{ "model": { "rank": 18020, "code": "thing-q1473749", "model_id": "vr.tr.m-llerian-agenesis", "name": "Müllerian agenesis", "purpose": "Let an agent explain Mullerian agenesis respectfully, relay features, diagnosis, associated conditions and care options from gynaecology sources, describe the named associations, route to specialist and psychological support, and distinguish it from androgen insensitivity, imperforate hymen, primary ovarian insufficiency and other causes of primary amenorrhoea, without diagnosing individuals.", "family": "Thing Registry", "category": "Activities and processes", "status": "research-draft", "kind": "thing", "plane": "ACT", "domain": "ACT.PRC", "industry": "", "version": "", "url": "/models/thing/q1473749/", "tier": 2, "score": 30, "payload": { "layer": "wikidata", "aliases": [ "Michels Caskey syndrome", "MURCS association" ], "aliasCount": 2, "merged": 2, "knownIn": 30, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q1473749", "url": "https://www.wikidata.org/wiki/Q1473749", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-14T02:52:00Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 4, "engine": "claude" }, "metaModel": { "id": "THING-Q1473749", "registryId": "vr.tr.m-llerian-agenesis", "name": "Müllerian agenesis", "version": "0.2.0-wave.4", "entryKind": "thing", "family": "Thing Registry", "domain": [ "ACT.PRC" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q1473749/", "model": { "registry_id": "vr.tr.m-llerian-agenesis", "name": "Müllerian agenesis", "purpose": "Let an agent explain Mullerian agenesis respectfully, relay features, diagnosis, associated conditions and care options from gynaecology sources, describe the named associations, route to specialist and psychological support, and distinguish it from androgen insensitivity, imperforate hymen, primary ovarian insufficiency and other causes of primary amenorrhoea, without diagnosing individuals.", "definition": "A congenital condition in which the uterus and upper vagina fail to develop or develop only partly, also called Mullerian agenesis or Mayer-Rokitansky-Kuster-Hauser syndrome, so that a person with typical female chromosomes and functioning ovaries is born without a fully formed uterus and vagina, with associated forms the registry aliases name such as the MURCS association, which adds kidney and skeletal features, and Michels-Caskey syndrome; it is usually discovered in adolescence when menstruation does not begin, and it affects fertility but not ovarian hormone function. Care is provided by specialist teams, and it is presented respectfully as a difference of reproductive development, with psychological support and options such as vaginal creation and, in some cases, uterine transplant discussed with clinicians.", "what_it_is_for": "Not applicable; a congenital reproductive difference.", "affordances": [ "explain features and diagnosis", "relay associated conditions", "relay care options respectfully", "route to specialist and psychological support" ], "distinguishing_features": [ "Absent or partial uterus and vagina", "Functioning ovaries", "Typical female chromosomes", "Found at adolescence" ], "appearance": "Not visible externally; typical external genitalia with an absent or short vagina and absent or rudimentary uterus.", "visual_identification": [ "Congenital underdevelopment of the uterus and upper vagina", "Michels Caskey syndrome, MURCS association", "Androgen insensitivity involves XY chromosomes; imperforate hymen blocks outflow; primary ovarian insufficiency affects ovaries; other causes differ" ], "physical_properties": [ { "quantity": "also called", "typical_range": "MRKH syndrome", "unit": "note", "note": "" }, { "quantity": "chromosomes", "typical_range": "typically 46,XX", "unit": "note", "note": "" }, { "quantity": "registry parents", "typical_range": "vaginal aplasia, agenesis", "unit": "note", "note": "" } ], "families_and_kinds": [ "isolated MRKH", "MURCS association", "related syndromes" ], "related_models": [ { "relation": "is a kind of", "target": "agenesis", "why": "in registry terms" }, { "relation": "is contrasted with", "target": "androgen insensitivity syndrome", "why": "" }, { "relation": "is contrasted with", "target": "imperforate hymen", "why": "" }, { "relation": "causes", "target": "primary amenorrhea", "why": "" } ], "identifiers": [], "standards_and_regulation": [ "Gynaecology and reproductive medicine guidelines", "Ethics rules for uterine transplant research" ], "failure_modes_and_hazards": [ "Insensitive or stigmatising framing", "Missing psychological support needs", "Confusing with other conditions" ], "in_scope": [], "out_of_scope": [], "characteristics": [] }, "sources": [], "structure": { "bundles": [ { "id": "understand", "name": "Understand", "description": "What Mullerian agenesis is.", "rationale": "Attribution.", "layers": [ { "id": "definition", "name": "Definition", "description": "Definition.", "findings": [ { "id": "definition-finding", "name": "Definition", "description": "Definition.", "questions": [ { "text": "Is a young person or family seeking care after delayed menstruation or a diagnosis, in which case a specialist gynaecology team and psychological support are recommended?", "kind": "boundary" }, { "text": "What is Mullerian agenesis, and how does it differ from androgen insensitivity, imperforate hymen and primary ovarian insufficiency?", "kind": "definition" } ] } ] }, { "id": "associations", "name": "Associations", "description": "Named associations.", "findings": [ { "id": "associations-finding", "name": "Associations", "description": "Associations.", "questions": [ { "text": "What are the MURCS association and Michels-Caskey syndrome?", "kind": "definition" }, { "text": "Which entry fits the specific association?", "kind": "action" } ] } ] } ] }, { "id": "features", "name": "Features", "description": "Features.", "rationale": "Science.", "layers": [ { "id": "development", "name": "Development", "description": "Mullerian development.", "findings": [ { "id": "development-finding", "name": "Development", "description": "Development.", "questions": [ { "text": "How does failure of Mullerian duct development cause the condition?