{ "model": { "rank": 4932, "code": "thing-q170617", "model_id": "vr.tr.glucagon", "name": "glucagon", "purpose": "Enable an agent to recognise glucagon, assess its molecular and functional state, and determine whether a particular material is suitable for a specified biological, analytical or pharmaceutical use.", "family": "Thing Registry", "category": "Physical world and living systems", "status": "research-draft", "kind": "thing", "plane": "PHY", "domain": "PHY.MAT", "industry": "", "version": "", "url": "/models/thing/q170617/", "tier": 2, "score": 71, "payload": { "layer": "wikidata", "aliases": [], "aliasCount": 0, "merged": 0, "knownIn": 71, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q170617", "url": "https://www.wikidata.org/wiki/Q170617", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-09T21:18:13Z", "providers": [ "Codex" ], "breadth": "recalled by Codex without web access - no source was read", "missingProviders": [], "pass": 2, "cost": { "grok": { "seconds": 21.5, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a08808-2d8a-70d2-ad32-c2a6c3bf224b\n--------\nuser\nDescribe what is already known about one registered thing. Answer as JSON only, no prose around it.\n\nThing: glucagon\nSense to describe: (none recorded)\nDomain code: PHY.MAT\nAlso known as: (none)\n\n\nContext for this batch of 1001 things:\n# Batch 005: 1001 regist", "usd": 0, "recall": true }, "codex": { "seconds": 61.5, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a08808-2d93-7033-a3d6-b169602bbbae\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: glucagon\nRegistry id: vr.tr.glucagon\nPlane / domain: PHY / PHY.MAT\nRegistry definition: (none recorded)\nNames folded into this entry: (none)\n\n\nContex" } } }, "metaModel": { "id": "THING-Q170617", "registryId": "vr.tr.glucagon", "name": "glucagon", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.MAT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q170617/", "model": { "registry_id": "vr.tr.glucagon", "name": "glucagon", "purpose": "Enable an agent to recognise glucagon, assess its molecular and functional state, and determine whether a particular material is suitable for a specified biological, analytical or pharmaceutical use.", "definition": "Glucagon is a 29-amino-acid peptide hormone produced principally by pancreatic alpha cells through processing of proglucagon, which raises blood glucose chiefly by stimulating hepatic glycogen breakdown and gluconeogenesis.", "scope_statement": "This model owns glucagon as a peptide substance, including mature molecular identity, endogenous origin, preparation-specific composition, biological activity and handling constraints; it distinguishes the molecule from its precursor, related peptides, analogues and finished medicinal products.", "in_scope": [ "Mature glucagon sequence, molecular form and substance identifiers", "Relationship to proglucagon, biological source and production route", "Preparation-specific content, purity, impurities and aggregation", "Glucagon-receptor activity and the conditions under which it is measured", "Storage, handling, stability and material-grade restrictions" ], "out_of_scope": [ "Whole-body glucose regulation and pancreatic physiology", "Proglucagon and other precursor-derived peptides as independent substances", "Glucagon analogues and multi-receptor agonists as independent substances", "Finished medicines, delivery devices and their product authorisations", "Patient diagnosis, prescribing, dosing and emergency treatment protocols", "Manufacturing facilities and production processes as operational systems" ], "distinguishing_features": [ "Confirm the mature glucagon sequence and termini; identifying a proglucagon-derived peptide alone does not establish glucagon identity.", "Distinguish glucagon from GLP-1 and GLP-2 by sequence and processing identity, despite their shared precursor relationship.", "Distinguish native-sequence glucagon from modified analogues by substitutions, conjugation and terminal modifications; receptor activity alone is insufficient.", "Distinguish glucagon content from the total mass of a salt-containing, hydrated or formulated preparation.", "Distinguish intact, functionally active glucagon from fragments or aggregates that may still produce a glucagon-related analytical signal." ], "characteristics": [ { "name": "Mature peptide identity", "kind": "category", "unit_or_values": "Amino-acid sequence, residue count, termini and reference accession", "why_it_matters": "Establishes whether the substance is glucagon rather than a precursor fragment, related peptide or analogue." }, { "name": "Molecular form", "kind": "category", "unit_or_values": "Unmodified or modified peptide; counterion, hydration and solvation state", "why_it_matters": "Controls identity boundaries and the interpretation of weighed material." }, { "name": "Substance identifiers", "kind": "relation", "unit_or_values": "Verified CAS, PubChem, EC or other identifiers with the exact form each identifies", "why_it_matters": "Supports record matching without treating identifiers for different forms or products as interchangeable." }, { "name": "Biological and production origin", "kind": "relation", "unit_or_values": "Species and precursor reference; endogenous isolation, recombinant production or chemical synthesis", "why_it_matters": "Connects the material to its sequence reference and likely impurity profile." }, { "name": "Glucagon content", "kind": "measurement", "unit_or_values": "mg per container, mg/mL or