{ "model": { "rank": 4095, "code": "thing-q134003", "model_id": "vr.tr.hemophilia", "name": "hemophilia", "purpose": "Let an agent explain hemophilia and its types in general terms, relay genetics, severity and treatment approaches from clinical sources, present history including contaminated blood scandals with attribution, and route personal medical questions to clinicians.", "family": "Thing Registry", "category": "Cross-cutting context", "status": "research-draft", "kind": "thing", "plane": "XCT", "domain": "XCT.STA", "industry": "", "version": "", "url": "/models/thing/q134003/", "tier": 2, "score": 78, "payload": { "layer": "wikidata", "aliases": [ "hemophilia C", "hemophilia A", "acquired factor XIII deficiency", "acquired hemophilia", "autosomal hemophilia A", "hemophilia A with vascular abnormality" ], "aliasCount": 6, "merged": 6, "knownIn": 78, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": "vr.tr.hemophilia", "source": { "dataset": "wikidata", "item": "Q134003", "url": "https://www.wikidata.org/wiki/Q134003", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-13T00:11:44Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 3, "engine": "claude" }, "metaModel": { "id": "THING-Q134003", "registryId": "vr.tr.hemophilia", "name": "hemophilia", "version": "0.2.0-wave.3", "entryKind": "thing", "family": "Thing Registry", "domain": [ "XCT.STA" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q134003/", "model": { "registry_id": "vr.tr.hemophilia", "name": "hemophilia", "purpose": "Let an agent explain hemophilia and its types in general terms, relay genetics, severity and treatment approaches from clinical sources, present history including contaminated blood scandals with attribution, and route personal medical questions to clinicians.", "definition": "A group of inherited bleeding disorders in which blood does not clot properly because of a deficiency of a coagulation factor, chiefly hemophilia A from factor VIII deficiency and hemophilia B from factor IX deficiency, both X-linked, and the rarer hemophilia C from factor XI deficiency, with acquired hemophilia arising from autoantibodies; severity depends on factor level, and treatment includes factor replacement, non-factor therapies and gene therapy.", "what_it_is_for": "Not applicable; a medical condition.", "affordances": [ "explain types and genetics", "relay treatment approaches in general terms", "present history with attribution", "route personal questions to clinicians" ], "distinguishing_features": [ "Factor deficiency", "X-linked inheritance for A and B", "Severity by factor level", "Advanced therapies" ], "appearance": "Not a visible object; a clinical diagnosis.", "visual_identification": [ "Inherited coagulation factor deficiency", "Hemophilia A, B, C and acquired forms", "Von Willebrand disease and platelet disorders are different bleeding disorders" ], "physical_properties": [ { "quantity": "hemophilia A prevalence", "typical_range": "about 1 in 5000", "unit": "male births", "note": "" }, { "quantity": "hemophilia B prevalence", "typical_range": "about 1 in 30000", "unit": "male births", "note": "" } ], "families_and_kinds": [ "hemophilia A, factor VIII", "hemophilia B, factor IX", "hemophilia C, factor XI, autosomal", "acquired hemophilia", "rare related factor deficiencies such as factor XIII deficiency", "carriers and symptomatic women" ], "related_models": [ { "relation": "is a kind of", "target": "inherited blood coagulation disease", "why": "in registry terms" }, { "relation": "is a kind of", "target": "coagulation factor deficiency", "why": "in registry terms" }, { "relation": "is treated with", "target": "coagulation factor concentrate", "why": "and newer therapies" }, { "relation": "is contrasted with", "target": "von Willebrand disease", "why": "another bleeding disorder" } ], "identifiers": [ { "scheme": "ICD-11", "value_or_pattern": "3B10", "note": "hereditary factor VIII deficiency" }, { "scheme": "OMIM", "value_or_pattern": "306700", "note": "hemophilia A" } ], "standards_and_regulation": [ "World Federation of Hemophilia guidelines", "Blood product safety regulation", "Gene therapy approval frameworks" ], "failure_modes_and_hazards": [ "Bleeding emergencies", "Inhibitor development", "Historical infections from contaminated blood products", "Agents giving personal medical advice" ], "in_scope": [], "out_of_scope": [], "characteristics": [] }, "sources": [], "structure": { "bundles": [ { "id": "understand", "name": "Understand", "description": "The condition.", "rationale": "Clinical.", "layers": [ { "id": "types", "name": "Types", "description": "Types and genetics.", "findings": [ { "id": "types-finding", "name": "Types", "description": "Types.", "questions": [ { "text": "What types of hemophilia exist, and how are they inherited?", "kind": "definition" }, { "text": "Is the question about hemophilia or another bleeding disorder?", "kind": "boundary" } ] } ] }, { "id": "severity", "name": "Severity", "description": "Severity and symptoms.", "findings": [ { "id": "severity-finding", "name": "Severity", "description": "Severity.", "questions": [ { "text": "How does severity relate to factor level, and what symptoms occur, in general terms?", "kind": "definition" }, { "text": "Is the user describing active bleeding, which needs urgent care?", "kind": "boundary" } ] } ] } ] }, { "id": "treat", "name": "Treat", "description": "Treatment.", "rationale": "Clinical.", "layers": [ { "id": "therapies", "name": "Therapies", "description": "Therapies.", "findings": [ { "id": "therapies-finding", "name": "Therapies", "description": "Therapies.", "questions": [ { "text": "What treatments exist, from factor replacement to non-factor and gene therapies, per guidelines?