{ "model": { "rank": 5650, "code": "thing-q180623", "model_id": "vr.tr.acetylcholine", "name": "acetylcholine", "purpose": "Enable an agent to recognise acetylcholine, assess its identity, integrity and biological context, and judge whether a particular sample is suitable for a specified use.", "family": "Thing Registry", "category": "Physical world and living systems", "status": "research-draft", "kind": "thing", "plane": "PHY", "domain": "PHY.MAT", "industry": "", "version": "", "url": "/models/thing/q180623/", "tier": 2, "score": 65, "payload": { "layer": "wikidata", "aliases": [], "aliasCount": 0, "merged": 0, "knownIn": 65, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q180623", "url": "https://www.wikidata.org/wiki/Q180623", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-09T22:51:20Z", "providers": [ "Codex" ], "breadth": "recalled by Codex without web access - no source was read", "missingProviders": [], "pass": 2, "cost": { "grok": { "seconds": 18.8, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a0885d-3a56-70a2-9fd1-7f0df650bab3\n--------\nuser\nDescribe what is already known about one registered thing. Answer as JSON only, no prose around it.\n\nThing: acetylcholine\nSense to describe: (none recorded)\nDomain code: PHY.MAT\nAlso known as: (none)\n\n\nContext for this batch of 188 things:\n# Batch 006: 1001 re", "usd": 0, "recall": true }, "codex": { "seconds": 74.2, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a0885d-3a65-7841-b3e1-f618dcd42806\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: acetylcholine\nRegistry id: vr.tr.acetylcholine\nPlane / domain: PHY / PHY.MAT\nRegistry definition: (none recorded)\nNames folded into this entry: (none" } } }, "metaModel": { "id": "THING-Q180623", "registryId": "vr.tr.acetylcholine", "name": "acetylcholine", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.MAT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q180623/", "model": { "registry_id": "vr.tr.acetylcholine", "name": "acetylcholine", "purpose": "Enable an agent to recognise acetylcholine, assess its identity, integrity and biological context, and judge whether a particular sample is suitable for a specified use.", "definition": "Acetylcholine is a permanently charged quaternary ammonium ester of choline and acetic acid that acts as a neurotransmitter at neuromuscular junctions, autonomic synapses and central nervous system synapses through nicotinic and muscarinic receptors.", "scope_statement": "This model owns vr.tr.acetylcholine in PHY / PHY.MAT: the acetylcholine chemical entity and the identity, condition, measurement and biological relationships needed to interpret its occurrence in samples, salts and preparations.", "in_scope": [ "Acetylcholine molecular identity and mappings to chemical identifiers", "Counterion, hydration, grade, purity and concentration of acetylcholine-containing material", "Sample conditions, hydrolysis, preservation and analytical validity", "Biological compartment, origin, receptor interactions and turnover relationships", "Evidence supporting handling requirements and suitability for a stated use" ], "out_of_scope": [ "Complete models of acetylcholine chloride or other salt forms as separately registered substances", "Finished medicinal products, formulations and administration protocols", "Full models of cholinergic receptors, enzymes and transport proteins", "Whole neural circuits, organs and cholinergic diseases", "Manufacturing processes and analytical instruments" ], "distinguishing_features": [ "Require the O-acetyl ester of choline with a quaternary ammonium group; choline without that ester is a different entity. Identity reference: [PubChem acetylcholine](https://pubchem.ncbi.nlm.nih.gov/compound/acetylcholine).", "Match the acetylcholine cation to C7H16NO2+, formal charge +1, PubChem CID 187 and CAS 51-84-3; a name match alone is insufficient. Reference: [PubChem acetylcholine](https://pubchem.ncbi.nlm.nih.gov/compound/acetylcholine).", "Distinguish the active cation from its complete salt: acetylcholine chloride has PubChem CID 6060 and includes chloride in its composition. Reference: [PubChem acetylcholine chloride](https://pubchem.ncbi.nlm.nih.gov/compound/6060).", "Require structural or analytical discrimination from related cholinergic compounds; shared receptor activity does not establish acetylcholine identity.", "Separate a measured acetylcholine amount from an inferred cholinergic response; receptor activation alone does not identify or quantify the substance." ], "characteristics": [ { "name": "Chemical identity", "kind": "category", "unit_or_values": "Structure identifier; molecular formula; formal charge; identifier authority and record", "why_it_matters": "Prevents confusion between acetylcholine, choline, related agonists and salt-specific records." }, { "name": "Material