D-methamphetamine
Enable an agent to identify D-methamphetamine, assess the identity and condition of a material sample, and determine which handling or transfer actions require further evidence or authorization.
Research draft, second pass
A second pass drafted this model: the structure a model of this thing needs, and what is known about it in the world. The line under this one says how the second half was obtained - researched against sources, or recalled without web access, in which case nothing here was read anywhere and every claim is a lead to verify. Unreviewed either way.
recalled by Codex without web access - no source was read
Researched by: Codex
Purpose and description
Enable an agent to identify D-methamphetamine, assess the identity and condition of a material sample, and determine which handling or transfer actions require further evidence or authorization.
D-methamphetamine, or dextromethamphetamine, is the dextrorotatory (S)-enantiomer of methamphetamine, a synthetic chiral secondary amine with potent central nervous system stimulant activity.
It can be Resolve a D-methamphetamine label to a verified stereochemical identity and chemical form.; Assess whether analytical evidence supports D-specific identification or only broader methamphetamine identification.; Compare assay and physical-property results after reconciling salt form, reporting basis, and measurement conditions.; Flag uncertain composition, deteriorated material, or unsupported hazard assumptions for qualified review.; Check documented authorization before routing a sample for analysis, storage, transfer, or disposal..
Distinguishing features
Identity evidence must establish the D enantiomer; a methamphetamine-positive result without stereochemical resolution does not establish this narrower identity.
Absolute stereochemistry and the D/d naming convention must be reconciled against an authoritative structure record rather than inferred from a label alone.
An enantiomer-resolving measurement distinguishes a D-enriched sample from the L enantiomer or a racemate; total methamphetamine concentration alone cannot do so.
Counterion and composition evidence distinguish the free base from a salt; their identifiers and physical-property values must not be interchanged.
A product containing D-methamphetamine is related to this substance through its ingredient composition and does not inherit a pure-substance identity for the whole product.
Scope
+ Molecular and stereochemical identity of the dextrorotatory methamphetamine enantiomer
+ Free-base and salt identity, including counterions and hydration where applicable
+ Chemical purity, enantiomeric composition, contaminants, and sample provenance
+ Physical state and measured properties under specified conditions
+ Evidence-backed hazards, storage condition, and sample deterioration
+ Jurisdiction-specific regulatory identity and permitted handling context
- L-methamphetamine and racemic methamphetamine as independently modeled substances
- Finished medicinal products, formulations, packaging, and prescribing decisions
- Synthesis routes, precursor selection, reaction optimization, and illicit manufacture
- Individual intoxication, substance use disorder, and treatment planning
- Manufacturing facilities, distribution organizations, and enforcement operations
Characteristics
- Stereochemically explicit identity
- Authoritative structure representation, absolute configuration, and documented D/d synonym mapping Prevents confusion with L-methamphetamine, racemic material, and records that leave stereochemistry unspecified.
- Form-specific registry identifiers
- Verified CAS number, PubChem CID, and EC number where assigned, each linked to its exact chemical form and source An identifier for a salt or stereochemically unspecified record may not identify the material under assessment.
- Chemical form
- Free base or named salt; counterion, stoichiometry, hydration, and solvation where established Determines which composition, property, and hazard records can be applied.
- Enantiomeric composition
- D and L fractions in % with denominator stated; enantiomeric excess in % where reported Tests whether a sample supports the D-specific identity and distinguishes stereochemical purity from chemical purity.
- Assay and reporting basis
- Mass fraction in %, or concentration in mg/mL; as-is, dry, salt, or free-base-equivalent basis explicitly stated Avoids comparing unlike quantities or confusing salt mass with the corresponding amount of methamphetamine.
- Impurity and residual-component profile
- Identified components in %, mg/kg, or another explicit unit, with detection limits and unknown fractions A strong methamphetamine signal does not establish sample purity or characterize additional hazards.
- Physical state and property conditions
- Observed phase; temperature in °C, pressure in kPa, and solvent or humidity context where relevant Connects observations and reference constants to the actual chemical form and environment.
- Form-specific physical constants
- Melting or decomposition interval in °C; boiling point in °C at stated pressure; solubility in g/L at stated temperature and solvent Supports consistency checks while preventing unsupported transfer of constants between the free base and salts.
- Hazard and exposure evidence
- Applicable safety data, GHS classification with issuing system and date, and exposure limits with authority and averaging period if established Supports handling decisions without inventing universal classifications or assuming an exposure limit exists.
