{ "model": { "rank": 5855, "code": "thing-q189474", "model_id": "vr.tr.keratins", "name": "keratins", "purpose": "Enable an AI agent to recognise keratin proteins and keratin-derived materials, assess their molecular and material state, and select actions supported by their identity, processing history and measured behaviour.", "family": "Thing Registry", "category": "Physical world and living systems", "status": "research-draft", "kind": "thing", "plane": "PHY", "domain": "PHY.MAT", "industry": "", "version": "", "url": "/models/thing/q189474/", "tier": 2, "score": 64, "payload": { "layer": "wikidata", "aliases": [ "keratin, type I", "Keratin, type I cytoskeletal 18", "Phakinin", "Keratin, type II", "Alpha-keratin", "beta-keratin", "hair keratin", "hair-specific keratins", "type I hair keratin", "type II hair keratin" ], "aliasCount": 10, "merged": 10, "knownIn": 64, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q189474", "url": "https://www.wikidata.org/wiki/Q189474", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-07T09:44:34Z", "providers": [ "Codex", "Grok" ], "missingProviders": [], "pass": 2, "cost": { "grok": { "usd": 0.00670344, "turns": 1, "seconds": 105.6, "error": null }, "codex": { "seconds": 109.3, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.3\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a07b3c-9cc4-7e10-b7c8-34a3eefeae79\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: keratins\nRegistry id: vr.tr.keratins\nPlane / domain: PHY / PHY.MAT\nRegistry definition: (none recorded)\nNames folded into this entry: (none)\n\nA Vercy" } } }, "metaModel": { "id": "THING-Q189474", "registryId": "vr.tr.keratins", "name": "keratins", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.MAT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q189474/", "model": { "registry_id": "vr.tr.keratins", "name": "keratins", "purpose": "Enable an AI agent to recognise keratin proteins and keratin-derived materials, assess their molecular and material state, and select actions supported by their identity, processing history and measured behaviour.", "definition": "Keratins are a family of cysteine-rich, intermediate-filament-forming fibrous proteins that assemble as obligate type I/type II heterodimers into ~10 nm filaments, conferring mechanical resilience to epithelia and to cornified appendages (hair, nails, claws, horns, feathers).", "scope_statement": "This model owns vr.tr.keratins in PHY.MAT: keratin protein identity, composition, assembly, chemical condition and material behaviour, including traceable extracted or modified forms; the registry boundary for materials historically called beta-keratin remains unresolved.", "in_scope": [ "Keratin protein identities, sequence variants and type I/type II composition", "Keratin assemblies and their relationship to the surrounding biological material", "Extracted keratin fractions, recombinant preparations and traceable keratin derivatives", "Chain integrity, sulfur chemistry, hydration and structural condition", "Evidence needed to select processing, storage, testing and material-use actions" ], "out_of_scope": [ "Whole hair, wool, nail, horn, feather and skin anatomy or product classification", "Keratin genes as genomic entities and their inheritance", "Clinical diagnosis and treatment of keratin-associated diseases", "Keratin-associated proteins as independent protein families", "Complete cosmetic, textile or biomedical formulations and their product-level approval" ], "distinguishing_features": [ "Require sequence or discriminating peptide evidence for keratin-family assignment; fibrous appearance, insolubility or a protein spectrum alone cannot distinguish keratins from collagen, silk or other structural proteins.", "For an intermediate-filament identity, record type I/type II assignment and evidence for compatible heterotypic assembly; assembly failure in a processed sample does not alone exclude keratin ancestry. See [recombinant keratin assembly experiments](https://pubmed.ncbi.nlm.nih.gov/1691189/).", "Distinguish a keratin protein fraction from a keratin-rich tissue or composite by identifying accompanying proteins and nonprotein constituents.", "For material labelled beta-keratin, require molecular-family identification before treating the label as equivalent to intermediate-filament keratin; a beta-sheet signal alone does not settle that boundary.", "Distinguish intact keratin preparations from hydrolysates and chemically modified derivatives using chain-size distribution and processing evidence. See [comparative wool extraction experiments](https://ourarchive.otago.ac.nz/esploro/outputs/journalArticle/Evaluation-of-keratin-extraction-from-wool/9926515221701891)." ], "characteristics": [ { "name": "Keratin molecular identity", "kind": "category", "unit_or_values": "Protein accession and version, species, sequence variant; unresolved mixture or unconfirmed label", "why_it_matters": "Determines whether evidence and expected behaviour apply to the material being assessed." }, { "name": "Biological or recombinant origin", "kind": "relation", "unit_or_values": "Source organism and tissue, or expression construct and host, linked to preparation", "why_it_matters": "Connects the keratin to expected constituents and relevant production history." }, { "name": "Type I/type II composition", "kind": "measurement", "unit_or_values": "Identified constituents and molar ratio, with analytical uncertainty; unknown where unresolved", "why_it_matters": "Supports evaluation of partner availability for filament assembly." }, { "name": "Keratin fraction", "kind": "measurement", "unit_or_values": "Mass percent on a stated wet or dry basis, with assay method", "why_it_matters": "Separates keratin properties from effects of associated proteins, additives and tissue residues." }, { "name": "Polypeptide size distribution", "kind": "measurement", "unit_or_values": "kDa