form", "kind": "category", "unit_or_values": "Biological occurrence, dissolved salt, isolated salt or formulated preparation; counterion and hydration specified", "why_it_matters": "Determines which mass basis, physical properties and handling evidence apply." }, { "name": "Molar mass basis", "kind": "measurement", "unit_or_values": "g/mol, explicitly assigned to the cation or complete salt including hydration", "why_it_matters": "Avoids concentration errors when converting weighed salt into acetylcholine amount." }, { "name": "Acetylcholine content", "kind": "measurement", "unit_or_values": "mol/L, mol/sample or mass fraction; analyte basis, uncertainty and sampling time", "why_it_matters": "Makes sample comparisons and preparation calculations interpretable." }, { "name": "Purity and grade", "kind": "category", "unit_or_values": "Declared grade, assay basis, impurity profile and certificate reference", "why_it_matters": "A grade label alone cannot establish suitability for an assay or regulated use." }, { "name": "Sample environment", "kind": "state", "unit_or_values": "Matrix, solvent, pH, temperature in °C, phase and elapsed time since preparation", "why_it_matters": "Acetylcholine integrity and measured availability must be interpreted under recorded conditions." }, { "name": "Hydrolytic integrity", "kind": "measurement", "unit_or_values": "Intact acetylcholine fraction or concentration over time; measured degradation products and method", "why_it_matters": "Distinguishes loss during collection or storage from the original sample state." }, { "name": "Biological location and origin", "kind": "relation", "unit_or_values": "Species, tissue, cell type, compartment and endogenous, administered or experimentally added origin", "why_it_matters": "Bulk content does not establish where acetylcholine acts or how it arrived there." }, { "name": "Receptor activity", "kind": "relation", "unit_or_values": "Target subtype, species, assay endpoint, exposure duration and concentration-response evidence", "why_it_matters": "Biological effects depend on the target and experimental context." }, { "name": "Applicable safety and regulatory identity", "kind": "category", "unit_or_values": "Form-specific CAS and EC records where verified; SDS revision; jurisdiction; GHS classification and exposure-limit status", "why_it_matters": "Prevents transferring a salt or product classification to every occurrence of acetylcholine." } ], "affordances": [ "Resolve a substance label to acetylcholine while retaining the identity of its salt or preparation.", "Calculate acetylcholine equivalents using verified counterion, hydration and assay information.", "Assess whether preservation and analytical controls support a reported concentration.", "Compare receptor-response evidence only across explicitly compatible biological and assay contexts.", "Select or reject a sample for a stated research use using purity, integrity and traceability evidence.", "Retrieve applicable handling requirements from the actual material's current documentation." ] }, "sources": [], "structure": { "bundles": [ { "id": "acetylcholine-identity", "name": "Acetylcholine identity", "description": "Establish which chemical entity a record or sample represents.", "rationale": "Acetylcholine names can refer to the cation, a salt or an ingredient in a preparation.", "layers": [ { "id": "molecular-recognition", "name": "Molecular recognition", "description": "Recognise acetylcholine through structure and authoritative identifiers.", "findings": [ { "id": "structure-supported-identity", "name": "Structure-supported identity", "description": "Require agreement between the assigned structure and identifier records, rather than relying on an abbreviation or biological effect.", "questions": [ { "text": "What structure and authoritative identifier record establish that the entity is acetylcholine?", "kind": "definition", "id": "structure-supported-identity-q01" }, { "text": "What evidence distinguishes it from choline and structurally related cholinergic compounds?", "kind": "boundary", "id": "structure-supported-identity-q02" } ] } ] }, { "id": "cation-and-material-boundary", "name": "Cation and material boundary", "description": "Connect the acetylcholine entity to the complete material being described.", "findings": [ { "id": "salt-aware-record-linkage", "name": "Salt-aware record linkage", "description": "Retain counterion and hydration information without treating a salt-specific identifier as the identifier of the cation.", "questions": [ { "text": "Does this record describe acetylcholine itself, a named salt or a preparation containing it?", "kind": "boundary", "id": "salt-aware-record-linkage-q01" }, { "text": "Which counterion, hydration state and salt-specific identifiers are verified for this material?", "kind": "provenance", "id": "salt-aware-record-linkage-q02" } ] } ] } ] }, { "id": "acetylcholine-material-quality", "name": "Acetylcholine