mol/L, with assay and mass basis", "why_it_matters": "Separates actual peptide quantity from gross preparation mass." }, { "name": "Purity and impurity profile", "kind": "measurement", "unit_or_values": "Method-specific purity percentage; identified and unidentified impurity levels", "why_it_matters": "Shows whether fragments, related peptides or process residues constrain the proposed use." }, { "name": "Physical and aggregation state", "kind": "state", "unit_or_values": "Dry or dissolved; soluble monomer, oligomer, fibril or precipitate, with method and conditions", "why_it_matters": "Helps distinguish an apparently intact preparation from material with altered availability or performance." }, { "name": "Receptor-mediated potency", "kind": "measurement", "unit_or_values": "Assay-specific concentration-response parameters or relative potency against a named reference", "why_it_matters": "Tests functional activity independently of chemical identity or immunoreactivity." }, { "name": "Stability conditions", "kind": "measurement", "unit_or_values": "Temperature in °C, pH, concentration, elapsed time and handling history", "why_it_matters": "Makes stability assessments specific to the actual preparation and its exposure history." }, { "name": "Material qualification", "kind": "state", "unit_or_values": "Research material, analytical reference or pharmaceutical substance; documented acceptance status", "why_it_matters": "Determines which uses the available quality evidence supports." } ], "affordances": [ "Match a substance record or sample to a defined glucagon sequence and molecular form.", "Compare glucagon preparations on a consistent peptide-content and purity basis.", "Assess whether chemical identity, aggregation and potency evidence support a proposed experiment.", "Select handling and storage conditions supported for the specific preparation.", "Trace unexpected assay behaviour to cross-reactivity, degradation, aggregation or composition differences.", "Accept, quarantine or reject material against documented use-specific criteria." ] }, "sources": [], "structure": { "bundles": [ { "id": "mature-peptide-identity", "name": "Mature peptide identity", "description": "Defines the glucagon molecule represented by the entry and separates it from neighbouring peptide identities.", "rationale": "A glucagon label or positive assay signal does not by itself establish the mature molecular species.", "layers": [ { "id": "sequence-and-form", "name": "Sequence and form", "description": "Establishes the reference sequence and the chemical form of the represented material.", "findings": [ { "id": "sequence-identity", "name": "Sequence identity", "description": "Record sequence, termini and modifications against an identified reference before accepting a material as glucagon.", "questions": [ { "text": "Which mature glucagon sequence, species reference and terminal structures define this material?", "kind": "definition", "id": "sequence-identity-q01" }, { "text": "What analytical evidence confirms that sequence and excludes substitutions, truncations or conjugation?", "kind": "measurement", "id": "sequence-identity-q02" } ] } ] }, { "id": "identifiers-and-neighbours", "name": "Identifiers and neighbours", "description": "Maps identifiers to exact substance forms while keeping precursors and analogues distinct.", "findings": [ { "id": "identity-boundaries", "name": "Identity boundaries", "description": "Treat identifiers as form-specific evidence and explicitly distinguish glucagon from proglucagon, related peptides and finished products.", "questions": [ { "text": "Which verified identifiers refer to this peptide form rather than a salt, formulation or branded medicine?", "kind": "provenance", "id": "identity-boundaries-q01" }, { "text": "Does the represented entity remain glucagon, or does its sequence or modification require a separate analogue model?", "kind": "boundary", "id": "identity-boundaries-q02" } ] } ] } ] }, { "id": "origin-and-preparation-composition", "name": "Origin and preparation composition", "description": "Connects glucagon to its precursor or production source and establishes what a preparation contains.", "rationale": "Identical peptide names can conceal different origins, content bases and impurity profiles.", "layers": [ { "id": "precursor-and-production-origin", "name": "Precursor and production origin", "description": "Records biological processing context or the route used to obtain the peptide.", "findings": [ { "id": "origin-traceability", "name": "Origin traceability", "description": "Link the mature peptide to a documented biological source or production route without treating that route as its identity.", "questions": [ { "text": "For endogenous material, which species, tissue and precursor-processing evidence establish mature glucagon?", "kind": "provenance", "id": "origin-traceability-q01" }, { "text": "For manufactured material, what production route and batch documentation support the declared peptide identity?", "kind": "provenance", "id": "origin-traceability-q02" } ] } ] }, { "id": "content-and-related-substances", "name": "Content and related substances", "description": "Separates glucagon quantity from counterions, water, additives and peptide impurities.", "findings": [ { "id": "composition-basis", "name": "Composition basis", "description": "Report peptide content and impurity measurements with their analytical methods and calculation bases.", "questions": [ { "text": "Is the stated amount based on glucagon