- Regulatory and custody status
- Jurisdiction, effective date, applicable substance definition, authorized custodian, and permitted activity Chemical identification alone does not establish permission to possess, analyze, transfer, or dispose of a sample.
Also called
Where this came from
wikidata · CC0 1.0
Drafted structure
Bundle to layer to finding to question, as the second pass will find it: 5 bundles · 9 layers · 17 findings · 27 questions.
Stereochemical identity Establish what the D-methamphetamine name denotes and whether a record or sample supports that identity.
The registry entry is narrower than generic methamphetamine and must preserve that distinction.
Name to structure
Resolve stereochemical naming and structure references.
D designation evidence
Record the evidence connecting D/d and other accepted synonyms to an explicit stereochemical structure.
- Which authoritative record establishes the absolute configuration and synonym mapping intended by D-methamphetamine? definition
- Does the source explicitly identify this enantiomer, or does it describe methamphetamine without stereochemical qualification? boundary
Form and parent boundaries
Separate stereochemical identity from salt identity and broader substance records.
Form-specific identifiers
Attach identifiers only to the chemical form and stereochemical scope they actually describe.
- Which verified identifiers describe the D free base, and which describe a particular salt? provenance
- Which existing methamphetamine model should supply shared properties, and which D-specific distinctions must remain here? boundary
Sample composition and evidence Characterize how closely a particular material sample matches the intended substance identity.
A name or total assay cannot establish enantiomeric composition, purity, or sample reliability.
Stereochemical confirmation
Evaluate evidence that distinguishes the D and L enantiomers.
Enantiomer-resolving result
Record method suitability, reference materials, and uncertainty for a D-specific assignment.
- Does the analytical method resolve the enantiomers, and what reference evidence supports its assignment of the D component? measurement
- What D and L fractions were measured, with what uncertainty and quantification limits? measurement
Assay and traceability
Relate composition results to an identifiable sample and an explicit quantity basis.
Interpretable sample composition
Keep chemical assay, enantiomeric purity, and uncharacterized material distinct.
- Is the assay expressed as free base, named salt, or free-base equivalent, and on an as-is or dry basis? measurement
- Which impurities, water, or residual solvents were measured, and what portion remains uncharacterized? measurement
- Which sample identifier, sampling record, and laboratory report connect these results to the material being assessed? provenance
Physical form and condition Interpret physical observations and material changes against the established chemical form.
Free-base and salt records can yield incompatible expectations if their conditions and forms are omitted.
Conditioned properties
Anchor phase and physical constants to form-specific evidence.
Applicable property record
Use physical properties as conditional consistency evidence rather than standalone proof of identity.
- What phase is observed at the recorded temperature and pressure, and is it consistent with the identified form? measurement
- Do melting, boiling, decomposition, and solubility references specify the same stereochemistry, salt form, and measurement conditions? provenance
Condition over time
Track evidence of contamination or change during storage.
Sample condition confidence
Record observations and storage history that affect whether earlier analytical results remain applicable.
- What storage history, container condition, or observed changes could affect the sample's composition or confidence in its identity? provenance
- What evidence would require the sample to be held for reassessment before its previous assay or identity result is reused? action
Hazards and authorized handling Connect the identified material to applicable hazard evidence and activity-specific authorization.
The agent must distinguish what the substance is from what a particular custodian may do with it.
Applicable hazard evidence
Determine which safety classifications and exposure references apply to the actual material.
Hazard record applicability
Evaluate safety information against stereochemical scope, chemical form, concentration, and known contaminants.
- Which safety data and GHS classifications apply to this chemical form and composition, under which issuing system and date? provenance
- Is an authoritative occupational exposure limit established for the relevant material, and what unit and averaging period does it use? measurement
- Which documented handling and incident procedures apply to this sample and its setting? action
Legal identity and custody
Evaluate permission for a specific activity using current jurisdictional evidence.
Activity-specific authorization
Tie regulatory coverage and custody documentation to the proposed handling action.
- Does the applicable legal definition explicitly cover this enantiomer and its salts in the relevant jurisdiction on the intended action date? boundary
- What verified authorization and custody records support the proposed possession, analysis, transfer, or disposal? action
Evidence and external alignment What the world already says about this thing, gathered so the model can be checked against it.
A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.
Reported evidence
Findings from the breadth pass, kept separate from the structural claims.
Check these first
Recalled without web access and unsourced; every item is a lead to verify.
- This is recalled knowledge; no sources were consulted.