material quality", "description": "Describe the amount, composition and physical state of material containing acetylcholine.", "rationale": "Sample suitability depends on what was supplied or collected and the basis on which its content is expressed.", "layers": [ { "id": "content-and-assay-basis", "name": "Content and assay basis", "description": "Make purity and concentration meaningful across salts and preparations.", "findings": [ { "id": "acetylcholine-equivalent-content", "name": "Acetylcholine-equivalent content", "description": "Tie each reported amount to its analyte basis, measured purity and complete material composition.", "questions": [ { "text": "Is the stated content expressed as acetylcholine cation, complete salt or total preparation?", "kind": "measurement", "id": "acetylcholine-equivalent-content-q01" }, { "text": "Which assay, water-content result and impurity evidence support conversion to acetylcholine equivalents?", "kind": "provenance", "id": "acetylcholine-equivalent-content-q02" } ] } ] }, { "id": "form-dependent-properties", "name": "Form-dependent properties", "description": "Assign physical properties only to the material and conditions actually investigated.", "findings": [ { "id": "qualified-physical-constants", "name": "Qualified physical constants", "description": "Require form-specific evidence for phase behaviour, solubility and thermal properties; do not assume a salt's constants describe the isolated cation.", "questions": [ { "text": "What phase, solvent, temperature and pressure describe the material under consideration?", "kind": "measurement", "id": "qualified-physical-constants-q01" }, { "text": "Do reported melting, boiling or decomposition observations apply to this exact salt and hydration state?", "kind": "boundary", "id": "qualified-physical-constants-q02" } ] } ] } ] }, { "id": "acetylcholine-integrity-and-measurement", "name": "Acetylcholine integrity and measurement", "description": "Determine whether a measurement represents acetylcholine present at the intended sampling time.", "rationale": "Rapid cholinesterase-mediated breakdown makes collection and measurement history material to interpretation. Reference: [PubChem acetylcholine](https://pubchem.ncbi.nlm.nih.gov/compound/acetylcholine).", "layers": [ { "id": "preservation-and-hydrolysis", "name": "Preservation and hydrolysis", "description": "Track conditions and interventions that can change acetylcholine after sampling.", "findings": [ { "id": "time-resolved-integrity", "name": "Time-resolved integrity", "description": "Assess intact analyte at relevant times using preservation records and validated stability evidence.", "questions": [ { "text": "What were the collection-to-quench interval, temperature, pH and storage history?", "kind": "provenance", "id": "time-resolved-integrity-q01" }, { "text": "What evidence quantifies acetylcholine loss under those specific conditions?", "kind": "measurement", "id": "time-resolved-integrity-q02" }, { "text": "Which preservation intervention is validated without compromising the intended measurement?", "kind": "action", "id": "time-resolved-integrity-q03" } ] } ] }, { "id": "analytical-specificity", "name": "Analytical specificity", "description": "Separate acetylcholine detection from interference, degradation and indirect response.", "findings": [ { "id": "validated-acetylcholine-result", "name": "Validated acetylcholine result", "description": "Require method-specific evidence of selectivity, recovery and quantification in the actual matrix.", "questions": [ { "text": "How does the method distinguish acetylcholine from choline, related compounds and matrix interference?", "kind": "measurement", "id": "validated-acetylcholine-result-q01" }, { "text": "What calibration, recovery, quantification limit and uncertainty support the reported result?", "kind": "measurement", "id": "validated-acetylcholine-result-q02" }, { "text": "Could an apparent absence reflect degradation or insufficient analytical sensitivity?", "kind": "boundary", "id": "validated-acetylcholine-result-q03" } ] } ] } ] }, { "id": "acetylcholine-biological-context", "name": "Acetylcholine biological context", "description": "Connect acetylcholine occurrence to location, origin and target-specific activity.", "rationale": "Acetylcholine is a neurotransmitter and cholinergic agonist, but those roles alone do not determine the effect of an individual occurrence. Reference: [PubChem acetylcholine](https://pubchem.ncbi.nlm.nih.gov/compound/acetylcholine).", "layers": [ { "id": "origin-compartment-and-turnover", "name": "Origin, compartment and turnover", "description": "Locate the observed acetylcholine and connect it to supported production, transport and breakdown relationships.", "findings": [ { "id": "located-acetylcholine-pool", "name": "Located