{ "model": { "rank": 3972, "code": "thing-q206901", "model_id": "vr.tr.amyotrophic-lateral-sclerosis", "name": "amyotrophic lateral sclerosis", "purpose": "Let an agent explain amyotrophic lateral sclerosis in general terms, route symptoms to neurological assessment, describe care, support and research with attribution, and support people and families with sensitivity.", "family": "Thing Registry", "category": "Cross-cutting context", "status": "research-draft", "kind": "thing", "plane": "XCT", "domain": "XCT.STA", "industry": "", "version": "", "url": "/models/thing/q206901/", "tier": 2, "score": 79, "payload": { "layer": "wikidata", "aliases": [ "FTDALS1", "Lytico-bodig disease", "amyotrophic lateral sclerosis type 4", "amyotrophic lateral sclerosis type 21", "amyotrophic lateral sclerosis type 5", "familial amyotrophic lateral sclerosis", "progressive muscular atrophy", "amyotrophic lateral sclerosis type 17", "amyotrophic lateral sclerosis type 25", "Amyotrophic lateral sclerosis 21", "amyotrophic lateral sclerosis type 8", "amyotrophic lateral sclerosis type 3", "amyotrophic lateral sclerosis type 9", "amyotrophic lateral sclerosis type 13", "amyotrophic lateral sclerosis type 7", "amyotrohpic lateral sclerosis type 22", "juvenile amyotrophic lateral sclerosis", "amyotrophic lateral sclerosis type 23", "brachial amyotrophic diplegia", "sporadic amyotrophic lateral sclerosis", "amyotrophic lateral sclerosis with polyglucosan bodies", "adult progressive spinal muscular atrophy, Aran Duchenne type", "juvenile amyotrophic lateral sclerosis with dementia" ], "aliasCount": 23, "merged": 23, "knownIn": 79, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": "vr.tr.amyotrophic-lateral-sclerosis", "source": { "dataset": "wikidata", "item": "Q206901", "url": "https://www.wikidata.org/wiki/Q206901", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-11T22:57:42Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 2, "engine": "claude" }, "metaModel": { "id": "THING-Q206901", "registryId": "vr.tr.amyotrophic-lateral-sclerosis", "name": "amyotrophic lateral sclerosis", "version": "0.2.0-wave.2", "entryKind": "thing", "family": "Thing Registry", "domain": [ "XCT.STA" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q206901/", "model": { "registry_id": "vr.tr.amyotrophic-lateral-sclerosis", "name": "amyotrophic lateral sclerosis", "purpose": "Let an agent explain amyotrophic lateral sclerosis in general terms, route symptoms to neurological assessment, describe care, support and research with attribution, and support people and families with sensitivity.", "definition": "A progressive neurodegenerative disease of motor neurons in the brain and spinal cord causing muscle weakness, wasting and eventually loss of movement, speech, swallowing and breathing, occurring sporadically or in familial forms linked to genes such as SOD1, C9orf72 and TARDBP and overlapping with frontotemporal dementia; there is no cure, and care focuses on symptom management, support and emerging therapies.", "what_it_is_for": "A motor neuron disease.", "affordances": [ "explain the disease and its forms", "route symptoms to assessment", "describe care and support", "describe research and trials" ], "distinguishing_features": [ "Motor neuron degeneration", "Progressive", "Genetic subtypes", "Multidisciplinary care" ], "appearance": "Progressive weakness, muscle wasting and twitching, speech and swallowing difficulty.", "visual_identification": [ "Progressive motor neuron degeneration", "Sporadic or familial", "Other causes of weakness are far more common" ], "physical_properties": [], "families_and_kinds": [ "sporadic ALS", "familial ALS by gene", "ALS with frontotemporal dementia", "regional forms such as Lytico-bodig disease", "numbered subtypes" ], "related_models": [ { "relation": "is a kind of", "target": "motor neuron disease", "why": "category" }, { "relation": "is a kind of", "target": "TDP-43 Proteinopathies", "why": "category" }, { "relation": "affects", "target": "neuron", "why": "motor neurons" }, { "relation": "is related to", "target": "X-linked intellectual disability", "why": "another genetic disease group" } ], "identifiers": [], "standards_and_regulation": [ "Neurology clinical guidelines for ALS", "Genetic counselling guidelines", "Regulation of therapies and trials" ], "failure_modes_and_hazards": [ "Delayed diagnosis", "Unproven treatments", "Agents diagnosing or advising on treatment" ], "in_scope": [], "out_of_scope": [], "characteristics": [] }, "sources": [], "structure": { "bundles": [ { "id": "care", "name": "Care", "description": "Symptoms and routing.", "rationale": "Assessment.", "layers": [ { "id": "symptoms", "name": "Symptoms", "description": "When to seek assessment.", "findings": [ { "id": "symptoms-finding", "name": "Symptoms", "description": "Symptoms.", "questions": [ { "text": "Which symptoms, such as progressive weakness, muscle wasting or speech and swallowing changes, warrant neurological assessment, according to guidance?", "kind": "provenance" }, { "text": "Is the user asking for a diagnosis, which needs a neurologist?", "kind": "boundary" } ] } ] }, { "id": "diagnosis", "name": "Diagnosis", "description": "Diagnosis.", "findings": [ { "id": "diagnosis-finding", "name": "Diagnosis", "description": "Diagnosis.", "questions": [ { "text": "How is ALS diagnosed, and why can diagnosis take time?", "kind": "provenance" }, { "text": "How does genetic testing and counselling work for familial ALS?", "kind": "provenance" } ] } ] } ] }, { "id": "understand", "name": "Understand", "description": "The