{ "model": { "rank": 5577, "code": "thing-q16501", "model_id": "vr.tr.hypothyroidism", "name": "hypothyroidism", "purpose": "Let an agent explain hypothyroidism and its causes and forms in general terms, relay diagnosis and treatment information from health bodies, describe iodine and public health aspects, and route personal medical questions to clinicians.", "family": "Thing Registry", "category": "Cross-cutting context", "status": "research-draft", "kind": "thing", "plane": "XCT", "domain": "XCT.STA", "industry": "", "version": "", "url": "/models/thing/q16501/", "tier": 2, "score": 66, "payload": { "layer": "wikidata", "aliases": [ "maternal hypothyroidism", "myxedema", "Van Wyk and Grumbach syndrome", "selective pituitary resistance to thyroid hormone", "Sign of Hertoghe", "postsurgical hypothyroidism", "iodine hypothyroidism", "Myxedema coma", "rare adult hypothyroidism", "peripheral resistance to thyroid hormones", "thyroid dysgenesis", "athyreosis", "thyroid ectopy", "Lingual Thyroid", "thyroid hypoplasia" ], "aliasCount": 15, "merged": 15, "knownIn": 66, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": "vr.tr.hypothyroidism", "source": { "dataset": "wikidata", "item": "Q16501", "url": "https://www.wikidata.org/wiki/Q16501", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-12T05:08:45Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 2, "engine": "claude" }, "metaModel": { "id": "THING-Q16501", "registryId": "vr.tr.hypothyroidism", "name": "hypothyroidism", "version": "0.2.0-wave.2", "entryKind": "thing", "family": "Thing Registry", "domain": [ "XCT.STA" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q16501/", "model": { "registry_id": "vr.tr.hypothyroidism", "name": "hypothyroidism", "purpose": "Let an agent explain hypothyroidism and its causes and forms in general terms, relay diagnosis and treatment information from health bodies, describe iodine and public health aspects, and route personal medical questions to clinicians.", "definition": "A condition in which the thyroid gland produces insufficient thyroid hormone, causing slowed metabolism with symptoms such as fatigue, weight gain, cold intolerance and, when severe, myxedema, arising from autoimmune thyroiditis, iodine deficiency, surgery, radiation, medications or congenital and pituitary causes, and occurring in forms such as maternal and postsurgical hypothyroidism; it is diagnosed by blood tests and treated with hormone replacement under clinical guidelines.", "what_it_is_for": "Underactive thyroid.", "affordances": [ "explain causes and forms", "relay diagnosis and treatment information", "describe public health aspects", "route personal questions" ], "distinguishing_features": [ "Low thyroid hormone", "Slowed metabolism", "Blood test diagnosis", "Hormone replacement" ], "appearance": "Not visible except by signs such as goitre or myxedema.", "visual_identification": [ "Insufficient thyroid hormone", "Autoimmune, iodine deficiency, surgical, congenital", "Hyperthyroidism is excess hormone; goitre is enlargement of the gland" ], "physical_properties": [], "families_and_kinds": [ "autoimmune hypothyroidism", "iodine deficiency hypothyroidism", "postsurgical and post-radiation hypothyroidism", "congenital hypothyroidism", "central and rare forms" ], "related_models": [ { "relation": "is a kind of", "target": "thyroid gland disease", "why": "category" }, { "relation": "is related to", "target": "iodine", "why": "a nutrient essential for thyroid hormone" }, { "relation": "is related to", "target": "infertility", "why": "a possible consequence of untreated disease" }, { "relation": "is related to", "target": "stress", "why": "symptoms sometimes confused with stress" } ], "identifiers": [], "standards_and_regulation": [ "Clinical guidelines for thyroid disease", "Newborn screening programmes", "Iodine fortification policies" ], "failure_modes_and_hazards": [ "Agents giving personal diagnosis or dosing advice", "Untreated congenital hypothyroidism", "Unproven thyroid supplements" ], "in_scope": [], "out_of_scope": [], "characteristics": [] }, "sources": [], "structure": { "bundles": [ { "id": "understand", "name": "Understand", "description": "What hypothyroidism is.", "rationale": "General information.", "layers": [ { "id": "concept", "name": "Concept", "description": "Concept and causes.", "findings": [ { "id": "concept-finding", "name": "Concept", "description": "Concept.", "questions": [ { "text": "What is hypothyroidism, and what are its main causes and forms?", "kind": "definition" }, { "text": "Is the user asking about their own symptoms or results, which need a clinician?", "kind": "boundary" } ] } ] }, { "id": "symptoms", "name": "Symptoms", "description": "Symptoms.", "findings": [ { "id": "symptoms-finding", "name": "Symptoms", "description": "Symptoms.", "questions": [ { "text": "What symptoms and signs do health bodies describe, including myxedema in severe cases?", "kind": "provenance" }, { "text": "Is urgent care needed, for example with severe