{ "model": { "rank": 3158, "code": "thing-q156871", "model_id": "vr.tr.pituitary-gland", "name": "pituitary gland", "purpose": "Enable an AI agent to recognise a pituitary gland, assess its anatomical integrity and endocrine function, and identify evidence and clinical authority needed before action.", "family": "Thing Registry", "category": "Physical world and living systems", "status": "research-draft", "kind": "thing", "plane": "PHY", "domain": "PHY.OBJ", "industry": "", "version": "", "url": "/models/thing/q156871/", "tier": 2, "score": 90, "payload": { "layer": "wikidata", "aliases": [ "human fetal pituitary" ], "aliasCount": 1, "merged": 1, "knownIn": 90, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q156871", "url": "https://www.wikidata.org/wiki/Q156871", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-07T15:06:32Z", "providers": [ "Codex", "Grok" ], "missingProviders": [], "pass": 2, "cost": { "grok": { "usd": 0.00489362, "turns": 1, "seconds": 73.1, "error": null }, "codex": { "seconds": 89, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.3\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a07c66-c0bf-7700-b562-bf4b84b12283\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: pituitary gland\nRegistry id: vr.tr.pituitary-gland\nPlane / domain: PHY / PHY.LIV\nRegistry definition: (none recorded)\nNames folded into this entry: (" } } }, "metaModel": { "id": "THING-Q156871", "registryId": "vr.tr.pituitary-gland", "name": "pituitary gland", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.LIV" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q156871/", "model": { "registry_id": "vr.tr.pituitary-gland", "name": "pituitary gland", "purpose": "Enable an AI agent to recognise a pituitary gland, assess its anatomical integrity and endocrine function, and identify evidence and clinical authority needed before action.", "definition": "The pituitary gland (hypophysis) is a pea-sized endocrine organ in the sella turcica of the sphenoid, suspended from the hypothalamus by the infundibulum, that secretes tropic and effector hormones from an anterior adenohypophysis of oral-ectoderm origin and a posterior neurohypophysis of neural origin, thereby coordinating growth, metabolism, reproduction, stress, and water balance.", "scope_statement": "Owns the organ-level identity, compartments, structural state, hormonal output, hypothalamic connections and intervention history of the pituitary gland registered as vr.tr.pituitary-gland in PHY / PHY.LIV; human anatomy is the provisional reference, with species explicitly recorded.", "in_scope": [ "Identity, species, anatomical location and developmental variants of the gland", "Anterior and posterior compartments, residual tissue and their relationship to the pituitary stalk", "Pituitary hormone production or release and evidence of preserved, deficient or excessive function", "Gland enlargement, focal abnormalities, tissue injury and effects on adjacent structures", "Pituitary-specific assessment, intervention constraints and longitudinal follow-up" ], "out_of_scope": [ "The hypothalamus as an independently modelled brain structure", "Whole-body endocrine regulation and downstream thyroid, adrenal and gonadal organ models", "Pituitary tumours as independently classified diseases, beyond their effects on this gland", "The optic apparatus, cavernous sinuses and skull base as separate anatomical entities", "Laboratory assays, imaging equipment, medicines and surgical procedures as independent things", "Patient-wide diagnosis, treatment planning and consent records beyond linked pituitary decisions" ], "distinguishing_features": [ "Check anatomical position and continuity with the hypothalamic stalk: the human pituitary normally occupies the sella turcica; displacement or ectopia requires supporting evidence rather than automatic exclusion. [Anatomical reference](https://www.ncbi.nlm.nih.gov/books/NBK425703/)", "Distinguish the gland from the hypothalamus by identifying its anterior endocrine tissue and posterior neural compartment, rather than treating the connected structures as one organ. [Anatomical reference](https://www.ncbi.nlm.nih.gov/books/NBK425703/)", "Distinguish posterior pituitary release from hormone synthesis: vasopressin and oxytocin originate in hypothalamic neurons and reach posterior pituitary terminals. [Functional reference](https://www.ncbi.nlm.nih.gov/books/NBK27/)", "Distinguish the whole gland from an adjacent or intrapituitary mass by recording identifiable gland tissue, lesion boundaries and displacement; a sellar mass alone does not establish gland identity." ], "characteristics": [ { "name": "Organism and physiological context", "kind": "relation", "unit_or_values": "Linked organism; species, age, reproductive state and relevant physiological context", "why_it_matters": "Determines which anatomical expectations and hormone reference intervals apply." }, { "name": "Location and compartment identification", "kind": "category", "unit_or_values": "Sellar, ectopic, displaced or indeterminate; anterior, posterior and stalk structures identified or unresolved", "why_it_matters": "Supports organ recognition and localisation of abnormalities." }, { "name": "Gland dimensions", "kind": "measurement", "unit_or_values": "Three orthogonal dimensions in mm; volume in mm³ if measured; modality, date and segmentation method", "why_it_matters": "Supports comparison over time without imposing one normal size across all contexts." }, { "name": "Residual