{ "model": { "rank": 12202, "code": "thing-q1474877", "model_id": "vr.tr.hypercalcemia", "name": "hypercalcemia", "purpose": "Let an agent explain hypercalcaemia, relay causes, symptoms, assessment and general management from endocrinology sources, describe the conditions the registry aliases name, and distinguish hypercalcaemia from hypocalcaemia, osteoporosis and calcium intake, routing severe symptoms urgently.", "family": "Thing Registry", "category": "Cross-cutting context", "status": "research-draft", "kind": "thing", "plane": "XCT", "domain": "XCT.STA", "industry": "", "version": "", "url": "/models/thing/q1474877/", "tier": 2, "score": 40, "payload": { "layer": "wikidata", "aliases": [ "Tertiary hyperparathyroidism", "familial hypocalciuric hypercalcemia", "familial hypocalciuric hypercalcemia 1", "familial hypocalciuric hypercalcemia 2", "familial hypocalciuric hypercalcemia 3", "Tumor induced hypercalcemia", "acute hypercalcemia", "milk-alkali syndrome", "hypercalcemia, infantile" ], "aliasCount": 9, "merged": 9, "knownIn": 40, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": "vr.tr.hypercalcemia", "source": { "dataset": "wikidata", "item": "Q1474877", "url": "https://www.wikidata.org/wiki/Q1474877", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-13T19:22:08Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 4, "engine": "claude" }, "metaModel": { "id": "THING-Q1474877", "registryId": "vr.tr.hypercalcemia", "name": "hypercalcemia", "version": "0.2.0-wave.4", "entryKind": "thing", "family": "Thing Registry", "domain": [ "XCT.STA" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q1474877/", "model": { "registry_id": "vr.tr.hypercalcemia", "name": "hypercalcemia", "purpose": "Let an agent explain hypercalcaemia, relay causes, symptoms, assessment and general management from endocrinology sources, describe the conditions the registry aliases name, and distinguish hypercalcaemia from hypocalcaemia, osteoporosis and calcium intake, routing severe symptoms urgently.", "definition": "An abnormally high level of calcium in the blood, most often caused by primary hyperparathyroidism or cancer, including tumour-induced hypercalcaemia, with other causes such as tertiary hyperparathyroidism in chronic kidney disease, vitamin D excess, medications and familial hypocalciuric hypercalcaemia types 1, 2 and 3, a usually benign inherited condition; symptoms range from none to thirst, confusion, kidney stones and heart rhythm problems. Severe symptoms need urgent care. The model routes people to clinicians.", "what_it_is_for": "Not applicable; a metabolic abnormality.", "affordances": [ "route severe symptoms first", "explain causes", "relay assessment and management", "distinguish related conditions" ], "distinguishing_features": [ "High calcium", "Often found on tests", "Parathyroid or cancer causes", "Benign familial form" ], "appearance": "Not a visible object; a blood test finding.", "visual_identification": [ "High blood calcium", "Tertiary hyperparathyroidism, familial hypocalciuric hypercalcaemia 1 to 3, tumour-induced hypercalcaemia", "Hypocalcaemia is low calcium; osteoporosis is bone loss; dietary calcium is intake" ], "physical_properties": [ { "quantity": "normal total calcium", "typical_range": "about 2.2-2.6", "unit": "mmol/L", "note": "varies by lab" }, { "quantity": "main causes", "typical_range": "primary hyperparathyroidism and cancer", "unit": "note", "note": "about 90 percent" }, { "quantity": "FHH genes", "typical_range": "CASR, GNA11, AP2S1", "unit": "list", "note": "types 1 to 3" } ], "families_and_kinds": [ "primary hyperparathyroidism", "secondary and tertiary hyperparathyroidism", "malignancy-associated hypercalcaemia", "familial hypocalciuric hypercalcaemia types 1 to 3", "vitamin D and drug-related hypercalcaemia" ], "related_models": [ { "relation": "is a kind of", "target": "calcium metabolism disease", "why": "in registry terms" }, { "relation": "is often caused by", "target": "primary hyperparathyroidism", "why": "" }, { "relation": "is contrasted with", "target": "hypocalcemia", "why": "" }, { "relation": "includes", "target": "familial hypocalciuric hypercalcemia", "why": "" } ], "identifiers": [ { "scheme": "ICD-10", "value_or_pattern": "E83.52", "note": "hypercalcemia" }, { "scheme": "MeSH", "value_or_pattern": "D006934", "note": "Hypercalcemia" } ], "standards_and_regulation": [ "Endocrinology guidelines on hyperparathyroidism", "Oncology guidelines on hypercalcaemia of malignancy" ], "failure_modes_and_hazards": [ "Missing severe hypercalcaemia", "Agents giving personal medical advice", "Unnecessary surgery in FHH" ], "in_scope": [], "out_of_scope": [], "characteristics": [] }, "sources": [], "structure": { "bundles": [ { "id": "understand", "name": "Understand", "description": "What hypercalcaemia is.", "rationale": "Clinical.", "layers": [ { "id": "definition", "name": "Definition", "description": "Definition.", "findings": [ { "id": "definition-finding", "name": "Definition", "description": "Definition.", "questions": [ { "text": "What is hypercalcaemia, and how does it differ from hypocalcaemia, osteoporosis and calcium intake?", "kind": "definition" }, { "text": "Does the user have confusion, severe