distribution and fragment fraction, with method", "why_it_matters": "Helps distinguish preserved chains from fragmented material and qualify processing options." }, { "name": "Assembly condition", "kind": "state", "unit_or_values": "Dispersed chains, oligomers, filaments, network, aggregates, mixed or unmeasured", "why_it_matters": "Identifies the structural level responsible for current behaviour." }, { "name": "Sulfur chemical condition", "kind": "measurement", "unit_or_values": "Free thiol and disulfide content in micromoles per gram; identified oxidised or derivatised sulfur species", "why_it_matters": "Supports decisions about reduction, oxidation and potential crosslinking without relying on total sulfur alone." }, { "name": "Secondary-structure signature", "kind": "measurement", "unit_or_values": "Method-specific spectral indicators or estimated helix, sheet and disordered fractions", "why_it_matters": "Helps track conformational changes while keeping them distinct from molecular-family identity." }, { "name": "Hydration", "kind": "measurement", "unit_or_values": "Grams of water per gram of dry material at stated temperature and relative humidity", "why_it_matters": "Makes comparisons of swelling and mechanical behaviour interpretable." }, { "name": "Soluble and dispersed fractions", "kind": "measurement", "unit_or_values": "Mass percent at specified solvent, pH, ionic strength, temperature and equilibration time", "why_it_matters": "Distinguishes dissolution from suspended particles when selecting processing conditions." }, { "name": "Mechanical response", "kind": "measurement", "unit_or_values": "Modulus and strength in MPa, strain in percent, or rheological moduli in Pa, with specimen and test conditions", "why_it_matters": "Supports use decisions for the tested material form without assigning one universal strength to keratins." }, { "name": "Processing lineage", "kind": "relation", "unit_or_values": "Ordered extraction, purification, chemical treatment, drying and storage events", "why_it_matters": "Explains which native properties may have been altered and which require remeasurement." } ], "affordances": [ "Assign or challenge a keratin identity using molecular evidence and explicit alternative identifications.", "Select complementary measurements to resolve composition, chain integrity, assembly and sulfur condition.", "Evaluate whether a preparation can be investigated for filament reassembly, dissolution, casting or crosslinking.", "Compare keratin preparations under matched hydration, composition and test conditions.", "Choose processing and storage conditions from preparation-specific evidence and identify properties requiring revalidation.", "Route an intended use to the relevant tissue, product or biological evaluation model with the keratin evidence attached." ] }, "sources": [ { "id": "schweizer-2006-nomenclature", "title": "New consensus nomenclature for mammalian keratins", "url": "https://doi.org/10.1083/jcb.200603161", "what_it_supports": "The K/KRT numbering system, type I versus type II classes, and the split between epithelial and hair keratins.", "url_status": "blocked" }, { "id": "bragulla-homberger-2009", "title": "Structure and functions of keratin proteins in simple, stratified, keratinized and cornified epithelia", "url": "https://doi.org/10.1111/j.1469-7580.2009.01076.x", "what_it_supports": "Tissue distribution, hard versus soft keratin, and the distinction from cornified-envelope proteins.", "url_status": "blocked" }, { "id": "hgnc-krt", "title": "HGNC gene group: Keratins (KRT)", "url": "https://www.genenames.org/data/genegroup/#!/group/725", "what_it_supports": "Official human gene symbols KRT1-KRT86 and the type I/type II gene grouping.", "url_status": "live" }, { "id": "uniprot-keratin", "title": "UniProtKB keyword: Keratin", "url": "https://www.uniprot.org/keywords/KW-0416", "what_it_supports": "Protein-family definition, cysteine-rich filament character, and accession-level identifiers for individual keratins.", "url_status": "live" } ], "structure": { "bundles": [ { "id": "keratin-identity-and-boundaries", "name": "Keratin identity and boundaries", "description": "Establish what the keratin designation refers to and how securely that identity is supported.", "rationale": "Keratin labels can refer to identified proteins, heterogeneous tissue extracts or extensively modified materials.", "layers": [ { "id": "molecular-family-assignment", "name": "Molecular family assignment", "description": "Resolve protein-family membership and constituent identities.", "findings": [ { "id": "identity-evidence", "name": "Identity evidence", "description": "Record the evidence supporting each keratin assignment and the alternatives it excludes.", "questions": [ { "text": "Which species-specific protein identities or sequence variants are supported by sequence, discriminating peptides or validated recognition assays?", "kind": "definition", "id": "identity-evidence-q01" }, { "text": "Can the evidence distinguish those keratins from other intermediate-filament proteins and accompanying structural proteins?", "kind": "boundary", "id": "identity-evidence-q02" } ] } ] }, { "id": "keratin-label-interpretation", "name": "Keratin label interpretation", "description": "Separate protein identity from tissue names, historical terms and derivative labels.", "findings": [ { "id": "label-to-material-boundary", "name": "Label-to-material boundary", "description": "State whether the subject is a protein, mixture, tissue constituent or derivative, preserving unresolved terminology.", "questions": [ { "text": "Does keratin here denote identified proteins, a keratin-rich material, an extract or a hydrolysate?", "kind": "definition", "id": "label-to-material-boundary-q01" }, { "text": "If beta-keratin is claimed, what molecular evidence resolves whether it denotes a corneous beta-protein or another use of the