tissue and structural integrity", "kind": "state", "unit_or_values": "Describe preserved, compressed, atrophic, injured, resected or unassessed tissue by compartment", "why_it_matters": "Separates the amount and condition of gland tissue from the size of any lesion." }, { "name": "Anterior pituitary hormone observations", "kind": "measurement", "unit_or_values": "ACTH, TSH, GH, prolactin, LH and FSH; laboratory-reported units, sampling time and assay-specific reference intervals", "why_it_matters": "Records the principal anterior outputs while preserving interpretation context. [Functional reference](https://www.ncbi.nlm.nih.gov/books/NBK27/)" }, { "name": "Endocrine axis interpretation", "kind": "state", "unit_or_values": "Per axis: preserved, suspected deficient, confirmed deficient, suspected excessive, confirmed excessive or indeterminate", "why_it_matters": "Prevents one hormone measurement from being treated as a verdict on the entire gland." }, { "name": "Water-balance evidence", "kind": "measurement", "unit_or_values": "Linked serum sodium in mmol/L, serum and urine osmolality in mOsm/kg, and urine output in mL/day or mL/kg/hour", "why_it_matters": "Provides evidence relevant to vasopressin function while retaining alternative explanations." }, { "name": "Stalk and hypothalamic connection", "kind": "relation", "unit_or_values": "Continuity, displacement, thickening, interruption or uncertain appearance; supporting examination", "why_it_matters": "Connects structural observations with hypotheses about impaired regulation or hormone transport." }, { "name": "Relationship to adjacent structures", "kind": "relation", "unit_or_values": "Reported separation, contact, displacement or compression involving optic apparatus and cavernous sinus structures", "why_it_matters": "Makes local consequences visible independently of endocrine function." }, { "name": "Intervention exposure", "kind": "relation", "unit_or_values": "Linked operation, irradiation, medication or other intervention; date, target and observed effects", "why_it_matters": "Supports attribution of changes and distinguishes treated state from intrinsic function." } ], "affordances": [ "Associate imaging, laboratory results and operative or pathology reports with the correct gland and compartment.", "Compare gland morphology and endocrine evidence across time using compatible methods and physiological context.", "Identify missing paired hormone measurements or specialist assessments needed to resolve a pituitary-specific uncertainty.", "Flag recorded acute structural or endocrine concerns for clinician review under an applicable clinical protocol.", "Support authorised clinicians in assessing intervention feasibility by exposing residual function, adjacent anatomy and prior treatment.", "Track whether a pituitary-directed intervention achieved its recorded objective and whether function changed afterward." ] }, "sources": [ { "id": "nih-endocrine", "title": "Pituitary Gland", "url": "https://www.ncbi.nlm.nih.gov/books/NBK459182/", "what_it_supports": "Clinical anatomy, hormone list, and disease spectrum used for definition, kinds, measurements, and failure modes.", "url_status": "live" }, { "id": "wiki-pituitary", "title": "Pituitary gland", "url": "https://en.wikipedia.org/wiki/Pituitary_gland", "what_it_supports": "Standard anatomical partition (adeno- vs neurohypophysis), embryology, and neighbour structures.", "url_status": "live" }, { "id": "wikidata-q155201", "title": "pituitary gland (Q155201)", "url": "https://www.wikidata.org/wiki/Q155201", "what_it_supports": "Canonical identifiers (Wikidata, FMA, UBERON, MeSH, TA) and cross-ontology mapping.", "url_status": "live" }, { "id": "who-icd11", "title": "ICD-11 - Diseases of the pituitary gland", "url": "https://icd.who.int/browse/2025-01/mms/en#1443711827", "what_it_supports": "Regulatory/classification codes for pituitary disorders used in standards_and_regulation.", "url_status": "live" } ], "structure": { "bundles": [ { "id": "gland-identity-and-compartments", "name": "Gland identity and compartments", "description": "Establish which organ is represented and how its constituent structures are recognised.", "rationale": "A sellar location or endocrine abnormality alone cannot identify the gland or its affected compartment.", "layers": [ { "id": "organ-identification", "name": "Organ identification", "description": "Anchor identity to the organism and observed anatomy.", "findings": [ { "id": "pituitary-identity-evidence", "name": "Pituitary identity evidence", "description": "Record the evidence identifying this structure as the pituitary, including atypical location or incomplete visualisation.", "questions": [ { "text": "Which organism and species does this gland belong to, and what evidence identifies it as the pituitary?", "kind": "definition", "id": "pituitary-identity-evidence-q01" }, { "text": "Which imaging, operative or anatomical record establishes its location and identity?", "kind": "provenance", "id": "pituitary-identity-evidence-q02" } ] } ] }, { "id": "compartment-boundaries", "name": "Compartment boundaries", "description": "Separate gland compartments from the stalk, hypothalamus and any lesion.", "findings": [ { "id": "identified-pituitary-tissue", "name": "Identified pituitary tissue", "description": "Record anterior and posterior tissue identification and the explicit boundary convention for stalk involvement.", "questions": [ { "text": "Which anterior and posterior