{ "model": { "rank": 6883, "code": "thing-q190265", "model_id": "vr.tr.pepsin", "name": "pepsin", "purpose": "Enable an AI agent to identify pepsin, assess the condition and demonstrated activity of a particular preparation, and determine whether it is suitable for an intended protein-digestion task.", "family": "Thing Registry", "category": "Physical world and living systems", "status": "research-draft", "kind": "thing", "plane": "PHY", "domain": "PHY.MAT", "industry": "", "version": "", "url": "/models/thing/q190265/", "tier": 2, "score": 58, "payload": { "layer": "wikidata", "aliases": [], "aliasCount": 0, "merged": 0, "knownIn": 58, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q190265", "url": "https://www.wikidata.org/wiki/Q190265", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-09T23:42:14Z", "providers": [ "Codex" ], "breadth": "recalled by Codex without web access - no source was read", "missingProviders": [], "pass": 2, "cost": { "grok": { "seconds": 22.6, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a0888b-f8ba-72a1-a960-23ec4a571e27\n--------\nuser\nDescribe what is already known about one registered thing. Answer as JSON only, no prose around it.\n\nThing: pepsin\nSense to describe: (none recorded)\nDomain code: PHY.MAT\nAlso known as: (none)\n\n\nContext for this batch of 1001 things:\n# Batch 007: 1001 register", "usd": 0, "recall": true }, "codex": { "seconds": 65.2, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a0888b-f8c5-7113-9e67-6dac738bab49\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: pepsin\nRegistry id: vr.tr.pepsin\nPlane / domain: PHY / PHY.MAT\nRegistry definition: (none recorded)\nNames folded into this entry: (none)\n\n\nContext fo" } } }, "metaModel": { "id": "THING-Q190265", "registryId": "vr.tr.pepsin", "name": "pepsin", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.MAT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q190265/", "model": { "registry_id": "vr.tr.pepsin", "name": "pepsin", "purpose": "Enable an AI agent to identify pepsin, assess the condition and demonstrated activity of a particular preparation, and determine whether it is suitable for an intended protein-digestion task.", "definition": "Pepsin is a gastric aspartic endopeptidase, formed by activation of pepsinogen in an acidic environment, that hydrolyses internal peptide bonds in proteins during digestion.", "scope_statement": "This model owns pepsin as a proteolytic enzyme material, including biological identity, preparation composition, measured activity, stability, and use constraints; it distinguishes the active enzyme from its precursor, other proteases, and products containing it.", "in_scope": [ "Pepsin identity, biological source, and distinctions between named enzyme variants", "Composition, purity, physical form, and grade of pepsin preparations", "Proteolytic activity, substrate dependence, and assay interpretation", "Effects of pH, temperature, storage, and handling on usable activity", "Evidence and restrictions governing a preparation's intended use" ], "out_of_scope": [ "Pepsinogen as a separately supplied precursor, beyond its relationship to pepsin", "Whole-organism gastric physiology and regulation of enzyme secretion", "Other digestive proteases and their independent models", "Complete pharmaceutical, supplement, or laboratory products containing pepsin", "Diagnosis or treatment of digestive disorders", "Full manufacturing processes and protein-digestion workflows" ], "distinguishing_features": [ "Identity evidence must establish pepsin rather than merely demonstrate nonspecific protein degradation.", "The preparation must distinguish active pepsin from pepsinogen; precursor content and activation history can affect interpretation of activity.", "Activity measurements must report acidic assay conditions and the substrate used; a generic protease activity label is insufficient identification.", "Species, variant, and preparation composition must be recorded before treating two materials labeled pepsin as interchangeable.", "A pepsin-containing mixture must identify its enzyme component separately from carriers, other enzymes, and formulation ingredients." ], "characteristics": [ { "name": "Enzyme identity", "kind": "category", "unit_or_values": "Documented pepsin name, variant, and enzyme classification; unresolved where evidence is absent", "why_it_matters": "Determines which biochemical entity the preparation represents." }, { "name": "Biological and production source", "kind": "relation", "unit_or_values": "Source organism, source tissue where applicable, or recombinant expression host", "why_it_matters": "Supports identity, traceability, and compatibility with sourcing requirements." }, { "name": "Maturation and precursor content", "kind": "state", "unit_or_values": "Active enzyme, precursor-containing preparation, mixed, or unresolved; quantified fractions where measured", "why_it_matters": "Separates available activity from activity that may arise during activation or testing." }, { "name": "Composition and purity", "kind": "measurement", "unit_or_values": "Pepsin and other component contents in mass fraction or concentration, with analytical method", "why_it_matters": "Distinguishes enzyme content from total powder mass or total protein." }, { "name": "Physical form and formulation", "kind": "category", "unit_or_values": "Powder, lyophilized