term?", "kind": "boundary", "id": "label-to-material-boundary-q02" } ] } ] } ] }, { "id": "keratin-origin-and-composition", "name": "Keratin origin and composition", "description": "Connect the preparation to its biological or recombinant source and account for its constituents.", "rationale": "Source names alone cannot establish the protein mixture or the contribution of accompanying material.", "layers": [ { "id": "source-context", "name": "Source context", "description": "Record where the keratin originated and which source details affect interpretation.", "findings": [ { "id": "source-to-preparation-link", "name": "Source-to-preparation link", "description": "Trace the preparation to a tissue source or recombinant production route.", "questions": [ { "text": "Which organism and tissue supplied the material, or which construct and expression host produced it?", "kind": "provenance", "id": "source-to-preparation-link-q01" }, { "text": "Which source lots were pooled, and which source details remain unavailable?", "kind": "provenance", "id": "source-to-preparation-link-q02" } ] } ] }, { "id": "constituent-balance", "name": "Constituent balance", "description": "Distinguish keratin constituents from associated proteins and nonprotein matter.", "findings": [ { "id": "keratin-and-companion-fractions", "name": "Keratin and companion fractions", "description": "Account for the measured composition and the unidentified remainder.", "questions": [ { "text": "What fractions are assigned to keratins, keratin-associated proteins, other proteins and nonprotein constituents on a stated mass basis?", "kind": "measurement", "id": "keratin-and-companion-fractions-q01" }, { "text": "Which extraction residues, additives or source constituents could account for behaviour attributed to keratin?", "kind": "boundary", "id": "keratin-and-companion-fractions-q02" } ] } ] } ] }, { "id": "keratin-assembly-and-architecture", "name": "Keratin assembly and architecture", "description": "Describe partner composition, assembly competence and observed organisation.", "rationale": "Identifying keratin chains does not establish whether they currently form functional filaments or a load-bearing network.", "layers": [ { "id": "heterotypic-partners", "name": "Heterotypic partners", "description": "Establish which type I and type II constituents are available and whether their assembly has been demonstrated.", "findings": [ { "id": "partner-availability-and-competence", "name": "Partner availability and competence", "description": "Record partner identities, relative abundance and preparation-specific assembly evidence.", "questions": [ { "text": "Which type I and type II constituents are present, and what is their measured molar ratio?", "kind": "measurement", "id": "partner-availability-and-competence-q01" }, { "text": "Under which tested conditions do these constituents assemble, and what evidence distinguishes filaments from nonspecific aggregates?", "kind": "measurement", "id": "partner-availability-and-competence-q02" } ] } ] }, { "id": "observed-keratin-organisation", "name": "Observed keratin organisation", "description": "Connect molecular conformation to filament, network and specimen architecture.", "findings": [ { "id": "assembly-state-and-alignment", "name": "Assembly state and alignment", "description": "Describe the organisation actually observed at each measured scale.", "questions": [ { "text": "What microscopy, scattering or spectroscopic evidence supports the reported chain, filament, aggregate or network state?", "kind": "measurement", "id": "assembly-state-and-alignment-q01" }, { "text": "What alignment, packing and matrix relationships must be recorded before interpreting the specimen's directional behaviour?", "kind": "measurement", "id": "assembly-state-and-alignment-q02" } ] } ] } ] }, { "id": "keratin-chemical-integrity", "name": "Keratin chemical integrity", "description": "Track chain preservation and chemical changes relevant to keratin behaviour.", "rationale": "Processing can change chain size and sulfur chemistry independently, so neither an origin label nor a single assay establishes current integrity.", "layers": [ { "id": "chain-preservation", "name": "Chain preservation", "description": "Assess fragmentation, modifications and preservation of regions needed for the intended function.", "findings": [ { "id": "intact-chains-and-fragments", "name": "Intact chains and fragments", "description": "Record chain-size evidence and limitations in assigning intactness.", "questions": [ { "text": "What molecular-size distribution and peptide coverage support the reported intact-chain and fragment fractions?", "kind": "measurement", "id": "intact-chains-and-fragments-q01" }, { "text": "Which observed truncations or modifications require testing before assuming filament assembly or film formation remains possible?", "kind": "action", "id": "intact-chains-and-fragments-q02" } ] } ] }, { "id": "sulfur-and-crosslink-condition", "name": "Sulfur and crosslink condition", "description": "Distinguish thiols, disulfides and chemically altered sulfur from other crosslinks.", "findings": [ { "id": "crosslink-reactivity", "name": "Crosslink reactivity", "description": "Record measured chemical species and evidence for their accessibility or participation in crosslinking.", "questions": [ { "text": "What free thiol, disulfide and oxidised or derivatised sulfur species have been measured, using which mass basis and assay?", "kind": "measurement", "id": "crosslink-reactivity-q01" }, { "text": "What evidence supports reduction, reoxidation or another crosslinking action for this preparation?", "kind": "action", "id": "crosslink-reactivity-q02" } ] } ] } ] }, { "id": "keratin-material-response", "name": "Keratin material response", "description": "Describe behaviour under defined hydration, solvent, load and exposure conditions.", "rationale": "An agent needs