{ "model": { "rank": 14185, "code": "thing-q1755122", "model_id": "vr.tr.neurodegeneration", "name": "neurodegeneration", "purpose": "Let an agent give accurate general information on neurodegeneration and related conditions, recognise situations needing assessment, explain research and care in general terms, and point to specialist care and support without individual medical advice.", "family": "Thing Registry", "category": "Cross-cutting context", "status": "research-draft", "kind": "thing", "plane": "XCT", "domain": "XCT.STA", "industry": "", "version": "", "url": "/models/thing/q1755122/", "tier": 2, "score": 36, "payload": { "layer": "wikidata", "aliases": [ "nerve plexus neoplasm", "brachial plexus neoplasm", "secondary parkinsonism", "Radiation-induced lumbar plexopathy", "GRN-related frontotemporal lobar degeneration with Tdp43 inclusions", "Upper motor neuron syndrome", "progressive bulbar palsy", "cerebral lipidosis", "hereditary spastic paraplegia 7", "infantile progressive bulbar palsy", "juvenile-onset diabetes mellitus-central and peripheral neurodegeneration syndrome", "autosomal recessive cerebellar ataxia", "demyelinating disease", "olivary degeneration", "cerebral degeneration", "Estrogen and neurodegenerative diseases", "eyelid degenerative disease", "frontotemporal lobar degeneration", "nervous system heredodegenerative disease", "proteopathy", "synucleinopathy", "tauopathy", "Nyssen-van Bogaert syndrome", "agenesis of the corpus callosum with peripheral neuropathy", "motor neuron disease", "trinucleotide repeat disorder", "hereditary ataxia", "Facial Onset Sensory Motor Neuropathy syndrome", "primary progressive apraxia of speech", "spastic pseudosclerosis", "neurodegenerative disease with chorea", "amyotrophic lateral sclerosis-parkinsonism/dementia complex 1", "plexopathy", "olivopontocerebellar atrophy", "Corneal-cerebellar syndrome", "muscular atrophy-ataxia-retinitis pigmentosa-diabetes mellitus syndrome", "tremor-ataxia-central hypomyelination syndrome", "polyradiculoneuropathy", "Multifocal motor neuropathy", "acquired motor neuron disease" ], "aliasCount": 108, "merged": 108, "knownIn": 36, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q1755122", "url": "https://www.wikidata.org/wiki/Q1755122", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-11T20:38:30Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 2, "engine": "claude" }, "metaModel": { "id": "THING-Q1755122", "registryId": "vr.tr.neurodegeneration", "name": "neurodegeneration", "version": "0.2.0-wave.2", "entryKind": "thing", "family": "Thing Registry", "domain": [ "XCT.STA" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q1755122/", "model": { "registry_id": "vr.tr.neurodegeneration", "name": "neurodegeneration", "purpose": "Let an agent give accurate general information on neurodegeneration and related conditions, recognise situations needing assessment, explain research and care in general terms, and point to specialist care and support without individual medical advice.", "definition": "The progressive loss of structure or function of neurons, including their death, underlying conditions such as Alzheimer disease, Parkinson disease, frontotemporal degeneration, motor neuron disease and Huntington disease, as well as secondary forms caused by injury, radiation or toxins; neurodegeneration is studied in neuroscience and managed by neurology with supportive and, increasingly, disease-modifying care.", "what_it_is_for": "A group of conditions requiring neurological care.", "affordances": [ "explain neurodegeneration and major conditions in general terms", "recognise changes needing assessment", "explain care and research with evidence", "find specialist services and support" ], "distinguishing_features": [ "Progressive neuron loss", "Many conditions", "Mostly chronic", "Active research field" ], "appearance": "Not physical; progressive changes in movement, memory or function.", "visual_identification": [ "Progressive neurological decline", "Specific patterns by condition", "Reversible causes of cognitive change are not neurodegeneration" ], "physical_properties": [], "families_and_kinds": [ "dementias such as Alzheimer and frontotemporal degeneration", "movement disorders such as Parkinson disease", "motor neuron diseases", "genetic neurodegenerative diseases", "secondary neurodegeneration from injury or toxins" ], "related_models": [ { "relation": "is a kind of", "target": "degenerative disease", "why": "category" }, { "relation": "is a kind of", "target": "central nervous system disease", "why": "category" }, { "relation": "is studied by", "target": "neuroscience", "why": "field" }, { "relation": "affects", "target": "brain", "why": "organ" } ], "identifiers": [], "standards_and_regulation": [ "Clinical guidelines from neurology societies", "Medicines regulation for disease-modifying therapies", "Care standards for people with dementia" ], "failure_modes_and_hazards": [ "Missing treatable causes of symptoms", "Agents diagnosing", "Unproven treatments" ], "in_scope": [], "out_of_scope": [], "characteristics": [] }, "sources": [], "structure": { "bundles": [ { "id": "assess", "name": "Assess", "description": "Changes to check.", "rationale": "Assessment first.", "layers": [ { "id": "signs", "name": "Signs", "description": "Warning changes.", "findings": [ { "id": "signs-finding", "name": "Signs", "description": "Warning changes.", "questions": [ { "text": "Are there progressive changes in memory, movement, speech or behaviour that warrant assessment?", "kind": "boundary" }, { "text": "Should the person see a doctor for