material, or solution; declared buffer, carriers, and additives", "why_it_matters": "Changes preparation, storage, exposure, and dosing requirements." }, { "name": "Proteolytic potency", "kind": "measurement", "unit_or_values": "Activity units per mass or volume, with exact unit definition, substrate, pH, temperature, and assay duration", "why_it_matters": "Makes potency interpretable and prevents unsupported comparisons across assay systems." }, { "name": "Specific activity", "kind": "measurement", "unit_or_values": "Assay-defined activity units per mg protein, with protein measurement method", "why_it_matters": "Relates functional activity to measured protein content without treating it as a direct purity measurement." }, { "name": "Activity and stability conditions", "kind": "measurement", "unit_or_values": "pH, temperature in °C, exposure time, and residual activity in %, with test conditions", "why_it_matters": "Distinguishes conditions supporting immediate catalysis from conditions preserving the enzyme over time." }, { "name": "Handling and storage state", "kind": "state", "unit_or_values": "Storage history, opening and reconstitution dates, expiry or retest status, and observed deviations", "why_it_matters": "Supports decisions about whether labeled potency remains credible." }, { "name": "Grade and use eligibility", "kind": "category", "unit_or_values": "Supplier-declared grade, supported intended uses, applicable jurisdiction, and supporting documents", "why_it_matters": "Prevents biochemical suitability from being mistaken for permission to use a preparation in food or medicines." } ], "affordances": [ "Check whether identity and composition evidence support recognizing a material as pepsin.", "Compare preparations when activity methods and normalization bases are compatible.", "Calculate an enzyme quantity from documented potency and a specified digestion protocol.", "Select preparation and reaction conditions supported by evidence for the particular material.", "Request activity retesting or quarantine a preparation after uncertain storage or handling.", "Screen a preparation against sourcing, grade, and exposure-control requirements for its intended use." ] }, "sources": [], "structure": { "bundles": [ { "id": "pepsin-identity-and-origin", "name": "Pepsin identity and origin", "description": "Establishes which pepsin entity is present and how its identity is supported.", "rationale": "A pepsin label alone does not resolve variant, biological source, precursor content, or mixture identity.", "layers": [ { "id": "enzyme-identity-boundaries", "name": "Enzyme identity boundaries", "description": "Separates pepsin from related enzymes and from formulations containing it.", "findings": [ { "id": "identity-evidence", "name": "Identity evidence", "description": "Record the specificity and limitations of evidence identifying the enzyme as pepsin.", "questions": [ { "text": "Which pepsin name, variant, enzyme classification, and identifiers are supported by the material's documentation?", "kind": "definition", "id": "identity-evidence-q01" }, { "text": "What evidence distinguishes this material from another acid protease or a mixed digestive-enzyme preparation?", "kind": "boundary", "id": "identity-evidence-q02" } ] } ] }, { "id": "source-and-maturation", "name": "Source and maturation", "description": "Connects biological origin and precursor processing to the supplied enzyme.", "findings": [ { "id": "origin-and-active-form", "name": "Origin and active form", "description": "Record source and activation evidence without assuming that all measured protein is active pepsin.", "questions": [ { "text": "Which organism and tissue, or recombinant production system, supplied the enzyme?", "kind": "provenance", "id": "origin-and-active-form-q01" }, { "text": "Does the preparation contain pepsinogen, and what evidence establishes its activation state before and during the activity assay?", "kind": "measurement", "id": "origin-and-active-form-q02" } ] } ] } ] }, { "id": "pepsin-preparation-composition", "name": "Pepsin preparation composition", "description": "Describes the actual enzyme material available for handling and dosing.", "rationale": "Powder mass, protein mass, pepsin content, and functional potency are different quantities.", "layers": [ { "id": "enzyme-content-and-impurities", "name": "Enzyme content and impurities", "description": "Resolves the relationship between pepsin, other proteins, and nonprotein components.", "findings": [ { "id": "composition-basis", "name": "Composition basis", "description": "Require a stated analytical basis for purity and concentration claims.", "questions": [ { "text": "How were pepsin content and total protein measured, and do reported percentages refer to dry material, supplied material, or protein content?", "kind": "measurement", "id": "composition-basis-q01" }, { "text": "Which other proteases, residual source proteins, or process residues are measured or explicitly uncontrolled?", "kind": "measurement", "id": "composition-basis-q02" } ] } ] }, { "id": "formulation-and-reconstitution", "name": "Formulation and reconstitution", "description": "Captures physical form and ingredients affecting usable enzyme concentration.", "findings": [ { "id": "prepared-enzyme-material", "name": "Prepared enzyme