tissues are identifiable, absent, displaced or unresolved?", "kind": "measurement", "id": "identified-pituitary-tissue-q01" }, { "text": "Where does this record place the boundary between the gland, stalk and hypothalamus?", "kind": "boundary", "id": "identified-pituitary-tissue-q02" }, { "text": "Can a reported lesion be distinguished from preserved gland tissue?", "kind": "boundary", "id": "identified-pituitary-tissue-q03" } ] } ] } ] }, { "id": "sellar-structure-and-local-effects", "name": "Sellar structure and local effects", "description": "Describe gland morphology, tissue integrity and relationships that affect nearby structures.", "rationale": "Structural abnormalities can matter independently of whether hormone secretion appears preserved.", "layers": [ { "id": "gland-morphology", "name": "Gland morphology", "description": "Record dimensions and structural changes with reproducible observation methods.", "findings": [ { "id": "morphology-and-residual-tissue", "name": "Morphology and residual tissue", "description": "Distinguish total gland dimensions, focal abnormalities and remaining recognisable tissue.", "questions": [ { "text": "What are the gland dimensions, and which modality, planes and date produced them?", "kind": "measurement", "id": "morphology-and-residual-tissue-q01" }, { "text": "What evidence describes focal lesions, compression, haemorrhage, infarction or loss of tissue, and how certain is each interpretation?", "kind": "provenance", "id": "morphology-and-residual-tissue-q02" } ] } ] }, { "id": "parasellar-relationships", "name": "Parasellar relationships", "description": "Connect gland or lesion extension with nearby anatomy and observed consequences.", "findings": [ { "id": "adjacent-structure-involvement", "name": "Adjacent structure involvement", "description": "Record reported contact or compression separately from demonstrated visual or neurological impairment.", "questions": [ { "text": "What relationship is reported between the gland or associated lesion and the optic apparatus or cavernous sinus structures?", "kind": "boundary", "id": "adjacent-structure-involvement-q01" }, { "text": "Which visual-field, acuity or cranial-nerve observations establish a functional consequence?", "kind": "measurement", "id": "adjacent-structure-involvement-q02" }, { "text": "Does the documented finding meet an applicable clinician-defined escalation criterion?", "kind": "action", "id": "adjacent-structure-involvement-q03" } ] } ] } ] }, { "id": "anterior-pituitary-output", "name": "Anterior pituitary output", "description": "Assess anterior endocrine function by axis and by the context of the evidence.", "rationale": "Pituitary output must be interpreted alongside downstream responses, feedback and sampling conditions.", "layers": [ { "id": "axis-specific-function", "name": "Axis-specific function", "description": "Represent each endocrine axis independently before forming an organ-level judgement.", "findings": [ { "id": "output-and-target-response", "name": "Output and target response", "description": "Pair pituitary observations with relevant target-organ or response markers and retain uncertain attribution.", "questions": [ { "text": "What do ACTH with cortisol, TSH with free T4, and LH or FSH with relevant gonadal markers show in their sampling context?", "kind": "measurement", "id": "output-and-target-response-q01" }, { "text": "What evidence supports the assessment of GH function and prolactin secretion?", "kind": "measurement", "id": "output-and-target-response-q02" }, { "text": "Does the evidence localise dysfunction to the pituitary, hypothalamus, target organ or an unresolved combination?", "kind": "boundary", "id": "output-and-target-response-q03" } ] } ] }, { "id": "endocrine-test-interpretation", "name": "Endocrine test interpretation", "description": "Preserve factors that determine whether basal or dynamic measurements support a conclusion.", "findings": [ { "id": "sampling-and-test-validity", "name": "Sampling and test validity", "description": "Record assay, timing, physiological state, medication exposure and any stimulation or suppression protocol.", "questions": [ { "text": "Which sampling times, reference intervals, medicines and physiological conditions affect interpretation?", "kind": "provenance", "id": "sampling-and-test-validity-q01" }, { "text": "If dynamic testing was performed, what protocol, timed results and interpretation criteria were used?", "kind": "measurement", "id": "sampling-and-test-validity-q02" }, { "text": "What unresolved question requires a clinician to consider repeat or dynamic testing?", "kind": "action", "id": "sampling-and-test-validity-q03" } ] } ] } ] }, { "id": "posterior-pituitary-and-stalk-function", "name": "Posterior pituitary and stalk function", "description": "Represent neurohypophyseal release and the integrity of hypothalamic connections.", "rationale": "Posterior release and stalk-mediated regulation require evidence distinct from anterior hormone production.", "layers": [ { "id": "neurohypophyseal-function", "name": "Neurohypophyseal function", "description": "Assess evidence concerning vasopressin-mediated water balance and context-specific oxytocin function.", "findings": [ { "id": "posterior-release-evidence", "name": "Posterior release evidence", "description": "Record measured consequences and specialist interpretations without assuming that a symptom proves posterior pituitary failure.", "questions": [ { "text": "What paired