acetylcholine pool", "description": "Keep tissue content, intracellular stores, extracellular availability and experimentally added acetylcholine distinguishable.", "questions": [ { "text": "Which species, tissue, cell type and compartment does the observation concern?", "kind": "provenance", "id": "located-acetylcholine-pool-q01" }, { "text": "What evidence establishes endogenous origin, experimental addition or administration?", "kind": "provenance", "id": "located-acetylcholine-pool-q02" }, { "text": "Which production, transport and degradation relationships are demonstrated for this pool?", "kind": "boundary", "id": "located-acetylcholine-pool-q03" } ] } ] }, { "id": "target-dependent-response", "name": "Target-dependent response", "description": "Interpret activity through a specified cholinergic target and assay.", "findings": [ { "id": "qualified-receptor-activity", "name": "Qualified receptor activity", "description": "Attach receptor claims to subtype, species and assay evidence using the acetylcholine ligand record as a research entry point. Reference: [IUPHAR/BPS acetylcholine](https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=294).", "questions": [ { "text": "Which nicotinic or muscarinic receptor subtype and species are implicated by the evidence?", "kind": "definition", "id": "qualified-receptor-activity-q01" }, { "text": "What concentration, exposure duration, endpoint and controls support the assigned response?", "kind": "measurement", "id": "qualified-receptor-activity-q02" }, { "text": "Does the experiment establish direct receptor activity or only a downstream effect compatible with it?", "kind": "boundary", "id": "qualified-receptor-activity-q03" } ] } ] } ] }, { "id": "acetylcholine-use-and-handling", "name": "Acetylcholine use and handling", "description": "Judge whether the identified material and its documentation support a proposed operation.", "rationale": "Chemical identity does not establish product quality, stability, handling classification or permission for a particular use.", "layers": [ { "id": "fitness-for-intended-use", "name": "Fitness for intended use", "description": "Evaluate acetylcholine material against the requirements of a stated activity.", "findings": [ { "id": "evidence-based-material-selection", "name": "Evidence-based material selection", "description": "Connect the intended operation to acceptance criteria for identity, concentration, impurities and remaining integrity.", "questions": [ { "text": "What purity, concentration accuracy, matrix compatibility and stability does the proposed use require?", "kind": "action", "id": "evidence-based-material-selection-q01" }, { "text": "Which lot-specific evidence demonstrates that these requirements are met?", "kind": "provenance", "id": "evidence-based-material-selection-q02" }, { "text": "Does the decision require a separate medicinal-product or formulation model?", "kind": "boundary", "id": "evidence-based-material-selection-q03" } ] } ] }, { "id": "material-specific-handling", "name": "Material-specific handling", "description": "Apply safety and regulatory evidence to the exact form, concentration and jurisdiction.", "findings": [ { "id": "verified-handling-basis", "name": "Verified handling basis", "description": "Distinguish a verified classification or exposure limit from missing information and from classifications belonging to other preparations.", "questions": [ { "text": "Which current SDS and jurisdiction-specific records cover this exact acetylcholine material?", "kind": "provenance", "id": "verified-handling-basis-q01" }, { "text": "What GHS classification and exposure-limit status are explicitly documented?", "kind": "definition", "id": "verified-handling-basis-q02" }, { "text": "What storage, containment and disposal actions follow from those records and the planned operation?", "kind": "action", "id": "verified-handling-basis-q03" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-confidence-notes", "name": "Check these first", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "This is recall only; no sources were consulted.", "Verify identifiers and physical properties against the exact salt, hydration state, purity and formulation being registered.", "Check current product labeling and substance-specific safety documentation before assigning regulatory status, GHS classifications or exposure limits." ], "questions": [ { "id": "evidence-confidence-notes-q01", "text": "Which of these check these first hold for the sense of acetylcholine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-identifiers", "name": "Identifiers and schemes", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "scheme": "CAS Registry Number", "value_or_pattern": "51-84-3", "note": "Identifies acetylcholine; its salts have separate registry numbers." }, { "scheme": "Molecular formula", "value_or_pattern": "C7H16NO2+", "note": "Describes the acetylcholine cation without a counterion." }, { "scheme": "Biochemical abbreviation", "value_or_pattern": "ACh", "note": "Common abbreviation, not a unique regulatory identifier." } ], "questions": [ { "id": "evidence-identifiers-q01", "text": "Which of these identifiers and schemes hold for the sense of acetylcholine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Acetylcholine chloride formulations are used to induce rapid pupil constriction during certain ophthalmic operations.", "Used experimentally to study cholinergic receptors, synaptic transmission and muscle contraction.", "Used in vascular physiology experiments to assess endothelium-dependent responses." ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of acetylcholine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-measurements", "name": "Typical measurements", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "quantity": "Molar mass of the acetylcholine cation", "typical_range": "146.21", "unit": "g/mol" } ], "questions": [ { "id": "evidence-measurements-q01", "text": "Which of these typical measurements hold for the sense of acetylcholine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Ester hydrolysis produces choline and acetate or acetic acid; solution stability depends on conditions including pH and temperature.", "Rapid enzymatic hydrolysis by cholinesterases limits its persistence in biological preparations.", "Excessive cholinergic activity can cause bradycardia, bronchoconstriction, increased secretions and gastrointestinal effects.", "Confusing cation mass with salt mass produces errors in concentration and dose calculations.", "Responses depend on receptor subtype, tissue and experimental conditions; acetylcholine does not uniformly excite every target." ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of acetylcholine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-regional-variation", "name": "Regional variation", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Approval, availability and labeling of acetylcholine-containing medicinal products vary by jurisdiction." ], "questions": [ { "id": "evidence-regional-variation-q01", "text": "Which of these regional variation hold for the sense of acetylcholine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "name": "Choline", "difference": "Choline has a free hydroxyl group; acetylcholine has that group esterified with an acetyl group." }, { "name": "Acetylcholine chloride", "difference": "The chloride salt includes a chloride counterion and has a different formula mass and registry identity from the acetylcholine cation." }, { "name": "Acetylcholinesterase", "difference": "An enzyme that hydrolyses acetylcholine, rather than the neurotransmitter itself." }, { "name": "Carbachol", "difference": "A carbamate analogue of choline with greater resistance to cholinesterase hydrolysis than acetylcholine." } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of acetylcholine this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Does an existing Vercy world model already own acetylcholine, and how should this registry entry link to it without duplicating ownership?", "Which EC identifiers, GHS classifications and exposure limits are verified for each relevant salt and jurisdiction, and where is information absent?", "Which form-specific thermal and solubility measurements are reliable, and do thermal observations describe melting, decomposition or another event?", "What preservation conditions and validated stability windows apply to the biological matrices and laboratory preparations this catalogue must support?", "Which receptor, compartment and turnover relationships need researched findings first, and what evidence supports their species-specific limits?" ], "statistics": { "bundles": 6, "layers": 11, "findings": 17, "questions": 33 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "chemical substance or material", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a acetylcholine, record what state it is in, and decide what may be done with it.", "whatItIs": "Enable an agent to recognise acetylcholine, assess its identity, integrity and biological context, and judge whether a particular sample is suitable for a specified use.", "characteristics": { "substance": "material", "origin": "natural", "agency": "inert", "mobility": "varies" }, "whatYouCanDoWithIt": [ "observed and measured", "consumed or used up" ], "distinguishingFeatures": [ "Described in 65 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a acetylcholine, and on what evidence are they told apart?" ], "whatItIsMadeOf": "matter you can touch", "physicalCharacter": [ "Mobility varies between examples.", "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state", "use it up, and then need more of it" ], "howItIsRecognised": [ "Not