material", "description": "Relate the supplied preparation to the solution or suspension used in digestion.", "questions": [ { "text": "What physical form, carriers, buffers, salts, and preservatives accompany the pepsin?", "kind": "definition", "id": "prepared-enzyme-material-q01" }, { "text": "Which reconstitution medium and procedure are supported, and what enzyme concentration and pH do they produce?", "kind": "action", "id": "prepared-enzyme-material-q02" } ] } ] } ] }, { "id": "proteolytic-performance", "name": "Proteolytic performance", "description": "Makes activity claims interpretable and relates them to an intended substrate.", "rationale": "Pepsin potency depends on how activity is defined and measured; labeled units alone cannot establish equivalent performance.", "layers": [ { "id": "activity-assay-definition", "name": "Activity assay definition", "description": "Preserves the conditions and normalization behind a potency result.", "findings": [ { "id": "interpretable-potency", "name": "Interpretable potency", "description": "Treat an activity value as inseparable from its assay method and denominator.", "questions": [ { "text": "What substrate, pH, temperature, incubation time, detection method, and unit definition produced the reported activity?", "kind": "measurement", "id": "interpretable-potency-q01" }, { "text": "Is potency normalized to supplied material, dry material, protein mass, or solution volume, and is any proposed unit conversion validated?", "kind": "boundary", "id": "interpretable-potency-q02" } ] } ] }, { "id": "target-substrate-performance", "name": "Target substrate performance", "description": "Connects reference-assay activity to the actual protein-digestion task.", "findings": [ { "id": "digestion-fit", "name": "Digestion fit", "description": "Require task-specific evidence before predicting digestion extent or peptide products.", "questions": [ { "text": "What evidence shows performance on the target protein under the intended pH, temperature, matrix, and enzyme-to-substrate ratio?", "kind": "measurement", "id": "digestion-fit-q01" }, { "text": "Which digestion endpoint must be reached, and how will incomplete digestion or excessive cleavage be detected?", "kind": "action", "id": "digestion-fit-q02" } ] } ] } ] }, { "id": "activity-preservation-and-loss", "name": "Activity preservation and loss", "description": "Tracks whether pepsin remains functionally usable through storage and processing.", "rationale": "Conditions permitting a short activity measurement do not necessarily preserve the preparation during prolonged exposure.", "layers": [ { "id": "ph-temperature-and-time", "name": "pH, temperature, and time", "description": "Separates reaction performance from loss of activity during exposure.", "findings": [ { "id": "condition-dependent-activity", "name": "Condition-dependent activity", "description": "Record preparation-specific activity and stability evidence rather than assigning one universal optimum or cutoff.", "questions": [ { "text": "What activity profile is measured across pH and temperature for the relevant substrate and exposure duration?", "kind": "measurement", "id": "condition-dependent-activity-q01" }, { "text": "After an adverse exposure, does activity recover under the reference assay conditions, or is persistent loss demonstrated?", "kind": "measurement", "id": "condition-dependent-activity-q02" } ] } ] }, { "id": "storage-and-retest-decisions", "name": "Storage and retest decisions", "description": "Uses preparation history to assess whether a potency claim remains applicable.", "findings": [ { "id": "remaining-usable-potency", "name": "Remaining usable potency", "description": "Connect storage deviations and time since preparation to evidence for continued use.", "questions": [ { "text": "What storage limits and stability data apply to the unopened material and to the reconstituted enzyme?", "kind": "provenance", "id": "remaining-usable-potency-q01" }, { "text": "Which excursions, age limits, or signs of degradation trigger retesting, quarantine, or disposal for this intended use?", "kind": "action", "id": "remaining-usable-potency-q02" } ] } ] } ] }, { "id": "use-eligibility-and-handling", "name": "Use eligibility and handling", "description": "Determines whether the documented pepsin preparation can be used and handled appropriately in its intended setting.", "rationale": "Enzyme activity does not establish product grade, acceptable biological origin, or preparation-specific handling requirements.", "layers": [ { "id": "grade-source-and-jurisdiction", "name": "Grade, source, and jurisdiction", "description": "Links intended use to evidence about grade, origin, and applicable requirements.", "findings": [ { "id": "documented-use-eligibility", "name": "Documented use eligibility", "description": "Keep supplier claims distinct from verified compliance and task-specific acceptance.", "questions": [ { "text": "Which lot documents and specifications support the preparation's claimed research, food, or pharmaceutical grade?", "kind": "provenance", "id": "documented-use-eligibility-q01" }, { "text": "Do applicable jurisdictional and sourcing requirements permit this preparation for the proposed use?", "kind": "action", "id": "documented-use-eligibility-q02" } ] } ] }, { "id": "enzyme-exposure-and-process-exit", "name": "Enzyme