water-balance observations, fluid intake and relevant treatment exposures support assessment of vasopressin function?", "kind": "measurement", "id": "posterior-release-evidence-q01" }, { "text": "What evidence separates a central release problem from renal response, intake or other causes?", "kind": "boundary", "id": "posterior-release-evidence-q02" }, { "text": "Where clinically relevant, what evidence supports an oxytocin-related functional assessment, and what remains unmeasured?", "kind": "measurement", "id": "posterior-release-evidence-q03" } ] } ] }, { "id": "hypothalamic-connections", "name": "Hypothalamic connections", "description": "Assess stalk findings and their possible effects on transport and anterior regulation.", "findings": [ { "id": "stalk-integrity-and-attribution", "name": "Stalk integrity and attribution", "description": "Keep observed stalk abnormalities separate from hypotheses about their endocrine effects.", "questions": [ { "text": "What examination documents stalk continuity, displacement, thickening or interruption?", "kind": "provenance", "id": "stalk-integrity-and-attribution-q01" }, { "text": "Which endocrine findings are attributed to altered hypothalamic input, and what supports that attribution?", "kind": "boundary", "id": "stalk-integrity-and-attribution-q02" } ] } ] } ] }, { "id": "pituitary-course-and-action", "name": "Pituitary course and action", "description": "Connect changes in gland state with prior interventions, follow-up needs and authorised clinical decisions.", "rationale": "Structural improvement, endocrine recovery and treatment dependence must be tracked separately.", "layers": [ { "id": "intervention-and-reassessment", "name": "Intervention and reassessment", "description": "Record why a pituitary-directed intervention occurred and what changed afterward.", "findings": [ { "id": "treatment-effects-and-residual-function", "name": "Treatment effects and residual function", "description": "Link intervention objectives to subsequent morphology, endocrine function and replacement dependence.", "questions": [ { "text": "Which operation, irradiation or medication affected this gland, and what was its documented objective?", "kind": "provenance", "id": "treatment-effects-and-residual-function-q01" }, { "text": "What changed in gland structure and each assessed endocrine function after the intervention?", "kind": "measurement", "id": "treatment-effects-and-residual-function-q02" }, { "text": "Which observations reflect hormone replacement or suppression rather than demonstrated intrinsic gland function?", "kind": "boundary", "id": "treatment-effects-and-residual-function-q03" } ] } ] }, { "id": "clinical-action-constraints", "name": "Clinical action constraints", "description": "Identify the evidence, authority and anatomical or endocrine constraints relevant to a proposed action.", "findings": [ { "id": "pituitary-decision-readiness", "name": "Pituitary decision readiness", "description": "Record whether observation, reassessment or intervention is supported by a documented clinical plan.", "questions": [ { "text": "What pituitary-specific uncertainty, change or risk is the proposed action intended to address?", "kind": "action", "id": "pituitary-decision-readiness-q01" }, { "text": "Which missing endocrine assessments, adjacent-structure evaluations or prior-treatment records could change that decision?", "kind": "action", "id": "pituitary-decision-readiness-q02" }, { "text": "Which responsible clinician, consent record and applicable protocol authorise the action and define follow-up or escalation?", "kind": "provenance", "id": "pituitary-decision-readiness-q03" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-kinds", "name": "Kinds and varieties", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "Adenohypophysis (anterior pituitary: pars distalis, and in many species pars intermedia and pars tuberalis)", "Neurohypophysis (posterior pituitary: pars nervosa plus infundibular stalk)", "Pars intermedia (intermediate lobe; vestigial or thin in adult humans, well developed in many other mammals)", "Pars tuberalis (collar of adenohypophyseal tissue around the infundibulum)", "Ectopic / pharyngeal pituitary remnants (Rathke-pouch rests along the craniopharyngeal canal)", "Pituitary adenoma (functional vs non-functioning; microadenoma vs macroadenoma - the main clinical 'kinds' of the gland as a diseased organ)", "Fetal vs adult pituitary (vascular and cellular composition change after birth; intermediate lobe regresses in humans)", "Veterinary / comparative pituitary (distinct pars intermedia and seasonal pars tuberalis function in horses, sheep, and other mammals)" ], "questions": [ { "id": "evidence-kinds-q01", "text": "Which of these kinds and varieties hold for the sense of pituitary gland this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-identifiers", "name": "Identifiers and schemes", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ { "scheme": "Wikidata", "value_or_pattern": "Q155201", "note": "Item 'pituitary gland'." }, { "scheme": "FMA", "value_or_pattern": "FMA:13889", "note": "Foundational Model of Anatomy class for hypophysis." }, { "scheme": "UBERON", "value_or_pattern": "UBERON:0000007", "note": "Uber-anatomy ontology 'pituitary gland'." }, { "scheme": "MeSH", "value_or_pattern": "D010902", "note": "Medical Subject Heading 'Pituitary Gland'." }, { "scheme": "Terminologia Anatomica", "value_or_pattern": "TA98 A11.1.00.001 / TA2 