condition-specific measurements to compare keratin materials and avoid transferring bulk tissue properties to isolated proteins.", "layers": [ { "id": "water-and-solvent-response", "name": "Water and solvent response", "description": "Separate water uptake, swelling, dissolution and dispersion.", "findings": [ { "id": "hydration-and-solubility-window", "name": "Hydration and solubility window", "description": "Record how the preparation responds to controlled moisture and liquid environments.", "questions": [ { "text": "What water uptake or swelling occurs at specified temperature, humidity or immersion conditions?", "kind": "measurement", "id": "hydration-and-solubility-window-q01" }, { "text": "What fraction dissolves rather than remains dispersed at the tested pH, ionic strength, solvent composition and exposure time?", "kind": "measurement", "id": "hydration-and-solubility-window-q02" } ] } ] }, { "id": "load-and-exposure-response", "name": "Load and exposure response", "description": "Assess mechanical performance and changes caused by relevant exposures.", "findings": [ { "id": "conditioned-performance", "name": "Conditioned performance", "description": "Tie performance to the specimen form, conditioning and evidence of deterioration.", "questions": [ { "text": "What mechanical or rheological response was measured at the stated hydration, geometry, orientation, temperature and loading rate?", "kind": "measurement", "id": "conditioned-performance-q01" }, { "text": "Which thermal, chemical or enzymatic exposures change chain integrity, mass or performance enough to rule out the intended action?", "kind": "action", "id": "conditioned-performance-q02" } ] } ] } ] }, { "id": "keratin-processing-and-use-decisions", "name": "Keratin processing and use decisions", "description": "Translate preparation history and measured condition into justified next actions.", "rationale": "Keratin provenance must remain connected to treatment-induced changes and the requirements of the intended use.", "layers": [ { "id": "extraction-and-transformation-history", "name": "Extraction and transformation history", "description": "Record treatments that produced the current keratin fraction.", "findings": [ { "id": "treatment-to-property-link", "name": "Treatment-to-property link", "description": "Connect extraction, purification and subsequent processing to measured changes.", "questions": [ { "text": "Which reduction, oxidation, sulfitolysis, hydrolysis or other treatments were applied, with what reagents, conditions and sequence?", "kind": "provenance", "id": "treatment-to-property-link-q01" }, { "text": "Which before-and-after measurements demonstrate retained identity, chain integrity and removal of processing residues?", "kind": "measurement", "id": "treatment-to-property-link-q02" } ] } ] }, { "id": "preparation-specific-action-selection", "name": "Preparation-specific action selection", "description": "Identify supported operations and the evidence still needed for the intended use.", "findings": [ { "id": "action-readiness", "name": "Action readiness", "description": "State whether this preparation is ready for a proposed operation or requires further characterisation.", "questions": [ { "text": "Which measured properties support the proposed reassembly, casting, blending, crosslinking or storage conditions?", "kind": "action", "id": "action-readiness-q01" }, { "text": "Which unresolved residues, stability limits or performance requirements require testing or referral to the intended product model before use?", "kind": "action", "id": "action-readiness-q02" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-kinds", "name": "Kinds and varieties", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "Type I (acidic) epithelial keratins (human K9-K28)", "Type II (basic/neutral) epithelial keratins (human K1-K8 and related)", "Hair/trichocyte keratins (type I K31-K40 and type II K81-K86, plus related hair keratins)", "Soft (epithelial/epidermal) keratins versus hard (appendage) keratins, distinguished by cysteine content and disulfide cross-linking", "α-keratins of mammals (coiled-coil intermediate-filament proteins)", "Reptile and bird corneous β-proteins, historically called β-keratins, which are not intermediate-filament keratins", "Cytokeratins, the pathology-lab name for epithelial keratins used in immunohistochemistry (e.g. CK7, CK20)", "Industrial/commodity keratins: wool, horn, hoof, feather, and hydrolyzed keratin used as fiber or cosmetic ingredient" ], "questions": [ { "id": "evidence-kinds-q01", "text": "Which of these kinds and varieties hold for the sense of keratins this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-identifiers", "name": "Identifiers and schemes", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ { "scheme": "Wikidata", "value_or_pattern": "Q169921", "note": "Item for keratin as a protein class." }, { "scheme": "HGNC gene symbol", "value_or_pattern": "KRT1-KRT86 (and related KRT genes)", "note": "Human gene nomenclature; protein products are often written K1, K14, etc." }, { "scheme": "UniProt keyword", "value_or_pattern": "KW-0416", "note": "Keyword Keratin; individual chains have their own UniProt accessions (e.g. P04264 for human KRT1)." }, { "scheme": "INCI (cosmetics)", "value_or_pattern": "Keratin; Hydrolyzed Keratin; Hydrolyzed Hair Keratin", "note": "Ingredient names for intact or hydrolyzed keratin in personal-care products." }, { "scheme": "CAS", "value_or_pattern": "68238-35-7 (keratin); 69430-36-0 (hydrolyzed keratin, commonly cited)", "note": "Commodity/cosmetic registry numbers, not a unique molecular identity." } ], "questions": [ { "id": "evidence-identifiers-q01", "text": "Which of these identifiers and schemes hold for the sense of keratins this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-standards-and-regulation", "name": "Standards and regulation", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "HUGO