cilium
Let an agent explain cilia, relay structure, types, functions and ciliopathies from cell biology sources, describe the forms the registry aliases name, and distinguish cilia from flagella, microvilli and stereocilia, with medical content given generally and routed to clinicians.
Research draft, second pass
A second pass drafted this model: the structure a model of this thing needs, and what is known about it in the world. The line under this one says how the second half was obtained - researched against sources, or recalled without web access, in which case nothing here was read anywhere and every claim is a lead to verify. Unreviewed either way.
written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify
Researched by: Claude
Purpose and description
Let an agent explain cilia, relay structure, types, functions and ciliopathies from cell biology sources, describe the forms the registry aliases name, and distinguish cilia from flagella, microvilli and stereocilia, with medical content given generally and routed to clinicians.
A slender, hair-like projection from the surface of many eukaryotic cells, built on a microtubule axoneme anchored by a basal body, occurring as motile cilia that beat to move fluid or cells, as in airways and oviducts, and non-motile primary cilia that act as sensory antennae in most cell types, with specialised forms such as the kinocilium of hair cells and the connecting cilium of photoreceptor cone and rod cells; stereocilia of the inner ear are actin-based microvilli despite the name. Defects in cilia cause ciliopathies.
What it is for: Not applicable; a cell organelle.
It can be explain structure and types; relay functions and diseases; describe specialised forms; distinguish related structures.
Distinguishing features
Microtubule core
Motile or sensory
Basal body anchored
Disease relevance
What it looks like
Not a visible object; tiny hair-like projections seen by microscopy.
Physical character
motile axoneme: 9+2 microtubule arrangement note
primary cilium axoneme: 9+0 note
diameter: about 0.25 micrometre
How it is recognised
Microtubule-based cell projection
Primary cilium, motile cilium, non-motile cilium, kinocilium, photoreceptor connecting cilium; stereocilia as actin-based
Flagella are longer, often single; microvilli are actin-based; stereocilia are specialised microvilli
Related models
is a kind of - in registry terms
is built on -
is contrasted with -
is defective in -
In practice
Families and kinds
motile cilia
primary cilia
nodal cilia
kinocilia of hair cells
photoreceptor connecting cilia
stereocilia as a distinct actin-based structure
Identifiers
GO GO:0005929 cilium
Standards and regulation
No regulation
Failure modes and hazards
Confusing stereocilia with true cilia
Agents giving personal medical advice about ciliopathies
Registry aliases mixing structures
Also called
Where this came from
wikidata · CC0 1.0
Drafted structure
Bundle to layer to finding to question, as the second pass will find it: 4 bundles · 8 layers · 8 findings · 16 questions.
Understand What a cilium is.
Science.
Definition
Definition.
Definition
Definition.
- What is a cilium, and how does it differ from a flagellum, microvillus and stereocilium? definition
- Is the question about cell biology, a specialised form or a ciliopathy needing a clinician? boundary
Types
Types.
Types
Types.
- What are motile, primary, non-motile, kinocilia and photoreceptor cilia? definition
- Which entry fits the specific type? action
Biology Structure and function.
Science.
Structure
Structure.
Structure
Structure.
- How are axonemes, basal bodies and intraflagellar transport organised? provenance
- Which references are standard? provenance
Function
Function.
Function
Function.
- How do motile cilia move fluid and primary cilia sense signals? provenance
- Which sources are cited? provenance
Medicine Ciliopathies.
Clinical.
Diseases
Ciliopathies.
Diseases
Diseases.
- What are primary ciliary dyskinesia, polycystic kidney disease and other ciliopathies, in general terms? provenance
- Which entry fits ciliopathy? action
Senses
Sensory cilia.
Senses
Senses.
- How do cilia contribute to vision, hearing and smell? provenance
- Which entry fits photoreceptor cell? action
Context Evolution and history.
Context.
Evolution
Evolution.
Evolution
Evolution.
- How did cilia evolve in early eukaryotes? provenance
- Which entry fits eukaryote? action
History
History.
History
History.
- How was the importance of primary cilia recognised in recent decades? provenance
- Which entry fits the history of cell biology? action
What the second pass must settle
- Should primary cilium and motile cilium be separate primary entries?
- How should cell biology sources be linked?
- The registry alias stereocilia is not a true cilium and should be reviewed