{ "model": { "rank": 6001, "code": "thing-q181619", "model_id": "vr.tr.l-glutamine", "name": "L-glutamine", "purpose": "Enable an AI agent to recognise L-glutamine, assess the identity and condition of a particular material, and determine whether a proposed handling or use is supported by evidence.", "family": "Thing Registry", "category": "Physical world and living systems", "status": "research-draft", "kind": "thing", "plane": "PHY", "domain": "PHY.MAT", "industry": "", "version": "", "url": "/models/thing/q181619/", "tier": 2, "score": 63, "payload": { "layer": "wikidata", "aliases": [], "aliasCount": 0, "merged": 0, "knownIn": 63, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q181619", "url": "https://www.wikidata.org/wiki/Q181619", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-07T10:41:54Z", "providers": [ "Codex", "Grok" ], "missingProviders": [], "pass": 2, "cost": { "grok": { "usd": 0.0084405, "turns": 1, "seconds": 159.2, "error": null }, "codex": { "seconds": 253.3, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.3\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a07b71-f6f3-7a71-a9c7-fc2f43717690\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: L-glutamine\nRegistry id: vr.tr.l-glutamine\nPlane / domain: PHY / PHY.MAT\nRegistry definition: (none recorded)\nNames folded into this entry: (none)\n\nA" } } }, "metaModel": { "id": "THING-Q181619", "registryId": "vr.tr.l-glutamine", "name": "L-glutamine", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.MAT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q181619/", "model": { "registry_id": "vr.tr.l-glutamine", "name": "L-glutamine", "purpose": "Enable an AI agent to recognise L-glutamine, assess the identity and condition of a particular material, and determine whether a proposed handling or use is supported by evidence.", "definition": "L-glutamine is the proteinogenic L-enantiomer of the amino acid glutamine (2,5-diamino-5-oxopentanoic acid), a polar amide-side-chain residue encoded by CAA/CAG that is both a protein building block and a major nitrogen shuttle and gut/immune fuel in mammals.", "scope_statement": "This model owns vr.tr.l-glutamine within PHY / PHY.MAT: L-glutamine as a chemical substance and the identity, composition, condition and use constraints of material containing it, with relations to formulations, biological systems and procedures.", "in_scope": [ "Chemical identity and evidence establishing L stereochemistry", "Free L-glutamine content in solids, solutions and mixtures", "Lot-specific assay, impurities and analytical evidence", "Preparation, storage and degradation history", "Suitability for a specified material use and handling operation" ], "out_of_scope": [ "D-glutamine, glutamate and chemically modified glutamine as independently modelled substances", "Glutamine-containing peptides and proteins as molecular entities", "Complete culture media, supplements and medicinal products", "Cellular metabolism, organism nutritional status and disease models", "Clinical prescribing, dosing and treatment effectiveness" ], "distinguishing_features": [ "Confirm agreement with the reference identity C5H10N2O3, CAS 56-85-9 and PubChem CID 5961; a matching formula alone is insufficient. Reference: [PubChem L-glutamine](https://pubchem.ncbi.nlm.nih.gov/compound/Glutamine).", "Require stereochemistry-sensitive evidence to distinguish L-glutamine from D-glutamine or an unresolved mixture; ordinary molecular-mass matching cannot establish handedness. Reference identities: [PubChem L-glutamine](https://pubchem.ncbi.nlm.nih.gov/compound/Glutamine) and [PubChem D-glutamine](https://pubchem.ncbi.nlm.nih.gov/compound/D-Glutamine).", "Establish the side-chain amide structure rather than relying on a similar name when distinguishing glutamine from glutamic acid or glutamate. Reference: [NIST L-glutamine](https://webbook.nist.gov/cgi/cbook.cgi?Name=L-Glutamine).", "Distinguish free L-glutamine from L-alanyl-L-glutamine; a product described as a glutamine substitute does not establish free L-glutamine identity or content. Reference: [GlutaMAX product information](https://assets.thermofisher.com/TFS-Assets/LSG/manuals/GlutaMAX_PI.pdf).", "Measure remaining L-glutamine separately from its degradation products rather than treating the original preparation label as current composition. Aqueous degradation can generate ammonia and pyrrolidone carboxylic acid. Reference: [Thermo Fisher glutamine guide](https://www.thermofisher.com/blog/life-in-the-lab/the-essential-guide-to-glutamine-in-cell-culture/)." ], "characteristics": [ { "name": "Chemical identity assignment", "kind": "category", "unit_or_values": "confirmed L-glutamine | provisional assignment | conflicting evidence | unidentified", "why_it_matters": "Determines whether the material can be treated as an instance of this registered thing." }, { "name": "Enantiomeric composition", "kind": "measurement", "unit_or_values": "L and D mole fractions or enantiomeric excess (%), with method and detection limits", "why_it_matters": "Separates chemical assay from evidence that the material has the required stereochemistry." }, { "name": "Material presentation", "kind": "category", "unit_or_values": "solid | aqueous solution | other solution | mixture component", "why_it_matters": "Selects relevant sampling, composition and stability questions." }, { "name": "L-glutamine assay", "kind": "measurement", "unit_or_values": "% mass fraction, with as-received or dry basis and analytical method", "why_it_matters": "Supports material quantity calculations without confusing chromatographic peak area with mass purity." }, { "name": "Free L-glutamine concentration", "kind": "measurement", "unit_or_values": "mmol/L or g/L, with matrix, measurement time and uncertainty", "why_it_matters": "Determines the actual free L-glutamine supplied by a solution." }, { "name": "Water content", "kind": "measurement", "unit_or_values": "% mass fraction, with method", "why_it_matters": "Explains