disease.", "rationale": "General information.", "layers": [ { "id": "mechanism", "name": "Mechanism", "description": "What happens.", "findings": [ { "id": "mechanism-finding", "name": "Mechanism", "description": "Mechanism.", "questions": [ { "text": "What happens to motor neurons in ALS, and what is known about causes including TDP-43 pathology and genes, according to research?", "kind": "provenance" }, { "text": "How does ALS overlap with frontotemporal dementia?", "kind": "provenance" } ] } ] }, { "id": "forms", "name": "Forms", "description": "Forms and course.", "findings": [ { "id": "forms-finding", "name": "Forms", "description": "Forms.", "questions": [ { "text": "How do sporadic, familial and regional forms differ, and how does the disease progress?", "kind": "provenance" }, { "text": "Which entry fits a specific subtype?", "kind": "action" } ] } ] } ] }, { "id": "support", "name": "Support", "description": "Living with ALS.", "rationale": "Care.", "layers": [ { "id": "care", "name": "Care", "description": "Multidisciplinary care.", "findings": [ { "id": "care-finding", "name": "Care", "description": "Care.", "questions": [ { "text": "What does multidisciplinary care involve, including respiratory, nutritional, communication and palliative support, according to guidelines?", "kind": "provenance" }, { "text": "Which treatments are approved, in general terms?", "kind": "provenance" } ] } ] }, { "id": "organisations", "name": "Organisations", "description": "Support organisations.", "findings": [ { "id": "organisations-finding", "name": "Organisations", "description": "Support.", "questions": [ { "text": "Which organisations support people with ALS and their families here?", "kind": "provenance" }, { "text": "Is a person in crisis now, requiring urgent support?", "kind": "boundary" } ] } ] } ] }, { "id": "research", "name": "Research", "description": "Research and awareness.", "rationale": "Context.", "layers": [ { "id": "trials", "name": "Trials", "description": "Research and trials.", "findings": [ { "id": "trials-finding", "name": "Trials", "description": "Trials.", "questions": [ { "text": "What are current research directions and trials in ALS, and how can people participate?", "kind": "provenance" }, { "text": "Which claims are unproven?", "kind": "provenance" } ] } ] }, { "id": "awareness", "name": "Awareness", "description": "Awareness and history.", "findings": [ { "id": "awareness-finding", "name": "Awareness", "description": "Awareness.", "questions": [ { "text": "How has ALS been recognised and named historically, and how has awareness grown?", "kind": "provenance" }, { "text": "Which misconceptions arise?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Should each genetic subtype be a separate entry?", "How should guidelines be linked?", "How should support organisations be localised?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "disease or condition", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a amyotrophic lateral sclerosis, record what state it is in, and decide what may be done with it.", "whatItIs": "Let an agent explain amyotrophic lateral sclerosis in general terms, route symptoms to neurological assessment, describe care, support and research with attribution, and support people and families with sensitivity.", "characteristics": { "substance": "abstract", "origin": "conceptual", "agency": "inert" }, "whatYouCanDoWithIt": [ "observed and measured" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: FTDALS1, Lytico-bodig disease, amyotrophic lateral sclerosis type 4, amyotrophic lateral sclerosis type 21, amyotrophic lateral sclerosis type 5, familial amyotrophic lateral sclerosis, progressive muscular atrophy, amyotrophic lateral sclerosis type 17, amyotrophic lateral sclerosis type 25, Amyotrophic lateral sclerosis 21, amyotrophic lateral sclerosis type 8, amyotrophic lateral sclerosis type 3.", "23 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 79 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a amyotrophic lateral sclerosis, and on what evidence are they told apart?" ], "whatItIsMadeOf": "an abstraction with no physical instance", "physicalCharacter": [ "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state" ], "howItIsRecognised": [ "Recognised by criteria applied to signs and findings, not by appearance. Two conditions can look identical and be distinguished only by test." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "FTDALS1", "Lytico-bodig disease", "amyotrophic lateral sclerosis type 4", "amyotrophic lateral sclerosis type 21", "amyotrophic lateral sclerosis type 5", "familial amyotrophic lateral sclerosis", "progressive muscular atrophy", "amyotrophic lateral sclerosis type 17", "amyotrophic lateral sclerosis type 25", "Amyotrophic lateral sclerosis 21", "amyotrophic lateral sclerosis type 8", "amyotrophic lateral sclerosis type 3" ] } ], "standing": "Described in 79 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 23 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one amyotrophic lateral sclerosis from another, and a amyotrophic lateral sclerosis from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a amyotrophic lateral sclerosis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a amyotrophic lateral sclerosis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a amyotrophic lateral sclerosis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a amyotrophic lateral sclerosis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a