{ "model": { "rank": 13585, "code": "thing-q2025687", "model_id": "vr.tr.iron-overload", "name": "iron overload", "purpose": "Let an agent explain iron overload and its causes and forms in general terms, relay diagnosis, treatment and screening information from health bodies, route acute iron poisoning to emergency services first, and route personal medical questions to clinicians.", "family": "Thing Registry", "category": "Cross-cutting context", "status": "research-draft", "kind": "thing", "plane": "XCT", "domain": "XCT.STA", "industry": "", "version": "", "url": "/models/thing/q2025687/", "tier": 2, "score": 37, "payload": { "layer": "wikidata", "aliases": [ "iron poisoning", "aceruloplasminemia", "atransferrinemia", "neonatal hemochromatosis", "hereditary haemochromatosis", "GRACILE syndrome", "rare hereditary hemochromatosis", "Hemochromatosis type 4", "hemochromatosis type 3", "hemochromatosis type 1", "hemochromatosis type 5", "African iron overload", "hemochromatosis type 2", "hemochromatosis type 2A", "hemochromatosis type 2B" ], "aliasCount": 15, "merged": 15, "knownIn": 37, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q2025687", "url": "https://www.wikidata.org/wiki/Q2025687", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-12T06:14:37Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 2, "engine": "claude" }, "metaModel": { "id": "THING-Q2025687", "registryId": "vr.tr.iron-overload", "name": "iron overload", "version": "0.2.0-wave.2", "entryKind": "thing", "family": "Thing Registry", "domain": [ "XCT.STA" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q2025687/", "model": { "registry_id": "vr.tr.iron-overload", "name": "iron overload", "purpose": "Let an agent explain iron overload and its causes and forms in general terms, relay diagnosis, treatment and screening information from health bodies, route acute iron poisoning to emergency services first, and route personal medical questions to clinicians.", "definition": "A condition in which the body accumulates excess iron, damaging the liver, heart, pancreas, joints and other organs, arising from hereditary haemochromatosis and rarer inherited disorders such as aceruloplasminaemia and atransferrinaemia, from repeated blood transfusions, from neonatal haemochromatosis, or acutely from iron poisoning after ingestion of iron tablets, a medical emergency especially in children; iron overload is diagnosed by blood tests and genetic testing and treated by removing blood or with chelating drugs.", "what_it_is_for": "Excess iron in the body.", "affordances": [ "explain causes and forms", "relay diagnosis and treatment information", "route poisoning emergencies", "route personal questions" ], "distinguishing_features": [ "Iron accumulation", "Genetic and acquired causes", "Organ damage", "Treatable by phlebotomy or chelation" ], "appearance": "Not visible; found by blood and genetic tests.", "visual_identification": [ "Excess body iron damaging organs", "Hereditary haemochromatosis, transfusional, neonatal, acute poisoning", "Iron deficiency is the opposite; anaemia of chronic disease involves iron handling but not overload" ], "physical_properties": [], "families_and_kinds": [ "hereditary haemochromatosis", "rare inherited iron disorders such as aceruloplasminaemia", "transfusional iron overload", "neonatal haemochromatosis", "acute iron poisoning" ], "related_models": [ { "relation": "is a kind of", "target": "iron metabolism disease", "why": "category" }, { "relation": "is a kind of", "target": "metal metabolism disorder", "why": "category" }, { "relation": "is related to", "target": "vitamin", "why": "supplements including iron and vitamin C affecting absorption" }, { "relation": "is related to", "target": "absorption", "why": "intestinal absorption of iron" } ], "identifiers": [], "standards_and_regulation": [ "Clinical guidelines for haemochromatosis", "Poison centre guidance for iron ingestion", "Genetic testing and screening standards" ], "failure_modes_and_hazards": [ "Failing to route acute poisoning to emergency care", "Agents giving personal treatment advice", "Unnecessary iron supplementation" ], "in_scope": [], "out_of_scope": [], "characteristics": [] }, "sources": [], "structure": { "bundles": [ { "id": "safety", "name": "Safety", "description": "Emergencies first.", "rationale": "Crisis routing.", "layers": [ { "id": "poisoning", "name": "Poisoning", "description": "Acute iron poisoning.", "findings": [ { "id": "poisoning-finding", "name": "Poisoning", "description": "Poisoning.", "questions": [ { "text": "Has someone, especially a child, ingested iron tablets or supplements, requiring emergency services or a poison centre now?", "kind": "boundary" }, { "text": "Which entry fits poison control?", "kind": "action" } ] } ] }, { "id": "signs", "name": "Signs", "description": "Warning signs.", "findings": [ { "id": "signs-finding", "name": "Signs", "description": "Signs.", "questions": [ { "text": "What warning signs of acute iron poisoning do poison centres describe?", "kind": "provenance" }, { "text": "Is urgent care needed