thyroid gland

Supported thyroid identity

Record the observed tissue, identification method and unresolved alternatives.

1. Which organism and species contain this gland, and what evidence identifies the tissue as thyroid? definition
2. Which examination, image or pathology report supports identification, and which alternatives remain unresolved? provenance

Mapped thyroid components

Record observed components and distinguish missing, removed and unobserved tissue.

1. Where are the observed lobes, isthmus, accessory tissue or remnants, and what are their dimensions? measurement
2. Which apparent boundaries or absent components are established, and which remain uncertain because of limited examination? boundary

Interpretable thyroid tests

Record TSH and relevant T4 or T3 results, units, intervals and collection context. These are established thyroid assessment tests. [NIDDK thyroid tests](https://www.niddk.nih.gov/health-information/diagnostic-tests/thyroid).

1. What TSH, free or total T4, and T3 results are available, with specimen dates, units and assay-specific reference intervals? measurement
2. What pregnancy, illness, medication, supplement or assay-interference context was documented when these samples were obtained? provenance

Gland function interpretation

Record the attributed functional state and competing explanations without treating blood concentrations as direct measurements of gland secretion.

1. What evidence supports the assigned functional state, and are laboratory results and clinical observations concordant? definition
2. How has interpretation distinguished gland production from hormone release, administered hormone or altered upstream regulation? boundary

Diffuse change assessment

Keep physical, imaging, antibody and diagnostic interpretations distinguishable.

1. What measurements or observations establish diffuse enlargement, altered tissue appearance or tenderness? measurement
2. Which evidence supports an inflammatory or autoimmune interpretation, and who made that interpretation? provenance

Traceable nodule evidence

Link each lesion's imaging features and any sampling result to the same target. Ultrasound and, when indicated, biopsy contribute to nodule evaluation. [American Thyroid Association thyroid nodules](https://www.thyroid.org/thyroid-nodules/).

1. For each lesion, what are its location, dimensions, composition and reported ultrasound risk category, including the classification system and version? measurement
2. Which lesion was sampled, what was the specimen adequacy and reported interpretation, and does that result resolve or leave uncertainty about that lesion? provenance

Local impact attribution

Record symptoms and anatomical findings separately, then preserve the evidence connecting them.

1. What breathing, swallowing or voice changes and what compression, displacement or extension findings have been documented? measurement
2. What evidence attributes these effects to the thyroid, and which findings require urgent clinical assessment under the applicable pathway? action

Supported state transition

Distinguish measured progression or recovery from changed methods, unmatched lesions or transient observations.

1. How have gland volume, individual lesions and thyroid test results changed across dated, comparable assessments? measurement
2. Which changes followed treatment or another documented exposure, and how strong is the evidence for attribution? provenance

Justified next investigation

Record why an investigation is proposed, what it could resolve and which prerequisites remain unmet.

1. What unresolved functional or structural question would the proposed thyroid test, scan or biopsy answer? action
2. What patient-specific constraints, prior iodine exposure, pregnancy or lactation context, target confirmation and clinical authorisation must be checked for this investigation? action

Authorised care and follow-up

Link observation, medication, ablation or surgery to its clinical indication, responsible professional and subsequent reassessment.

1. What thyroid-directed plan has been authorised, for which indication and target, and with what documented constraints involving adjacent structures or host condition? action
2. What thyroid tissue and functional capacity remain after treatment, and what monitoring or hormone replacement plan has been documented? action

Kinds and varieties

Reported by the breadth pass; each item needs checking against its source before it becomes normative.

1. Which of these kinds and varieties hold for the sense of thyroid gland this model covers, and on what evidence? provenance

Identifiers and schemes

Reported by the breadth pass; each item needs checking against its source before it becomes normative.

1. Which of these identifiers and schemes hold for the sense of thyroid gland this model covers, and on what evidence? provenance

Standards and regulation

Reported by the breadth pass; each item needs checking against its source before it becomes normative.

1. Which of these standards and regulation hold for the sense of thyroid gland this model covers, and on what evidence? provenance

Real-world use

Reported by the breadth pass; each item needs checking against its source before it becomes normative.

1. Which of these real-world use hold for the sense of thyroid gland this model covers, and on what evidence? provenance

Typical measurements

Reported by the breadth pass; each item needs checking against its source before it becomes normative.

1. Which of these typical measurements hold for the sense of thyroid gland this model covers, and on what evidence? provenance

Failure modes and hazards

Reported by the breadth pass; each item needs checking against its source before it becomes normative.

1. Which of these failure modes and hazards hold for the sense of thyroid gland this model covers, and on what evidence? provenance

Regional variation

Reported by the breadth pass; each item needs checking against its source before it becomes normative.

1. Which of these regional variation hold for the sense of thyroid gland this model covers, and on what evidence? provenance

Neighbouring kinds and how to tell them apart

Reported by the breadth pass; each item needs checking against its source before it becomes normative.

1. Which of these neighbouring kinds and how to tell them apart hold for the sense of thyroid gland this model covers, and on what evidence? provenance