differences between weighed material and the amount of L-glutamine delivered." }, { "name": "Solution pH", "kind": "measurement", "unit_or_values": "pH, with temperature and measurement time", "why_it_matters": "Provides context for interpreting solution condition and applicable stability evidence." }, { "name": "Degradation product profile", "kind": "measurement", "unit_or_values": "ammonia/ammonium and pyrrolidone carboxylic acid concentrations, with methods and reporting basis", "why_it_matters": "Supports assessment of deterioration and downstream compatibility." }, { "name": "Temperature and elapsed exposure", "kind": "measurement", "unit_or_values": "°C and hours or days since preparation, opening or temperature excursion", "why_it_matters": "Connects the material's actual history to applicable stability evidence." }, { "name": "Lot and preparation lineage", "kind": "relation", "unit_or_values": "supplier lot, certificate, parent material, preparation record and analytical sample", "why_it_matters": "Prevents results from one lot or preparation being assigned to another." }, { "name": "Use-specific disposition", "kind": "state", "unit_or_values": "unassessed | supported for named use | hold for testing | unsuitable for named use", "why_it_matters": "Makes suitability conditional on an explicit application and its acceptance criteria." } ], "affordances": [ "Resolve a glutamine-labelled material against chemical and stereochemical reference evidence.", "Calculate the amount of free L-glutamine delivered using assay, water basis and measured concentration.", "Prepare, dilute or aliquot material under a linked procedure while retaining preparation lineage.", "Select identity, stereochemical, concentration or degradation testing to resolve a specific uncertainty.", "Compare documented condition with application-specific criteria to release, hold or reject material for that use.", "Evaluate a proposed glutamine-source substitution while referring formulation and biological equivalence decisions to their owning models." ] }, "sources": [ { "id": "pubchem-l-glutamine", "title": "L-Glutamine (Compound CID 5961)", "url": "https://pubchem.ncbi.nlm.nih.gov/compound/L-glutamine", "what_it_supports": "Canonical identity: L-enantiomer of glutamine, formula C5H10N2O3, CAS 56-85-9, InChIKey ZDXPYRJPNDTMRX-VKHMYHEASA-N, proteinogenic amino acid with carboxamide side chain.", "url_status": "live" }, { "id": "fda-glutamine-label", "title": "GLUTAMINE powder, for oral solution - prescribing information (NDA 203722, Endari)", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/208587s000lbl.pdf", "what_it_supports": "US FDA-approved pharmaceutical use of L-glutamine oral powder to reduce acute complications of sickle cell disease; dosing, adverse reactions, and that the drug substance is L-glutamine.", "url_status": "live" }, { "id": "ema-gln-dipeptide", "title": "Scientific discussion / product information for glutamine-containing parenteral amino-acid products (alanyl-glutamine dipeptide)", "url": "", "what_it_supports": "In parenteral nutrition, free L-glutamine is unstable in aqueous solution; clinical products therefore use the dipeptide L-alanyl-L-glutamine rather than free glutamine.", "url_status": "dead" }, { "id": "usp-fcc-identity", "title": "USP-NF monograph Glutamine / FCC L-Glutamine (identity, assay, specific rotation)", "url": "https://www.usp.org/", "what_it_supports": "Pharmacopeial identity of L-glutamine as a named article (assay, optical rotation, related substances) used for food and pharmaceutical grades.", "url_status": "blocked" } ], "structure": { "bundles": [ { "id": "l-glutamine-identity", "name": "L-glutamine identity", "description": "Establish whether the material is the registered chemical entity and whether its L designation is supported.", "rationale": "A glutamine name, formula or assay can leave stereochemistry and molecular form unresolved.", "layers": [ { "id": "molecular-assignment", "name": "Molecular assignment", "description": "Connect the claimed identity to structural evidence.", "findings": [ { "id": "glutamine-structure-confirmation", "name": "Glutamine structure confirmation", "description": "Record evidence identifying the glutamine structure and resolving plausible related compounds.", "questions": [ { "text": "Which reference identity and analytical observations support assigning this material to L-glutamine?", "kind": "definition", "id": "glutamine-structure-confirmation-q01" }, { "text": "Does the method distinguish glutamine from glutamate and other plausible components of this sample?", "kind": "measurement", "id": "glutamine-structure-confirmation-q02" } ] } ] }, { "id": "stereochemical-assignment", "name": "Stereochemical assignment", "description": "Determine what supports the L designation.", "findings": [ { "id": "l-configuration-evidence", "name": "L-configuration evidence", "description": "Keep evidence of handedness separate from evidence of chemical purity.", "questions": [ { "text": "Which stereochemistry-sensitive measurement or traceable reference supports the L assignment?", "kind": "provenance", "id": "l-configuration-evidence-q01" }, { "text": "What D-glutamine fraction was measured or bounded, and what uncertainty remains?", "kind": "measurement", "id": "l-configuration-evidence-q02" } ] } ] } ] }, { "id": "free-glutamine-and-material-context", "name": "Free glutamine and material context", "description": "Identify what physical material is present and what its glutamine quantity represents.", "rationale": "Free L-glutamine, peptide-bound glutamine and a glutamine-containing formulation are different objects of assessment.", "layers": [ { "id": "chemical-form-boundary", "name": "Chemical form boundary", "description": "Separate free L-glutamine from related molecular forms.", "findings": [ { "id": "free-versus-bound-glutamine", "name": "Free versus bound glutamine", "description": "Record whether the reported amount refers to free