IGF1R

Registered referent

Record whether the entry denotes a protein, gene or broader concept, retaining unresolved mapping explicitly.

1. Does the originating registry record identify the IGF1R protein or its encoding gene? boundary
2. Which originating identifier and definition establish that interpretation? provenance

Reference and construct identity

Capture organism, accession version, sequence changes and experimental coverage.

1. Which organism and protein sequence version define this IGF1R observation? definition
2. Which substitutions, truncations or tags distinguish the observed material from that reference? boundary

Observed molecular form

Require evidence for processing and chain coverage rather than inferring intact receptor from one signal.

1. What evidence distinguishes precursor IGF1R from processed alpha and beta chains in this preparation? measurement
2. Which chain regions and modifications account for the observed bands or molecular masses? measurement

Assembly assignment

Separate demonstrated complex composition from inferred association or cellular coexpression.

1. What evidence establishes an IGF1R-only receptor versus an IGF1R-INSR hybrid? measurement
2. Does the assay resolve individual assemblies or report an unresolved mixture? boundary

Ligand-specific binding evidence

IGF1R binds IGF1 and can also bind IGF2 and insulin; measurements must specify the ligand and receptor preparation. [UniProt](https://www.uniprot.org/uniprotkb/P08069)

1. Which ligand, concentration range and receptor assembly were used to measure binding? measurement
2. Is the reported value an equilibrium Kd, competition IC50 or functional EC50? definition

Activation evidence

Ligand binding can activate IGF1R kinase and receptor autophosphorylation; record direct activity and proxy readouts separately. [UniProt](https://www.uniprot.org/uniprotkb/P08069)

1. Which IGF1R phosphosites or catalytic substrates were measured, using which reference coordinates? measurement
2. What time course, baseline and total-receptor normalization support the activation assignment? measurement

Accessible receptor pool

Record surface abundance and localization with methods that can distinguish them from total protein.

1. How much IGF1R is surface-accessible versus intracellular in the specified cells? measurement
2. Which observations distinguish internalization, recycling, degradation and altered receptor production? measurement

Signal attribution

Record measured proximal partners and responses, with competing receptor contributions made explicit.

1. Which proximal signaling partners show measured association or phosphorylation following IGF1R activation? measurement
2. What evidence separates IGF1R contribution from INSR, hybrids and other active receptors? boundary

Detection specificity

Tie detection claims to reagent validation, epitope coverage and controls for related receptors.

1. Which validation demonstrates that the antibody, probe or peptide measurement discriminates IGF1R from INSR? provenance
2. Which orthogonal measurement is needed if the assay cannot resolve receptor identity or assembly? action

Intervention interpretability

Record whether a perturbation changes receptor abundance, ligand access or catalytic activity and how specifically it does so.

1. Does the intervention alter IGF1R abundance, binding or kinase activity, and what exposure was tested? action
2. Which selectivity, target-engagement and rescue controls support attributing the observed response to IGF1R? provenance

Check these first

Recalled without web access and unsourced; every item is a lead to verify.

1. Which of these check these first hold for the sense of IGF1R this model covers, and on what evidence? provenance

Identifiers and schemes

Recalled without web access and unsourced; every item is a lead to verify.

1. Which of these identifiers and schemes hold for the sense of IGF1R this model covers, and on what evidence? provenance

Real-world use

Recalled without web access and unsourced; every item is a lead to verify.

1. Which of these real-world use hold for the sense of IGF1R this model covers, and on what evidence? provenance

Typical measurements

Recalled without web access and unsourced; every item is a lead to verify.

1. Which of these typical measurements hold for the sense of IGF1R this model covers, and on what evidence? provenance

Failure modes and hazards

Recalled without web access and unsourced; every item is a lead to verify.

1. Which of these failure modes and hazards hold for the sense of IGF1R this model covers, and on what evidence? provenance

Neighbouring kinds and how to tell them apart

Recalled without web access and unsourced; every item is a lead to verify.

1. Which of these neighbouring kinds and how to tell them apart hold for the sense of IGF1R this model covers, and on what evidence? provenance