peptide, gross powder mass or a formulated preparation, and how were water and counterions accounted for?", "kind": "measurement", "id": "composition-basis-q01" }, { "text": "Which related peptides, degradation products and process residues were measured, and which remain unresolved?", "kind": "measurement", "id": "composition-basis-q02" } ] } ] } ] }, { "id": "physical-state-and-stability", "name": "Physical state and stability", "description": "Tracks whether glucagon remains dissolved, chemically intact and suitably dispersed under actual handling conditions.", "rationale": "A preparation's usable state cannot be inferred from its initial identity or nominal concentration.", "layers": [ { "id": "solution-and-aggregation", "name": "Solution and aggregation", "description": "Characterises dissolution, aggregation and precipitation in a specified medium.", "findings": [ { "id": "available-peptide-state", "name": "Available peptide state", "description": "Assess soluble peptide and aggregation using methods capable of detecting changes beyond visible precipitation.", "questions": [ { "text": "At what pH, concentration, temperature and solvent composition was glucagon dissolved and characterised?", "kind": "measurement", "id": "available-peptide-state-q01" }, { "text": "What evidence distinguishes soluble monomer from oligomers, fibrils or precipitated material in this preparation?", "kind": "measurement", "id": "available-peptide-state-q02" } ] } ] }, { "id": "handling-history-and-integrity", "name": "Handling history and integrity", "description": "Relates chemical integrity and recovery to storage, reconstitution and subsequent exposure.", "findings": [ { "id": "preparation-specific-stability", "name": "Preparation-specific stability", "description": "Apply stability evidence only to the molecular form, medium, container and handling conditions it covers.", "questions": [ { "text": "What storage, reconstitution, agitation, freeze-thaw and container-contact history has this material experienced?", "kind": "provenance", "id": "preparation-specific-stability-q01" }, { "text": "Which measured changes in intact peptide, recovery or aggregation determine whether it can still be used?", "kind": "action", "id": "preparation-specific-stability-q02" } ] } ] } ] }, { "id": "biological-activity-and-detection", "name": "Biological activity and detection", "description": "Distinguishes receptor-mediated function from analytical detection of glucagon-related material.", "rationale": "Chemical content, immunoreactivity and biological potency answer different questions about a glucagon sample.", "layers": [ { "id": "receptor-mediated-function", "name": "Receptor-mediated function", "description": "Measures glucagon activity in a defined receptor and assay context.", "findings": [ { "id": "functional-potency", "name": "Functional potency", "description": "Attach potency claims to a receptor system, response endpoint and reference preparation.", "questions": [ { "text": "Which receptor species, assay system and response endpoint were used to measure glucagon activity?", "kind": "measurement", "id": "functional-potency-q01" }, { "text": "How does the concentration-response relationship compare with a qualified glucagon reference under the same conditions?", "kind": "measurement", "id": "functional-potency-q02" } ] } ] }, { "id": "analytical-specificity", "name": "Analytical specificity", "description": "Establishes what a reported glucagon signal actually measures.", "findings": [ { "id": "signal-interpretation", "name": "Signal interpretation", "description": "Interpret glucagon measurements in light of assay selectivity, sample matrix and preanalytical handling.", "questions": [ { "text": "Can this method distinguish mature glucagon from precursor-derived peptides, fragments and modified forms?", "kind": "boundary", "id": "signal-interpretation-q01" }, { "text": "What matrix effects, sample handling losses or cross-reactivity could change the reported glucagon concentration?", "kind": "measurement", "id": "signal-interpretation-q02" } ] } ] } ] }, { "id": "material-qualification-and-use", "name": "Material qualification and use", "description": "Connects the evidence about a glucagon preparation to permissible material-level actions.", "rationale": "Recognising glucagon does not establish that a particular batch meets the requirements of its intended use.", "layers": [ { "id": "grade-and-acceptance", "name": "Grade and acceptance", "description": "Defines use-specific qualification without inheriting the status of a finished medicine.", "findings": [ { "id": "fitness-for-intended-use", "name": "Fitness for intended use", "description": "Assess material against documented requirements for reference, research or pharmaceutical-substance use.", "questions": [ { "text": "What intended use and material grade are claimed, and which certificates or specifications support them?", "kind": "provenance", "id": "fitness-for-intended-use-q01" }, { "text": "Which identity, content, impurity, potency and relevant microbiological criteria must pass before this batch is accepted?", "kind": "action", "id": "fitness-for-intended-use-q02" } ] } ] }, { "id": "handling-and-product-boundary", "name": "Handling and product boundary", "description": "Records applicable substance handling evidence and separates material decisions from clinical product decisions.", "findings": [ { "id": "supported-actions", "name": "Supported actions", "description": "Ground laboratory handling