{ "model": { "rank": 4223, "code": "thing-q184627", "model_id": "vr.tr.human-papillomavirus-infection", "name": "human papillomavirus infection", "purpose": "Let an agent explain HPV infection and its outcomes in neutral clinical terms, relay transmission, vaccination, screening and treatment of consequences from public health and oncology sources, describe HPV-related cancers, and route personal questions to clinicians.", "family": "Thing Registry", "category": "Cross-cutting context", "status": "research-draft", "kind": "thing", "plane": "XCT", "domain": "XCT.QLT", "industry": "", "version": "", "url": "/models/thing/q184627/", "tier": 2, "score": 77, "payload": { "layer": "wikidata", "aliases": [ "Head and neck cancer VPH-positive", "human papillomavirus related carcinoma", "human papillomavirus related adenocarcinoma", "human papilloma virus related endocervical adenocarcinoma", "Bowenoid papulosis", "AIDS-related Human papillomavirus infectious disease" ], "aliasCount": 6, "merged": 6, "knownIn": 77, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q184627", "url": "https://www.wikidata.org/wiki/Q184627", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-13T06:32:40Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 3, "engine": "claude" }, "metaModel": { "id": "THING-Q184627", "registryId": "vr.tr.human-papillomavirus-infection", "name": "human papillomavirus infection", "version": "0.2.0-wave.3", "entryKind": "thing", "family": "Thing Registry", "domain": [ "XCT.QLT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q184627/", "model": { "registry_id": "vr.tr.human-papillomavirus-infection", "name": "human papillomavirus infection", "purpose": "Let an agent explain HPV infection and its outcomes in neutral clinical terms, relay transmission, vaccination, screening and treatment of consequences from public health and oncology sources, describe HPV-related cancers, and route personal questions to clinicians.", "definition": "Infection with human papillomaviruses, a large group of DNA viruses transmitted mainly by skin and sexual contact, most infections clearing without symptoms, with low-risk types causing warts and lesions such as bowenoid papulosis and high-risk types causing persistent infection that can lead to cervical, anal, penile, vulvar and HPV-positive head and neck cancers including carcinomas and endocervical adenocarcinomas, with higher risk in people with HIV; HPV infection is prevented by vaccination and its consequences by screening.", "what_it_is_for": "Not applicable; an infection.", "affordances": [ "explain the infection and types", "relay prevention and screening", "describe related cancers", "route personal questions" ], "distinguishing_features": [ "Very common", "Usually clears", "High and low-risk types", "Vaccine-preventable" ], "appearance": "Not a visible object; usually silent, sometimes warts or lesions.", "visual_identification": [ "Infection with human papillomaviruses", "Low-risk types causing warts and bowenoid papulosis; high-risk types causing HPV-related carcinomas and adenocarcinomas; HPV in people with HIV", "Herpes is a different virus; cervical cancer is one outcome; genital warts are one manifestation" ], "physical_properties": [ { "quantity": "HPV types", "typical_range": "over 200", "unit": "count", "note": "" }, { "quantity": "high-risk types", "typical_range": "16 and 18 cause about 70 percent of cervical cancers", "unit": "note", "note": "" }, { "quantity": "vaccine introduced", "typical_range": "2006", "unit": "year", "note": "" }, { "quantity": "lifetime infection", "typical_range": "most sexually active people", "unit": "note", "note": "" } ], "families_and_kinds": [ "low-risk infections causing common, plantar and genital warts", "lesions such as bowenoid papulosis", "persistent high-risk infection and precancerous lesions", "HPV-related cervical, anal, penile, vulvar and vaginal cancers including endocervical adenocarcinoma", "HPV-positive oropharyngeal and head and neck cancers", "HPV infection in people with HIV" ], "related_models": [ { "relation": "is a kind of", "target": "Papillomavirus infections", "why": "in registry terms" }, { "relation": "is caused by", "target": "human papillomavirus", "why": "of many types" }, { "relation": "is prevented by", "target": "HPV vaccine", "why": "in adolescents and adults" }, { "relation": "can lead to", "target": "cervical cancer", "why": "and other cancers" } ], "identifiers": [ { "scheme": "ICD-11", "value_or_pattern": "1A95 and related", "note": "anogenital warts and HPV infection codes" }, { "scheme": "MeSH", "value_or_pattern": "D030361", "note": "papillomavirus infections" } ], "standards_and_regulation": [ "WHO recommendations on HPV vaccination and cervical screening", "National immunisation schedules", "Cervical cancer elimination strategy" ], "failure_modes_and_hazards": [ "Agents giving personal medical advice", "Stigma around sexually transmitted infection", "Vaccine misinformation" ], "in_scope": [], "out_of_scope": [], "characteristics": [] }, "sources": [], "structure": { "bundles": [ { "id": "help", "name": "Help", "description": "Personal questions first.", "rationale": "Safety.", "layers": [ { "id": "symptoms", "name": "Symptoms", "description": "Symptoms and results.", "findings": [ { "id": "symptoms-finding", "name": "Symptoms", "description": "Symptoms.", "questions": [ { "text": "Why do genital warts, abnormal screening results or persistent lumps and ulcers need a clinician?", "kind": "action" }, { "text": "Is the user asking about their own infection, result or exposure, which needs a