Gene Nomenclature Committee (HGNC): official KRT gene symbols and the keratin gene group.", "Schweizer et al. 2006 consensus (Journal of Cell Biology / accompanying keratin community agreement): protein numbering K1, K5, K14, etc., replacing older cytokeratin catalog numbers in cell biology.", "EU Cosmetic Products Regulation (EC) No 1223/2009 and CosIng/INCI: naming and safety listing of Keratin and Hydrolyzed Keratin as cosmetic ingredients.", "ISO 17751 (parts 1-2) and related IWTO/ISO wool-fibre test methods: identification and quantification of animal-hair (keratin) fibres in textiles.", "Clinical immunohistochemistry practice (CAP/CLSI-aligned lab protocols, not a single keratin statute): cytokeratin panels (CK7/CK20 and others) used to classify epithelial tumours." ], "questions": [ { "id": "evidence-standards-and-regulation-q01", "text": "Which of these standards and regulation hold for the sense of keratins this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "Structural protein of human epidermis, hair shafts, nails, and of wool, horn, hoof, claw, and feather.", "Diagnostic IHC: epithelial versus non-epithelial lineage, and CK7/CK20 (and other keratin) profiles to suggest primary site of carcinoma.", "Mutation diagnostics: KRT5/KRT14 in epidermolysis bullosa simplex; KRT1/KRT10 in epidermolytic ichthyosis; selected hair-keratin genes in monilethrix and related shaft disorders.", "Textiles and materials: wool and other animal-hair fibres; historic horn and hoof goods; research use of extracted keratin as films, sponges, and wound-dressing scaffolds.", "Personal care: hydrolyzed keratin as a film-former/conditioner in hair and nail products." ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of keratins this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-measurements", "name": "Typical measurements", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ { "quantity": "Monomer molecular mass (epithelial keratins)", "typical_range": "40-70", "unit": "kDa" }, { "quantity": "Intermediate-filament diameter", "typical_range": "8-12 (nominal ~10)", "unit": "nm" }, { "quantity": "Cysteine content (soft epithelial versus hard appendage keratins)", "typical_range": "~2-7 (soft) vs ~8-18 (hard/hair/wool), residue percent; wool often cited near 11-12% Cys", "unit": "mol% Cys (or g Cys/100 g protein)" }, { "quantity": "Isoelectric point (type I acidic versus type II basic)", "typical_range": "~4.9-5.4 (type I) vs ~6.5-8.5 (type II)", "unit": "pI" }, { "quantity": "α-helix content of α-keratins (coiled-coil rod)", "typical_range": "~40-60 of the chain in the rod domain; fibre α-keratins often ~40-50 overall", "unit": "%" } ], "questions": [ { "id": "evidence-measurements-q01", "text": "Which of these typical measurements hold for the sense of keratins this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "Dominant or recessive KRT mutations causing epidermolysis bullosa simplex, epidermolytic ichthyosis, pachyonychia congenita, palmoplantar keratodermas, and selected hair-shaft diseases (e.g. monilethrix).", "Chemical or thermal damage to hair/wool: cleavage of disulfide cross-links by bleaching, perming, or high heat, with loss of tensile strength and cuticle integrity.", "Misclassification in pathology if a limited cytokeratin panel is over-interpreted (some non-epithelial tumours can express keratins; some carcinomas lose them).", "Rare contact allergy or irritation attributed to hydrolyzed keratin or other animal-protein hydrolysates in cosmetics.", "Conservation and fraud issues around keratinous wildlife products (rhino horn, pangolin scale, tortoise shell) sold as traditional materials or medicines; these are keratin (or keratin-like corneous) tissues, not a distinct bioactive drug." ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of keratins this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-regional-variation", "name": "Regional variation", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ "Clinical pathology, especially in older and North American lab usage, still says 'cytokeratin' (CK5/6, CK7, CK20); cell biology and HGNC use keratin/KRT.", "Herpetology and ornithology long used 'β-keratin' for sauropsid corneous proteins; current literature often prefers corneous beta-proteins (CBPs) to avoid implying they are intermediate-filament keratins.", "Textile trade names fibres by animal and processing (wool, cashmere, mohair, alpaca) rather than by keratin isoform.", "East Asian pharmacopoeial and folk practice historically treats horn, antler, and scale as materia medica; modern conservation law, not keratin chemistry, now dominates that trade." ], "questions": [ { "id": "evidence-regional-variation-q01", "text": "Which of these regional variation hold for the sense of keratins this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Reported by the breadth pass; each item needs checking against its source before it becomes normative.", "evidence": [ { "name": "Collagen", "difference": "Collagen is an extracellular triple-helical protein rich in Gly-X-Y and hydroxyproline; keratins are intracellular (or residual cornified) intermediate-filament proteins rich in Cys and lack that collagen repeat. IHC (keratin vs collagen types) and amino-acid composition separate them." }, { "name": "Other intermediate filaments (vimentin, desmin, neurofilaments, lamins)", "difference": "Same ~10 nm filament architecture and rod-domain fold, but different genes, tissue restriction, and antibody profiles (e.g. vimentin in mesenchymal cells vs keratins in epithelia)." }, { "name": "Keratin-associated proteins (KAPs / KRTAPs)", "difference": "Matrix proteins that cross-link hair-keratin intermediate filaments; they do not form the IF polymer themselves. Named KRTAP, not KRT." }, { "name": "Cornified-envelope proteins (involucrin, loricrin, filaggrin)", "difference": "They scaffold or