in the specific preparation's documentation and route clinical decisions to the relevant product and care models.", "questions": [ { "text": "Which current safety documentation and jurisdiction-specific classifications apply to this exact glucagon preparation?", "kind": "provenance", "id": "supported-actions-q01" }, { "text": "Which proposed actions are supported by material qualification, and which require a finished-product authorisation or clinical protocol?", "kind": "boundary", "id": "supported-actions-q02" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-confidence-notes", "name": "Check these first", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "This account uses recalled knowledge, without consulted sources; confirm identifiers and current compendial requirements before publication.", "Production categories do not necessarily differ in peptide sequence; purity, impurities, potency and formulation distinguish particular preparations.", "Product-specific labeling should establish contraindications and storage requirements; no universal GHS classification, melting point or boiling point is asserted here." ], "questions": [ { "id": "evidence-confidence-notes-q01", "text": "Which of these check these first hold for the sense of glucagon this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-kinds", "name": "Kinds and varieties", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Endogenous glucagon", "Recombinant human glucagon", "Chemically synthesized glucagon" ], "questions": [ { "id": "evidence-kinds-q01", "text": "Which of these kinds and varieties hold for the sense of glucagon this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-identifiers", "name": "Identifiers and schemes", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "scheme": "CAS Registry Number", "value_or_pattern": "16941-32-5", "note": "Identifies glucagon; formulations, salts and peptide analogues require separate identity checks." }, { "scheme": "International Nonproprietary Names (WHO)", "value_or_pattern": "glucagon", "note": "Names the medicinal active substance rather than a particular finished product." } ], "questions": [ { "id": "evidence-identifiers-q01", "text": "Which of these identifiers and schemes hold for the sense of glucagon this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-standards-and-regulation", "name": "Standards and regulation", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "United States Pharmacopeia-National Formulary (USP-NF), issued by the United States Pharmacopeial Convention, includes compendial requirements for glucagon.", "US Food and Drug Administration approval and prescribing information govern individual glucagon medicinal products in the United States." ], "questions": [ { "id": "evidence-standards-and-regulation-q01", "text": "Which of these standards and regulation hold for the sense of glucagon this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Endogenous regulation of blood glucose during fasting and hypoglycemia.", "Medicinal treatment of severe hypoglycemia.", "Temporary inhibition of gastrointestinal motility during selected diagnostic procedures.", "Research on pancreatic endocrine function, hepatic metabolism and glucagon-receptor signaling." ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of glucagon this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-measurements", "name": "Typical measurements", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "quantity": "Length of the mature human peptide", "typical_range": "29", "unit": "amino-acid residues" }, { "quantity": "Average molecular mass of unmodified human glucagon", "typical_range": "Approximately 3482.8", "unit": "Da" } ], "questions": [ { "id": "evidence-measurements-q01", "text": "Which of these typical measurements hold for the sense of glucagon this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Medicinal administration can cause nausea and vomiting.", "The glucose-raising response can be reduced when hepatic glycogen stores are depleted.", "Glucagon can aggregate or form fibrils in solution; stability depends on formulation, temperature, pH and storage time.", "Hypersensitivity reactions can occur with medicinal products.", "Medicinal glucagon has contraindications involving pheochromocytoma and insulinoma because of potentially dangerous physiological responses." ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of glucagon this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-regional-variation", "name": "Regional variation", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Approved indications, routes of administration, formulations and availability differ between jurisdictions." ], "questions": [ { "id": "evidence-regional-variation-q01", "text": "Which of these regional variation hold for the sense of glucagon this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "name": "Proglucagon", "difference": "Proglucagon is the larger precursor polypeptide; glucagon is one of its tissue-dependent processing products." }, { "name": "Glucagon-like peptide-1", "difference": "GLP-1 is a distinct proglucagon-derived peptide acting through a different receptor and promoting glucose-dependent insulin secretion." }, { "name": "Insulin", "difference": "Insulin is a distinct pancreatic beta-cell hormone that generally lowers blood glucose, whereas glucagon promotes hepatic glucose output." }, { "name": "Glucagon receptor", "difference": "The receptor is the membrane signaling protein activated by