{ "model": { "rank": 3172, "code": "thing-q1318776", "model_id": "vr.tr.testosterone", "name": "testosterone", "purpose": "Enable an AI agent to identify testosterone, assess the reliability and condition of a particular occurrence, and determine which measurement, handling or use actions its evidence supports.", "family": "Thing Registry", "category": "Physical world and living systems", "status": "research-draft", "kind": "thing", "plane": "PHY", "domain": "PHY.MAT", "industry": "", "version": "", "url": "/models/thing/q1318776/", "tier": 2, "score": 90, "payload": { "layer": "wikidata", "aliases": [], "aliasCount": 0, "merged": 0, "knownIn": 90, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q1318776", "url": "https://www.wikidata.org/wiki/Q1318776", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-07T15:13:49Z", "providers": [ "Codex", "Grok" ], "missingProviders": [], "pass": 2, "cost": { "grok": { "usd": 0.01103606, "turns": 1, "seconds": 174.5, "error": null }, "codex": { "seconds": 85.5, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.3\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a07c6b-c67d-7093-af9b-5956e5b04330\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: testosterone\nRegistry id: vr.tr.testosterone\nPlane / domain: PHY / PHY.MAT\nRegistry definition: (none recorded)\nNames folded into this entry: (none)\n" } } }, "metaModel": { "id": "THING-Q1318776", "registryId": "vr.tr.testosterone", "name": "testosterone", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.MAT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q1318776/", "model": { "registry_id": "vr.tr.testosterone", "name": "testosterone", "purpose": "Enable an AI agent to identify testosterone, assess the reliability and condition of a particular occurrence, and determine which measurement, handling or use actions its evidence supports.", "definition": "Testosterone is the principal circulating C19 androgen (17β-hydroxyandrost-4-en-3-one) secreted mainly by testicular Leydig cells, with lesser ovarian-theca and adrenal production, that signals through the androgen receptor and, after 5α-reduction or aromatization, through dihydrotestosterone and estradiol pathways to drive male sexual differentiation, secondary sex characteristics, support of spermatogenesis, and anabolic effects on muscle, bone and red-cell mass.", "scope_statement": "This model owns testosterone as the chemical substance registered as vr.tr.testosterone in PHY / PHY.MAT, including its identity, material occurrences, analytical state and action constraints; it links to specimens, organisms, derivatives and medicinal products without owning their complete models.", "in_scope": [ "Molecular identity and evidence distinguishing testosterone from related steroids", "Occurrences in biological specimens, reference materials, bulk substances and formulations", "Amount, concentration, purity and the basis on which each is reported", "Biological binding fraction and evidence about endogenous or introduced origin", "Material integrity, analytical suitability and supported handling or use decisions" ], "out_of_scope": [ "Diagnosis and management of endocrine conditions", "Patient-specific prescribing, dosing and treatment monitoring", "Whole-organism endocrine regulation and reproductive development", "Complete models of testosterone esters, metabolites and other androgens", "Finished medicinal product manufacture, delivery-device operation and inventory", "Determination of a person's sex, gender, fertility or athletic eligibility" ], "distinguishing_features": [ "Match the complete stereochemical structure, rather than the name or molecular formula alone: testosterone is the 17β-hydroxy, 3-oxo steroid with a C4-C5 double bond. [PubChem testosterone identity](https://pubchem.ncbi.nlm.nih.gov/compound/Testosterone)", "Require identity evidence capable of resolving the relevant neighbouring steroid, including epitestosterone, dihydrotestosterone or androstenedione, before treating an analytical signal as testosterone.", "Check whether the named material is unesterified testosterone, a testosterone ester or a formulation containing either; record any testosterone-equivalent quantity separately from the actual compound quantity.", "Distinguish a testosterone molecule or material from a reported testosterone result: total, free and other operationally defined fractions must retain their measurement definitions.", "Separate molecular identity from origin: identifying testosterone does not by itself establish whether it was produced biologically or introduced." ], "characteristics": [ { "name": "Molecular identity evidence", "kind": "relation", "unit_or_values": "Reference structure and identifiers linked to identity-test evidence", "why_it_matters": "Prevents related steroids, derivatives or ambiguous labels from being accepted as testosterone." }, { "name": "Occurrence context", "kind": "category", "unit_or_values": "Bulk substance; reference material; biological specimen; formulation constituent; other specified matrix", "why_it_matters": "Determines which measures of condition and suitability apply." }, { "name": "Chemical form represented", "kind": "category", "unit_or_values": "Unesterified testosterone; linked derivative; testosterone-equivalent reporting; unresolved", "why_it_matters": "Prevents substitution of derivative mass or product strength for testosterone amount." }, { "name": "Amount or concentration", "kind": "measurement", "unit_or_values": "Amount in mol or mg; concentration in nmol/L, ng/dL or a stated matrix-appropriate unit", "why_it_matters": "Supports comparison and accounting only when matrix, denominator and analyte basis are explicit." }, { "name": "Reported biological fraction", "kind": "category", "unit_or_values": "Total; free; bioavailable with explicit