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "diagnosis", "name": "Diagnosis", "description": "Diagnosis.", "findings": [ { "id": "diagnosis-finding", "name": "Diagnosis", "description": "Diagnosis.", "questions": [ { "text": "How is Mullerian agenesis diagnosed, often after primary amenorrhoea?", "kind": "provenance" }, { "text": "Which sources are cited?", "kind": "provenance" } ] } ] } ] }, { "id": "care", "name": "Care", "description": "Care options.", "rationale": "Attribution.", "layers": [ { "id": "options", "name": "Options", "description": "Care options.", "findings": [ { "id": "options-finding", "name": "Options", "description": "Options.", "questions": [ { "text": "What care options such as vaginal creation and support do specialists offer, in general terms?", "kind": "provenance" }, { "text": "Is the information current?", "kind": "boundary" } ] } ] }, { "id": "fertility", "name": "Fertility", "description": "Fertility.", "findings": [ { "id": "fertility-finding", "name": "Fertility", "description": "Fertility.", "questions": [ { "text": "How does the condition affect fertility, and what options such as surrogacy or uterine transplant exist, with status attributed?", "kind": "provenance" }, { "text": "Is the presentation neutral and attributed?", "kind": "boundary" } ] } ] } ] }, { "id": "context", "name": "Context", "description": "Support.", "rationale": "Attribution.", "layers": [ { "id": "psychological", "name": "Psychological", "description": "Psychological support.", "findings": [ { "id": "psychological-finding", "name": "Psychological", "description": "Psychological.", "questions": [ { "text": "Why is psychological support important, as clinicians and advocates describe?", "kind": "provenance" }, { "text": "Is the presentation respectful and attributed?", "kind": "boundary" } ] } ] }, { "id": "community", "name": "Community", "description": "Support communities.", "findings": [ { "id": "community-finding", "name": "Community", "description": "Community.", "questions": [ { "text": "What support organisations exist for people with MRKH?", "kind": "provenance" }, { "text": "Which entry fits MRKH support?", "kind": "action" } ] } ] } ] } ] }, "openQuestions": [ "Should the MURCS association be a separate entry?", "How should care and support options be linked?", "How should uterine transplant status be kept current?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "abstract concept", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a Müllerian agenesis, record what state it is in, and decide what may be done with it.", "whatItIs": "Let an agent explain Mullerian agenesis respectfully, relay features, diagnosis, associated conditions and care options from gynaecology sources, describe the named associations, route to specialist and psychological support, and distinguish it from androgen insensitivity, imperforate hymen, primary ovarian insufficiency and other causes of primary amenorrhoea, without diagnosing individuals.", "characteristics": { "substance": "activity", "origin": "conceptual", "agency": "inert" }, "whatYouCanDoWithIt": [ "observed and measured" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: Michels Caskey syndrome, MURCS association.", "2 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 30 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a Müllerian agenesis, and on what evidence are they told apart?" ], "whatItIsMadeOf": "something that happens over time", "physicalCharacter": [ "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state" ], "howItIsRecognised": [ "Nothing to see. What is recognised is an instance of it, and which instances count is exactly what is argued about." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "Michels Caskey syndrome", "MURCS association" ] } ], "standing": "Described in 30 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 2 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one Müllerian agenesis from another, and a Müllerian agenesis from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a Müllerian agenesis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a Müllerian agenesis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a Müllerian agenesis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a Müllerian agenesis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a Müllerian agenesis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a Müllerian agenesis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a Müllerian agenesis sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a Müllerian agenesis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a Müllerian agenesis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a Müllerian agenesis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a Müllerian agenesis from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a Müllerian agenesis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a Müllerian agenesis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a Müllerian agenesis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a Müllerian agenesis passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a Müllerian agenesis between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a Müllerian agenesis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a Müllerian agenesis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a Müllerian agenesis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a Müllerian agenesis, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a Müllerian agenesis is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a