clinician?", "kind": "boundary" } ] } ] }, { "id": "vaccine", "name": "Vaccine", "description": "Vaccination and screening.", "findings": [ { "id": "vaccine-finding", "name": "Vaccine", "description": "Vaccine.", "questions": [ { "text": "Who is offered HPV vaccination and cervical screening, according to WHO and national programmes?", "kind": "provenance" }, { "text": "Which entry fits HPV vaccine?", "kind": "action" } ] } ] } ] }, { "id": "understand", "name": "Understand", "description": "The infection.", "rationale": "Clinical.", "layers": [ { "id": "types", "name": "Types", "description": "Types and outcomes.", "findings": [ { "id": "types-finding", "name": "Types", "description": "Types.", "questions": [ { "text": "How do low-risk and high-risk HPV types differ, and how does persistent infection lead to cancer?", "kind": "definition" }, { "text": "Is the question about HPV infection, a related cancer or another infection?", "kind": "boundary" } ] } ] }, { "id": "transmission", "name": "Transmission", "description": "Transmission.", "findings": [ { "id": "transmission-finding", "name": "Transmission", "description": "Transmission.", "questions": [ { "text": "How is HPV transmitted, and why is it so common?", "kind": "definition" }, { "text": "Which entry fits sexually transmitted infection?", "kind": "action" } ] } ] } ] }, { "id": "cancers", "name": "Cancers", "description": "HPV-related cancers.", "rationale": "Clinical.", "layers": [ { "id": "cancers", "name": "Cancers", "description": "Cancers.", "findings": [ { "id": "cancers-finding", "name": "Cancers", "description": "Cancers.", "questions": [ { "text": "What are HPV-related cervical, anal, penile, vulvar and head and neck cancers, in general terms?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "hiv", "name": "HIV", "description": "HPV and HIV.", "findings": [ { "id": "hiv-finding", "name": "HIV", "description": "HIV.", "questions": [ { "text": "Why is HPV disease more common and severe in people with HIV, and what care is recommended?", "kind": "provenance" }, { "text": "Which sources are cited?", "kind": "provenance" } ] } ] } ] }, { "id": "context", "name": "Context", "description": "Prevention and history.", "rationale": "Context.", "layers": [ { "id": "elimination", "name": "Elimination", "description": "Elimination strategy.", "findings": [ { "id": "elimination-finding", "name": "Elimination", "description": "Elimination.", "questions": [ { "text": "What is the WHO cervical cancer elimination strategy, and what progress has been made, with data attributed?", "kind": "provenance" }, { "text": "Which entry fits cervical cancer elimination?", "kind": "action" } ] } ] }, { "id": "history", "name": "History", "description": "History.", "findings": [ { "id": "history-finding", "name": "History", "description": "History.", "questions": [ { "text": "How did zur Hausen link HPV to cervical cancer, and how did vaccines develop?", "kind": "provenance" }, { "text": "Which entry fits the history of the HPV vaccine?", "kind": "action" } ] } ] } ] } ] }, "openQuestions": [ "Should HPV vaccine and cervical screening be separate primary entries?", "How should public health sources be linked?", "The registry entry has merged aliases naming specific cancers and lesions; should they be split off?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "disease or condition", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a human papillomavirus infection, record what state it is in, and decide what may be done with it.", "whatItIs": "Let an agent explain HPV infection and its outcomes in neutral clinical terms, relay transmission, vaccination, screening and treatment of consequences from public health and oncology sources, describe HPV-related cancers, and route personal questions to clinicians.", "characteristics": { "substance": "abstract", "origin": "conceptual", "agency": "inert" }, "whatYouCanDoWithIt": [ "observed and measured" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: Head and neck cancer VPH-positive, human papillomavirus related carcinoma, human papillomavirus related adenocarcinoma, human papilloma virus related endocervical adenocarcinoma, Bowenoid papulosis, AIDS-related Human papillomavirus infectious disease.", "6 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 77 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a human papillomavirus infection, and on what evidence are they told apart?" ], "whatItIsMadeOf": "an abstraction with no physical instance", "physicalCharacter": [ "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state" ], "howItIsRecognised": [ "Recognised by criteria applied to signs and findings, not by appearance. Two conditions can look identical and be distinguished only by test." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "Head and neck cancer VPH-positive", "human papillomavirus related carcinoma", "human papillomavirus related adenocarcinoma", "human papilloma virus related endocervical adenocarcinoma", "Bowenoid papulosis", "AIDS-related Human papillomavirus infectious disease" ] } ], "standing": "Described in 77 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 6 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one human papillomavirus infection from another, and a human papillomavirus infection from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a human papillomavirus infection, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a human papillomavirus infection, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a human papillomavirus infection is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a human papillomavirus