definition; specified bound fraction; unspecified; not applicable", "why_it_matters": "Prevents unlike testosterone measurements from being treated as interchangeable." }, { "name": "Measurement uncertainty and limits", "kind": "measurement", "unit_or_values": "Uncertainty in result units or percent; detection and quantification limits in result units", "why_it_matters": "Distinguishes a supported quantity from an estimate, an upper bound or an uninterpretable signal." }, { "name": "Testosterone purity or content", "kind": "measurement", "unit_or_values": "Mass fraction or percent with assay basis; chromatographic area percent recorded separately", "why_it_matters": "Separates actual testosterone content from nominal material mass and method-dependent purity indicators." }, { "name": "Binding context", "kind": "relation", "unit_or_values": "Links to SHBG, albumin and other specified binding observations or calculation inputs", "why_it_matters": "Makes biological fraction assignments and calculated results traceable." }, { "name": "Origin attribution", "kind": "state", "unit_or_values": "Endogenous supported; introduced supported; mixed supported; unresolved", "why_it_matters": "Prevents source attribution from being inferred solely from identity or concentration." }, { "name": "Integrity and suitability", "kind": "state", "unit_or_values": "Supported for specified use; assessment pending; compromised; rejected", "why_it_matters": "Connects storage, contamination and analytical evidence to a concrete intended action." } ], "affordances": [ "Resolve a testosterone label against a stereochemical reference and flag unresolved related compounds.", "Normalize testosterone quantities while preserving matrix, fraction, units and derivative-equivalence assumptions.", "Select or request an identity or quantification method suitable for the matrix and expected concentration.", "Assess a specimen, reference standard or material lot for a specified analytical or handling purpose.", "Trace binding, conversion and origin claims to supporting observations and neighbouring models.", "Route proposed handling or use through the applicable product, laboratory or clinical authority." ] }, "sources": [ { "id": "bhasin-2018-jcem", "title": "Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline (Bhasin et al.). Journal of Clinical Endocrinology & Metabolism, Endocrine Society, 2018.", "url": "https://doi.org/10.1210/jc.2018-00229", "what_it_supports": "Clinical diagnosis of hypogonadism, formulation classes, monitoring (hematocrit, PSA, fertility), and major labelled risks of testosterone therapy.", "url_status": "blocked" }, { "id": "travison-2017-jcem", "title": "Harmonized Reference Ranges for Circulating Testosterone Levels in Men of Four Cohort Studies in the United States and Europe (Travison et al.). Journal of Clinical Endocrinology & Metabolism, Endocrine Society, 2017.", "url": "https://doi.org/10.1210/jc.2016-2935", "what_it_supports": "CDC-standardized adult-male total-testosterone reference interval used in measurements.", "url_status": "blocked" }, { "id": "pubchem-cid-6013", "title": "PubChem Compound Summary for CID 6013, Testosterone. National Center for Biotechnology Information, U.S. National Library of Medicine.", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/6013", "what_it_supports": "CAS, UNII, InChIKey, molecular formula/mass and other substance identifiers.", "url_status": "live" }, { "id": "wada-prohibited-list", "title": "World Anti-Doping Code International Standard: Prohibited List, class S1 Anabolic Agents. World Anti-Doping Agency.", "url": "https://www.wada-ama.org/en/prohibited-list", "what_it_supports": "Status of testosterone and its esters as prohibited anabolic agents and the doping-control context (including T/E ratio follow-up).", "url_status": "live" }, { "id": "wikidata-q131877", "title": "Wikidata item Q131877 (testosterone). Wikimedia Foundation / Wikidata.", "url": "https://www.wikidata.org/wiki/Q131877", "what_it_supports": "Crosswalk among CAS, ChEBI, DrugBank, ATC and related identifiers.", "url_status": "live" }, { "id": "fda-testosterone-info", "title": "Testosterone Information (product class page and related drug-safety communications). U.S. Food and Drug Administration.", "url": "", "what_it_supports": "U.S. approved uses, secondary dermal-transfer warnings, and cardiovascular/hematocrit labelling for testosterone products." }, { "id": "dea-schedule-iii", "title": "Controlled substance schedules: anabolic steroids including testosterone and its esters, Schedule III. U.S. Drug Enforcement Administration / Controlled Substances Act.", "url": "", "what_it_supports": "U.S. legal control of testosterone as an anabolic steroid." } ], "structure": { "bundles": [ { "id": "testosterone-identity", "name": "Testosterone identity", "description": "Establish what chemical entity a testosterone reference actually denotes.", "rationale": "Steroid names, shared structural features and derivative labels are insufficient to establish testosterone identity.", "layers": [ { "id": "stereochemical-recognition", "name": "Stereochemical recognition", "description": "Resolve the claimed substance against a complete testosterone reference structure.", "findings": [ { "id": "identity-supported", "name": "Identity supported", "description": "Record the reference identity, observed evidence and remaining chemical ambiguity.", "questions": [ { "text": "Which stereochemical structure and authoritative identifiers define testosterone in this record?", "kind": "definition", "id": "identity-supported-q01" }, { "text": "What evidence distinguishes this occurrence from epitestosterone, dihydrotestosterone, androstenedione and other plausible interferents?", "kind": "measurement", "id": "identity-supported-q02" } ] } ] }, { "id": "parent-derivative-boundary", "name": "Parent