symptoms?", "kind": "boundary" } ] } ] } ] }, { "id": "manage", "name": "Manage", "description": "Diagnosis and treatment.", "rationale": "Guidance.", "layers": [ { "id": "diagnosis", "name": "Diagnosis", "description": "Diagnosis.", "findings": [ { "id": "diagnosis-finding", "name": "Diagnosis", "description": "Diagnosis.", "questions": [ { "text": "How is hypothyroidism diagnosed with blood tests, in general terms?", "kind": "provenance" }, { "text": "Which entry fits thyroid function tests?", "kind": "action" } ] } ] }, { "id": "treatment", "name": "Treatment", "description": "Treatment.", "findings": [ { "id": "treatment-finding", "name": "Treatment", "description": "Treatment.", "questions": [ { "text": "How is hypothyroidism treated with hormone replacement, and what monitoring do guidelines describe?", "kind": "provenance" }, { "text": "Is the presentation free of dosing advice?", "kind": "boundary" } ] } ] } ] }, { "id": "public", "name": "Public", "description": "Public health.", "rationale": "Policy.", "layers": [ { "id": "iodine", "name": "Iodine", "description": "Iodine and prevention.", "findings": [ { "id": "iodine-finding", "name": "Iodine", "description": "Iodine.", "questions": [ { "text": "How does iodine deficiency cause hypothyroidism, and how do fortification programmes address it?", "kind": "provenance" }, { "text": "Which entry fits iodine?", "kind": "action" } ] } ] }, { "id": "screening", "name": "Screening", "description": "Screening.", "findings": [ { "id": "screening-finding", "name": "Screening", "description": "Screening.", "questions": [ { "text": "How do newborn screening and pregnancy care address hypothyroidism?", "kind": "provenance" }, { "text": "Which entry fits newborn screening?", "kind": "action" } ] } ] } ] }, { "id": "learn", "name": "Learn", "description": "Research and teaching.", "rationale": "Education.", "layers": [ { "id": "research", "name": "Research", "description": "Research.", "findings": [ { "id": "research-finding", "name": "Research", "description": "Research.", "questions": [ { "text": "What research questions remain in hypothyroidism, with findings attributed?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "teach", "name": "Teach", "description": "Teaching.", "findings": [ { "id": "teach-finding", "name": "Teach", "description": "Teaching.", "questions": [ { "text": "How can thyroid disease be taught in health education?", "kind": "action" }, { "text": "Which misconceptions arise?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Should congenital hypothyroidism be a separate entry?", "How should guidelines be linked?", "How should screening programmes be linked?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "abstract concept", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a hypothyroidism, record what state it is in, and decide what may be done with it.", "whatItIs": "Let an agent explain hypothyroidism and its causes and forms in general terms, relay diagnosis and treatment information from health bodies, describe iodine and public health aspects, and route personal medical questions to clinicians.", "characteristics": { "substance": "abstract", "origin": "conceptual", "agency": "inert" }, "whatYouCanDoWithIt": [ "observed and measured" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: maternal hypothyroidism, myxedema, Van Wyk and Grumbach syndrome, selective pituitary resistance to thyroid hormone, Sign of Hertoghe, postsurgical hypothyroidism, iodine hypothyroidism, Myxedema coma, rare adult hypothyroidism, peripheral resistance to thyroid hormones, thyroid dysgenesis, athyreosis.", "15 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 66 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a hypothyroidism, and on what evidence are they told apart?" ], "whatItIsMadeOf": "an abstraction with no physical instance", "physicalCharacter": [ "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state" ], "howItIsRecognised": [ "Nothing to see. What is recognised is an instance of it, and which instances count is exactly what is argued about." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "maternal hypothyroidism", "myxedema", "Van Wyk and Grumbach syndrome", "selective pituitary resistance to thyroid hormone", "Sign of Hertoghe", "postsurgical hypothyroidism", "iodine hypothyroidism", "Myxedema coma", "rare adult hypothyroidism", "peripheral resistance to thyroid hormones", "thyroid dysgenesis", "athyreosis" ] } ], "standing": "Described in 66 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 15 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one hypothyroidism from another, and a hypothyroidism from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a hypothyroidism, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a hypothyroidism, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a hypothyroidism is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a hypothyroidism, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a hypothyroidism, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a