glucagon; glucagon is its peptide ligand." }, { "name": "Dasiglucagon", "difference": "Dasiglucagon is a sequence-modified glucagon analogue, rather than the native human peptide." }, { "name": "Glucagon medicinal product", "difference": "A finished medicine contains glucagon together with a specified formulation and delivery system; the registered substance is the peptide itself." } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of glucagon this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Does this registry entry cover glucagon across species or specifically the human mature sequence, and which reference establishes that boundary?", "Which authoritative identifiers distinguish the peptide from salt forms, hydrated materials and medicinal preparations?", "Which stability and aggregation limits are supported for the relevant concentrations, solvents, containers and handling conditions?", "Which analytical methods adequately separate mature glucagon from related precursor products in the intended sample matrices?", "Which current material specifications, hazard classifications and jurisdiction-specific requirements apply to each intended grade and use?" ], "statistics": { "bundles": 6, "layers": 11, "findings": 19, "questions": 29 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "chemical substance or material", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a glucagon, record what state it is in, and decide what may be done with it.", "whatItIs": "Enable an agent to recognise glucagon, assess its molecular and functional state, and determine whether a particular material is suitable for a specified biological, analytical or pharmaceutical use.", "characteristics": { "substance": "material", "origin": "natural", "agency": "inert", "mobility": "varies" }, "whatYouCanDoWithIt": [ "observed and measured", "consumed or used up" ], "distinguishingFeatures": [ "Described in 71 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a glucagon, and on what evidence are they told apart?" ], "whatItIsMadeOf": "matter you can touch", "physicalCharacter": [ "Mobility varies between examples.", "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state", "use it up, and then need more of it" ], "howItIsRecognised": [ "Not recognisable by sight in any reliable way. Appearance varies with grade, form and additives; identification is by label, by documentation, or by assay." ], "relatedModels": [], "standing": "Described in 71 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one glucagon from another, and a glucagon from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a glucagon, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a glucagon, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a glucagon is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a glucagon, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a glucagon, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a glucagon is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a glucagon sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a glucagon, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a glucagon, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a glucagon is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a glucagon from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a glucagon, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a glucagon, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a glucagon is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "form-and-composition", "name": "Form, composition and condition", "description": "What a glucagon is made of, what shape and size it takes, and what state it is in.", "rationale": "A physical thing can be measured, and a model that cannot record its measurements cannot support any decision that depends on them.", "layers": [ { "id": "form-and-dimensions", "name": "Form and dimensions", "description": "Shape, size, mass and the ranges these take across examples.", "findings": [ { "id": "measurable-dimensions", "name": "Measurable dimensions and their units", "description": "The quantities worth recording and the units they are recorded in.", "questions": [ { "id": "measurable-dimensions-q01", "text": "What identifies and describes the dimensions of a glucagon, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "measurable-dimensions-q02", "text": "Who or what asserted this about the dimensions of a glucagon, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "measurable-dimensions-q03", "text": "What may an agent decide or do once the dimensions of a glucagon is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "material-and-composition", "name": "Material and composition", "description": "Materials, parts and how they are put together.", "findings": [ { "id": "parts-and-materials", "name": "Parts and materials", "description": "What a glucagon is built from and which parts are replaceable.", "questions": [ { "id": "parts-and-materials-q01", "text": "What identifies and describes the composition of a glucagon, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "parts-and-materials-q02", "text": "Who or what asserted this about the composition of a glucagon, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "parts-and-materials-q03", "text": "What may an agent decide or do once the composition of a glucagon is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "condition-and-integrity", "name": "Condition and integrity", "description": "Wear, damage, health and the