weakness, vomiting or heart rhythm problems, which need urgent care?", "kind": "boundary" } ] } ] }, { "id": "causes", "name": "Causes", "description": "Causes.", "findings": [ { "id": "causes-finding", "name": "Causes", "description": "Causes.", "questions": [ { "text": "What are tertiary hyperparathyroidism, FHH types 1 to 3 and tumour-induced hypercalcaemia?", "kind": "definition" }, { "text": "Which entry fits the specific cause?", "kind": "action" } ] } ] } ] }, { "id": "science", "name": "Science", "description": "Physiology.", "rationale": "Science.", "layers": [ { "id": "regulation", "name": "Regulation", "description": "Calcium regulation.", "findings": [ { "id": "regulation-finding", "name": "Regulation", "description": "Regulation.", "questions": [ { "text": "How do parathyroid hormone, vitamin D and the calcium-sensing receptor regulate calcium?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "genetics", "name": "Genetics", "description": "Genetics.", "findings": [ { "id": "genetics-finding", "name": "Genetics", "description": "Genetics.", "questions": [ { "text": "Which genes cause FHH types 1 to 3?", "kind": "provenance" }, { "text": "Which sources are cited?", "kind": "provenance" } ] } ] } ] }, { "id": "care", "name": "Care", "description": "Assessment and management.", "rationale": "Clinical.", "layers": [ { "id": "assessment", "name": "Assessment", "description": "Assessment.", "findings": [ { "id": "assessment-finding", "name": "Assessment", "description": "Assessment.", "questions": [ { "text": "How is hypercalcaemia investigated, in general terms?", "kind": "provenance" }, { "text": "Which entry fits parathyroid hormone test?", "kind": "action" } ] } ] }, { "id": "management", "name": "Management", "description": "Management.", "findings": [ { "id": "management-finding", "name": "Management", "description": "Management.", "questions": [ { "text": "What general management approaches do guidelines describe?", "kind": "provenance" }, { "text": "Which entry fits parathyroidectomy?", "kind": "action" } ] } ] } ] }, { "id": "context", "name": "Context", "description": "Cancer and kidneys.", "rationale": "Context.", "layers": [ { "id": "cancer", "name": "Cancer", "description": "Malignancy.", "findings": [ { "id": "cancer-finding", "name": "Cancer", "description": "Cancer.", "questions": [ { "text": "How does cancer cause hypercalcaemia, in general terms?", "kind": "provenance" }, { "text": "Which entry fits hypercalcemia of malignancy?", "kind": "action" } ] } ] }, { "id": "kidney", "name": "Kidney", "description": "Kidney disease.", "findings": [ { "id": "kidney-finding", "name": "Kidney", "description": "Kidney.", "questions": [ { "text": "How does chronic kidney disease lead to tertiary hyperparathyroidism?", "kind": "provenance" }, { "text": "Which entry fits chronic kidney disease?", "kind": "action" } ] } ] } ] } ] }, "openQuestions": [ "Should familial hypocalciuric hypercalcaemia be a separate primary entry?", "How should endocrinology sources be linked?", "The registry entry has merged aliases naming genetic subtypes; should they be grouped?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "abstract concept", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a hypercalcemia, record what state it is in, and decide what may be done with it.", "whatItIs": "Let an agent explain hypercalcaemia, relay causes, symptoms, assessment and general management from endocrinology sources, describe the conditions the registry aliases name, and distinguish hypercalcaemia from hypocalcaemia, osteoporosis and calcium intake, routing severe symptoms urgently.", "characteristics": { "substance": "abstract", "origin": "conceptual", "agency": "inert" }, "whatYouCanDoWithIt": [ "observed and measured" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: Tertiary hyperparathyroidism, familial hypocalciuric hypercalcemia, familial hypocalciuric hypercalcemia 1, familial hypocalciuric hypercalcemia 2, familial hypocalciuric hypercalcemia 3, Tumor induced hypercalcemia, acute hypercalcemia, milk-alkali syndrome, hypercalcemia, infantile.", "9 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 40 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a hypercalcemia, and on what evidence are they told apart?" ], "whatItIsMadeOf": "an abstraction with no physical instance", "physicalCharacter": [ "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state" ], "howItIsRecognised": [ "Nothing to see. What is recognised is an instance of it, and which instances count is exactly what is argued about." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "Tertiary hyperparathyroidism", "familial hypocalciuric hypercalcemia", "familial hypocalciuric hypercalcemia 1", "familial hypocalciuric hypercalcemia 2", "familial hypocalciuric hypercalcemia 3", "Tumor induced hypercalcemia", "acute hypercalcemia", "milk-alkali syndrome", "hypercalcemia, infantile" ] } ], "standing": "Described in 40 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 9 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one hypercalcemia from another, and a hypercalcemia from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a hypercalcemia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a hypercalcemia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a hypercalcemia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a hypercalcemia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a hypercalcemia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a hypercalcemia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a hypercalcemia sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a hypercalcemia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a hypercalcemia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a hypercalcemia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a hypercalcemia from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a hypercalcemia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a hypercalcemia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a hypercalcemia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a hypercalcemia passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a hypercalcemia between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a hypercalcemia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a hypercalcemia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a hypercalcemia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a hypercalcemia, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a hypercalcemia is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a hypercalcemia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a hypercalcemia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a hypercalcemia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "definitions-in-contest", "name": "Definitions and who holds them", "description": "What hypercalcemia is taken to mean, and by whom.", "rationale": "When a field disagrees about a concept, the disagreement is the content. A model that picks one definition silently destroys the information.", "layers": [ { "id": "competing-definitions", "name": "Competing definitions", "description": "The main readings and the traditions behind them.", "findings": [ { "id": "definition-map", "name": "Definitions and their holders", "description": "Each definition with the school or body that holds it.", "questions": [ { "id": "definition-map-q01", "text": "Which definitions of hypercalcemia are in use, and which tradition or body holds each?", "kind": "definition" }, { "id": "definition-map-q02", "text": "What turns on the difference between them in practice?", "kind": "boundary" } ] } ] }, { "id": "operationalisation", "name": "Operationalisation", "description": "How it is measured or applied when it has to be.", "findings": [ { "id": "operational-record", "name": "Measures and proxies", "description": "Instruments and indicators used to stand in for it.", "questions": [ { "id": "operational-record-q01", "text": "How is hypercalcemia operationalised or measured in practice, and by what instrument?", "kind": "measurement" }, { "id": "operational-record-q02", "text": "What does that operationalisation leave out, and when does that matter?", "kind": "boundary" } ] } ] } ] }, { "id": "instances-and-use", "name": "Instances, use and consequence", "description": "What counts as an instance of hypercalcemia and what follows from calling something that.", "rationale": "Applying a concept is an act with consequences, so a model must say what the label licenses and what it does not.", "layers": [ { "id": "instances", "name": "What counts as an instance", "description": "Clear cases, borderline cases and non-cases.", "findings": [ { "id": "instance-tests", "name": "Tests for an instance", "description": "What would settle whether something falls under it.", "questions": [ { "id": "instance-tests-q01", "text": "What would settle whether something is an instance of hypercalcemia?", "kind": "boundary" }, { "id": "instance-tests-q02", "text": "Which borderline cases are argued about, and on what grounds?", "kind": "definition" } ] } ] }, { "id": "consequence", "name": "Consequence of application", "description": "Rights, duties or decisions that follow from the label.", "findings": [ { "id": "consequence-record", "name": "What the label licenses", "description": "What an agent may do once something is classified this way.", "questions": [ { "id": "consequence-record-q01", "text": "What follows practically once something is treated as hypercalcemia?", "kind": "action" }, { "id": "consequence-record-q02", "text": "What must an agent not infer from the label alone?", "kind": "action" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a hypercalcemia came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a hypercalcemia and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a hypercalcemia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a hypercalcemia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a hypercalcemia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a hypercalcemia is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a hypercalcemia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a hypercalcemia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a hypercalcemia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 5, "layers": 10, "findings": 12, "questions": 32 } } } }