exposure and process exit", "description": "Addresses handling exposure and the fate of active pepsin after digestion.", "findings": [ { "id": "preparation-specific-controls", "name": "Preparation-specific controls", "description": "Base handling and reaction-termination decisions on the actual preparation and downstream task.", "questions": [ { "text": "What does the current safety documentation specify for this preparation's enzyme dust or aerosol exposure, sensitization hazards, and protective controls?", "kind": "provenance", "id": "preparation-specific-controls-q01" }, { "text": "What validated removal or inactivation method prevents residual pepsin activity from affecting the downstream material or measurement?", "kind": "action", "id": "preparation-specific-controls-q02" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-confidence-notes", "name": "Check these first", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "This is recall-based information; no sources were consulted.", "Resolve whether the registry means pepsin A specifically, the broader pepsin group or a commercial enzyme preparation.", "Verify preparation-specific activity, source species, hazard classification and applicable compendial or food-enzyme requirements; a universal molecular formula, melting point or boiling point would be misleading." ], "questions": [ { "id": "evidence-confidence-notes-q01", "text": "Which of these check these first hold for the sense of pepsin this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-kinds", "name": "Kinds and varieties", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Pepsin A", "Pepsin C (gastricsin)", "Porcine pepsin preparations", "Bovine pepsin preparations" ], "questions": [ { "id": "evidence-kinds-q01", "text": "Which of these kinds and varieties hold for the sense of pepsin this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-identifiers", "name": "Identifiers and schemes", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "scheme": "CAS Registry Number", "value_or_pattern": "9001-75-6", "note": "Commonly used for pepsin; does not specify species, isoenzyme, purity or preparation activity." }, { "scheme": "IUBMB Enzyme Commission classification", "value_or_pattern": "EC 3.4.23.1", "note": "Pepsin A; pepsin C has the separate classification EC 3.4.23.3." } ], "questions": [ { "id": "evidence-identifiers-q01", "text": "Which of these identifiers and schemes hold for the sense of pepsin this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Gastric digestion of dietary proteins.", "Laboratory protein digestion under acidic conditions.", "Production of antibody F(ab')2 fragments by controlled digestion of IgG.", "Preparation of protein hydrolysates.", "Milk coagulation in some cheese-making enzyme preparations." ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of pepsin this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-measurements", "name": "Typical measurements", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "quantity": "Approximate optimum pH for pepsin A activity", "typical_range": "1.5-3; depends on substrate and assay", "unit": "pH" }, { "quantity": "Approximate molecular mass of mature pepsin A", "typical_range": "About 35; varies with species and molecular form", "unit": "kDa" }, { "quantity": "Proteolytic activity per mass of preparation", "typical_range": "Preparation-specific; requires a stated substrate, pH, temperature and unit definition", "unit": "assay-defined activity units/mg" } ], "questions": [ { "id": "evidence-measurements-q01", "text": "Which of these typical measurements hold for the sense of pepsin this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Activity can be lost through unsuitable pH, heating or storage conditions.", "Excessive digestion can destroy target proteins or desired antibody fragments.", "Autolysis can change activity during handling and incubation.", "Airborne enzyme dust can cause respiratory sensitization; contact may irritate eyes or skin.", "Species, purity and assay differences can make nominally similar preparations perform differently." ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of pepsin this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-regional-variation", "name": "Regional variation", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Requirements for food, pharmaceutical and laboratory preparations depend on jurisdiction and intended use.", "Animal source can affect acceptance under religious dietary certification and local sourcing requirements." ], "questions": [ { "id": "evidence-regional-variation-q01", "text": "Which of these regional variation hold for the sense of pepsin this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "name": "Pepsinogen", "difference": "The inactive precursor contains an activation segment that is removed during formation of active pepsin." }, { "name": "Trypsin", "difference": "A serine endopeptidase that preferentially cleaves after lysine or arginine and functions under substantially less acidic conditions." }, { "name": "Chymosin", "difference": "A related gastric aspartic protease distinguished by its strong milk-clotting action through cleavage of κ-casein." }, { "name": "Pepsin preparation", "difference": "A formulated material may contain carriers, salts and multiple enzyme forms; its mass is not