3853", "note": "Official anatomical name hypophysis / glandula pituitaria." }, { "scheme": "SNOMED CT", "value_or_pattern": "56329008", "note": "Body-structure concept 'Pituitary structure'." }, { "scheme": "ICD-11", "value_or_pattern": "5A6* (block: disorders of the pituitary gland)", "note": "Disease classification of the organ, not the organ itself; WHO MMS." } ], "questions": [ { "id": "evidence-identifiers-q01", "text": "Which of these identifiers and schemes hold for the sense of pituitary gland this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-standards-and-regulation", "name": "Standards and regulation", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "Terminologia Anatomica (TA98/TA2) - Federative International Programme for Anatomical Terminology (FIPAT / IFAA): official names hypophysis, adenohypophysis, neurohypophysis.", "WHO ICD-11 chapter 5A60-5A6Z - World Health Organization: classification of hyperfunction, hypofunction, and neoplasms of the pituitary.", "Endocrine Society Clinical Practice Guidelines (acromegaly, Cushing, hypopituitarism, prolactinoma) - Endocrine Society: diagnostic thresholds and treatment pathways.", "WHO Classification of Tumours of Endocrine Organs / 5th-edition CNS and endocrine volumes - IARC/WHO: histopathology of pituitary neuroendocrine tumours (PitNETs).", "Human Tissue Act 2004 (England, Wales, Northern Ireland) and equivalent EU/US tissue rules - national competent authorities: pituitary as relevant material for research and transplant (historical cadaveric GH).", "EMA/FDA product monographs for recombinant GH, desmopressin, dopamine agonists, somatostatin analogues, and ACTH/cosyntropin tests - EMA and FDA: licensed uses that act on or replace pituitary function." ], "questions": [ { "id": "evidence-standards-and-regulation-q01", "text": "Which of these standards and regulation hold for the sense of pituitary gland this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "Target of MRI (sella protocol) and inferior-petrosal-sinus sampling in suspected Cushing disease or adenoma.", "Source of clinically measured tropic hormones (TSH, ACTH, GH, PRL, LH/FSH) in blood panels.", "Surgical field in transsphenoidal adenomectomy and hypophysectomy.", "Historical source of cadaveric human growth hormone (withdrawn after iatrogenic CJD).", "Comparative-anatomy and veterinary object (equine pituitary pars intermedia dysfunction / PPID).", "Teaching specimen in anatomy and histology (Rathke-pouch remnant, acidophils/basophils/chromophobes)." ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of pituitary gland this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-measurements", "name": "Typical measurements", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ { "quantity": "Gland mass (adult human)", "typical_range": "0.5-0.9 (larger in parous women, up to ~1.0)", "unit": "g" }, { "quantity": "Gland dimensions (adult, MRI/autopsy)", "typical_range": "height 3-8; width ~10; anteroposterior ~8 (height higher in young women and pregnancy)", "unit": "mm" }, { "quantity": "Serum prolactin (non-pregnant adult)", "typical_range": "roughly 5-25 (assay-dependent; pregnancy much higher)", "unit": "µg/L" }, { "quantity": "IGF-1 / GH axis", "typical_range": "age- and sex-specific IGF-1 SDS; nadir GH on OGTT typically <0.4 for excluding acromegaly (assay-dependent)", "unit": "µg/L (GH); nmol/L or µg/L (IGF-1)" }, { "quantity": "Morning serum cortisol as ACTH-axis screen", "typical_range": "failure suggested if <~100-140; pass often >~400-500 (cut-offs guideline- and assay-dependent)", "unit": "nmol/L" }, { "quantity": "Adenoma size class", "typical_range": "microadenoma <10; macroadenoma ≥10; giant often ≥40", "unit": "mm" } ], "questions": [ { "id": "evidence-measurements-q01", "text": "Which of these typical measurements hold for the sense of pituitary gland this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "Hypopituitarism (partial or pan-) after adenoma, surgery, radiation, apoplexy, Sheehan syndrome, or infiltration - risk of adrenal crisis if ACTH is lost.", "Hormone hypersecretion: prolactinoma (hypogonadism, galactorrhea), GH (acromegaly/gigantism), ACTH (Cushing disease), TSH-oma, gonadotrophinoma.", "Mass effect: optic-chiasm compression (bitemporal hemianopia), cranial-nerve palsy in cavernous sinus, hydrocephalus, headache.", "Pituitary apoplexy: acute haemorrhage or infarction - neurosurgical emergency.", "Diabetes insipidus from posterior-lobe or stalk injury (central DI).", "Iatrogenic: transsphenoidal CSF leak, meningitis, carotid injury; historical cadaveric GH transmitting prion disease (iCJD).", "Empty-sella and stalk interruption syndromes with variable endocrine deficit.", "Drug effects: glucocorticoids, opioids, and immune-checkpoint inhibitors causing secondary adrenal insufficiency; dopamine antagonists raising prolactin." ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of pituitary gland this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-regional-variation", "name": "Regional variation", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "English clinical usage prefers 'pituitary'; many European anatomical texts still lead with 'hypophysis' (TA).", "Adult human pars intermedia is a thin residual cleft; it is a full lobe in most other mammals - veterinary diagnosis (PPID in horses) does not map 1:1 to human 'intermediate-lobe' disease.", "Access to inferior-petrosal-sinus sampling, stereotactic radiosurgery, and pituitary MDTs is concentrated in tertiary centres; much of the world diagnoses by basal hormones and non-specialist MRI only.", "SI units (nmol/L cortisol, mIU/L gonadotrophins) vs US conventional units (µg/dL, mIU/mL) change numeric cut-offs in guidelines." ], "questions": [ { "id": "evidence-regional-variation-q01", "text": "Which of these regional variation hold for the sense of pituitary gland this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ { "name": "Hypothalamus", "difference": "Hypothalamus is diencephalic neural tissue that releases releasing/inhibiting factors into the portal system and makes ADH/oxytocin; the pituitary is the sella organ that stores (posterior) or secretes tropic hormones (anterior). MRI: above vs inside the sella, separated by the diaphragma sellae / stalk." }, { "name": "Pineal gland", "difference": "Pineal is a midline epithalamic melatonin organ in the quadrigeminal cistern, not in the sella; no adenohypophyseal histology." }, { "name": "Rathke cleft cyst / craniopharyngioma", "difference": "Both arise from Rathke-pouch remnants; they are cystic/epithelial tumours adjacent to or compressing the gland, not the gland's native anterior/posterior parenchyma. Histology (adamantinomatous/papillary craniopharyngioma or simple Rathke epithelium) and MRI (T1-bright proteinaceous cyst vs enhancing adenoma) separate them." }, { "name": "Sella turcica / cavernous sinus contents", "difference": "Bone and venous/neural envelope around the gland (ICA, CN III-VI); invasion is diagnosed when adenoma crosses the thin medial cavernous wall (Knosp grade), not when the gland merely sits in the sella." }, { "name": "Primary hypothyroidism with thyrotroph hyperplasia", "difference": "Looks like a pituitary mass but TSH is high with low free T4; the 'mass' regresses on levothyroxine, unlike a primary TSH-secreting adenoma (high T4 with unsuppressed TSH)." }, { "name": "Posterior pituitary bright spot vs lipoma/haemorrhage", "difference": "Normal T1-hyperintense ADH-neurosecretory granules in the posterior lobe; lost in central DI. Distinguish from fat (fat-sat) and from haemorrhage (evolution on T1/T2, clinical apoplexy)." } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of pituitary gland this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Does the registry intend a human-only model or a cross-species model requiring different compartment descriptions and endocrine expectations?", "Does an existing Vercy world model already own this concept, requiring this registry entry to link to it rather than create a second model?", "Which anatomical convention should govern inclusion of the infundibulum and pars intermedia within this organ model?", "Which authoritative clinical references and local protocols should supply context-specific reference intervals, dynamic-test criteria and escalation thresholds?", "What evidence standard should establish intrinsic endocrine recovery after treatment, particularly when replacement or suppressive medicines complicate interpretation?" ], "statistics": { "bundles": 6, "layers": 11, "findings": 18, "questions": 35 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "device, machine or tool", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a pituitary gland, record what state it is in, and decide what may be done with it.", "whatItIs": "Enable an AI agent to recognise a pituitary gland, assess its anatomical integrity and endocrine function, and identify evidence and clinical authority needed before action.", "characteristics": { "substance": "material", "origin": "manufactured", "agency": "inert", "mobility": "varies" }, "whatYouCanDoWithIt": [ "observed and measured" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: human fetal pituitary.", "1 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 90 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a pituitary gland, and on what evidence are they told apart?" ], "whatItIsMadeOf": "matter you can touch", "physicalCharacter": [ "Mobility varies between examples.", "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state" ], "howItIsRecognised": [ "Recognised by form, by the arrangement of its controls, and by markings - a plate, a model number, a certification mark. Form alone rarely separates two models that do very different things." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "human fetal pituitary" ] } ], "standing": "Described in 90 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 1 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one pituitary gland from another, and a pituitary gland from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a pituitary gland, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a pituitary gland, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a pituitary gland is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a pituitary gland, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a pituitary gland, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a pituitary gland is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a pituitary gland sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a pituitary gland, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a pituitary gland, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a pituitary gland is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a pituitary gland from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a pituitary gland, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a