now?", "kind": "boundary" } ] } ] } ] }, { "id": "understand", "name": "Understand", "description": "What iron overload is.", "rationale": "General information.", "layers": [ { "id": "concept", "name": "Concept", "description": "Concept and causes.", "findings": [ { "id": "concept-finding", "name": "Concept", "description": "Concept.", "questions": [ { "text": "What is iron overload, and how do hereditary, transfusional, neonatal and acute forms differ?", "kind": "definition" }, { "text": "Is the user asking about their own condition, which needs a clinician?", "kind": "boundary" } ] } ] }, { "id": "effects", "name": "Effects", "description": "Effects on organs.", "findings": [ { "id": "effects-finding", "name": "Effects", "description": "Effects.", "questions": [ { "text": "How does excess iron damage the liver, heart, pancreas and joints, and what symptoms do health bodies describe?", "kind": "provenance" }, { "text": "Which entry fits haemochromatosis?", "kind": "action" } ] } ] } ] }, { "id": "manage", "name": "Manage", "description": "Diagnosis and treatment.", "rationale": "Guidance.", "layers": [ { "id": "diagnosis", "name": "Diagnosis", "description": "Diagnosis and screening.", "findings": [ { "id": "diagnosis-finding", "name": "Diagnosis", "description": "Diagnosis.", "questions": [ { "text": "How is iron overload diagnosed by blood and genetic tests, and who should be screened, according to guidelines?", "kind": "provenance" }, { "text": "Which entry fits genetic testing?", "kind": "action" } ] } ] }, { "id": "treatment", "name": "Treatment", "description": "Treatment.", "findings": [ { "id": "treatment-finding", "name": "Treatment", "description": "Treatment.", "questions": [ { "text": "How are phlebotomy and chelation used to treat iron overload, in general terms?", "kind": "provenance" }, { "text": "Is the presentation free of personal dosing advice?", "kind": "boundary" } ] } ] } ] }, { "id": "learn", "name": "Learn", "description": "Research and teaching.", "rationale": "Education.", "layers": [ { "id": "research", "name": "Research", "description": "Research.", "findings": [ { "id": "research-finding", "name": "Research", "description": "Research.", "questions": [ { "text": "What research is under way on iron metabolism and new treatments, with findings attributed?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "teach", "name": "Teach", "description": "Teaching.", "findings": [ { "id": "teach-finding", "name": "Teach", "description": "Teaching.", "questions": [ { "text": "How can iron metabolism disorders be taught?", "kind": "action" }, { "text": "Which misconceptions arise?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Should hereditary haemochromatosis be a separate entry?", "How should poison centre guidance be linked?", "How should guidelines be linked?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "abstract concept", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a iron overload, record what state it is in, and decide what may be done with it.", "whatItIs": "Let an agent explain iron overload and its causes and forms in general terms, relay diagnosis, treatment and screening information from health bodies, route acute iron poisoning to emergency services first, and route personal medical questions to clinicians.", "characteristics": { "substance": "abstract", "origin": "conceptual", "agency": "inert" }, "whatYouCanDoWithIt": [ "observed and measured" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: iron poisoning, aceruloplasminemia, atransferrinemia, neonatal hemochromatosis, hereditary haemochromatosis, GRACILE syndrome, rare hereditary hemochromatosis, Hemochromatosis type 4, hemochromatosis type 3, hemochromatosis type 1, hemochromatosis type 5, African iron overload.", "15 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 37 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a iron overload, and on what evidence are they told apart?" ], "whatItIsMadeOf": "an abstraction with no physical instance", "physicalCharacter": [ "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state" ], "howItIsRecognised": [ "Nothing to see. What is recognised is an instance of it, and which instances count is exactly what is argued about." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "iron poisoning", "aceruloplasminemia", "atransferrinemia", "neonatal hemochromatosis", "hereditary haemochromatosis", "GRACILE syndrome", "rare hereditary hemochromatosis", "Hemochromatosis type 4", "hemochromatosis type 3", "hemochromatosis type 1", "hemochromatosis type 5", "African iron overload" ] } ], "standing": "Described in 37 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 15 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one iron overload from another, and a iron overload from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a iron overload, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a iron overload, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a iron overload is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a iron