recognisable by sight in any reliable way. Appearance varies with grade, form and additives; identification is by label, by documentation, or by assay." ], "relatedModels": [], "standing": "Described in 65 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one acetylcholine from another, and a acetylcholine from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a acetylcholine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a acetylcholine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a acetylcholine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a acetylcholine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a acetylcholine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a acetylcholine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a acetylcholine sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a acetylcholine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a acetylcholine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a acetylcholine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a acetylcholine from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a acetylcholine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a acetylcholine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a acetylcholine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "form-and-composition", "name": "Form, composition and condition", "description": "What a acetylcholine is made of, what shape and size it takes, and what state it is in.", "rationale": "A physical thing can be measured, and a model that cannot record its measurements cannot support any decision that depends on them.", "layers": [ { "id": "form-and-dimensions", "name": "Form and dimensions", "description": "Shape, size, mass and the ranges these take across examples.", "findings": [ { "id": "measurable-dimensions", "name": "Measurable dimensions and their units", "description": "The quantities worth recording and the units they are recorded in.", "questions": [ { "id": "measurable-dimensions-q01", "text": "What identifies and describes the dimensions of a acetylcholine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "measurable-dimensions-q02", "text": "Who or what asserted this about the dimensions of a acetylcholine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "measurable-dimensions-q03", "text": "What may an agent decide or do once the dimensions of a acetylcholine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "material-and-composition", "name": "Material and composition", "description": "Materials, parts and how they are put together.", "findings": [ { "id": "parts-and-materials", "name": "Parts and materials", "description": "What a acetylcholine is built from and which parts are replaceable.", "questions": [ { "id": "parts-and-materials-q01", "text": "What identifies and describes the composition of a acetylcholine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "parts-and-materials-q02", "text": "Who or what asserted this about the composition of a acetylcholine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "parts-and-materials-q03", "text": "What may an agent decide or do once the composition of a acetylcholine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "condition-and-integrity", "name": "Condition and integrity", "description": "Wear, damage, health and the difference between working and broken.", "findings": [ { "id": "condition-assessment", "name": "Condition, damage and health", "description": "How the condition of a acetylcholine is judged and by whom.", "questions": [ { "id": "condition-assessment-q01", "text": "What identifies and describes the condition of a acetylcholine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "condition-assessment-q02", "text": "Who or what asserted this about the condition of a acetylcholine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "condition-assessment-q03", "text": "What may an agent decide or do once the condition of a acetylcholine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "place-and-movement", "name": "Place and movement", "description": "Where a acetylcholine is, how it got there and where it may go (varies).", "rationale": "A thing that can move needs its position recorded with a time, or every later claim about it is about a place it has left.", "layers": [ { "id": "location-and-placement", "name": "Location and placement", "description": "Position, containment and the reference frame the position is given in.", "findings": [ { "id": "position-and-frame", "name": "Position, container and reference frame", "description": "Where a acetylcholine is, and what that position is measured against.", "questions": [ { "id": "position-and-frame-q01", "text": "What identifies and describes the location of a acetylcholine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "position-and-frame-q02", "text": "Who