pituitary gland, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a pituitary gland is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "form-and-composition", "name": "Form, composition and condition", "description": "What a pituitary gland is made of, what shape and size it takes, and what state it is in.", "rationale": "A physical thing can be measured, and a model that cannot record its measurements cannot support any decision that depends on them.", "layers": [ { "id": "form-and-dimensions", "name": "Form and dimensions", "description": "Shape, size, mass and the ranges these take across examples.", "findings": [ { "id": "measurable-dimensions", "name": "Measurable dimensions and their units", "description": "The quantities worth recording and the units they are recorded in.", "questions": [ { "id": "measurable-dimensions-q01", "text": "What identifies and describes the dimensions of a pituitary gland, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "measurable-dimensions-q02", "text": "Who or what asserted this about the dimensions of a pituitary gland, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "measurable-dimensions-q03", "text": "What may an agent decide or do once the dimensions of a pituitary gland is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "material-and-composition", "name": "Material and composition", "description": "Materials, parts and how they are put together.", "findings": [ { "id": "parts-and-materials", "name": "Parts and materials", "description": "What a pituitary gland is built from and which parts are replaceable.", "questions": [ { "id": "parts-and-materials-q01", "text": "What identifies and describes the composition of a pituitary gland, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "parts-and-materials-q02", "text": "Who or what asserted this about the composition of a pituitary gland, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "parts-and-materials-q03", "text": "What may an agent decide or do once the composition of a pituitary gland is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "condition-and-integrity", "name": "Condition and integrity", "description": "Wear, damage, health and the difference between working and broken.", "findings": [ { "id": "condition-assessment", "name": "Condition, damage and health", "description": "How the condition of a pituitary gland is judged and by whom.", "questions": [ { "id": "condition-assessment-q01", "text": "What identifies and describes the condition of a pituitary gland, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "condition-assessment-q02", "text": "Who or what asserted this about the condition of a pituitary gland, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "condition-assessment-q03", "text": "What may an agent decide or do once the condition of a pituitary gland is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "place-and-movement", "name": "Place and movement", "description": "Where a pituitary gland is, how it got there and where it may go (varies).", "rationale": "A thing that can move needs its position recorded with a time, or every later claim about it is about a place it has left.", "layers": [ { "id": "location-and-placement", "name": "Location and placement", "description": "Position, containment and the reference frame the position is given in.", "findings": [ { "id": "position-and-frame", "name": "Position, container and reference frame", "description": "Where a pituitary gland is, and what that position is measured against.", "questions": [ { "id": "position-and-frame-q01", "text": "What identifies and describes the location of a pituitary gland, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "position-and-frame-q02", "text": "Who or what asserted this about the location of a pituitary gland, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "position-and-frame-q03", "text": "What may an agent decide or do once the location of a pituitary gland is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "movement-and-transfer", "name": "Movement and transfer", "description": "How a pituitary gland is carried, installed or relocated.", "findings": [ { "id": "movement-events", "name": "Movement events and constraints", "description": "What counts as a movement, what records it and what limits it.", "questions": [ { "id": "movement-events-q01", "text": "What identifies and describes the movement of a pituitary gland, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "movement-events-q02", "text": "Who or what asserted this about the movement of a pituitary gland, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "movement-events-q03", "text": "What may an agent decide or do once the movement of a pituitary gland is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a pituitary gland passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a pituitary gland between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a pituitary gland, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a pituitary gland, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a pituitary gland is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a pituitary gland, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a pituitary gland is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a pituitary gland, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a pituitary gland, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a pituitary gland