infection, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a human papillomavirus infection, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a human papillomavirus infection is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a human papillomavirus infection sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a human papillomavirus infection, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a human papillomavirus infection, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a human papillomavirus infection is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a human papillomavirus infection from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a human papillomavirus infection, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a human papillomavirus infection, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a human papillomavirus infection is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a human papillomavirus infection passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a human papillomavirus infection between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a human papillomavirus infection, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a human papillomavirus infection, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a human papillomavirus infection is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a human papillomavirus infection, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a human papillomavirus infection is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a human papillomavirus infection, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a human papillomavirus infection, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a human papillomavirus infection is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "diagnosis-and-criteria", "name": "Diagnosis, criteria and coding", "description": "What makes a case of human papillomavirus infection a case, and under which revision.", "rationale": "Criteria change between revisions, so a diagnosis without its coding revision cannot be compared with a later one.", "layers": [ { "id": "criteria", "name": "Diagnostic criteria", "description": "The criteria in force and who issues them.", "findings": [ { "id": "criteria-record", "name": "Criteria, issuer and revision", "description": "What must be true for a diagnosis, according to whom.", "questions": [ { "id": "criteria-record-q01", "text": "What criteria define human papillomavirus infection, issued by which body, in which revision?", "kind": "definition" }, { "id": "criteria-record-q02", "text": "What changed between revisions that would reclassify existing cases?", "kind": "boundary" } ] } ] }, { "id": "coding", "name": "Coding and terminology", "description": "The codes used to record it and their mapping.", "findings": [ { "id": "coding-record", "name": "Codes and mappings", "description": "Which classification codes apply and how they map.", "questions": [ { "id": "coding-record-q01", "text": "Which classification and terminology codes cover human papillomavirus infection, and how do they map to each other?", "kind": "definition" }, { "id": "coding-record-q02", "text": "What is lost when a case is mapped from one scheme to another?", "kind": "boundary" } ] } ] } ] }, { "id": "course-and-population", "name": "Course, population and care", "description": "How human papillomavirus infection develops, whom it affects, and what is done about it.", "rationale": "The condition, the diagnosis and the episode of care are three different things, and an agent must not merge them.", "layers": [ { "id": "course", "name": "Course and stages", "description": "Onset, progression, remission and outcome.", "findings": [ { "id": "course-record", "name": "Stages and transitions", "description": "The stages recorded and what moves a case between them.", "questions": [ { "id": "course-record-q01", "text": "What course does human papillomavirus infection typically take, and what marks each stage?", "kind": "definition" }, { "id": "course-record-q02", "text": "What separates the condition itself from an episode of care for it?", "kind": "boundary" } ] } ] }, { "id": "population", "name": "Affected populations", "description": "Who is affected, how often, and on what evidence.", "findings": [ { "id": "epidemiology", "name": "Prevalence and its basis", "description": "Rates with their population, period and source.", "questions": [ { "id": "epidemiology-q01", "text": "What prevalence or incidence is reported for human papillomavirus infection, in which population and period?", "kind": "measurement" }, { "id": "epidemiology-q02", "text": "What may an agent not conclude about an individual from a population rate?", "kind": "action" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a human papillomavirus infection came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a human papillomavirus infection and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a human papillomavirus infection, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a human papillomavirus infection, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a human papillomavirus infection is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a human papillomavirus infection is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a human papillomavirus infection, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a human papillomavirus infection, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a human papillomavirus infection is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 5, "layers": 10, "findings": 12, "questions": 32 } } } }