material or glutamine released or inferred from another substance.", "questions": [ { "text": "Does the reported glutamine amount mean free L-glutamine, peptide-bound residues or glutamine equivalents?", "kind": "definition", "id": "free-versus-bound-glutamine-q01" }, { "text": "Does the sample contain L-alanyl-L-glutamine, another derivative or a distinct salt form requiring a linked identity assessment?", "kind": "boundary", "id": "free-versus-bound-glutamine-q02" } ] } ] }, { "id": "physical-presentation-and-matrix", "name": "Physical presentation and matrix", "description": "Describe the solid or solution in which L-glutamine is assessed.", "findings": [ { "id": "matrix-qualified-material-state", "name": "Matrix-qualified material state", "description": "Record presentation, matrix and homogeneity so measurements refer to the material actually handled.", "questions": [ { "text": "Is the material a solid, a stock solution or a component of a mixture, and what solvent or matrix surrounds it?", "kind": "definition", "id": "matrix-qualified-material-state-q01" }, { "text": "Is the material fully dissolved or homogeneous at the point of sampling, and how was that established?", "kind": "measurement", "id": "matrix-qualified-material-state-q02" } ] } ] } ] }, { "id": "glutamine-quantity-and-quality", "name": "Glutamine quantity and quality", "description": "Determine how much L-glutamine is present and which other constituents affect its proposed use.", "rationale": "Nominal mass, assay percentage and free-glutamine concentration cannot be used interchangeably.", "layers": [ { "id": "assay-and-amount-basis", "name": "Assay and amount basis", "description": "Make L-glutamine quantity calculations traceable to a stated analytical basis.", "findings": [ { "id": "usable-glutamine-quantity", "name": "Usable glutamine quantity", "description": "Record the quantity of free L-glutamine with its basis and uncertainty.", "questions": [ { "text": "What free L-glutamine mass fraction or concentration was measured, by which method and at what time?", "kind": "measurement", "id": "usable-glutamine-quantity-q01" }, { "text": "Does the reported assay use an as-received, dry-mass or chromatographic-area basis, and what corrections are justified?", "kind": "definition", "id": "usable-glutamine-quantity-q02" } ] } ] }, { "id": "impurities-and-use-requirements", "name": "Impurities and use requirements", "description": "Assess constituents and contamination against the named application.", "findings": [ { "id": "application-relevant-quality-evidence", "name": "Application-relevant quality evidence", "description": "Attach relevant impurity and contamination results without treating a grade label as universal suitability.", "questions": [ { "text": "Which related substances, residual constituents or contamination measures does the proposed use require, and what results are available?", "kind": "measurement", "id": "application-relevant-quality-evidence-q01" }, { "text": "Which lot-specific specification supports the claimed grade, including sterility or endotoxin criteria when applicable?", "kind": "provenance", "id": "application-relevant-quality-evidence-q02" } ] } ] } ] }, { "id": "aqueous-degradation-and-storage", "name": "Aqueous degradation and storage", "description": "Connect preparation and exposure history to evidence about remaining L-glutamine and degradation products.", "rationale": "The original amount added does not establish the current condition of a stored glutamine solution.", "layers": [ { "id": "preparation-and-exposure-history", "name": "Preparation and exposure history", "description": "Capture the conditions needed to interpret stability claims.", "findings": [ { "id": "stability-evidence-applicability", "name": "Stability evidence applicability", "description": "Determine whether available stability evidence matches this material and its handling history.", "questions": [ { "text": "When was this lot dissolved or opened, and what temperature, pH and freeze-thaw history is documented?", "kind": "provenance", "id": "stability-evidence-applicability-q01" }, { "text": "Does the cited storage or beyond-use limit cover this concentration, matrix, container and actual exposure history?", "kind": "boundary", "id": "stability-evidence-applicability-q02" } ] } ] }, { "id": "remaining-glutamine-and-degradants", "name": "Remaining glutamine and degradants", "description": "Assess current composition rather than inferring it from appearance or preparation records.", "findings": [ { "id": "degradation-status", "name": "Degradation status", "description": "Record remaining L-glutamine and relevant degradation measurements with uncertainty.", "questions": [ { "text": "What are the current free L-glutamine, ammonia/ammonium and pyrrolidone carboxylic acid measurements?", "kind": "measurement", "id": "degradation-status-q01" }, { "text": "Could the matrix or biological activity explain the observed ammonia independently of storage degradation?", "kind": "boundary", "id": "degradation-status-q02" }, { "text": "Do the results support continued use, require retesting or exceed the named application's acceptance limits?", "kind": "action", "id": "degradation-status-q03" } ] } ] } ] }, { "id": "glutamine-use-and-transformations", "name": "Glutamine use and transformations", "description": "Determine which handling operations and application decisions are supported for this material.", "rationale": "Chemical identity alone cannot establish whether a lot is suitable or whether another glutamine source is interchangeable.", "layers": [ { "id": "preparation-and-release", "name": "Preparation and release", "description": "Link handling and disposition decisions to the material's assessed condition.", "findings": [ { "id": "supported-preparation-operation", "name": "Supported preparation operation", "description": "Record an authorised procedure, its required inputs and the evidence needed to assess the resulting