is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "function-and-principle", "name": "Function and operating principle", "description": "What pituitary gland is for and how it achieves it.", "rationale": "Two devices with the same name can work on different principles, and the principle is what predicts failure and constrains use.", "layers": [ { "id": "intended-function", "name": "Intended function", "description": "The job it does, and the jobs it is used for anyway.", "findings": [ { "id": "function-record", "name": "Function, principle and variants", "description": "What it does, how, and which variants do it differently.", "questions": [ { "id": "function-record-q01", "text": "What function does pituitary gland perform, on what operating principle, and which variants differ in that principle?", "kind": "definition" }, { "id": "function-record-q02", "text": "What use falls outside the intended function but happens in practice?", "kind": "boundary" } ] } ] }, { "id": "capacity-and-rating", "name": "Capacity and rating", "description": "The numbers that say what it can do and where it stops.", "findings": [ { "id": "ratings", "name": "Ratings and their conditions", "description": "Rated capacity, power, throughput and the conditions each assumes.", "questions": [ { "id": "ratings-q01", "text": "What ratings characterise pituitary gland, in what units, and under what stated conditions?", "kind": "measurement" }, { "id": "ratings-q02", "text": "What happens beyond the rating - degradation, refusal, damage - and how is that detected?", "kind": "action" } ] } ] } ] }, { "id": "operation-and-state", "name": "Operation, controls and state", "description": "How pituitary gland is operated and what state it is in right now.", "rationale": "An agent acting on a device needs its current state and the controls that change it, not just its specification.", "layers": [ { "id": "controls-and-modes", "name": "Controls and modes", "description": "What can be set, what that changes, and what is interlocked.", "findings": [ { "id": "control-surface", "name": "Control surface and interlocks", "description": "The settings available and the conditions that block them.", "questions": [ { "id": "control-surface-q01", "text": "What controls and modes does pituitary gland have, and what does each change?", "kind": "definition" }, { "id": "control-surface-q02", "text": "Which actions are interlocked or forbidden in which state, and what must be true before acting?", "kind": "action" } ] } ] }, { "id": "condition-and-maintenance", "name": "Condition and maintenance", "description": "Wear, service intervals, consumables and the line between working and broken.", "findings": [ { "id": "service-record", "name": "Condition, service and consumables", "description": "What is consumed, what is serviced, and how condition is judged.", "questions": [ { "id": "service-record-q01", "text": "What consumables and service does pituitary gland need, at what interval, and on whose authority?", "kind": "measurement" }, { "id": "service-record-q02", "text": "What evidence separates a unit that is working from one that is out of service?", "kind": "boundary" } ] } ] } ] }, { "id": "kind-model-unit", "name": "Kind, model and unit", "description": "Whether a claim about pituitary gland is about the kind, a product line, or one physical unit.", "rationale": "This is the boundary most often got wrong for made things, and getting it wrong mixes a catalogue entry with the machine in the yard.", "layers": [ { "id": "level-of-reference", "name": "Level of reference", "description": "The three levels and what belongs at each.", "findings": [ { "id": "level-rules", "name": "What belongs to kind, model and unit", "description": "Which properties are shared by all of them and which are not.", "questions": [ { "id": "level-rules-q01", "text": "Which facts about pituitary gland hold for every one of them, which for a model, and which only for one unit?", "kind": "boundary" }, { "id": "level-rules-q02", "text": "What identifies an individual unit, and what should an agent do when it has only the kind?", "kind": "action" } ] } ] }, { "id": "standards-and-conformity", "name": "Standards and conformity", "description": "The standards a working example must meet and who attests it.", "findings": [ { "id": "conformity", "name": "Standards, marks and attestation", "description": "Which standard applies, who certifies, and what the mark means.", "questions": [ { "id": "conformity-q01", "text": "Which standards govern pituitary gland, issued by whom, and what does conformity actually assert?", "kind": "provenance" }, { "id": "conformity-q02", "text": "What may an agent conclude from a certification mark, and what may it not?", "kind": "boundary" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a pituitary gland came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a pituitary gland and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a pituitary gland, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a pituitary gland, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a pituitary gland is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a pituitary gland is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a pituitary gland, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a pituitary gland, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a pituitary gland is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 8, "layers": 17, "findings": 19, "questions": 51 } } } }