and derivative boundary", "description": "Separate testosterone itself from linked derivatives and testosterone-equivalent reporting.", "findings": [ { "id": "chemical-form-resolved", "name": "Chemical form resolved", "description": "Identify the actual compound represented by a label or quantity without creating an unsupported registry split.", "questions": [ { "text": "Does the record denote unesterified testosterone, an ester, another derivative or a mixture containing testosterone?", "kind": "boundary", "id": "chemical-form-resolved-q01" }, { "text": "If a quantity is expressed as testosterone equivalent, which actual compound, conversion basis and evidence support it?", "kind": "provenance", "id": "chemical-form-resolved-q02" } ] } ] } ] }, { "id": "testosterone-occurrence", "name": "Testosterone occurrence", "description": "Locate the substance in a specific material or biological setting and qualify its attributed origin.", "rationale": "The same identity requires different interpretation in a serum specimen, a reference solution and a medicinal formulation.", "layers": [ { "id": "matrix-and-carrier", "name": "Matrix and carrier", "description": "Specify where testosterone occurs and what the record's quantity describes.", "findings": [ { "id": "occurrence-anchored", "name": "Occurrence anchored", "description": "Link testosterone to its specimen, lot or formulation and preserve the relevant sampling context.", "questions": [ { "text": "Which specimen, material lot or formulation contains the testosterone, and in which matrix or carrier?", "kind": "provenance", "id": "occurrence-anchored-q01" }, { "text": "Does the quantity describe the original material, a sampled aliquot, an extract or a prepared dilution?", "kind": "measurement", "id": "occurrence-anchored-q02" } ] } ] }, { "id": "origin-evidence", "name": "Origin evidence", "description": "Represent biological production or introduction as an evidence-dependent attribution.", "findings": [ { "id": "origin-qualified", "name": "Origin qualified", "description": "Separate established identity from claims about how testosterone entered the material or organism.", "questions": [ { "text": "What manufacturing, administration, sampling or analytical evidence supports the claimed origin of this testosterone?", "kind": "provenance", "id": "origin-qualified-q01" }, { "text": "Can the available evidence distinguish endogenous, introduced and mixed contributions, or must origin remain unresolved?", "kind": "boundary", "id": "origin-qualified-q02" } ] } ] } ] }, { "id": "testosterone-measurement", "name": "Testosterone measurement", "description": "Define the measured quantity and establish whether the result is analytically usable.", "rationale": "Testosterone results can differ in fraction, preparation, method and reporting basis even when their labels appear identical.", "layers": [ { "id": "measurand-and-fraction", "name": "Measurand and fraction", "description": "Make the testosterone quantity, biological fraction and preparation basis explicit.", "findings": [ { "id": "quantity-defined", "name": "Quantity defined", "description": "Preserve what was measured and distinguish direct observations from calculated values.", "questions": [ { "text": "Is the result total testosterone, free testosterone, explicitly defined bioavailable testosterone or another specified quantity?", "kind": "definition", "id": "quantity-defined-q01" }, { "text": "What units, matrix, preparation steps and direct-measurement or calculation basis define the reported value?", "kind": "measurement", "id": "quantity-defined-q02" } ] } ] }, { "id": "selectivity-and-comparability", "name": "Selectivity and comparability", "description": "Assess whether an assay supports identification, quantification and comparison in the stated setting.", "findings": [ { "id": "result-qualified", "name": "Result qualified", "description": "Attach calibration, interference, uncertainty and comparability evidence to the testosterone result.", "questions": [ { "text": "What testosterone calibration traceability, matrix validation, interference assessment and quantification limits support this result?", "kind": "measurement", "id": "result-qualified-q01" }, { "text": "Do fraction, method, collection time, exposure timing and reference-population context permit the proposed comparison?", "kind": "boundary", "id": "result-qualified-q02" } ] } ] } ] }, { "id": "testosterone-biological-relations", "name": "Testosterone biological relations", "description": "Record binding and transformation relationships needed to interpret a biological occurrence.", "rationale": "A testosterone concentration alone does not establish its binding distribution, subsequent conversion or biological effect.", "layers": [ { "id": "binding-distribution", "name": "Binding distribution", "description": "Connect a testosterone fraction to the binding observations or assumptions supporting it.", "findings": [ { "id": "fraction-evidence-linked", "name": "Fraction evidence linked", "description": "Expose the evidence and assumptions behind free, bound or bioavailable assignments.", "questions": [ { "text": "Which SHBG, albumin or other binding measurements are linked to this testosterone occurrence?", "kind": "measurement", "id": "fraction-evidence-linked-q01" }, { "text": "If a testosterone fraction is calculated, which equation, input measurements and applicability evidence support the estimate?", "kind": "provenance", "id": "fraction-evidence-linked-q02" } ] } ] }, { "id": "conversion-and-effect-boundaries", "name": "Conversion and effect boundaries", "description": "Link testosterone to investigated metabolites and biological responses without treating them as the same thing.", "findings": [ { "id": "biological-inference-bounded", "name": "Biological