preparation.", "questions": [ { "text": "Which procedure governs dissolution, dilution, aliquoting or filtration for the intended use?", "kind": "action", "id": "supported-preparation-operation-q01" }, { "text": "What concentration, quality and stability checks must the resulting preparation satisfy before release?", "kind": "action", "id": "supported-preparation-operation-q02" } ] } ] }, { "id": "substitution-and-model-handoffs", "name": "Substitution and model handoffs", "description": "Keep chemical amount comparisons distinct from application equivalence.", "findings": [ { "id": "glutamine-source-substitution", "name": "Glutamine-source substitution", "description": "Record what a proposed substitute supplies and route equivalence decisions to the relevant formulation or biological model.", "questions": [ { "text": "Would the proposed replacement supply free L-glutamine directly or require conversion from another molecule?", "kind": "boundary", "id": "glutamine-source-substitution-q01" }, { "text": "What application-specific evidence supports the replacement amount, availability and accompanying constituents?", "kind": "provenance", "id": "glutamine-source-substitution-q02" }, { "text": "Which linked model or responsible authority decides whether this substitution is acceptable?", "kind": "action", "id": "glutamine-source-substitution-q03" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-kinds", "name": "Kinds and varieties", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "proteinogenic free L-glutamine (endogenous / dietary amino acid)", "USP/Ph. Eur. pharmaceutical-grade L-glutamine (oral or parenteral amino-acid component)", "food-supplement / sports-nutrition L-glutamine (powder, capsule)", "parenteral nutrition amino-acid mix component (often as L-alanyl-L-glutamine dipeptide, not free glutamine)", "cell-culture / bioprocess L-glutamine (media supplement; also as GlutaMAX-type dipeptide)", "isotopically labelled L-glutamine (13C/15N tracers)", "L-glutamine as a pharmacopeial reference standard", "conditionally essential / stress-state L-glutamine (clinical nutrition use, not a chemical isomer)" ], "questions": [ { "id": "evidence-kinds-q01", "text": "Which of these kinds and varieties hold for the sense of L-glutamine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-identifiers", "name": "Identifiers and schemes", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ { "scheme": "CAS Registry Number", "value_or_pattern": "56-85-9", "note": "L-glutamine (not the racemate or D-enantiomer)" }, { "scheme": "PubChem CID", "value_or_pattern": "5961", "note": "Compound record for L-glutamine" }, { "scheme": "IUPAC InChIKey", "value_or_pattern": "ZDXPYRJPNDTMRX-VKHMYHEASA-N", "note": "Stereospecific key; the racemate/D-form have different stereo layers" }, { "scheme": "UNII (FDA SRS)", "value_or_pattern": "0RH81L854J", "note": "Preferred substance identifier for L-glutamine in US drug listings" }, { "scheme": "ChEBI", "value_or_pattern": "CHEBI:18050", "note": "L-glutamine; parent glutamine is CHEBI:28300" }, { "scheme": "IUPAC name", "value_or_pattern": "(2S)-2,5-diamino-5-oxopentanoic acid", "note": "Also (2S)-2-amino-4-carbamoylbutanoic acid" }, { "scheme": "EC number (EINECS)", "value_or_pattern": "200-292-1", "note": "European inventory number for L-glutamine" }, { "scheme": "DrugBank", "value_or_pattern": "DB00130", "note": "L-glutamine as an approved/nutraceutical substance" }, { "scheme": "ATC (WHO)", "value_or_pattern": "A16AA03", "note": "Glutamine as an alimentary-tract / metabolic product (amino acids and derivatives)" }, { "scheme": "Wikidata", "value_or_pattern": "Q181619", "note": "item for L-glutamine" }, { "scheme": "HS / trade", "value_or_pattern": "2922.49 (amino-acids and their esters, other)", "note": "Typical customs heading for bulk amino acids; confirm with local tariff" } ], "questions": [ { "id": "evidence-identifiers-q01", "text": "Which of these identifiers and schemes hold for the sense of L-glutamine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-standards-and-regulation", "name": "Standards and regulation", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "United States Pharmacopeia-National Formulary (USP-NF): Glutamine monograph (identity, assay, specific rotation, related compounds) - USP", "European Pharmacopoeia (Ph. Eur.): Glutamine / L-glutamine related monographs and parenteral amino-acid preparation requirements - EDQM / Council of Europe", "FCC (Food Chemicals Codex): L-Glutamine food-grade specification - USP (FCC)", "US FDA: L-glutamine oral powder approved to reduce acute complications of sickle cell disease (Endari, NDA 208587); also GRAS/food-use as an amino acid in conventional foods and supplements under DSHEA when labeled as a dietary ingredient - FDA", "EMA / national EU medicines agencies: glutamine for parenteral nutrition is typically authorised as L-alanyl-L-glutamine (e.g. Dipeptiven) because free glutamine is unstable in heat-sterilised aqueous PN solutions - EMA", "WHO ATC classification A16AA03 (glutamine) - WHO Collaborating Centre for Drug Statistics Methodology", "Codex / JECFA amino-acid food-additive and nutrient evaluations (as applicable to L-amino acids used in foods) - FAO/WHO", "EU food-supplement and novel-food framework: L-glutamine is a conventional amino-acid ingredient, not a novel food, but health-claim use is restricted (EFSA has not authorised glutamine sports/immune claims) - European Commission / EFSA" ], "questions": [ { "id": "evidence-standards-and-regulation-q01", "text": "Which of these standards and regulation hold for the sense of L-glutamine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "Endogenous proteinogenic amino acid: incorporated into proteins; also the most abundant free amino acid in human plasma and skeletal muscle, used to shuttle nitrogen (as the amide) between tissues.", "Clinical medicine: oral L-glutamine powder (Endari) to reduce sickle-cell acute complications (pain crises, acute