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Research draft

hepatitis C

vr.tr.hepatitis-c · XCT.QLT

Let an agent explain hepatitis C accurately and without stigma, relay transmission, testing, treatment and elimination goals from WHO and hepatology sources, describe the forms and populations the registry aliases name, and distinguish hepatitis C from hepatitis A, B and other liver diseases, routing people to testing and treatment.

Thing Registry Cross-cutting context

Research draft, second pass

A second pass drafted this model: the structure a model of this thing needs, and what is known about it in the world. The line under this one says how the second half was obtained - researched against sources, or recalled without web access, in which case nothing here was read anywhere and every claim is a lead to verify. Unreviewed either way.

written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify

Researched by: Claude

Purpose and description

Let an agent explain hepatitis C accurately and without stigma, relay transmission, testing, treatment and elimination goals from WHO and hepatology sources, describe the forms and populations the registry aliases name, and distinguish hepatitis C from hepatitis A, B and other liver diseases, routing people to testing and treatment.

A liver infection caused by the hepatitis C virus, transmitted mainly through blood, historically including unscreened blood products and today mostly through unsafe injections and injecting drug use, which becomes chronic hepatitis C in most untreated people and can lead to cirrhosis and hepatocellular carcinoma; it is curable in most cases with direct-acting antiviral medicines, and special considerations apply to children and pregnancy. The model is stigma-free and routes people to testing and care.

What it is for: Not applicable; an infection.

It can be explain the infection without stigma; relay testing and cure; route to testing and care; distinguish related hepatitis.

Distinguishing features

Blood-borne

Often silent

Curable

No vaccine

What it looks like

Not a visible object; a viral liver infection, often without symptoms.

Physical character

people with chronic HCV: about 50 million - WHO 2024 estimate

cure rate with DAAs: over 95 percent

virus identified: 1989 year

Nobel Prize: 2020 year - Alter, Houghton, Rice

How it is recognised

Liver infection with hepatitis C virus

Chronic hepatitis C, HCV-related liver cancer, infection from blood products, HCV in children and pregnancy

Hepatitis A is food-borne and acute; hepatitis B has a vaccine; fatty liver and alcohol-related disease are non-viral

Related models

is a kind of - in registry terms

viral hepatitis

is caused by -

hepatitis C virus

is treated with -

direct-acting antiviral

can lead to -

hepatocellular carcinoma

In practice

Families and kinds

acute hepatitis C

chronic hepatitis C

HCV-related cirrhosis and liver cancer

transfusion-associated infection historically

HCV in children and pregnancy

genotypes 1 to 8

Identifiers

ICD-10 B17.1 and B18.2 acute and chronic hepatitis C

MeSH D006526 Hepatitis C

Standards and regulation

WHO hepatitis elimination strategy

Blood safety screening rules

Harm reduction programmes

Failure modes and hazards

Stigmatising people who use drugs

Agents giving personal medical advice

Missing testing opportunities

Also called

hepatitis C virus related hepatocellular carcinomahépatitis C infection by blood productsHCV in children and pregnancychronic hepatitis C

Where this came from

wikidata · CC0 1.0

Source repository Registry entry point

Drafted structure

Bundle to layer to finding to question, as the second pass will find it: 4 bundles · 8 layers · 8 findings · 16 questions.

Understand What hepatitis C is.

Clinical.

Definition

Definition.

Definition

Definition.

  1. What is hepatitis C, and how does it differ from hepatitis A and B and non-viral liver disease? definition
  2. Does the user want testing, treatment or harm reduction services, which local health services can provide confidentially? boundary

Forms

Forms and populations.

Forms

Forms.

  1. What are acute and chronic hepatitis C, HCV-related liver cancer, transfusion-related infection and HCV in children and pregnancy? definition
  2. Which entry fits the specific topic? action
Transmission Transmission and prevention.

Clinical.

Routes

Routes.

Routes

Routes.

  1. How is hepatitis C transmitted and not transmitted, as health authorities describe? provenance
  2. Which references are standard? provenance

Prevention

Prevention.

Prevention

Prevention.

  1. How do blood screening, safe injections and harm reduction prevent infection? provenance
  2. Which sources are cited? provenance
Care Testing and cure.

Clinical.

Testing

Testing.

Testing

Testing.

  1. How is hepatitis C tested with antibody and RNA tests, in general terms? provenance
  2. Which entry fits hepatitis C test? action

Cure

Treatment.

Cure

Cure.

  1. How do direct-acting antivirals cure hepatitis C, and how is access being expanded? provenance
  2. Which entry fits direct-acting antiviral? action
Context Elimination and history.

Context.

Elimination

Elimination goals.

Elimination

Elimination.

  1. What are WHO elimination targets, and how are countries progressing, as reported? provenance
  2. Is the presentation stigma-free? boundary

History

History.

History

History.

  1. How was the virus discovered, and what were blood product scandals, with facts attributed? provenance
  2. Which entry fits contaminated blood scandal? action

What the second pass must settle

  • Should chronic hepatitis C and HCV in pregnancy be separate primary entries?
  • How should WHO and hepatology sources be linked?
  • The registry entry has merged aliases naming complications and populations; should they be split off?
Draft as JSON