inference bounded", "description": "Distinguish measured testosterone from evidence of conversion, receptor activity or downstream response.", "questions": [ { "text": "What evidence supports any claimed conversion involving testosterone, dihydrotestosterone or estradiol in this biological context?", "kind": "provenance", "id": "biological-inference-bounded-q01" }, { "text": "Which proposed conclusions require separate metabolite, receptor, tissue or organism evidence beyond this testosterone measurement?", "kind": "boundary", "id": "biological-inference-bounded-q02" } ] } ] } ] }, { "id": "testosterone-fitness-and-actions", "name": "Testosterone fitness and actions", "description": "Connect material condition and applicable authority to a specific proposed action.", "rationale": "Identity and nominal content alone cannot establish whether testosterone material is suitable for calibration, processing, handling or medicinal use.", "layers": [ { "id": "content-and-integrity", "name": "Content and integrity", "description": "Assess testosterone content and condition against requirements for the intended use.", "findings": [ { "id": "fitness-supported", "name": "Fitness supported", "description": "Record assay basis, relevant impurities and condition evidence without assuming one specification fits every occurrence.", "questions": [ { "text": "What testosterone content, impurity profile and acceptance specification apply to this material and intended use?", "kind": "measurement", "id": "fitness-supported-q01" }, { "text": "Do documented storage, preparation, container and handling conditions support continued suitability, or require reassessment?", "kind": "action", "id": "fitness-supported-q02" } ] } ] }, { "id": "use-and-handling-authority", "name": "Use and handling authority", "description": "Resolve the prerequisites for acting on the particular testosterone material.", "findings": [ { "id": "next-action-grounded", "name": "Next action grounded", "description": "Identify supported actions and link medicinal or regulated decisions to the models and authorities that own them.", "questions": [ { "text": "Which current safety information, product instructions and jurisdiction-specific requirements apply to the proposed testosterone handling or use?", "kind": "provenance", "id": "next-action-grounded-q01" }, { "text": "Does the evidence support analysis, preparation, transfer or disposal, or require quarantine, further testing or referral to an authorised decision-maker?", "kind": "action", "id": "next-action-grounded-q02" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-kinds", "name": "Kinds and varieties", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "Unesterified parent steroid (crystalline API, pellets, some gels)", "Injectable esters used in replacement and sport (propionate, enanthate, cypionate, undecanoate)", "Oral testosterone undecanoate (lymphatic absorption, not 17α-alkylated)", "Transdermal products (hydroalcoholic gels, solutions, patches)", "Circulating total testosterone as reported by immunoassay or LC-MS/MS", "Free testosterone (unbound) and bioavailable testosterone (free plus albumin-bound)", "Endogenous secretion versus exogenous pharmaceutical or anabolic-androgenic supply", "Isotopically labelled assay standards (for example 13C- or 2H-testosterone) used as LC-MS/MS internal standards" ], "questions": [ { "id": "evidence-kinds-q01", "text": "Which of these kinds and varieties hold for the sense of testosterone this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-identifiers", "name": "Identifiers and schemes", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ { "scheme": "Wikidata", "value_or_pattern": "Q131877", "note": "Item for the parent steroid testosterone." }, { "scheme": "CAS Registry Number", "value_or_pattern": "58-22-0", "note": "Unesterified testosterone; each ester has its own CAS number." }, { "scheme": "PubChem CID", "value_or_pattern": "6013", "note": "NCBI compound record for testosterone." }, { "scheme": "FDA UNII", "value_or_pattern": "3XMK78S47O", "note": "Substance identifier used in U.S. product labelling." }, { "scheme": "ATC", "value_or_pattern": "G03BA03", "note": "WHO Anatomical Therapeutic Chemical code (androgens, 3-oxoandrostenes)." }, { "scheme": "InChIKey", "value_or_pattern": "MUMGGOZAMZWBJJ-DYKIIFRCSA-N", "note": "Standard InChIKey of 17β-hydroxyandrost-4-en-3-one." }, { "scheme": "ChEBI", "value_or_pattern": "CHEBI:17347", "note": "ChEBI identifier for testosterone." }, { "scheme": "DrugBank", "value_or_pattern": "DB00624", "note": "DrugBank drug record; esters are separate records." } ], "questions": [ { "id": "evidence-identifiers-q01", "text": "Which of these identifiers and schemes hold for the sense of testosterone this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-standards-and-regulation", "name": "Standards and regulation", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "U.S. Controlled Substances Act / DEA: testosterone and esters are Schedule III anabolic steroids.", "FDA: approved new-drug applications and labelling for TRT products, including boxed warnings on secondary gel exposure and hematocrit/cardiovascular cautions.", "EMA and national EU agencies: marketing authorisations for testosterone replacement products (gels, injections, oral undecanoate).", "WADA Prohibited List (S1 Anabolic Agents): testosterone and its esters are prohibited in sport; urine T/E ratio and IRMS are the control methods.", "USP and Ph. Eur. monographs for testosterone and named esters (identity, assay, related substances).", "CDC Hormone Standardization (HoST) program: assay standardization and harmonized male reference interval for total testosterone.", "Endocrine Society (2018) and AUA/EAU hypogonadism guidelines: practice standards for