necessarily the mass of pure pepsin." } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of pepsin this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Does the registry intend pepsin to denote a particular enzyme variant or the broader conventional category, and which identifiers correctly match that scope?", "Which authoritative sources establish the relevant species and variant distinctions without splitting the registered entry unnecessarily?", "Which activity standards and unit systems occur in the preparations to be modeled, and which comparisons or conversions have experimental support?", "What preparation-specific evidence establishes stability after reconstitution and after pH or temperature excursions?", "Which current jurisdiction-specific identity, grade, and hazard requirements apply to the actual intended uses and preparations?" ], "statistics": { "bundles": 6, "layers": 11, "findings": 18, "questions": 28 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "chemical substance or material", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a pepsin, record what state it is in, and decide what may be done with it.", "whatItIs": "Enable an AI agent to identify pepsin, assess the condition and demonstrated activity of a particular preparation, and determine whether it is suitable for an intended protein-digestion task.", "characteristics": { "substance": "material", "origin": "natural", "agency": "inert", "mobility": "varies" }, "whatYouCanDoWithIt": [ "observed and measured", "consumed or used up" ], "distinguishingFeatures": [ "Described in 58 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a pepsin, and on what evidence are they told apart?" ], "whatItIsMadeOf": "matter you can touch", "physicalCharacter": [ "Mobility varies between examples.", "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state", "use it up, and then need more of it" ], "howItIsRecognised": [ "Not recognisable by sight in any reliable way. Appearance varies with grade, form and additives; identification is by label, by documentation, or by assay." ], "relatedModels": [], "standing": "Described in 58 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one pepsin from another, and a pepsin from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a pepsin, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a pepsin, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a pepsin is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a pepsin, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a pepsin, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a pepsin is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a pepsin sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a pepsin, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a pepsin, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a pepsin is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a pepsin from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a pepsin, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a pepsin, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a pepsin is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "form-and-composition", "name": "Form, composition and condition", "description": "What a pepsin is made of, what shape and size it takes, and what state it is in.", "rationale": "A physical thing can be measured, and a model that cannot record its measurements cannot support any decision that depends on them.", "layers": [ { "id": "form-and-dimensions", "name": "Form and dimensions", "description": "Shape, size, mass and the ranges these take across examples.", "findings": [ { "id": "measurable-dimensions", "name": "Measurable dimensions and their units", "description": "The quantities worth recording and the units they are recorded in.", "questions": [ { "id": "measurable-dimensions-q01", "text": "What identifies and describes the dimensions of a pepsin, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "measurable-dimensions-q02", "text": "Who or what asserted this about the dimensions of a pepsin, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "measurable-dimensions-q03", "text": "What may an agent decide or do once the dimensions of a pepsin is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "material-and-composition", "name": "Material and composition", "description": "Materials, parts and how they are put together.", "findings": [ { "id": "parts-and-materials", "name": "Parts and materials", "description": "What a pepsin is built from and which parts are replaceable.", "questions": [ { "id": "parts-and-materials-q01", "text": "What identifies and describes the composition of a pepsin, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "parts-and-materials-q02", "text": "Who or what asserted this about the composition of a pepsin, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "parts-and-materials-q03", "text": "What may an agent decide or do once the composition of a pepsin is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "condition-and-integrity", "name": "Condition and integrity", "description": "Wear, damage, health and the difference between working and broken.", "findings": [ { "id": "condition-assessment", "name": "Condition, damage and health", "description": "How the condition of a pepsin is judged and by whom.", "questions": [ { "id": "condition-assessment-q01", "text": "What identifies and describes the condition of a pepsin, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "condition-assessment-q02", "text": "Who or what asserted this about the condition of a pepsin, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "condition-assessment-q03", "text": "What may an agent decide or do once the condition of a pepsin is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "place-and-movement", "name": "Place and movement", "description": "Where a pepsin is, how it got there and where it may go (varies).", "rationale": "A thing that can move needs its position recorded with a time, or every later claim about it is about a place it has left.", "layers": [ { "id": "location-and-placement", "name": "Location and placement", "description": "Position, containment and the reference frame the position is given in.", "findings": [ { "id": "position-and-frame", "name": "Position, container and reference frame", "description": "Where a pepsin is, and what that position is measured against.", "questions": [ { "id": "position-and-frame-q01", "text": "What identifies and describes the location of a pepsin, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "position-and-frame-q02", "text": "Who or what asserted this about the location of a pepsin, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "position-and-frame-q03", "text": "What may an agent decide or do once the location of a pepsin is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "movement-and-transfer", "name": "Movement and transfer", "description": "How a pepsin is carried, installed or relocated.", "findings": [ { "id": "movement-events", "name": "Movement events and constraints", "description": "What counts as a movement, what records it and what limits it.", "questions": [ { "id": "movement-events-q01", "text": "What identifies and describes the movement of a pepsin, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "movement-events-q02", "text": "Who or what asserted this about the movement of a pepsin, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "movement-events-q03", "text": "What may an agent decide or do once the movement of a pepsin is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a pepsin passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a pepsin between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a pepsin, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a pepsin, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a pepsin is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a pepsin, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a pepsin is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a pepsin, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a pepsin, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a pepsin is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "use-and-operation", "name": "Use and operation", "description": "What can be done with a pepsin and what it takes to do it.", "rationale": "An agent that can recognise a thing but not act on it has only half a model.", "layers": [ { "id": "intended-use", "name": "Intended use and function", "description": "What a pepsin is for, and what it is used for anyway.", "findings": [ { "id": "function-and-purpose", "name": "Function, purpose and misuse", "description": "The function a pepsin performs and the uses that fall outside it.", "questions": [ { "id": "function-and-purpose-q01", "text": "What identifies and describes the use of a pepsin, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "function-and-purpose-q02", "text": "Who or what asserted this about the use of a pepsin, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "function-and-purpose-q03", "text": "What may an agent decide or do once the use of a pepsin is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "handling-and-procedure", "name": "Handling and procedure", "description": "The steps, skills and tools involved in using a pepsin.", "findings": [ { "id": "procedures-and-skills", "name": "Procedures, skills and required tools", "description": "What an agent needs before it can act on a pepsin at all.", "questions": [ { "id": "procedures-and-skills-q01", "text": "What identifies and describes handling a pepsin, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "procedures-and-skills-q02", "text": "Who or what asserted this about handling a pepsin, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "procedures-and-skills-q03", "text": "What may an agent decide or do once handling a pepsin is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "supply-and-consumption", "name": "Supply and consumption", "description": "Quantities, rates and what running out means.", "findings": [ { "id": "consumption-and-stock", "name": "Consumption, stock and replenishment", "description": "How much of a pepsin there is and how fast it goes.", "questions": [ { "id": "consumption-and-stock-q01", "text": "What identifies and describes the supply of a pepsin, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "consumption-and-stock-q02", "text": "Who or what asserted this about the supply of a pepsin, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "consumption-and-stock-q03", "text": "What may an agent decide or do once the supply of a pepsin