chest, hospitalisations) in patients ≥5 years.", "Clinical nutrition: supplied in parenteral nutrition almost always as the dipeptide L-alanyl-L-glutamine (not free L-glutamine) to support intestinal mucosa and immune cells in catabolic patients; also used in some enteral formulas.", "Dietary supplements / sports nutrition: bulk powder or capsules marketed for recovery, gut integrity, and immune support; evidence for healthy athletes is mixed and EU health claims are not authorised.", "Biopharmaceutical manufacturing and research: essential (or 'essential in culture') amino acid in mammalian cell-culture media (CHO, HEK); consumed rapidly and degrades to pyroglutamate and ammonia, so often replaced by alanyl-glutamine or glycyl-glutamine dipeptides.", "Chemical / diagnostic: chiral building block; 13C/15N-L-glutamine used as a metabolic tracer in cancer and immunology research (glutaminolysis).", "Food processing: minor direct food use as an amino acid; related enzyme glutaminase / glutamine transglutaminase uses are about other reagents, not bulk L-glutamine as the food itself." ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of L-glutamine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-measurements", "name": "Typical measurements", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ { "quantity": "Molecular mass (anhydrous)", "typical_range": "146.14", "unit": "g·mol⁻¹" }, { "quantity": "Specific optical rotation [α]D (pharmacopeial identity of the L-enantiomer)", "typical_range": "about +6.3 to +7.3 (c = 4, in water; confirm monograph conditions)", "unit": "° (degrees)" }, { "quantity": "Aqueous solubility (20-25 °C)", "typical_range": "roughly 25-45", "unit": "g·L⁻¹" }, { "quantity": "Human fasting plasma L-glutamine", "typical_range": "about 500-800 (typically ~600)", "unit": "µmol·L⁻¹" }, { "quantity": "Skeletal-muscle free glutamine (intracellular)", "typical_range": "about 20", "unit": "mmol·kg⁻¹ wet weight (order of magnitude)" }, { "quantity": "Oral pharmaceutical dose (sickle cell, Endari)", "typical_range": "5-15 g twice daily, weight-banded (10-65 kg+)", "unit": "g·day⁻¹ (as two divided doses)" }, { "quantity": "Supplement serving (sports/gut products)", "typical_range": "5-10 per serving; 5-30 total", "unit": "g·day⁻¹" }, { "quantity": "Cell-culture media concentration (free L-glutamine)", "typical_range": "2-4 (often 2)", "unit": "mmol·L⁻¹" }, { "quantity": "Assay (USP/FCC)", "typical_range": "98.0-101.0 (dried basis, typical amino-acid monograph window)", "unit": "% w/w" }, { "quantity": "Isoelectric point (pI)", "typical_range": "about 5.65", "unit": "pH units" } ], "questions": [ { "id": "evidence-measurements-q01", "text": "Which of these typical measurements hold for the sense of L-glutamine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "Chemical instability in water: cyclises to pyroglutamic acid (5-oxoproline) and releases ammonia, especially with heat, time, and non-neutral pH - the reason free glutamine is omitted from heat-sterilised PN bags.", "Ammonia load: degradation in media or in vivo deamidation (glutaminase) produces NH3/NH4+, toxic to cells in culture and a concern in hepatic encephalopathy.", "Clinical inefficacy / over-claim: sports and 'immune booster' uses often fail to show benefit in well-fed athletes; marketing claims can outrun evidence.", "GI adverse effects at high oral doses: nausea, vomiting, abdominal pain, constipation or gas (seen in the Endari trials and in supplement use).", "Drug-disease caution: extra nitrogen/glutamate-glutamine flux is used carefully in severe hepatic disease; glutamine is a preferred fuel of some cancers (glutaminolysis), which complicates high-dose use in oncology (still investigational).", "Confusion with MSG / free glutamate: oral glutamine is not the same exposure as monosodium glutamate, but both sit on the glutamate-glutamine axis and are mixed up in public discussion.", "Powder handling: hygroscopic caking; microbial contamination of bulk amino-acid powders if poorly stored; not a high-potency toxin but pharmaceutical grades require endotoxin/bioburden control.", "D-glutamine or racemate substitution: wrong stereoisomer is not proteinogenic in humans and would fail pharmacopeial optical-rotation tests." ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of L-glutamine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-regional-variation", "name": "Regional variation", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "United States: L-glutamine exists both as an FDA-approved drug (Endari for sickle cell) and as a widely sold dietary supplement; the same molecule, different legal pathways and labeling.", "European Union: no authorised EFSA health claims for glutamine in foods/supplements; parenteral glutamine is typically the dipeptide (Dipeptiven and generics), not free L-glutamine in the bag.", "Japan / East Asia: L-glutamine has a longer clinical-nutrition and GI-mucosal tradition (e.g. hospital enteral use, some OTCs); food-additive and pharma grades follow JP (Japanese Pharmacopoeia) as well as USP/Ph. Eur.", "Sports-nutrition markets (US, Brazil, UK): high visibility as a recovery powder; in the EU the same products cannot carry immune or muscle claims.", "Naming: 'glutamine' in clinical PN almost always means alanyl-glutamine dipeptide; in gym supplements it means free L-glutamine powder; in biochemistry it may mean the residue Gln/Q.", "Sickle-cell indication is a US (and some other) regulatory approval, not a universal standard of care worldwide." ], "questions": [ { "id": "evidence-regional-variation-q01", "text": "Which of these regional variation hold for the sense of L-glutamine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ { "name": "D-glutamine", "difference": "Mirror-image enantiomer (CAS 5959-95-5). Separate by specific optical rotation (L is dextrorotatory under USP conditions) or chiral HPLC; only L is proteinogenic in animals." }, { "name": "DL-glutamine (racemate)", "difference": "Equimolar L+D (CAS 6899-04-3). Optical rotation ~0; pharmacopeial [α]D and chiral chromatography distinguish it from L." }, { "name": "L-glutamic acid / glutamate (Glu, E)", "difference": "Same carbon skeleton but a free γ-carboxylate instead of the carboxamide. Ninhydrin/HPLC amino-acid analysis, mass (147.13 vs 146.14), and side-chain pKa; glutamate is an excitatory neurotransmitter and the residue after glutaminase action." }, { "name": "Monosodium glutamate (MSG)", "difference": "Sodium salt of L-glutamic acid used as a flavour enhancer (E621), not the amide. Label, sodium content, and IR/NMR of carboxylate vs amide; MSG is not a glutamine supplement." }, { "name": "L-alanyl-L-glutamine (and glycyl-L-glutamine) dipeptides", "difference": "Heat-stable PN/media forms that release glutamine after hydrolysis. Different MW (217 vs 146), peptide bond in NMR/MS, and labeled as dipeptide APIs (e.g. Dipeptiven), not 'L-glutamine USP'." }, { "name": "Pyroglutamic acid (5-oxoproline)", "difference": "Cyclisation/degradation product of glutamine (and also of glutathione metabolism). No primary amine of an α-amino acid in the same way; appears as a related-substance peak in stability studies." }, { "name": "Asparagine (L-Asn)", "difference": "Homologous shorter amide (C4 vs C5). Amino-acid analyser retention time and mass (132.12 vs 146.14); both are amide amino acids but Asn is encoded by AAY and is not the main plasma nitrogen shuttle." }, { "name": "Glutaminase / glutamine synthetase (enzymes) and gluten", "difference": "Name-neighbours only. Enzymes are proteins that make or break glutamine; gluten is a wheat storage-protein mixture. Identity is by CAS/InChI of the small molecule versus protein/foodstuff class." } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of L-glutamine this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Does an existing Vercy world model already own this chemical concept, and which canonical publication should this registry entry reference?", "Should isotopically labelled L-glutamine and explicitly isolated salt forms be represented as variants here or linked registered things?", "Which authoritative specifications and analytical methods should govern identity, enantiomeric composition and assay for each intended grade?", "What stability evidence supports storage and beyond-use limits for the actual solid or solution, concentration, matrix and handling history?", "Which application-specific limits for degradation products and contamination determine whether a particular lot remains usable?" ], "statistics": { "bundles": 6, "layers": 11, "findings": 18, "questions": 30 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "chemical substance or material", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a L-glutamine, record what state it is in, and decide what may be done with it.", "whatItIs": "Enable an AI agent to recognise L-glutamine, assess the identity and condition of a particular material, and determine whether a proposed handling or use is supported by evidence.", "characteristics": { "substance": "material", "origin": "natural", "agency": "inert", "mobility": "varies" }, "whatYouCanDoWithIt": [ "observed and measured", "consumed or used up" ], "distinguishingFeatures": [ "Described in 63 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a L-glutamine, and on what evidence are they told apart?" ], "whatItIsMadeOf": "matter you can touch", "physicalCharacter": [ "Mobility varies between examples.", "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state", "use it up, and then need more of it" ], "howItIsRecognised": [ "Not recognisable by sight in any reliable way. Appearance varies with grade, form and additives; identification is by label, by documentation, or by assay." ], "relatedModels": [], "standing": "Described in 63 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one L-glutamine from another, and a L-glutamine from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a L-glutamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a L-glutamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a L-glutamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a L-glutamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a L-glutamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a L-glutamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a L-glutamine sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a L-glutamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a L-glutamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a L-glutamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a L-glutamine from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a L-glutamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a L-glutamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a L-glutamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "form-and-composition", "name": "Form, composition and condition", "description": "What a L-glutamine is made of, what shape and size it takes, and what state it is in.", "rationale": "A physical thing can be measured, and a model that cannot record its measurements cannot support any decision that depends on them.", "layers": [ { "id": "form-and-dimensions", "name": "Form and dimensions", "description": "Shape, size, mass and the ranges these take across examples.", "findings": [ { "id": "measurable-dimensions", "name": "Measurable dimensions and their units", "description": "The quantities worth recording and the units they are recorded in.", "questions": [ { "id": "measurable-dimensions-q01", "text": "What identifies and describes the dimensions of a L-glutamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "measurable-dimensions-q02", "text": "Who or what asserted this about the dimensions of a L-glutamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "measurable-dimensions-q03", "text": "What may an agent decide or do once the dimensions of a