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Research draft

atrophy

vr.tr.atrophy · XCT.STA

Let an agent explain atrophy and its causes and kinds in general terms, distinguish it from hypertrophy and hypoplasia, relay assessment and management information from clinical sources, and route personal questions to clinicians.

Thing Registry Cross-cutting context

Research draft, second pass

A second pass drafted this model: the structure a model of this thing needs, and what is known about it in the world. The line under this one says how the second half was obtained - researched against sources, or recalled without web access, in which case nothing here was read anywhere and every claim is a lead to verify. Unreviewed either way.

written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify

Researched by: Claude

Purpose and description

Let an agent explain atrophy and its causes and kinds in general terms, distinguish it from hypertrophy and hypoplasia, relay assessment and management information from clinical sources, and route personal questions to clinicians.

The wasting or shrinking of a tissue or organ through loss of cell size or number, caused by disuse, loss of nerve supply, poor blood supply, malnutrition, hormone changes, ageing or disease; atrophy affects muscle, brain, optic nerve and many organs, is sometimes reversible when the cause is removed, and is assessed by examination and imaging.

What it is for: Not applicable; a tissue change.

It can be explain causes and mechanisms; distinguish atrophy from related terms; relay examples and assessment in general terms; route personal questions to clinicians.

Distinguishing features

Loss of tissue mass

Many causes

Partly reversible in some cases

Marker of disease or ageing

What it looks like

Not visible as a process; seen as shrinkage or wasting of a muscle or organ.

How it is recognised

Reduction in size of a tissue or organ

Caused by disuse, denervation, ischaemia or disease

Hypoplasia is failure to develop; hypertrophy is enlargement

Related models

is a kind of - a reduction in tissue

hypotrophy

is the opposite of - enlargement

hypertrophy

is confused with - underdevelopment

hypoplasia

occurs in - a main example

muscle

In practice

Families and kinds

disuse muscle atrophy

neurogenic atrophy

brain and cerebellar atrophy

optic atrophy

atrophy from ageing such as sarcopenia

hormonal and pressure atrophy

Identifiers

MeSH D001284 atrophy

ICD-10 M62.5 and others by site

Standards and regulation

Clinical guidelines on muscle wasting and sarcopenia

Rehabilitation standards

Failure modes and hazards

Progressive disability

Falls and frailty

Missed treatable causes

Agents giving personal medical advice

Also called

disuse atrophyglaucomatous atrophy of optic discearly-onset X-linked optic atrophyoptic atrophy 7cerebellar atrophyoptic atrophy associated with retinal dystrophyoptic atrophyoptic atrophy 10optic atrophy 2optic atrophy 9primary optic atrophypartial optic atrophyhereditary optic atrophyHagemoser–Weinstein–Bresnick syndromemuscle atrophysmooth muscle atrophystriated muscle atrophyvillous atrophybrain atrophy

Where this came from

wikidata · CC0 1.0

Source repository Registry entry point

Also registered as vr.tr.atrophy

Drafted structure

Bundle to layer to finding to question, as the second pass will find it: 4 bundles · 8 layers · 8 findings · 16 questions.

Concept What atrophy is.

Definition.

Definition

Definition.

Definition

Definition.

  1. What is atrophy, and how does it differ from hypoplasia and hypertrophy? definition
  2. Is the user asking about their own condition, which needs a clinician? boundary

Causes

Causes.

Causes

Causes.

  1. What causes atrophy, and what mechanisms are involved? definition
  2. Which entry fits a specific cause? action
Examples Kinds and sites.

Examples.

Muscle

Muscle atrophy.

Muscle

Muscle.

  1. How does muscle atrophy arise from disuse, denervation and ageing? provenance
  2. Which entry fits sarcopenia? action

Organs

Brain, nerve and organs.

Organs

Organs.

  1. What are brain, optic and organ atrophy, in general terms? provenance
  2. Which entry fits a specific condition? action
Assess Assessment and management.

Clinical.

Assessment

Assessment.

Assessment

Assessment.

  1. How is atrophy assessed by examination, imaging and function tests? measurement
  2. Which methods are standard? provenance

Management

Management.

Management

Management.

  1. What management do guidelines describe, from rehabilitation to treating the cause? provenance
  2. Is the presentation free of personal treatment advice? boundary
Study Research and teaching.

Study.

Research

Research.

Research

Research.

  1. What is known about mechanisms and reversibility, with findings attributed? provenance
  2. Which references are standard? provenance

Teach

Teaching.

Teach

Teaching.

  1. How is atrophy taught in pathology? action
  2. Which misconceptions arise? provenance

What the second pass must settle

  • Should muscle and brain atrophy be separate entries?
  • How should guidelines be linked?
  • The registry entry has merged aliases for rare genetic optic atrophies; should they be split off?
Draft as JSON