difference between working and broken.", "findings": [ { "id": "condition-assessment", "name": "Condition, damage and health", "description": "How the condition of a glucagon is judged and by whom.", "questions": [ { "id": "condition-assessment-q01", "text": "What identifies and describes the condition of a glucagon, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "condition-assessment-q02", "text": "Who or what asserted this about the condition of a glucagon, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "condition-assessment-q03", "text": "What may an agent decide or do once the condition of a glucagon is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "place-and-movement", "name": "Place and movement", "description": "Where a glucagon is, how it got there and where it may go (varies).", "rationale": "A thing that can move needs its position recorded with a time, or every later claim about it is about a place it has left.", "layers": [ { "id": "location-and-placement", "name": "Location and placement", "description": "Position, containment and the reference frame the position is given in.", "findings": [ { "id": "position-and-frame", "name": "Position, container and reference frame", "description": "Where a glucagon is, and what that position is measured against.", "questions": [ { "id": "position-and-frame-q01", "text": "What identifies and describes the location of a glucagon, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "position-and-frame-q02", "text": "Who or what asserted this about the location of a glucagon, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "position-and-frame-q03", "text": "What may an agent decide or do once the location of a glucagon is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "movement-and-transfer", "name": "Movement and transfer", "description": "How a glucagon is carried, installed or relocated.", "findings": [ { "id": "movement-events", "name": "Movement events and constraints", "description": "What counts as a movement, what records it and what limits it.", "questions": [ { "id": "movement-events-q01", "text": "What identifies and describes the movement of a glucagon, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "movement-events-q02", "text": "Who or what asserted this about the movement of a glucagon, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "movement-events-q03", "text": "What may an agent decide or do once the movement of a glucagon is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a glucagon passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a glucagon between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a glucagon, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a glucagon, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a glucagon is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a glucagon, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a glucagon is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a glucagon, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a glucagon, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a glucagon is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "use-and-operation", "name": "Use and operation", "description": "What can be done with a glucagon and what it takes to do it.", "rationale": "An agent that can recognise a thing but not act on it has only half a model.", "layers": [ { "id": "intended-use", "name": "Intended use and function", "description": "What a glucagon is for, and what it is used for anyway.", "findings": [ { "id": "function-and-purpose", "name": "Function, purpose and misuse", "description": "The function a glucagon performs and the uses that fall outside it.", "questions": [ { "id": "function-and-purpose-q01", "text": "What identifies and describes the use of a glucagon, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "function-and-purpose-q02", "text": "Who or what asserted this about the use of a glucagon, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "function-and-purpose-q03", "text": "What may an agent decide or do once the use of a glucagon is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "handling-and-procedure", "name": "Handling and procedure", "description": "The steps, skills and tools involved in using a glucagon.", "findings": [ { "id": "procedures-and-skills", "name": "Procedures, skills and required tools", "description": "What an agent needs before it can act on a glucagon at all.", "questions": [ { "id": "procedures-and-skills-q01", "text": "What identifies and describes handling a glucagon, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "procedures-and-skills-q02", "text": "Who or what asserted this about handling a glucagon, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "procedures-and-skills-q03", "text": "What may an agent decide or do once handling a glucagon is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "supply-and-consumption", "name": "Supply and consumption", "description": "Quantities, rates and what running out means.", "findings": [ { "id": "consumption-and-stock", "name": "Consumption, stock and replenishment", "description": "How much of a glucagon there is and how fast it goes.", "questions": [ { "id": "consumption-and-stock-q01", "text": "What identifies and describes the supply of a glucagon, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "consumption-and-stock-q02", "text": "Who or what asserted this about the supply of a