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Research draft

sterol

vr.tr.sterol · PHY.MAT

Let an agent explain sterols by structure, biological role, sources and analysis, and give general sourced health information about cholesterol without personal medical advice.

Thing Registry Physical world and living systems

Research draft, second pass

A second pass drafted this model: the structure a model of this thing needs, and what is known about it in the world. The line under this one says how the second half was obtained - researched against sources, or recalled without web access, in which case nothing here was read anywhere and every claim is a lead to verify. Unreviewed either way.

written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify

Researched by: Claude

Purpose and description

Let an agent explain sterols by structure, biological role, sources and analysis, and give general sourced health information about cholesterol without personal medical advice.

A subgroup of steroids with a hydroxyl group at the 3-position of the ring system, including cholesterol in animals, phytosterols such as sitosterol in plants and ergosterol in fungi; sterols are key components of cell membranes and precursors of hormones, bile acids and vitamin D.

What it is for: Biochemistry, nutrition and pharmacology.

It can be describe sterol structure and examples; explain membrane and precursor roles; find information on dietary sterols; understand cholesterol tests in general terms.

Distinguishing features

Steroid alcohols

Membrane components

Precursors of hormones and bile acids

Differ by kingdom

What it looks like

Waxy white solids when isolated; mostly present within membranes and foods.

How it is recognised

Four-ring steroid skeleton with 3-hydroxyl

Cholesterol, sitosterol, ergosterol

Steroid hormones are related but distinct

Related models

is a kind of - category

steroid

includes - example

cholesterol

is part of - location

cell membrane

is precursor of - products

vitamin D and bile acids

In practice

Families and kinds

zoosterols such as cholesterol

phytosterols and stanols

mycosterols such as ergosterol

oxysterols

bile acid intermediates

Identifiers

ChEBI class sterol ontology class

Standards and regulation

Rules on health claims for plant sterols in foods

Clinical guidelines on lipid testing

Failure modes and hazards

Agents interpreting personal cholesterol results

Overstated health claims

Confusing sterols with steroid drugs

Also called

3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestan-26-al3alpha,7alpha-Dihydroxy-5beta-cholestan-26-oic acid5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol26-hydroxycholesterol3Alpha,7Alpha,12Alpha-trihydroxy-5Beta-cholestan-26-oic acid3alpha,7alpha-dihydroxy-5beta-cholestan-26-al5beta-cholestane-3alpha,7alpha,26-triol26-hydroxycholesterol 3-sulfate3alpha,7alpha,24-Trihydroxy-5beta-cholestan-26-oic acid7alpha,26-dihydroxy-5beta-cholestan-3-one7alpha,26-dihydroxycholest-4-en-3-one7alpha,12alpha,26-trihydroxycholest-4-en-3-one7alpha,12alpha,26-trihydroxy-5beta-cholestan-3-one7α,26-dihydroxycholesterol6alpha-Glucuronosylhyodeoxycholate(1-)4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol(1-)4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol(1-)paricalcitolcholest-5-ene3beta-hydroxy-5alpha-cholest-8-ene-4alpha-carboxylate6-({1,7-dihydroxy-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H-cyclopenta[a]phenanthren-2-yl}oxy)-3,4,5-trihydroxyoxane-2-carboxylic acidbeta-Estradiol-17-glucuronide(25S)-Delta(4)-dafachronic acid(25R)-Delta(4)-dafachronic acid(25S)-Delta(7)-dafachronic acid(25R)-Delta(7)-dafachronic acid(5alpha,25S)-3-oxocholestan-26-oic acid3-dehydro-4-methylzymosterol2-[4-(3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoylamino]ethanesulfonic acidursodioltaurocholic acidglycocholic acidbitocholic acidcholic acidglycochenodeoxycholic acidtaurochenodeoxycholic acid3beta-Hydroxysterolcucurbitacin Dcucurbitacin aCucurbitacin C

+761

Where this came from

wikidata · CC0 1.0

Source repository Registry entry point

Drafted structure

Bundle to layer to finding to question, as the second pass will find it: 4 bundles · 8 layers · 8 findings · 16 questions.

Structure Chemistry.

Structure defines sterols.

Class

Membership.

Class

Class membership.

  1. Does this compound have the sterol skeleton with a 3-hydroxyl group? boundary
  2. What is its source organism? provenance

Identifiers

Databases.

Identifiers

Identifiers.

  1. What are its identifiers in ChEBI or LIPID MAPS? provenance
  2. Which name is systematic? provenance
Biology Roles.

Sterols do many jobs.

Membrane

Membrane role.

Membrane

Membrane role.

  1. How do sterols affect membrane fluidity? definition
  2. Why do fungi use ergosterol? definition

Precursor

Biosynthesis.

Precursor

Precursor role.

  1. How are sterols converted into hormones, bile acids and vitamin D? definition
  2. Which pathways are involved? provenance
Health Cholesterol and diet.

General information only.

Cholesterol

Tests.

Cholesterol

Cholesterol tests.

  1. What do cholesterol tests measure, in general terms, according to health services? provenance
  2. Is the user asking about their own results or treatment? boundary

Diet

Plant sterols.

Diet

Plant sterols.

  1. Which health claims for plant sterols are authorised, and under what conditions? provenance
  2. Who should avoid fortified products? provenance
Analysis Methods.

Methods measure sterols.

Methods

Lab analysis.

Methods

Lab analysis.

  1. Which analytical methods measure sterols, such as GC-MS? definition
  2. What standards apply? provenance

Antifungal

Drug targets.

Antifungal

Antifungal targets.

  1. Why is ergosterol synthesis a target for antifungal medicines, in general terms? definition
  2. Is the user asking about their own treatment? boundary

What the second pass must settle

  • Should each sterol be a separate entry?
  • How should lipid databases be linked?
  • How should health claims be tracked?
Draft as JSON