidence.", "findings": [ { "id": "epidemiology", "name": "Prevalence and its basis", "description": "Rates with their population, period and source.", "questions": [ { "id": "epidemiology-q01", "text": "What prevalence or incidence is reported for atherosclerosis, in which population and period?", "kind": "measurement" }, { "id": "epidemiology-q02", "text": "What may an agent not conclude about an individual from a population rate?", "kind": "action" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a atherosclerosis came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a atherosclerosis and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a atherosclerosis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a atherosclerosis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a atherosclerosis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a atherosclerosis is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a atherosclerosis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a atherosclerosis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a atherosclerosis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 5, "layers": 10, "findings": 12, "questions": 32 } } } }