Müllerian agenesis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a Müllerian agenesis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a Müllerian agenesis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "process-and-outcome", "name": "Process, inputs and outcome", "description": "How a Müllerian agenesis proceeds, what it needs and what it leaves behind.", "rationale": "An activity is known by its steps and its results, and both have to be recordable while it is still running.", "layers": [ { "id": "steps-and-sequence", "name": "Steps and sequence", "description": "The steps of a Müllerian agenesis, their order and what may run in parallel.", "findings": [ { "id": "steps-and-preconditions", "name": "Steps, preconditions and completion", "description": "What has to be true before each step of a Müllerian agenesis and what marks it done.", "questions": [ { "id": "steps-and-preconditions-q01", "text": "What identifies and describes a step of a Müllerian agenesis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "steps-and-preconditions-q02", "text": "Who or what asserted this about a step of a Müllerian agenesis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "steps-and-preconditions-q03", "text": "What may an agent decide or do once a step of a Müllerian agenesis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "inputs-and-results", "name": "Inputs, resources and results", "description": "What a Müllerian agenesis consumes and what it produces.", "findings": [ { "id": "inputs-and-outputs", "name": "Inputs, outputs and side effects", "description": "The resources a Müllerian agenesis takes and the results it leaves, wanted or not.", "questions": [ { "id": "inputs-and-outputs-q01", "text": "What identifies and describes the inputs and results of a Müllerian agenesis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "inputs-and-outputs-q02", "text": "Who or what asserted this about the inputs and results of a Müllerian agenesis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "inputs-and-outputs-q03", "text": "What may an agent decide or do once the inputs and results of a Müllerian agenesis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "definitions-in-contest", "name": "Definitions and who holds them", "description": "What Müllerian agenesis is taken to mean, and by whom.", "rationale": "When a field disagrees about a concept, the disagreement is the content. A model that picks one definition silently destroys the information.", "layers": [ { "id": "competing-definitions", "name": "Competing definitions", "description": "The main readings and the traditions behind them.", "findings": [ { "id": "definition-map", "name": "Definitions and their holders", "description": "Each definition with the school or body that holds it.", "questions": [ { "id": "definition-map-q01", "text": "Which definitions of Müllerian agenesis are in use, and which tradition or body holds each?", "kind": "definition" }, { "id": "definition-map-q02", "text": "What turns on the difference between them in practice?", "kind": "boundary" } ] } ] }, { "id": "operationalisation", "name": "Operationalisation", "description": "How it is measured or applied when it has to be.", "findings": [ { "id": "operational-record", "name": "Measures and proxies", "description": "Instruments and indicators used to stand in for it.", "questions": [ { "id": "operational-record-q01", "text": "How is Müllerian agenesis operationalised or measured in practice, and by what instrument?", "kind": "measurement" }, { "id": "operational-record-q02", "text": "What does that operationalisation leave out, and when does that matter?", "kind": "boundary" } ] } ] } ] }, { "id": "instances-and-use", "name": "Instances, use and consequence", "description": "What counts as an instance of Müllerian agenesis and what follows from calling something that.", "rationale": "Applying a concept is an act with consequences, so a model must say what the label licenses and what it does not.", "layers": [ { "id": "instances", "name": "What counts as an instance", "description": "Clear cases, borderline cases and non-cases.", "findings": [ { "id": "instance-tests", "name": "Tests for an instance", "description": "What would settle whether something falls under it.", "questions": [ { "id": "instance-tests-q01", "text": "What would settle whether something is an instance of Müllerian agenesis?", "kind": "boundary" }, { "id": "instance-tests-q02", "text": "Which borderline cases are argued about, and on what grounds?", "kind": "definition" } ] } ] }, { "id": "consequence", "name": "Consequence of application", "description": "Rights, duties or decisions that follow from the label.", "findings": [ { "id": "consequence-record", "name": "What the label licenses", "description": "What an agent may do once something is classified this way.", "questions": [ { "id": "consequence-record-q01", "text": "What follows practically once something is treated as Müllerian agenesis?", "kind": "action" }, { "id": "consequence-record-q02", "text": "What must an agent not infer from the label alone?", "kind": "action" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a Müllerian agenesis came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a Müllerian agenesis and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a Müllerian agenesis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a Müllerian agenesis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a Müllerian agenesis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a Müllerian agenesis is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a Müllerian agenesis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a Müllerian agenesis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a Müllerian agenesis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 6, "layers": 12, "findings": 14, "questions": 38 } } } }