glucagon, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "consumption-and-stock-q03", "text": "What may an agent decide or do once the supply of a glucagon is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "composition-and-identity", "name": "Composition, grade and chemical identity", "description": "What glucagon is made of and how pure the thing in hand is.", "rationale": "Grade decides what a substance may be used for, so a model that records only the name cannot support any decision about use.", "layers": [ { "id": "chemical-identity", "name": "Chemical identity", "description": "Formula, structure and the registry numbers that name it unambiguously.", "findings": [ { "id": "identity-record", "name": "Identity and registry numbers", "description": "What identifies this substance across suppliers and regulators.", "questions": [ { "id": "identity-record-q01", "text": "What formula, structure and registry identifiers name glucagon unambiguously?", "kind": "definition" }, { "id": "identity-record-q02", "text": "Which related substances share a name in common use but not an identifier?", "kind": "boundary" } ] } ] }, { "id": "grade-and-impurities", "name": "Grade, purity and impurities", "description": "The specification a batch meets and what else is in it.", "findings": [ { "id": "specification", "name": "Specification and assay", "description": "How purity is stated and measured, and which impurities matter.", "questions": [ { "id": "specification-q01", "text": "What grades of glucagon exist, how is purity assayed, and which impurities are limited?", "kind": "measurement" }, { "id": "specification-q02", "text": "Which use requires which grade, and what happens when a lower grade is substituted?", "kind": "action" } ] } ] } ] }, { "id": "properties-and-behaviour", "name": "Properties and behaviour", "description": "How glucagon behaves under conditions an agent can measure or change.", "rationale": "Physical constants are the part of a substance model that transfers between contexts, and each needs its unit and its conditions.", "layers": [ { "id": "physical-constants", "name": "Physical constants", "description": "Values that hold for the pure substance, with their conditions.", "findings": [ { "id": "constants-record", "name": "Constants and conditions", "description": "The quantities worth recording and the state they apply in.", "questions": [ { "id": "constants-record-q01", "text": "What are the defining physical constants of glucagon, in what units and under what conditions?", "kind": "measurement" }, { "id": "constants-record-q02", "text": "Which of these values change with grade or form rather than being fixed?", "kind": "boundary" } ] } ] }, { "id": "stability-and-reactivity", "name": "Stability and reactivity", "description": "What it reacts with, degrades into, and how it is stored.", "findings": [ { "id": "incompatibilities", "name": "Incompatibilities and degradation", "description": "What must not meet it, and what it becomes over time.", "questions": [ { "id": "incompatibilities-q01", "text": "What is glucagon incompatible with, and what does it degrade into under storage?", "kind": "definition" }, { "id": "incompatibilities-q02", "text": "What storage and handling does that require, and who is competent to do it?", "kind": "action" } ] } ] } ] }, { "id": "hazard-and-regulation", "name": "Hazard classification and regulation", "description": "How glucagon can harm, and what the law says about holding and moving it.", "rationale": "A substance model without its hazard class and its regulatory identity is unusable in exactly the situations that matter.", "layers": [ { "id": "hazard-class", "name": "Hazard classification", "description": "Classified hazards, exposure limits and protective measures.", "findings": [ { "id": "classified-hazards", "name": "Classified hazards and limits", "description": "The classification, the scheme it belongs to, and the limits set.", "questions": [ { "id": "classified-hazards-q01", "text": "How is glucagon classified for hazard, under which scheme, and what exposure limits apply?", "kind": "definition" }, { "id": "classified-hazards-q02", "text": "What protection does handling require, and what must an agent refuse to do without it?", "kind": "action" } ] } ] }, { "id": "regulatory-identity", "name": "Regulatory identity and control", "description": "Registration, restriction and transport rules by jurisdiction.", "findings": [ { "id": "controls", "name": "Controls and jurisdiction", "description": "Where it is restricted and what the restriction attaches to.", "questions": [ { "id": "controls-q01", "text": "Which registrations, restrictions or transport rules cover glucagon, and where?", "kind": "provenance" }, { "id": "controls-q02", "text": "Does the control attach to the substance, its concentration, or its intended use?", "kind": "boundary" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a glucagon came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a glucagon and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a glucagon, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a glucagon, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a glucagon is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a glucagon is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a glucagon, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a glucagon, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a glucagon is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 9, "layers": 20, "findings": 22, "questions": 60 } } } }