CASP7

Gene and product boundary

The symbol is anchored provisionally to the gene; protein observations must identify the linked product rather than silently change the entry's meaning.

1. Does the originating registry record identify a gene, a protein or the CASP7 assessment event? boundary
2. Which original identifier or description establishes that interpretation? provenance

Species-qualified anchor

Human CASP7 provides a provisional reference, not evidence that every CASP7-labelled observation concerns humans.

1. Which organism and gene accession does the registry entry intend? definition
2. Are records from another species ortholog relationships or observations of the same intended entity? boundary

Reference-qualified variant

A CASP7 variant record must preserve its reference sequence and distinguish predicted consequences from measured effects.

1. Which assembly or versioned sequence defines the reported CASP7 position? provenance
2. Was the proposed effect on CASP7 expression or protein function predicted or experimentally measured? measurement

Resolved transcript and product

Transcript-level evidence must specify whether the measurement distinguishes individual CASP7 transcripts or aggregates them.

1. Which CASP7 transcript accession and encoded protein sequence are represented? definition
2. Can the primers, reads or other assay features distinguish that transcript from other CASP7 transcripts? measurement

Contextualized abundance

A CASP7 abundance observation needs the biological sample, measured molecular species and normalization method.

1. Which tissue, cell population, condition and time point produced the CASP7 measurement? provenance
2. Does the result measure RNA or protein, and in what units relative to which reference? measurement

Processing evidence

Detection of a processed form must retain the molecular evidence and remain distinct from a direct activity measurement.

1. Which epitope, peptide or fragment identifies the detected caspase-7 form? measurement
2. What additional evidence is needed before treating the processing observation as evidence of catalytic activity? action

CASP7-specific readout

An assay label alone does not establish CASP7 specificity; substrate, controls and alternative contributors must be recorded.

1. Which substrate, conditions and rate calculation define the reported activity? measurement
2. What evidence separates caspase-7 activity from caspase-3 or other contributors to the signal? boundary

Supported functional inference

A functional claim must distinguish verified CASP7 perturbation, associated outcomes and evidence supporting a causal link.

1. How was the intended change to CASP7 verified independently of the downstream outcome? measurement
2. Which rescue experiment or independent perturbation would address alternative explanations? action

Check these first

Recalled without web access and unsourced; every item is a lead to verify.

1. Which of these check these first hold for the sense of CASP7 this model covers, and on what evidence? provenance

Identifiers and schemes

Recalled without web access and unsourced; every item is a lead to verify.

1. Which of these identifiers and schemes hold for the sense of CASP7 this model covers, and on what evidence? provenance

Real-world use

Recalled without web access and unsourced; every item is a lead to verify.

1. Which of these real-world use hold for the sense of CASP7 this model covers, and on what evidence? provenance

Failure modes and hazards

Recalled without web access and unsourced; every item is a lead to verify.

1. Which of these failure modes and hazards hold for the sense of CASP7 this model covers, and on what evidence? provenance

Neighbouring kinds and how to tell them apart

Recalled without web access and unsourced; every item is a lead to verify.

1. Which of these neighbouring kinds and how to tell them apart hold for the sense of CASP7 this model covers, and on what evidence? provenance