diagnosis and monitoring, not statutes.", "UK Misuse of Drugs Act 1971: anabolic steroids including testosterone are Class C / Schedule 4 Part II.", "WHO INN: testosterone (parent) with separate INNs for esters (e.g. testosterone enantate, cypionate, undecanoate)." ], "questions": [ { "id": "evidence-standards-and-regulation-q01", "text": "Which of these standards and regulation hold for the sense of testosterone this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "Morning serum total testosterone is the first-line laboratory test when adult male hypogonadism is suspected, with confirmation on a second morning sample, preferably by LC-MS/MS.", "Prescribed intramuscular esters (typically enanthate or cypionate every 1-2 weeks, or undecanoate at longer intervals) and daily transdermal gel for confirmed hypogonadism.", "Masculinizing gender-affirming hormone therapy, using the same ester and gel products at doses aimed at adult-male ranges.", "Induction of puberty in delayed puberty or hypogonadotropic hypogonadism.", "Elite-sport doping control: urinary testosterone, epitestosterone and the T/E ratio, with GC-C-IRMS when the ratio is abnormal.", "Non-medical anabolic use in bodybuilding and image-enhancement, usually as high-dose esters, often stacked with other AAS.", "Clinical-chemistry calibrators, proficiency-testing materials and isotopically labelled internal standards." ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of testosterone this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-measurements", "name": "Typical measurements", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ { "quantity": "Harmonized total testosterone, healthy non-obese men 19-39 y (CDC-standardized LC-MS/MS)", "typical_range": "264-916", "unit": "ng/dL" }, { "quantity": "Same adult-male total testosterone interval in SI units", "typical_range": "9.2-31.8", "unit": "nmol/L" }, { "quantity": "Total testosterone, premenopausal adult women (method-dependent; LC-MS/MS preferred)", "typical_range": "15-70", "unit": "ng/dL" }, { "quantity": "Free testosterone, eugonadal adult men (equilibrium dialysis or valid calculation; highly method-dependent)", "typical_range": "5-21", "unit": "ng/dL" }, { "quantity": "Molar mass of C19H28O2", "typical_range": "288.42", "unit": "g/mol" }, { "quantity": "Unbound fraction of circulating testosterone in adult men", "typical_range": "1-3", "unit": "%" }, { "quantity": "Plasma half-life of unesterified testosterone", "typical_range": "10-100", "unit": "min" } ], "questions": [ { "id": "evidence-measurements-q01", "text": "Which of these typical measurements hold for the sense of testosterone this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "Secondary erythrocytosis: hematocrit commonly rises on TRT and can require dose reduction or phlebotomy.", "Reversible suppression of the hypothalamic-pituitary-gonadal axis and spermatogenesis, causing oligo/azoospermia and infertility while exposed.", "Transdermal gel transfer to partners or children, causing unintended virilization (labelled risk).", "Acne, seborrhoea and androgenetic alopecia; gynecomastia via aromatization to estradiol.", "Labelled contraindication in known prostate or male breast cancer; PSA and digital rectal exam are used for monitoring, not because T is proven to cause prostate cancer.", "Venous thromboembolism and cardiovascular-risk labelling; evidence of net CV harm at replacement doses remains contested.", "Worsening of untreated obstructive sleep apnea.", "Pulmonary oil microembolism and anaphylaxis with some intramuscular undecanoate products (U.S. Aveed REMS).", "Low-range immunoassay inaccuracy (women, children, severely hypogonadal men) versus LC-MS/MS, causing misclassification.", "Diversion and supraphysiologic AAS use: dyslipidemia, left-ventricular hypertrophy, dependence, and HPG shutdown after cessation." ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of testosterone this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-regional-variation", "name": "Regional variation", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "U.S. clinical labs conventionally report ng/dL; most of Europe, the UK and Australia report nmol/L (multiply ng/dL by 0.0347).", "Testosterone cypionate dominates U.S. clinic and compounding practice; enanthate and intramuscular undecanoate are more typical in Europe and Australia.", "Diagnostic cut-offs differ by society: Endocrine Society harmonized ~264 ng/dL (9.2 nmol/L), AUA often 300 ng/dL, some European pathways 8-12 nmol/L.", "Direct-to-consumer and cash-pay 'TRT clinic' prescribing is a large U.S. pattern; many public systems restrict treatment to documented organic hypogonadism.", "Criminal and sporting control of non-prescribed AAS is Schedule III in the U.S., Class C in the UK, and more variable elsewhere, which changes street supply and ester mix.", "Brand gels differ by market (for example AndroGel in the U.S., Testogel in much of Europe) with different concentrations and transfer-warning wording." ], "questions": [ { "id": "evidence-regional-variation-q01", "text": "Which of these regional variation hold for the sense of testosterone this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ { "name": "5α-Dihydrotestosterone (DHT)", "difference": "5α-reduced, non-aromatizable, higher androgen-receptor affinity; separate LC-MS/MS (or dedicated immunoassay) and clinical use of 5α-reductase inhibitors to lower DHT while testosterone may rise slightly." }, { "name": "Androstenedione", "difference": "17-keto precursor with weak androgen activity; distinguished by C17 oxidation state on LC-MS/MS and by much lower circulating androgen-receptor occupancy." }, { "name": "Epitestosterone", "difference": "17α-epimer with negligible androgen activity; doping control uses the urinary testosterone/epitestosterone (T/E) ratio, then GC-C-IRMS for carbon isotope ratio when the ratio is elevated." }, { "name": "Nandrolone (19-nortestosterone)", "difference": "19-nor anabolic steroid; urinary 19-norandrosterone on GC-MS/MS, not native testosterone metabolites." }, { "name": "Methyltestosterone and other 17α-alkylated androgens", "difference": "17α-methyl (or similar) substitution enables oral bioavailability but adds hepatotoxicity; mass-spectrometric 17α-alkyl fragment, not present on native testosterone." }, { "name": "Dehydroepiandrosterone (DHEA) / DHEA-S", "difference": "Δ5 adrenal precursor, mainly sulfated; immunoassay or LC-MS for DHEA-S, which does not track testicular Leydig output the way testosterone does." }, { "name": "Estradiol", "difference": "Aromatase product of testosterone; measured as E2, not T, and used to explain gynecomastia or to monitor aromatization on high-dose androgens." } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of testosterone this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Does an existing Vercy world model already own testosterone, requiring this registry entry to link to it rather than receive a separate publication?", "How should isotope-labelled testosterone reference materials be represented within this entry while respecting existing registry granularity?", "Which authoritative measurement procedures and traceability requirements should govern each supported matrix and testosterone fraction?", "Which context-specific evidence is sufficient to attribute endogenous, introduced or mixed testosterone origin, and what uncertainty must remain explicit?", "Which validated storage, impurity and fitness criteria apply to each material form and intended use, and which belong in linked product or specimen models?" ], "statistics": { "bundles": 6, "layers": 11, "findings": 18, "questions": 28 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "chemical substance or material", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a testosterone, record what state it is in, and decide what may be done with it.", "whatItIs": "Enable an AI agent to identify testosterone, assess the reliability and condition of a particular occurrence, and determine which measurement, handling or use actions its evidence supports.", "characteristics": { "substance": "material", "origin": "natural", "agency": "inert", "mobility": "varies" }, "whatYouCanDoWithIt": [ "observed and measured", "consumed or used up" ], "distinguishingFeatures": [ "Described in 90 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a testosterone, and on what evidence are they told apart?" ], "whatItIsMadeOf": "matter you can touch", "physicalCharacter": [ "Mobility varies between examples.", "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state", "use it up, and then need more of it" ], "howItIsRecognised": [ "Not recognisable by sight in any reliable way. Appearance varies with grade, form and additives; identification is by label, by documentation, or by assay." ], "relatedModels": [], "standing": "Described in 90 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one testosterone from another, and a testosterone from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a testosterone, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a testosterone, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a testosterone is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a testosterone, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a testosterone, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a testosterone is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a testosterone sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a testosterone, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a testosterone, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a testosterone is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a testosterone from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a testosterone, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a testosterone, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a testosterone is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "form-and-composition", "name": "Form, composition and condition", "description": "What a testosterone is made of, what shape and size it takes, and what state it is in.", "rationale": "A physical thing can be measured, and a model that cannot record its measurements cannot support any decision that depends on them.", "layers": [ { "id": "form-and-dimensions", "name": "Form and dimensions", "description": "Shape, size, mass and the ranges these take across examples.", "findings": [ { "id": "measurable-dimensions", "name": "Measurable dimensions and their units", "description": "The quantities worth recording and the units they are recorded in.", "questions": [ { "id": "measurable-dimensions-q01", "text": "What identifies and describes the dimensions of a testosterone, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "measurable-dimensions-q02", "text": "Who or what asserted this about the dimensions of a testosterone, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "measurable-dimensions-q03", "text": "What may an agent decide or do once the dimensions of a testosterone is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "material-and-composition", "name": "Material and composition", "description": "Materials, parts and how they are put together.", "findings": [ { "id": "parts-and-materials", "name": "Parts and materials", "description": "What a testosterone is built from and which parts are replaceable.", "questions": [ { "id": "parts-and-materials-q01", "text": "What identifies and describes the composition of a testosterone, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "parts-and-materials-q02", "text": "Who