or what asserted this about the location of a acetylcholine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "position-and-frame-q03", "text": "What may an agent decide or do once the location of a acetylcholine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "movement-and-transfer", "name": "Movement and transfer", "description": "How a acetylcholine is carried, installed or relocated.", "findings": [ { "id": "movement-events", "name": "Movement events and constraints", "description": "What counts as a movement, what records it and what limits it.", "questions": [ { "id": "movement-events-q01", "text": "What identifies and describes the movement of a acetylcholine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "movement-events-q02", "text": "Who or what asserted this about the movement of a acetylcholine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "movement-events-q03", "text": "What may an agent decide or do once the movement of a acetylcholine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a acetylcholine passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a acetylcholine between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a acetylcholine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a acetylcholine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a acetylcholine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a acetylcholine, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a acetylcholine is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a acetylcholine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a acetylcholine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a acetylcholine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "use-and-operation", "name": "Use and operation", "description": "What can be done with a acetylcholine and what it takes to do it.", "rationale": "An agent that can recognise a thing but not act on it has only half a model.", "layers": [ { "id": "intended-use", "name": "Intended use and function", "description": "What a acetylcholine is for, and what it is used for anyway.", "findings": [ { "id": "function-and-purpose", "name": "Function, purpose and misuse", "description": "The function a acetylcholine performs and the uses that fall outside it.", "questions": [ { "id": "function-and-purpose-q01", "text": "What identifies and describes the use of a acetylcholine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "function-and-purpose-q02", "text": "Who or what asserted this about the use of a acetylcholine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "function-and-purpose-q03", "text": "What may an agent decide or do once the use of a acetylcholine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "handling-and-procedure", "name": "Handling and procedure", "description": "The steps, skills and tools involved in using a acetylcholine.", "findings": [ { "id": "procedures-and-skills", "name": "Procedures, skills and required tools", "description": "What an agent needs before it can act on a acetylcholine at all.", "questions": [ { "id": "procedures-and-skills-q01", "text": "What identifies and describes handling a acetylcholine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "procedures-and-skills-q02", "text": "Who or what asserted this about handling a acetylcholine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "procedures-and-skills-q03", "text": "What may an agent decide or do once handling a acetylcholine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "supply-and-consumption", "name": "Supply and consumption", "description": "Quantities, rates and what running out means.", "findings": [ { "id": "consumption-and-stock", "name": "Consumption, stock and replenishment", "description": "How much of a acetylcholine there is and how fast it goes.", "questions": [ { "id": "consumption-and-stock-q01", "text": "What identifies and describes the supply of a acetylcholine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "consumption-and-stock-q02", "text": "Who or what asserted this about the supply of a acetylcholine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "consumption-and-stock-q03", "text": "What may an agent decide or do once the supply of a acetylcholine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "composition-and-identity", "name": "Composition, grade and chemical identity", "description": "What acetylcholine is made of and how pure the thing in hand is.", "rationale": "Grade decides what a substance may be used for, so a model that records only the name cannot support any decision about use.", "layers": [ { "id": "chemical-identity", "name": "Chemical identity", "description": "Formula, structure and the registry numbers that name it unambiguously.", "findings": [ { "id": "identity-record", "name": "Identity and registry numbers", "description": "What