L-glutamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "material-and-composition", "name": "Material and composition", "description": "Materials, parts and how they are put together.", "findings": [ { "id": "parts-and-materials", "name": "Parts and materials", "description": "What a L-glutamine is built from and which parts are replaceable.", "questions": [ { "id": "parts-and-materials-q01", "text": "What identifies and describes the composition of a L-glutamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "parts-and-materials-q02", "text": "Who or what asserted this about the composition of a L-glutamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "parts-and-materials-q03", "text": "What may an agent decide or do once the composition of a L-glutamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "condition-and-integrity", "name": "Condition and integrity", "description": "Wear, damage, health and the difference between working and broken.", "findings": [ { "id": "condition-assessment", "name": "Condition, damage and health", "description": "How the condition of a L-glutamine is judged and by whom.", "questions": [ { "id": "condition-assessment-q01", "text": "What identifies and describes the condition of a L-glutamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "condition-assessment-q02", "text": "Who or what asserted this about the condition of a L-glutamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "condition-assessment-q03", "text": "What may an agent decide or do once the condition of a L-glutamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "place-and-movement", "name": "Place and movement", "description": "Where a L-glutamine is, how it got there and where it may go (varies).", "rationale": "A thing that can move needs its position recorded with a time, or every later claim about it is about a place it has left.", "layers": [ { "id": "location-and-placement", "name": "Location and placement", "description": "Position, containment and the reference frame the position is given in.", "findings": [ { "id": "position-and-frame", "name": "Position, container and reference frame", "description": "Where a L-glutamine is, and what that position is measured against.", "questions": [ { "id": "position-and-frame-q01", "text": "What identifies and describes the location of a L-glutamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "position-and-frame-q02", "text": "Who or what asserted this about the location of a L-glutamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "position-and-frame-q03", "text": "What may an agent decide or do once the location of a L-glutamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "movement-and-transfer", "name": "Movement and transfer", "description": "How a L-glutamine is carried, installed or relocated.", "findings": [ { "id": "movement-events", "name": "Movement events and constraints", "description": "What counts as a movement, what records it and what limits it.", "questions": [ { "id": "movement-events-q01", "text": "What identifies and describes the movement of a L-glutamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "movement-events-q02", "text": "Who or what asserted this about the movement of a L-glutamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "movement-events-q03", "text": "What may an agent decide or do once the movement of a L-glutamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a L-glutamine passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a L-glutamine between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a L-glutamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a L-glutamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a L-glutamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a L-glutamine, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a L-glutamine is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a L-glutamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a L-glutamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a L-glutamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "use-and-operation", "name": "Use and operation", "description": "What can be done with a L-glutamine and what it takes to do it.", "rationale": "An agent that can recognise a thing but not act on it has only half a model.", "layers": [ { "id": "intended-use", "name": "Intended use and function", "description": "What a L-glutamine is for, and what it is used for anyway.", "findings": [ { "id": "function-and-purpose", "name": "Function, purpose and misuse", "description": "The function a L-glutamine performs and the uses that fall outside it.", "questions": [ { "id": "function-and-purpose-q01", "text": "What identifies and describes the use of a L-glutamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "function-and-purpose-q02", "text": "Who or what asserted this about the use of a L-glutamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "function-and-purpose-q03", "text": "What may an agent decide or do once the use of a L-glutamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "handling-and-procedure", "name": "Handling and procedure", "description": "The steps, skills and tools involved in using a L-glutamine.", "findings": [ { "id": "procedures-and-skills", "name": "Procedures, skills and required tools", "description": "What an agent needs before it can act on a L-glutamine at all.", "questions": [ { "id": "procedures-and-skills-q01", "text": "What identifies and describes handling a L-glutamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "procedures-and-skills-q02", "text": "Who or what asserted this about handling a L-glutamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "procedures-and-skills-q03", "text": "What may an agent decide or do once handling a L-glutamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "supply-and-consumption", "name": "Supply and consumption", "description": "Quantities, rates and what running out means.", "findings": [ { "id": "consumption-and-stock", "name": "Consumption, stock and replenishment", "description": "How much of a L-glutamine there is and how fast it goes.", "questions": [ { "id": "consumption-and-stock-q01", "text": "What identifies and describes the supply of a L-glutamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "consumption-and-stock-q02", "text": "Who or what asserted this about the supply of a L-glutamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "consumption-and-stock-q03", "text": "What may an agent decide or do once the supply of a L-glutamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "composition-and-identity", "name": "Composition, grade and chemical identity", "description": "What L-glutamine is made of and how pure the thing in hand is.", "rationale": "Grade decides what a substance may be used for, so a model that records only the name cannot support any decision about use.", "layers": [ { "id": "chemical-identity", "name": "Chemical identity", "description": "Formula, structure and the registry numbers that name it unambiguously.", "findings": [ { "id": "identity-record", "name": "Identity and registry numbers", "description": "What identifies this substance across suppliers and regulators.", "questions": [ { "id": "identity-record-q01", "text": "What formula, structure and registry identifiers name L-glutamine unambiguously?", "kind": "definition" }, { "id": "identity-record-q02", "text": "Which related substances share a name in common use but not an identifier?", "kind": "boundary" } ] } ] }, { "id": "grade-and-impurities", "name": "Grade, purity and impurities", "description": "The specification a batch meets and what else is in it.", "findings": [ { "id": "specification", "name": "Specification and assay", "description": "How purity is stated and measured, and which impurities matter.", "questions": [ { "id": "specification-q01", "text": "What grades of L-glutamine exist, how is purity assayed, and which impurities are limited?", "kind": "measurement" }, { "id": "specification-q02", "text": "Which use requires which grade, and what happens when a lower grade is substituted?", "kind": "action" } ] } ] } ] }, { "id": "properties-and-behaviour", "name": "Properties and behaviour", "description": "How L-glutamine behaves under conditions an agent can measure or change.", "rationale": "Physical constants are the part of a substance model that transfers between contexts, and each needs its unit and its conditions.", "layers": [ { "id": "physical-constants", "name": "Physical constants", "description": "Values that hold for the pure substance, with their conditions.", "findings": [ { "id": "constants-record", "name": "Constants and conditions", "description": "The quantities worth recording and the state they apply in.", "questions": [ { "id": "constants-record-q01", "text": "What are the defining physical constants of L-glutamine, in what units and under what conditions?", "kind": "measurement" }, { "id": "constants-record-q02", "text": "Which of these values change with grade or form rather than being fixed?", "kind": "boundary" } ] } ] }, { "id": "stability-and-reactivity", "name": "Stability and reactivity", "description": "What it reacts with, degrades into, and how it is stored.", "findings": [ { "id": "incompatibilities", "name": "Incompatibilities and degradation", "description": "What must not meet it, and what it becomes over time.", "questions": [ { "id": "incompatibilities-q01", "text": "What is L-glutamine incompatible with, and what does it degrade into under storage?", "kind": "definition" }, { "id": "incompatibilities-q02", "text": "What storage and handling does that require, and who is competent to do it?", "kind": "action" } ] } ] } ] }, { "id": "hazard-and-regulation", "name": "Hazard classification and regulation", "description": "How L-glutamine can harm, and what the law says about holding and moving it.", "rationale": "A substance model without its hazard class and its regulatory identity is unusable in exactly the situations that matter.", "layers": [ { "id": "hazard-class", "name": "Hazard classification", "description": "Classified hazards, exposure limits and protective measures.", "findings": [ { "id": "classified-hazards", "name": "Classified hazards and limits", "description": "The classification, the scheme it belongs to, and the limits set.", "questions": [ { "id": "classified-hazards-q01", "text": "How is L-glutamine classified for hazard, under which scheme, and what exposure limits apply?", "kind": "definition" }, { "id": "classified-hazards-q02", "text": "What protection does handling require, and what must an agent refuse to do without it?", "kind": "action" } ] } ] }, { "id": "regulatory-identity", "name": "Regulatory identity and control", "description": "Registration, restriction and transport rules by jurisdiction.", "findings": [ { "id": "controls", "name": "Controls and jurisdiction", "description": "Where it is restricted and what the restriction attaches to.", "questions": [ { "id": "controls-q01", "text": "Which registrations, restrictions or transport rules cover L-glutamine, and where?", "kind": "provenance" }, { "id": "controls-q02", "text": "Does the control attach to the substance, its concentration, or its intended use?", "kind": "boundary" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a L-glutamine came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a L-glutamine and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a L-glutamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a L-glutamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a L-glutamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a L-glutamine is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a L-glutamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a L-glutamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a L-glutamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 9, "layers": 20, "findings": 22, "questions": 60 } } } }