or what asserted this about the composition of a testosterone, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "parts-and-materials-q03", "text": "What may an agent decide or do once the composition of a testosterone is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "condition-and-integrity", "name": "Condition and integrity", "description": "Wear, damage, health and the difference between working and broken.", "findings": [ { "id": "condition-assessment", "name": "Condition, damage and health", "description": "How the condition of a testosterone is judged and by whom.", "questions": [ { "id": "condition-assessment-q01", "text": "What identifies and describes the condition of a testosterone, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "condition-assessment-q02", "text": "Who or what asserted this about the condition of a testosterone, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "condition-assessment-q03", "text": "What may an agent decide or do once the condition of a testosterone is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "place-and-movement", "name": "Place and movement", "description": "Where a testosterone is, how it got there and where it may go (varies).", "rationale": "A thing that can move needs its position recorded with a time, or every later claim about it is about a place it has left.", "layers": [ { "id": "location-and-placement", "name": "Location and placement", "description": "Position, containment and the reference frame the position is given in.", "findings": [ { "id": "position-and-frame", "name": "Position, container and reference frame", "description": "Where a testosterone is, and what that position is measured against.", "questions": [ { "id": "position-and-frame-q01", "text": "What identifies and describes the location of a testosterone, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "position-and-frame-q02", "text": "Who or what asserted this about the location of a testosterone, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "position-and-frame-q03", "text": "What may an agent decide or do once the location of a testosterone is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "movement-and-transfer", "name": "Movement and transfer", "description": "How a testosterone is carried, installed or relocated.", "findings": [ { "id": "movement-events", "name": "Movement events and constraints", "description": "What counts as a movement, what records it and what limits it.", "questions": [ { "id": "movement-events-q01", "text": "What identifies and describes the movement of a testosterone, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "movement-events-q02", "text": "Who or what asserted this about the movement of a testosterone, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "movement-events-q03", "text": "What may an agent decide or do once the movement of a testosterone is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a testosterone passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a testosterone between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a testosterone, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a testosterone, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a testosterone is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a testosterone, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a testosterone is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a testosterone, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a testosterone, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a testosterone is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "use-and-operation", "name": "Use and operation", "description": "What can be done with a testosterone and what it takes to do it.", "rationale": "An agent that can recognise a thing but not act on it has only half a model.", "layers": [ { "id": "intended-use", "name": "Intended use and function", "description": "What a testosterone is for, and what it is used for anyway.", "findings": [ { "id": "function-and-purpose", "name": "Function, purpose and misuse", "description": "The function a testosterone performs and the uses that fall outside it.", "questions": [ { "id": "function-and-purpose-q01", "text": "What identifies and describes the use of a testosterone, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "function-and-purpose-q02", "text": "Who or what asserted this about the use of a testosterone, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "function-and-purpose-q03", "text": "What may an agent decide or do once the use of a testosterone is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "handling-and-procedure", "name": "Handling and procedure", "description": "The steps, skills and tools involved in using a testosterone.", "findings": [ { "id": "procedures-and-skills", "name": "Procedures, skills and required tools", "description": "What an agent needs before it can act on a testosterone at all.", "questions": [ { "id": "procedures-and-skills-q01", "text": "What identifies and describes handling a testosterone, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "procedures-and-skills-q02", "text": "Who or what asserted this about handling a testosterone, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "procedures-and-skills-q03", "text": "What may an agent decide or do once handling a testosterone is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "supply-and-consumption", "name": "Supply and consumption", "description": "Quantities, rates and what running out means.", "findings": [ { "id": "consumption-and-stock", "name": "Consumption, stock and replenishment", "description": "How much of a testosterone there is and how fast it goes.", "questions": [ { "id": "consumption-and-stock-q01", "text": "What identifies and