hypothyroidism is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a hypothyroidism sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a hypothyroidism, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a hypothyroidism, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a hypothyroidism is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a hypothyroidism from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a hypothyroidism, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a hypothyroidism, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a hypothyroidism is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a hypothyroidism passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a hypothyroidism between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a hypothyroidism, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a hypothyroidism, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a hypothyroidism is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a hypothyroidism, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a hypothyroidism is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a hypothyroidism, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a hypothyroidism, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a hypothyroidism is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "definitions-in-contest", "name": "Definitions and who holds them", "description": "What hypothyroidism is taken to mean, and by whom.", "rationale": "When a field disagrees about a concept, the disagreement is the content. A model that picks one definition silently destroys the information.", "layers": [ { "id": "competing-definitions", "name": "Competing definitions", "description": "The main readings and the traditions behind them.", "findings": [ { "id": "definition-map", "name": "Definitions and their holders", "description": "Each definition with the school or body that holds it.", "questions": [ { "id": "definition-map-q01", "text": "Which definitions of hypothyroidism are in use, and which tradition or body holds each?", "kind": "definition" }, { "id": "definition-map-q02", "text": "What turns on the difference between them in practice?", "kind": "boundary" } ] } ] }, { "id": "operationalisation", "name": "Operationalisation", "description": "How it is measured or applied when it has to be.", "findings": [ { "id": "operational-record", "name": "Measures and proxies", "description": "Instruments and indicators used to stand in for it.", "questions": [ { "id": "operational-record-q01", "text": "How is hypothyroidism operationalised or measured in practice, and by what instrument?", "kind": "measurement" }, { "id": "operational-record-q02", "text": "What does that operationalisation leave out, and when does that matter?", "kind": "boundary" } ] } ] } ] }, { "id": "instances-and-use", "name": "Instances, use and consequence", "description": "What counts as an instance of hypothyroidism and what follows from calling something that.", "rationale": "Applying a concept is an act with consequences, so a model must say what the label licenses and what it does not.", "layers": [ { "id": "instances", "name": "What counts as an instance", "description": "Clear cases, borderline cases and non-cases.", "findings": [ { "id": "instance-tests", "name": "Tests for an instance", "description": "What would settle whether something falls under it.", "questions": [ { "id": "instance-tests-q01", "text": "What would settle whether something is an instance of hypothyroidism?", "kind": "boundary" }, { "id": "instance-tests-q02", "text": "Which borderline cases are argued about, and on what grounds?", "kind": "definition" } ] } ] }, { "id": "consequence", "name": "Consequence of application", "description": "Rights, duties or decisions that follow from the label.", "findings": [ { "id": "consequence-record", "name": "What the label licenses", "description": "What an agent may do once something is classified this way.", "questions": [ { "id": "consequence-record-q01", "text": "What follows practically once something is treated as hypothyroidism?", "kind": "action" }, { "id": "consequence-record-q02", "text": "What must an agent not infer from the label alone?", "kind": "action" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a hypothyroidism came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a hypothyroidism and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a hypothyroidism, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a hypothyroidism, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a hypothyroidism is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a hypothyroidism is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a hypothyroidism, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a hypothyroidism, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a hypothyroidism is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 5, "layers": 10, "findings": 12, "questions": 32 } } } }