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "living", "name": "Living", "description": "Living with hemophilia.", "findings": [ { "id": "living-finding", "name": "Living", "description": "Living.", "questions": [ { "text": "How is hemophilia managed day to day, and what support organisations exist?", "kind": "provenance" }, { "text": "Is the user asking about their own care, which needs their treatment centre?", "kind": "boundary" } ] } ] } ] }, { "id": "access", "name": "Access", "description": "Access and policy.", "rationale": "Sources.", "layers": [ { "id": "global", "name": "Global", "description": "Global access.", "findings": [ { "id": "global-finding", "name": "Global", "description": "Global.", "questions": [ { "text": "What do reports say about diagnosis and treatment access worldwide, with sources?", "kind": "provenance" }, { "text": "Which sources are cited?", "kind": "provenance" } ] } ] }, { "id": "costs", "name": "Costs", "description": "Costs and policy.", "findings": [ { "id": "costs-finding", "name": "Costs", "description": "Costs.", "questions": [ { "text": "How are high-cost therapies funded and debated, with positions attributed?", "kind": "provenance" }, { "text": "Is the presentation neutral?", "kind": "boundary" } ] } ] } ] }, { "id": "history", "name": "History", "description": "History.", "rationale": "Attribution.", "layers": [ { "id": "history", "name": "History", "description": "History.", "findings": [ { "id": "history-finding", "name": "History", "description": "History.", "questions": [ { "text": "How was hemophilia understood historically, including in European royal families?", "kind": "provenance" }, { "text": "Which entry fits the history of hematology?", "kind": "action" } ] } ] }, { "id": "scandal", "name": "Scandal", "description": "Contaminated blood.", "findings": [ { "id": "scandal-finding", "name": "Scandal", "description": "Scandal.", "questions": [ { "text": "What happened in the contaminated blood scandals, as inquiries have found?", "kind": "provenance" }, { "text": "Which entry fits the specific inquiry?", "kind": "action" } ] } ] } ] } ] }, "openQuestions": [ "Should hemophilia A and B be separate primary entries?", "How should guidelines be linked?", "The registry entry has merged aliases naming subtypes and a distinct factor XIII deficiency; should they be split off?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "abstract concept", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a hemophilia, record what state it is in, and decide what may be done with it.", "whatItIs": "Let an agent explain hemophilia and its types in general terms, relay genetics, severity and treatment approaches from clinical sources, present history including contaminated blood scandals with attribution, and route personal medical questions to clinicians.", "characteristics": { "substance": "abstract", "origin": "conceptual", "agency": "inert" }, "whatYouCanDoWithIt": [ "observed and measured" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: hemophilia C, hemophilia A, acquired factor XIII deficiency, acquired hemophilia, autosomal hemophilia A, hemophilia A with vascular abnormality.", "6 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 78 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a hemophilia, and on what evidence are they told apart?" ], "whatItIsMadeOf": "an abstraction with no physical instance", "physicalCharacter": [ "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state" ], "howItIsRecognised": [ "Nothing to see. What is recognised is an instance of it, and which instances count is exactly what is argued about." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "hemophilia C", "hemophilia A", "acquired factor XIII deficiency", "acquired hemophilia", "autosomal hemophilia A", "hemophilia A with vascular abnormality" ] } ], "standing": "Described in 78 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 6 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one hemophilia from another, and a hemophilia from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a hemophilia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a hemophilia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a hemophilia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a hemophilia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a hemophilia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a hemophilia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a hemophilia sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a hemophilia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a hemophilia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a hemophilia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a hemophilia from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a hemophilia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a hemophilia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a hemophilia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a hemophilia passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a hemophilia between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a hemophilia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a hemophilia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a hemophilia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a hemophilia, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a hemophilia is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a hemophilia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a hemophilia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a hemophilia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "definitions-in-contest", "name": "Definitions and who holds them", "description": "What hemophilia is taken to mean, and by whom.", "rationale": "When a field disagrees about a concept, the disagreement is the content. A model that picks one definition silently destroys the information.", "layers": [ { "id": "competing-definitions", "name": "Competing definitions", "description": "The main readings and the traditions behind them.", "findings": [ { "id": "definition-map", "name": "Definitions and their holders", "description": "Each definition with the school or body that holds it.", "questions": [ { "id": "definition-map-q01", "text": "Which definitions of hemophilia are in use, and which tradition or body holds each?", "kind": "definition" }, { "id": "definition-map-q02", "text": "What turns on the difference between them in practice?", "kind": "boundary" } ] } ] }, { "id": "operationalisation", "name": "Operationalisation", "description": "How it is measured or applied when it has to be.", "findings": [ { "id": "operational-record", "name": "Measures and proxies", "description": "Instruments and indicators used to stand in for it.", "questions": [ { "id": "operational-record-q01", "text": "How is hemophilia operationalised or measured in practice, and by what instrument?", "kind": "measurement" }, { "id": "operational-record-q02", "text": "What does that operationalisation leave out, and when does that matter?", "kind": "boundary" } ] } ] } ] }, { "id": "instances-and-use", "name": "Instances, use and consequence", "description": "What counts as an instance of hemophilia and what follows from calling something that.", "rationale": "Applying a concept is an act with consequences, so a model must say what the label licenses and what it does not.", "layers": [ { "id": "instances", "name": "What counts as an instance", "description": "Clear cases, borderline cases and non-cases.", "findings": [ { "id": "instance-tests", "name": "Tests for an instance", "description": "What would settle whether something falls under it.", "questions": [ { "id": "instance-tests-q01", "text": "What would settle whether something is an instance of hemophilia?", "kind": "boundary" }, { "id": "instance-tests-q02", "text": "Which borderline cases are argued about, and on what grounds?", "kind": "definition" } ] } ] }, { "id": "consequence", "name": "Consequence of application", "description": "Rights, duties or decisions that follow from the label.", "findings": [ { "id": "consequence-record", "name": "What the label licenses", "description": "What an agent may do once something is classified this way.", "questions": [ { "id": "consequence-record-q01", "text": "What follows practically once something is treated as hemophilia?", "kind": "action" }, { "id": "consequence-record-q02", "text": "What must an agent not infer from the label alone?", "kind": "action" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a hemophilia came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a hemophilia and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a hemophilia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a hemophilia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a hemophilia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a hemophilia is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a hemophilia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a hemophilia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a hemophilia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 5, "layers": 10, "findings": 12, "questions": 32 } } } }