is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "composition-and-identity", "name": "Composition, grade and chemical identity", "description": "What pepsin is made of and how pure the thing in hand is.", "rationale": "Grade decides what a substance may be used for, so a model that records only the name cannot support any decision about use.", "layers": [ { "id": "chemical-identity", "name": "Chemical identity", "description": "Formula, structure and the registry numbers that name it unambiguously.", "findings": [ { "id": "identity-record", "name": "Identity and registry numbers", "description": "What identifies this substance across suppliers and regulators.", "questions": [ { "id": "identity-record-q01", "text": "What formula, structure and registry identifiers name pepsin unambiguously?", "kind": "definition" }, { "id": "identity-record-q02", "text": "Which related substances share a name in common use but not an identifier?", "kind": "boundary" } ] } ] }, { "id": "grade-and-impurities", "name": "Grade, purity and impurities", "description": "The specification a batch meets and what else is in it.", "findings": [ { "id": "specification", "name": "Specification and assay", "description": "How purity is stated and measured, and which impurities matter.", "questions": [ { "id": "specification-q01", "text": "What grades of pepsin exist, how is purity assayed, and which impurities are limited?", "kind": "measurement" }, { "id": "specification-q02", "text": "Which use requires which grade, and what happens when a lower grade is substituted?", "kind": "action" } ] } ] } ] }, { "id": "properties-and-behaviour", "name": "Properties and behaviour", "description": "How pepsin behaves under conditions an agent can measure or change.", "rationale": "Physical constants are the part of a substance model that transfers between contexts, and each needs its unit and its conditions.", "layers": [ { "id": "physical-constants", "name": "Physical constants", "description": "Values that hold for the pure substance, with their conditions.", "findings": [ { "id": "constants-record", "name": "Constants and conditions", "description": "The quantities worth recording and the state they apply in.", "questions": [ { "id": "constants-record-q01", "text": "What are the defining physical constants of pepsin, in what units and under what conditions?", "kind": "measurement" }, { "id": "constants-record-q02", "text": "Which of these values change with grade or form rather than being fixed?", "kind": "boundary" } ] } ] }, { "id": "stability-and-reactivity", "name": "Stability and reactivity", "description": "What it reacts with, degrades into, and how it is stored.", "findings": [ { "id": "incompatibilities", "name": "Incompatibilities and degradation", "description": "What must not meet it, and what it becomes over time.", "questions": [ { "id": "incompatibilities-q01", "text": "What is pepsin incompatible with, and what does it degrade into under storage?", "kind": "definition" }, { "id": "incompatibilities-q02", "text": "What storage and handling does that require, and who is competent to do it?", "kind": "action" } ] } ] } ] }, { "id": "hazard-and-regulation", "name": "Hazard classification and regulation", "description": "How pepsin can harm, and what the law says about holding and moving it.", "rationale": "A substance model without its hazard class and its regulatory identity is unusable in exactly the situations that matter.", "layers": [ { "id": "hazard-class", "name": "Hazard classification", "description": "Classified hazards, exposure limits and protective measures.", "findings": [ { "id": "classified-hazards", "name": "Classified hazards and limits", "description": "The classification, the scheme it belongs to, and the limits set.", "questions": [ { "id": "classified-hazards-q01", "text": "How is pepsin classified for hazard, under which scheme, and what exposure limits apply?", "kind": "definition" }, { "id": "classified-hazards-q02", "text": "What protection does handling require, and what must an agent refuse to do without it?", "kind": "action" } ] } ] }, { "id": "regulatory-identity", "name": "Regulatory identity and control", "description": "Registration, restriction and transport rules by jurisdiction.", "findings": [ { "id": "controls", "name": "Controls and jurisdiction", "description": "Where it is restricted and what the restriction attaches to.", "questions": [ { "id": "controls-q01", "text": "Which registrations, restrictions or transport rules cover pepsin, and where?", "kind": "provenance" }, { "id": "controls-q02", "text": "Does the control attach to the substance, its concentration, or its intended use?", "kind": "boundary" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a pepsin came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a pepsin and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a pepsin, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a pepsin, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a pepsin is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a pepsin is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a pepsin, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a pepsin, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a pepsin is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 9, "layers": 20, "findings": 22, "questions": 60 } } } }