evaluation, including of treatable causes?", "kind": "action" } ] } ] }, { "id": "urgent", "name": "Urgent", "description": "Urgent situations.", "findings": [ { "id": "urgent-finding", "name": "Urgent", "description": "Urgent situations.", "questions": [ { "text": "Are there sudden changes suggesting stroke or another emergency rather than gradual decline?", "kind": "boundary" }, { "text": "Should emergency care be sought?", "kind": "action" } ] } ] } ] }, { "id": "understand", "name": "Understand", "description": "The conditions.", "rationale": "General information.", "layers": [ { "id": "types", "name": "Types", "description": "Conditions and mechanisms.", "findings": [ { "id": "types-finding", "name": "Types", "description": "Conditions.", "questions": [ { "text": "What is known about the mechanisms of this neurodegenerative condition, according to research?", "kind": "provenance" }, { "text": "Is the user asking about their own diagnosis?", "kind": "boundary" } ] } ] }, { "id": "genetics", "name": "Genetics", "description": "Genetic factors.", "findings": [ { "id": "genetics-finding", "name": "Genetics", "description": "Genetics.", "questions": [ { "text": "Which neurodegenerative conditions have genetic causes, and who is eligible for genetic counselling?", "kind": "provenance" }, { "text": "How are risk genes described without overstatement?", "kind": "boundary" } ] } ] } ] }, { "id": "care", "name": "Care", "description": "Treatment and support.", "rationale": "Evidence-based care.", "layers": [ { "id": "treatment", "name": "Treatment", "description": "Care options.", "findings": [ { "id": "treatment-finding", "name": "Treatment", "description": "Care options.", "questions": [ { "text": "Which treatments and supportive care exist for this condition, in general terms, and what is the evidence for new therapies?", "kind": "provenance" }, { "text": "Which questions should be asked of the neurologist?", "kind": "action" } ] } ] }, { "id": "unproven", "name": "Unproven", "description": "Unproven treatments.", "findings": [ { "id": "unproven-finding", "name": "Unproven", "description": "Unproven treatments.", "questions": [ { "text": "Does this offered treatment have regulatory approval and evidence?", "kind": "boundary" }, { "text": "What do regulators warn about?", "kind": "provenance" } ] } ] } ] }, { "id": "support", "name": "Support", "description": "Living with the condition.", "rationale": "Support for all.", "layers": [ { "id": "orgs", "name": "Organisations", "description": "Support organisations.", "findings": [ { "id": "orgs-finding", "name": "Organisations", "description": "Support.", "questions": [ { "text": "Which organisations support people with this condition and their carers here?", "kind": "provenance" }, { "text": "Which services and planning tools exist?", "kind": "provenance" } ] } ] }, { "id": "research", "name": "Research", "description": "Research participation.", "findings": [ { "id": "research-finding", "name": "Research", "description": "Research.", "questions": [ { "text": "Which trials and registries are recruiting, according to registries?", "kind": "provenance" }, { "text": "How can someone discuss participation with their team?", "kind": "action" } ] } ] } ] } ] }, "openQuestions": [ "Should each disease be a separate entry?", "How should guidelines be linked?", "How should support services be localised?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "abstract concept", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a neurodegeneration, record what state it is in, and decide what may be done with it.", "whatItIs": "Let an agent give accurate general information on neurodegeneration and related conditions, recognise situations needing assessment, explain research and care in general terms, and point to specialist care and support without individual medical advice.", "characteristics": { "substance": "abstract", "origin": "conceptual", "agency": "inert" }, "whatYouCanDoWithIt": [ "observed and measured" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: nerve plexus neoplasm, brachial plexus neoplasm, secondary parkinsonism, Radiation-induced lumbar plexopathy, GRN-related frontotemporal lobar degeneration with Tdp43 inclusions, Upper motor neuron syndrome, progressive bulbar palsy, cerebral lipidosis, hereditary spastic paraplegia 7, infantile progressive bulbar palsy, juvenile-onset diabetes mellitus-central and peripheral neurodegeneration syndrome, autosomal recessive cerebellar ataxia.", "108 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 36 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a neurodegeneration, and on what evidence are they told apart?" ], "whatItIsMadeOf": "an abstraction with no physical instance", "physicalCharacter": [ "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state" ], "howItIsRecognised": [ "Nothing to see. What is recognised is an instance of it, and which instances count is exactly what is argued about." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "nerve plexus neoplasm", "brachial plexus neoplasm", "secondary parkinsonism", "Radiation-induced lumbar plexopathy", "GRN-related frontotemporal lobar degeneration with Tdp43 inclusions", "Upper motor neuron syndrome", "progressive bulbar palsy", "cerebral lipidosis", "hereditary spastic paraplegia 7", "infantile progressive bulbar palsy", "juvenile-onset diabetes mellitus-central and peripheral neurodegeneration syndrome", "autosomal recessive cerebellar ataxia" ] } ], "standing": "Described in 36 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 108 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one neurodegeneration from another, and a neurodegeneration from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a neurodegeneration, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a neurodegeneration, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a neurodegeneration is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a neurodegeneration, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a neurodegeneration, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a neurodegeneration is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a neurodegeneration sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a neurodegeneration, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a neurodegeneration, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a neurodegeneration is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a neurodegeneration from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a neurodegeneration, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a neurodegeneration, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a neurodegeneration is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a neurodegeneration passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a neurodegeneration between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a neurodegeneration, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a neurodegeneration, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a neurodegeneration is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a neurodegeneration, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a neurodegeneration is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a neurodegeneration, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a neurodegeneration, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a neurodegeneration is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "definitions-in-contest", "name": "Definitions and who holds them", "description": "What neurodegeneration is taken to mean, and by whom.", "rationale": "When a field disagrees about a concept, the disagreement is the content. A model that picks one definition silently destroys the information.", "layers": [ { "id": "competing-definitions", "name": "Competing definitions", "description": "The main readings and the traditions behind them.", "findings": [ { "id": "definition-map", "name": "Definitions and their holders", "description": "Each definition with the school or body that holds it.", "questions": [ { "id": "definition-map-q01", "text": "Which definitions of neurodegeneration are in use, and which tradition or body holds each?", "kind": "definition" }, { "id": "definition-map-q02", "text": "What turns on the difference between them in practice?", "kind": "boundary" } ] } ] }, { "id": "operationalisation", "name": "Operationalisation", "description": "How it is measured or applied when it has to be.", "findings": [ { "id": "operational-record", "name": "Measures and proxies", "description": "Instruments and indicators used to stand in for it.", "questions": [ { "id": "operational-record-q01", "text": "How is neurodegeneration operationalised or measured in practice, and by what instrument?", "kind": "measurement" }, { "id": "operational-record-q02", "text": "What does that operationalisation leave out, and when does that matter?", "kind": "boundary" } ] } ] } ] }, { "id": "instances-and-use", "name": "Instances, use and consequence", "description": "What counts as an instance of neurodegeneration and what follows from calling something that.", "rationale": "Applying a concept is an act with consequences, so a model must say what the label licenses and what it does not.", "layers": [ { "id": "instances", "name": "What counts as an instance", "description": "Clear cases, borderline cases and non-cases.", "findings": [ { "id": "instance-tests", "name": "Tests for an instance", "description": "What would settle whether something falls under it.", "questions": [ { "id": "instance-tests-q01", "text": "What would settle whether something is an instance of neurodegeneration?", "kind": "boundary" }, { "id": "instance-tests-q02", "text": "Which borderline cases are argued about, and on what grounds?", "kind": "definition" } ] } ] }, { "id": "consequence", "name": "Consequence of application", "description": "Rights, duties or decisions that follow from the label.", "findings": [ { "id": "consequence-record", "name": "What the label licenses", "description": "What an agent may do once something is classified this way.", "questions": [ { "id": "consequence-record-q01", "text": "What follows practically once something is treated as neurodegeneration?", "kind": "action" }, { "id": "consequence-record-q02", "text": "What must an agent not infer from the label alone?", "kind": "action" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a neurodegeneration came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a neurodegeneration and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a neurodegeneration, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a neurodegeneration, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a neurodegeneration is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a neurodegeneration is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a neurodegeneration, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a neurodegeneration, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a neurodegeneration is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 5, "layers": 10, "findings": 12, "questions": 32 } } } }