aggregate keratin filaments during cornification but are not keratins; detected by distinct antibodies and genes (IVL, LORICRIN, FLG)." }, { "name": "Silk fibroin", "difference": "A β-sheet structural protein of silkworm/spider silk, not an intermediate-filament keratin; fibre origin (Bombyx/spider vs hair/wool) and sequence/IR spectroscopy separate them." }, { "name": "Chitin", "difference": "A polysaccharide of arthropod cuticle and fungal walls, not a protein; dissolved by chitinase or detected as GlcNAc polymer, whereas keratin is a protein digestible by keratinases/proteases after disulfide reduction." }, { "name": "Sauropsid corneous β-proteins (historical 'β-keratins')", "difference": "Small β-sheet corneous proteins of feathers, scales, and claws; they are not type I/II IF keratins. Sequence family (corneous beta vs KRT) is the discriminator." } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of keratins this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Does the registry intend keratins to include corneous beta-proteins historically labelled beta-keratin, or should this entry record only a boundary relation to them?", "What evidence threshold should distinguish a verified keratin constituent from a commercial keratin claim in a highly processed mixture?", "At what degree of hydrolysis or chemical modification should a material be owned by a neighbouring peptide or derivative model while retaining its keratin provenance?", "Which assay combinations permit reliable comparison of chain integrity, sulfur condition and assembly competence across native, extracted and recombinant preparations?", "Which preparation-specific stability and performance limits can research substantiate for the intended uses, without extrapolating from whole keratinous tissues?" ], "statistics": { "bundles": 7, "layers": 13, "findings": 20, "questions": 32 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "chemical substance or material", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a keratins, record what state it is in, and decide what may be done with it.", "whatItIs": "Enable an AI agent to recognise keratin proteins and keratin-derived materials, assess their molecular and material state, and select actions supported by their identity, processing history and measured behaviour.", "characteristics": { "substance": "material", "origin": "natural", "agency": "inert", "mobility": "varies" }, "whatYouCanDoWithIt": [ "observed and measured", "consumed or used up" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: keratin, type I, Keratin, type I cytoskeletal 18, Phakinin, Keratin, type II, Alpha-keratin, beta-keratin, hair keratin, hair-specific keratins, type I hair keratin, type II hair keratin.", "10 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 64 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a keratins, and on what evidence are they told apart?" ], "whatItIsMadeOf": "matter you can touch", "physicalCharacter": [ "Mobility varies between examples.", "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state", "use it up, and then need more of it" ], "howItIsRecognised": [ "Not recognisable by sight in any reliable way. Appearance varies with grade, form and additives; identification is by label, by documentation, or by assay." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "keratin, type I", "Keratin, type I cytoskeletal 18", "Phakinin", "Keratin, type II", "Alpha-keratin", "beta-keratin", "hair keratin", "hair-specific keratins", "type I hair keratin", "type II hair keratin" ] } ], "standing": "Described in 64 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 10 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one keratins from another, and a keratins from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a keratins, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a keratins, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a keratins is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a keratins, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a keratins, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a keratins is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a keratins sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a keratins, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a keratins, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a keratins is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a keratins from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a keratins, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a keratins, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a keratins is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "form-and-composition", "name": "Form, composition and condition", "description": "What a keratins is made of, what shape and size it takes, and what state it is in.", "rationale": "A physical thing can be measured, and a model that cannot record its measurements cannot support any decision that depends on them.", "layers": [ { "id": "form-and-dimensions", "name": "Form and dimensions", "description": "Shape, size, mass and the ranges these take across examples.", "findings": [ { "id": "measurable-dimensions", "name": "Measurable dimensions and their units", "description": "The quantities worth recording and the units they are recorded in.", "questions": [ { "id": "measurable-dimensions-q01", "text": "What identifies and describes the dimensions of a keratins, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "measurable-dimensions-q02", "text": "Who or what asserted this about the dimensions of a keratins, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "measurable-dimensions-q03", "text": "What may an agent decide or do once the dimensions of a keratins is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "material-and-composition", "name": "Material and composition", "description": "Materials, parts