- Verify CAS, PubChem and EC identifiers against the exact stereoisomer and salt form; none are asserted here.
- Check current local regulation and product authorizations, and obtain form-specific physical constants, purity specifications and hazard classifications.
- Which of these check these first hold for the sense of D-methamphetamine this model covers, and on what evidence? provenance
Kinds and varieties
Recalled without web access and unsourced; every item is a lead to verify.
- D-methamphetamine free base
- D-methamphetamine hydrochloride
- Which of these kinds and varieties hold for the sense of D-methamphetamine this model covers, and on what evidence? provenance
Identifiers and schemes
Recalled without web access and unsourced; every item is a lead to verify.
- IUPAC chemical nomenclature - (2S)-N-methyl-1-phenylpropan-2-amine - Specifies the stereochemistry of the free base.
- Molecular formula - C10H15N - Free-base composition; the formula alone does not distinguish enantiomers.
- Which of these identifiers and schemes hold for the sense of D-methamphetamine this model covers, and on what evidence? provenance
Standards and regulation
Recalled without web access and unsourced; every item is a lead to verify.
- United Nations Convention on Psychotropic Substances, 1971: international control framework covering methamphetamine.
- United States Controlled Substances Act, administered by the Drug Enforcement Administration: methamphetamine is a Schedule II controlled substance.
- Which of these standards and regulation hold for the sense of D-methamphetamine this model covers, and on what evidence? provenance
Real-world use
Recalled without web access and unsourced; every item is a lead to verify.
- Restricted prescription use of the hydrochloride salt for attention-deficit/hyperactivity disorder.
- Analytical reference material in forensic and toxicological laboratories.
- Research on monoamine signalling and stimulant pharmacology.
- Nonmedical use for stimulant and euphoric effects.
- Which of these real-world use hold for the sense of D-methamphetamine this model covers, and on what evidence? provenance
Typical measurements
Recalled without web access and unsourced; every item is a lead to verify.
- Molar mass of free base - 149.23 - g/mol
- Molar mass of anhydrous hydrochloride salt - 185.69 - g/mol
- Which of these typical measurements hold for the sense of D-methamphetamine this model covers, and on what evidence? provenance
Failure modes and hazards
Recalled without web access and unsourced; every item is a lead to verify.
- High potential for misuse, dependence and compulsive use.
- Acute toxicity can include severe hypertension, arrhythmias, hyperthermia, seizures and death.
- Exposure can cause agitation, insomnia, paranoia and psychosis.
- Repeated use can cause cardiovascular injury and cognitive or psychiatric impairment.
- Unregulated material can have uncertain identity, concentration, enantiomeric composition and contaminants.
- Which of these failure modes and hazards hold for the sense of D-methamphetamine this model covers, and on what evidence? provenance
Regional variation
Recalled without web access and unsourced; every item is a lead to verify.
- Medical availability, approved indications and prescribing restrictions differ by jurisdiction.
- Possession, manufacture, supply and analytical handling are subject to jurisdiction-specific controlled-substance requirements.
- Which of these regional variation hold for the sense of D-methamphetamine this model covers, and on what evidence? provenance
Neighbouring kinds and how to tell them apart
Recalled without web access and unsourced; every item is a lead to verify.
- Methamphetamine - The broader name may leave stereochemistry unspecified; D-methamphetamine specifically denotes the (S)-enantiomer.
- L-methamphetamine - The opposite, (R)-enantiomer; it generally has weaker central stimulant effects.
- Racemic methamphetamine - Contains equal amounts of the D and L enantiomers rather than the D-enantiomer alone.
- D-amphetamine - Lacks the nitrogen-bound methyl group present in D-methamphetamine.
- D-methamphetamine hydrochloride - The hydrochloride is a protonated salt form with a chloride counterion, rather than the neutral free base.
- Which of these neighbouring kinds and how to tell them apart hold for the sense of D-methamphetamine this model covers, and on what evidence? provenance
What the second pass must settle
- Does an existing world model already cover D-methamphetamine, requiring this registry entry to link to it rather than create a duplicate?
- Which authoritative records establish the exact D/d synonym mapping and form-specific CAS, PubChem, and EC identifiers?
- What evidentiary threshold should distinguish a confirmed D-methamphetamine sample from D-enriched, racemic, or stereochemically unresolved methamphetamine material?
- Which physical constants and stability observations are supported specifically for the D free base and relevant salts, with adequate measurement conditions?
- Which hazard classifications, exposure limits if any, and regulatory definitions apply in the intended jurisdictions and handling settings?