amyotrophic lateral sclerosis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a amyotrophic lateral sclerosis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a amyotrophic lateral sclerosis sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a amyotrophic lateral sclerosis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a amyotrophic lateral sclerosis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a amyotrophic lateral sclerosis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a amyotrophic lateral sclerosis from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a amyotrophic lateral sclerosis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a amyotrophic lateral sclerosis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a amyotrophic lateral sclerosis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a amyotrophic lateral sclerosis passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a amyotrophic lateral sclerosis between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a amyotrophic lateral sclerosis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a amyotrophic lateral sclerosis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a amyotrophic lateral sclerosis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a amyotrophic lateral sclerosis, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a amyotrophic lateral sclerosis is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a amyotrophic lateral sclerosis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a amyotrophic lateral sclerosis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a amyotrophic lateral sclerosis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "diagnosis-and-criteria", "name": "Diagnosis, criteria and coding", "description": "What makes a case of amyotrophic lateral sclerosis a case, and under which revision.", "rationale": "Criteria change between revisions, so a diagnosis without its coding revision cannot be compared with a later one.", "layers": [ { "id": "criteria", "name": "Diagnostic criteria", "description": "The criteria in force and who issues them.", "findings": [ { "id": "criteria-record", "name": "Criteria, issuer and revision", "description": "What must be true for a diagnosis, according to whom.", "questions": [ { "id": "criteria-record-q01", "text": "What criteria define amyotrophic lateral sclerosis, issued by which body, in which revision?", "kind": "definition" }, { "id": "criteria-record-q02", "text": "What changed between revisions that would reclassify existing cases?", "kind": "boundary" } ] } ] }, { "id": "coding", "name": "Coding and terminology", "description": "The codes used to record it and their mapping.", "findings": [ { "id": "coding-record", "name": "Codes and mappings", "description": "Which classification codes apply and how they map.", "questions": [ { "id": "coding-record-q01", "text": "Which classification and terminology codes cover amyotrophic lateral sclerosis, and how do they map to each other?", "kind": "definition" }, { "id": "coding-record-q02", "text": "What is lost when a case is mapped from one scheme to another?", "kind": "boundary" } ] } ] } ] }, { "id": "course-and-population", "name": "Course, population and care", "description": "How amyotrophic lateral sclerosis develops, whom it affects, and what is done about it.", "rationale": "The condition, the diagnosis and the episode of care are three different things, and an agent must not merge them.", "layers": [ { "id": "course", "name": "Course and stages", "description": "Onset, progression, remission and outcome.", "findings": [ { "id": "course-record", "name": "Stages and transitions", "description": "The stages recorded and what moves a case between them.", "questions": [ { "id": "course-record-q01", "text": "What course does amyotrophic lateral sclerosis typically take, and what marks each stage?", "kind": "definition" }, { "id": "course-record-q02", "text": "What separates the condition itself from an episode of care for it?", "kind": "boundary" } ] } ] }, { "id": "population", "name": "Affected populations", "description": "Who is affected, how often, and on what evidence.", "findings": [ { "id": "epidemiology", "name": "Prevalence and its basis", "description": "Rates with their population, period and source.", "questions": [ { "id": "epidemiology-q01", "text": "What prevalence or incidence is reported for amyotrophic lateral sclerosis, in which population and period?", "kind": "measurement" }, { "id": "epidemiology-q02", "text": "What may an agent not conclude about an individual from a population rate?", "kind": "action" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a amyotrophic lateral sclerosis came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a amyotrophic lateral sclerosis and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a amyotrophic lateral sclerosis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a amyotrophic lateral sclerosis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a amyotrophic lateral sclerosis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a amyotrophic lateral sclerosis is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a amyotrophic lateral sclerosis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a amyotrophic lateral sclerosis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a amyotrophic lateral sclerosis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 5, "layers": 10, "findings": 12, "questions": 32 } } } }