and how they are put together.", "findings": [ { "id": "parts-and-materials", "name": "Parts and materials", "description": "What a keratins is built from and which parts are replaceable.", "questions": [ { "id": "parts-and-materials-q01", "text": "What identifies and describes the composition of a keratins, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "parts-and-materials-q02", "text": "Who or what asserted this about the composition of a keratins, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "parts-and-materials-q03", "text": "What may an agent decide or do once the composition of a keratins is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "condition-and-integrity", "name": "Condition and integrity", "description": "Wear, damage, health and the difference between working and broken.", "findings": [ { "id": "condition-assessment", "name": "Condition, damage and health", "description": "How the condition of a keratins is judged and by whom.", "questions": [ { "id": "condition-assessment-q01", "text": "What identifies and describes the condition of a keratins, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "condition-assessment-q02", "text": "Who or what asserted this about the condition of a keratins, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "condition-assessment-q03", "text": "What may an agent decide or do once the condition of a keratins is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "place-and-movement", "name": "Place and movement", "description": "Where a keratins is, how it got there and where it may go (varies).", "rationale": "A thing that can move needs its position recorded with a time, or every later claim about it is about a place it has left.", "layers": [ { "id": "location-and-placement", "name": "Location and placement", "description": "Position, containment and the reference frame the position is given in.", "findings": [ { "id": "position-and-frame", "name": "Position, container and reference frame", "description": "Where a keratins is, and what that position is measured against.", "questions": [ { "id": "position-and-frame-q01", "text": "What identifies and describes the location of a keratins, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "position-and-frame-q02", "text": "Who or what asserted this about the location of a keratins, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "position-and-frame-q03", "text": "What may an agent decide or do once the location of a keratins is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "movement-and-transfer", "name": "Movement and transfer", "description": "How a keratins is carried, installed or relocated.", "findings": [ { "id": "movement-events", "name": "Movement events and constraints", "description": "What counts as a movement, what records it and what limits it.", "questions": [ { "id": "movement-events-q01", "text": "What identifies and describes the movement of a keratins, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "movement-events-q02", "text": "Who or what asserted this about the movement of a keratins, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "movement-events-q03", "text": "What may an agent decide or do once the movement of a keratins is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a keratins passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a keratins between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a keratins, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a keratins, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a keratins is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a keratins, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a keratins is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a keratins, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a keratins, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a keratins is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "use-and-operation", "name": "Use and operation", "description": "What can be done with a keratins and what it takes to do it.", "rationale": "An agent that can recognise a thing but not act on it has only half a model.", "layers": [ { "id": "intended-use", "name": "Intended use and function", "description": "What a keratins is for, and what it is used for anyway.", "findings": [ { "id": "function-and-purpose", "name": "Function, purpose and misuse", "description": "The function a keratins performs and the uses that fall outside it.", "questions": [ { "id": "function-and-purpose-q01", "text": "What identifies and describes the use of a keratins, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "function-and-purpose-q02", "text": "Who or what asserted this about the use of a keratins, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "function-and-purpose-q03", "text": "What may an agent decide or do once the use of a keratins is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "handling-and-procedure", "name": "Handling and procedure", "description": "The steps, skills and tools involved in using a keratins.", "findings": [ { "id": "procedures-and-skills", "name": "Procedures, skills and required tools", "description": "What an agent needs before it can act on a keratins at all.", "questions": [ { "id": "procedures-and-skills-q01", "text": "What identifies and describes handling a keratins, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "procedures-and-skills-q02", "text": "Who or what asserted this about handling a keratins, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "procedures-and-skills-q03", "text": "What may an agent decide or do once handling a keratins is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "supply-and-consumption", "name": "Supply and consumption", "description": "Quantities, rates and what running out means.", "findings": [ { "id": "consumption-and-stock", "name": "Consumption, stock