describes the supply of a testosterone, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "consumption-and-stock-q02", "text": "Who or what asserted this about the supply of a testosterone, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "consumption-and-stock-q03", "text": "What may an agent decide or do once the supply of a testosterone is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "composition-and-identity", "name": "Composition, grade and chemical identity", "description": "What testosterone is made of and how pure the thing in hand is.", "rationale": "Grade decides what a substance may be used for, so a model that records only the name cannot support any decision about use.", "layers": [ { "id": "chemical-identity", "name": "Chemical identity", "description": "Formula, structure and the registry numbers that name it unambiguously.", "findings": [ { "id": "identity-record", "name": "Identity and registry numbers", "description": "What identifies this substance across suppliers and regulators.", "questions": [ { "id": "identity-record-q01", "text": "What formula, structure and registry identifiers name testosterone unambiguously?", "kind": "definition" }, { "id": "identity-record-q02", "text": "Which related substances share a name in common use but not an identifier?", "kind": "boundary" } ] } ] }, { "id": "grade-and-impurities", "name": "Grade, purity and impurities", "description": "The specification a batch meets and what else is in it.", "findings": [ { "id": "specification", "name": "Specification and assay", "description": "How purity is stated and measured, and which impurities matter.", "questions": [ { "id": "specification-q01", "text": "What grades of testosterone exist, how is purity assayed, and which impurities are limited?", "kind": "measurement" }, { "id": "specification-q02", "text": "Which use requires which grade, and what happens when a lower grade is substituted?", "kind": "action" } ] } ] } ] }, { "id": "properties-and-behaviour", "name": "Properties and behaviour", "description": "How testosterone behaves under conditions an agent can measure or change.", "rationale": "Physical constants are the part of a substance model that transfers between contexts, and each needs its unit and its conditions.", "layers": [ { "id": "physical-constants", "name": "Physical constants", "description": "Values that hold for the pure substance, with their conditions.", "findings": [ { "id": "constants-record", "name": "Constants and conditions", "description": "The quantities worth recording and the state they apply in.", "questions": [ { "id": "constants-record-q01", "text": "What are the defining physical constants of testosterone, in what units and under what conditions?", "kind": "measurement" }, { "id": "constants-record-q02", "text": "Which of these values change with grade or form rather than being fixed?", "kind": "boundary" } ] } ] }, { "id": "stability-and-reactivity", "name": "Stability and reactivity", "description": "What it reacts with, degrades into, and how it is stored.", "findings": [ { "id": "incompatibilities", "name": "Incompatibilities and degradation", "description": "What must not meet it, and what it becomes over time.", "questions": [ { "id": "incompatibilities-q01", "text": "What is testosterone incompatible with, and what does it degrade into under storage?", "kind": "definition" }, { "id": "incompatibilities-q02", "text": "What storage and handling does that require, and who is competent to do it?", "kind": "action" } ] } ] } ] }, { "id": "hazard-and-regulation", "name": "Hazard classification and regulation", "description": "How testosterone can harm, and what the law says about holding and moving it.", "rationale": "A substance model without its hazard class and its regulatory identity is unusable in exactly the situations that matter.", "layers": [ { "id": "hazard-class", "name": "Hazard classification", "description": "Classified hazards, exposure limits and protective measures.", "findings": [ { "id": "classified-hazards", "name": "Classified hazards and limits", "description": "The classification, the scheme it belongs to, and the limits set.", "questions": [ { "id": "classified-hazards-q01", "text": "How is testosterone classified for hazard, under which scheme, and what exposure limits apply?", "kind": "definition" }, { "id": "classified-hazards-q02", "text": "What protection does handling require, and what must an agent refuse to do without it?", "kind": "action" } ] } ] }, { "id": "regulatory-identity", "name": "Regulatory identity and control", "description": "Registration, restriction and transport rules by jurisdiction.", "findings": [ { "id": "controls", "name": "Controls and jurisdiction", "description": "Where it is restricted and what the restriction attaches to.", "questions": [ { "id": "controls-q01", "text": "Which registrations, restrictions or transport rules cover testosterone, and where?", "kind": "provenance" }, { "id": "controls-q02", "text": "Does the control attach to the substance, its concentration, or its intended use?", "kind": "boundary" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a testosterone came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a testosterone and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a testosterone, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a testosterone, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a testosterone is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a testosterone is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a testosterone, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a testosterone, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a testosterone is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 9, "layers": 20, "findings": 22, "questions": 60 } } } }