overload, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a iron overload, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a iron overload is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a iron overload sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a iron overload, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a iron overload, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a iron overload is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a iron overload from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a iron overload, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a iron overload, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a iron overload is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a iron overload passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a iron overload between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a iron overload, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a iron overload, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a iron overload is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a iron overload, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a iron overload is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a iron overload, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a iron overload, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a iron overload is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "definitions-in-contest", "name": "Definitions and who holds them", "description": "What iron overload is taken to mean, and by whom.", "rationale": "When a field disagrees about a concept, the disagreement is the content. A model that picks one definition silently destroys the information.", "layers": [ { "id": "competing-definitions", "name": "Competing definitions", "description": "The main readings and the traditions behind them.", "findings": [ { "id": "definition-map", "name": "Definitions and their holders", "description": "Each definition with the school or body that holds it.", "questions": [ { "id": "definition-map-q01", "text": "Which definitions of iron overload are in use, and which tradition or body holds each?", "kind": "definition" }, { "id": "definition-map-q02", "text": "What turns on the difference between them in practice?", "kind": "boundary" } ] } ] }, { "id": "operationalisation", "name": "Operationalisation", "description": "How it is measured or applied when it has to be.", "findings": [ { "id": "operational-record", "name": "Measures and proxies", "description": "Instruments and indicators used to stand in for it.", "questions": [ { "id": "operational-record-q01", "text": "How is iron overload operationalised or measured in practice, and by what instrument?", "kind": "measurement" }, { "id": "operational-record-q02", "text": "What does that operationalisation leave out, and when does that matter?", "kind": "boundary" } ] } ] } ] }, { "id": "instances-and-use", "name": "Instances, use and consequence", "description": "What counts as an instance of iron overload and what follows from calling something that.", "rationale": "Applying a concept is an act with consequences, so a model must say what the label licenses and what it does not.", "layers": [ { "id": "instances", "name": "What counts as an instance", "description": "Clear cases, borderline cases and non-cases.", "findings": [ { "id": "instance-tests", "name": "Tests for an instance", "description": "What would settle whether something falls under it.", "questions": [ { "id": "instance-tests-q01", "text": "What would settle whether something is an instance of iron overload?", "kind": "boundary" }, { "id": "instance-tests-q02", "text": "Which borderline cases are argued about, and on what grounds?", "kind": "definition" } ] } ] }, { "id": "consequence", "name": "Consequence of application", "description": "Rights, duties or decisions that follow from the label.", "findings": [ { "id": "consequence-record", "name": "What the label licenses", "description": "What an agent may do once something is classified this way.", "questions": [ { "id": "consequence-record-q01", "text": "What follows practically once something is treated as iron overload?", "kind": "action" }, { "id": "consequence-record-q02", "text": "What must an agent not infer from the label alone?", "kind": "action" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a iron overload came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a iron overload and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a iron overload, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a iron overload, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a iron overload is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a iron overload is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a iron overload, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a iron overload, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a iron overload is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 5, "layers": 10, "findings": 12, "questions": 32 } } } }