and replenishment", "description": "How much of a keratins there is and how fast it goes.", "questions": [ { "id": "consumption-and-stock-q01", "text": "What identifies and describes the supply of a keratins, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "consumption-and-stock-q02", "text": "Who or what asserted this about the supply of a keratins, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "consumption-and-stock-q03", "text": "What may an agent decide or do once the supply of a keratins is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "composition-and-identity", "name": "Composition, grade and chemical identity", "description": "What keratins is made of and how pure the thing in hand is.", "rationale": "Grade decides what a substance may be used for, so a model that records only the name cannot support any decision about use.", "layers": [ { "id": "chemical-identity", "name": "Chemical identity", "description": "Formula, structure and the registry numbers that name it unambiguously.", "findings": [ { "id": "identity-record", "name": "Identity and registry numbers", "description": "What identifies this substance across suppliers and regulators.", "questions": [ { "id": "identity-record-q01", "text": "What formula, structure and registry identifiers name keratins unambiguously?", "kind": "definition" }, { "id": "identity-record-q02", "text": "Which related substances share a name in common use but not an identifier?", "kind": "boundary" } ] } ] }, { "id": "grade-and-impurities", "name": "Grade, purity and impurities", "description": "The specification a batch meets and what else is in it.", "findings": [ { "id": "specification", "name": "Specification and assay", "description": "How purity is stated and measured, and which impurities matter.", "questions": [ { "id": "specification-q01", "text": "What grades of keratins exist, how is purity assayed, and which impurities are limited?", "kind": "measurement" }, { "id": "specification-q02", "text": "Which use requires which grade, and what happens when a lower grade is substituted?", "kind": "action" } ] } ] } ] }, { "id": "properties-and-behaviour", "name": "Properties and behaviour", "description": "How keratins behaves under conditions an agent can measure or change.", "rationale": "Physical constants are the part of a substance model that transfers between contexts, and each needs its unit and its conditions.", "layers": [ { "id": "physical-constants", "name": "Physical constants", "description": "Values that hold for the pure substance, with their conditions.", "findings": [ { "id": "constants-record", "name": "Constants and conditions", "description": "The quantities worth recording and the state they apply in.", "questions": [ { "id": "constants-record-q01", "text": "What are the defining physical constants of keratins, in what units and under what conditions?", "kind": "measurement" }, { "id": "constants-record-q02", "text": "Which of these values change with grade or form rather than being fixed?", "kind": "boundary" } ] } ] }, { "id": "stability-and-reactivity", "name": "Stability and reactivity", "description": "What it reacts with, degrades into, and how it is stored.", "findings": [ { "id": "incompatibilities", "name": "Incompatibilities and degradation", "description": "What must not meet it, and what it becomes over time.", "questions": [ { "id": "incompatibilities-q01", "text": "What is keratins incompatible with, and what does it degrade into under storage?", "kind": "definition" }, { "id": "incompatibilities-q02", "text": "What storage and handling does that require, and who is competent to do it?", "kind": "action" } ] } ] } ] }, { "id": "hazard-and-regulation", "name": "Hazard classification and regulation", "description": "How keratins can harm, and what the law says about holding and moving it.", "rationale": "A substance model without its hazard class and its regulatory identity is unusable in exactly the situations that matter.", "layers": [ { "id": "hazard-class", "name": "Hazard classification", "description": "Classified hazards, exposure limits and protective measures.", "findings": [ { "id": "classified-hazards", "name": "Classified hazards and limits", "description": "The classification, the scheme it belongs to, and the limits set.", "questions": [ { "id": "classified-hazards-q01", "text": "How is keratins classified for hazard, under which scheme, and what exposure limits apply?", "kind": "definition" }, { "id": "classified-hazards-q02", "text": "What protection does handling require, and what must an agent refuse to do without it?", "kind": "action" } ] } ] }, { "id": "regulatory-identity", "name": "Regulatory identity and control", "description": "Registration, restriction and transport rules by jurisdiction.", "findings": [ { "id": "controls", "name": "Controls and jurisdiction", "description": "Where it is restricted and what the restriction attaches to.", "questions": [ { "id": "controls-q01", "text": "Which registrations, restrictions or transport rules cover keratins, and where?", "kind": "provenance" }, { "id": "controls-q02", "text": "Does the control attach to the substance, its concentration, or its intended use?", "kind": "boundary" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a keratins came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a keratins and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a keratins, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a keratins, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a keratins is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a keratins is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a keratins, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a keratins, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a keratins is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 9, "layers": 20, "findings": 22, "questions": 60 } } } }