identifies this substance across suppliers and regulators.", "questions": [ { "id": "identity-record-q01", "text": "What formula, structure and registry identifiers name acetylcholine unambiguously?", "kind": "definition" }, { "id": "identity-record-q02", "text": "Which related substances share a name in common use but not an identifier?", "kind": "boundary" } ] } ] }, { "id": "grade-and-impurities", "name": "Grade, purity and impurities", "description": "The specification a batch meets and what else is in it.", "findings": [ { "id": "specification", "name": "Specification and assay", "description": "How purity is stated and measured, and which impurities matter.", "questions": [ { "id": "specification-q01", "text": "What grades of acetylcholine exist, how is purity assayed, and which impurities are limited?", "kind": "measurement" }, { "id": "specification-q02", "text": "Which use requires which grade, and what happens when a lower grade is substituted?", "kind": "action" } ] } ] } ] }, { "id": "properties-and-behaviour", "name": "Properties and behaviour", "description": "How acetylcholine behaves under conditions an agent can measure or change.", "rationale": "Physical constants are the part of a substance model that transfers between contexts, and each needs its unit and its conditions.", "layers": [ { "id": "physical-constants", "name": "Physical constants", "description": "Values that hold for the pure substance, with their conditions.", "findings": [ { "id": "constants-record", "name": "Constants and conditions", "description": "The quantities worth recording and the state they apply in.", "questions": [ { "id": "constants-record-q01", "text": "What are the defining physical constants of acetylcholine, in what units and under what conditions?", "kind": "measurement" }, { "id": "constants-record-q02", "text": "Which of these values change with grade or form rather than being fixed?", "kind": "boundary" } ] } ] }, { "id": "stability-and-reactivity", "name": "Stability and reactivity", "description": "What it reacts with, degrades into, and how it is stored.", "findings": [ { "id": "incompatibilities", "name": "Incompatibilities and degradation", "description": "What must not meet it, and what it becomes over time.", "questions": [ { "id": "incompatibilities-q01", "text": "What is acetylcholine incompatible with, and what does it degrade into under storage?", "kind": "definition" }, { "id": "incompatibilities-q02", "text": "What storage and handling does that require, and who is competent to do it?", "kind": "action" } ] } ] } ] }, { "id": "hazard-and-regulation", "name": "Hazard classification and regulation", "description": "How acetylcholine can harm, and what the law says about holding and moving it.", "rationale": "A substance model without its hazard class and its regulatory identity is unusable in exactly the situations that matter.", "layers": [ { "id": "hazard-class", "name": "Hazard classification", "description": "Classified hazards, exposure limits and protective measures.", "findings": [ { "id": "classified-hazards", "name": "Classified hazards and limits", "description": "The classification, the scheme it belongs to, and the limits set.", "questions": [ { "id": "classified-hazards-q01", "text": "How is acetylcholine classified for hazard, under which scheme, and what exposure limits apply?", "kind": "definition" }, { "id": "classified-hazards-q02", "text": "What protection does handling require, and what must an agent refuse to do without it?", "kind": "action" } ] } ] }, { "id": "regulatory-identity", "name": "Regulatory identity and control", "description": "Registration, restriction and transport rules by jurisdiction.", "findings": [ { "id": "controls", "name": "Controls and jurisdiction", "description": "Where it is restricted and what the restriction attaches to.", "questions": [ { "id": "controls-q01", "text": "Which registrations, restrictions or transport rules cover acetylcholine, and where?", "kind": "provenance" }, { "id": "controls-q02", "text": "Does the control attach to the substance, its concentration, or its intended use?", "kind": "boundary" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a acetylcholine came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a acetylcholine and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a acetylcholine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a acetylcholine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a acetylcholine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a acetylcholine is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a acetylcholine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a acetylcholine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a acetylcholine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 9, "layers": 20, "findings": 22, "questions": 60 } } } }