{ "model": { "rank": 6238, "code": "thing-q208413", "model_id": "vr.tr.botulinum-toxin-group", "name": "botulinum toxin group", "purpose": "Enable an AI agent to recognise members of the botulinum toxin group, assess the identity and condition of a documented material, and determine which uses require further evidence or authorisation.", "family": "Thing Registry", "category": "Physical world and living systems", "status": "research-draft", "kind": "thing", "plane": "PHY", "domain": "PHY.MAT", "industry": "", "version": "", "url": "/models/thing/q208413/", "tier": 2, "score": 61, "payload": { "layer": "wikidata", "aliases": [ "botulinum toxin type A", "botA ser-430 phosphorylated", "botA ser-454 phosphorylated", "botA ser-454 phosphorylated [plasma membrane]", "botA ser-430 phosphorylated [plasma membrane]", "botA ser-454 phosphorylated [synaptic vesicle membrane]", "botA ser-430 phosphorylated [synaptic vesicle membrane]", "botA HC disulfide bonded [extracellular region]", "botA LC disulfide bonded [extracellular region]", "botA HC disulfide bonded [plasma membrane]", "botA LC disulfide bonded [plasma membrane]", "botA HC disulfide bonded [synaptic vesicle membrane]", "botA LC disulfide bonded [synaptic vesicle membrane]" ], "aliasCount": 13, "merged": 13, "knownIn": 61, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q208413", "url": "https://www.wikidata.org/wiki/Q208413", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-09T22:58:12Z", "providers": [ "Codex" ], "breadth": "recalled by Codex without web access - no source was read", "missingProviders": [], "pass": 2, "cost": { "grok": { "seconds": 23.9, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a08863-a003-77e3-b0fb-ac8ec3526626\n--------\nuser\nDescribe what is already known about one registered thing. Answer as JSON only, no prose around it.\n\nThing: botulinum toxin group\nSense to describe: (none recorded)\nDomain code: PHY.MAT\nAlso known as: (none)\n\n\nContext for this batch of 188 things:\n# Batch 006:", "usd": 0, "recall": true }, "codex": { "seconds": 66.8, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a08863-a00d-7e10-9ae2-21365bef4487\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: botulinum toxin group\nRegistry id: vr.tr.botulinum-toxin-group\nPlane / domain: PHY / PHY.MAT\nRegistry definition: (none recorded)\nNames folded into t" } } }, "metaModel": { "id": "THING-Q208413", "registryId": "vr.tr.botulinum-toxin-group", "name": "botulinum toxin group", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.MAT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q208413/", "model": { "registry_id": "vr.tr.botulinum-toxin-group", "name": "botulinum toxin group", "purpose": "Enable an AI agent to recognise members of the botulinum toxin group, assess the identity and condition of a documented material, and determine which uses require further evidence or authorisation.", "definition": "Botulinum toxins are a family of bacterial protein neurotoxins, produced principally by Clostridium botulinum and some related clostridia, that cleave neuronal SNARE proteins and inhibit acetylcholine release at peripheral cholinergic nerve terminals.", "scope_statement": "This model owns the group-level identity of botulinum neurotoxins and the evidence needed to describe particular members and material instances, while distinguishing the toxin from producing organisms, formulated medicines, and diseases.", "in_scope": [ "Group membership, nomenclature, and relationships among named toxin types and variants", "Protein identity and distinctions between neurotoxin and associated protein complexes", "Material composition, purity, integrity, and documented biological activity", "Provenance and traceability of reference materials and material instances", "Hazard evidence and restrictions applicable to a specified material and jurisdiction" ], "out_of_scope": [ "Taxonomy, cultivation, and genetic modification of toxin-producing organisms", "Toxin production, extraction, purification, or potency-enhancement procedures", "Botulism diagnosis and patient management", "Medicinal product formulation, prescribing, dosing, and administration", "Detailed transport, containment, decontamination, and disposal procedures" ], "distinguishing_features": [ "The referent is a toxin protein or defined toxin group, rather than a bacterium, bacterial spore, or toxin-encoding gene.", "Group membership requires documented identification; a shared neurotoxic effect alone does not establish that a material is botulinum toxin.", "A named toxin type or variant is a member-level identity, not automatically a synonym for the entire group.", "The neurotoxin component is distinguished from preparations containing associated proteins, excipients, or other constituents.", "A commercial medicine containing botulinum toxin has a separate product identity; its label and activity units do not define every member of the toxin group." ], "characteristics": [ { "name": "Identity resolution", "kind": "state", "unit_or_values": "Group only; member identified; mixture; unresolved", "why_it_matters": "Prevents an agent from assigning member-specific properties to an unspecified group reference." }, { "name": "Toxin designation", "kind": "category", "unit_or_values": "Source-supported type, subtype, or variant designation with naming authority and version", "why_it_matters": "Supports recognition without treating evolving or conflicting names as settled equivalences." }, { "name": "Molecular reference", "kind": "relation", "unit_or_values": "Curated protein accession and version, with the represented sequence or molecular entity identified", "why_it_matters": "Connects a name to an explicit molecular referent." }, { "name": "Material composition", "kind": "category", "unit_or_values": "Neurotoxin component; associated protein complex; formulated preparation; mixture; unknown", "why_it_matters": "Determines which observations apply to the toxin itself and which apply to the preparation." }, { "name": "Toxin concentration", "kind": "measurement", "unit_or_values": "Mass per volume or amount per volume, with analyte definition, method, uncertainty, and matrix", "why_it_matters": "Records quantity without equating protein amount with biological activity." }, { "name": "Purity", "kind": "measurement", "unit_or_values": "Percentage with explicit analytical basis, measured constituents, and method", "why_it_matters": "Makes purity claims interpretable and prevents incompatible measurements from being compared directly." }, { "name": "Biological activity", "kind": "measurement", "unit_or_values": "Assay-defined units with endpoint, reference standard, method, date, and uncertainty", "why_it_matters": "Activity values require their measurement context and cannot be presumed interchangeable." }, { "name": "Molecular integrity", "kind": "state", "unit_or_values": "Evidence-supported intact, altered, fragmented, aggregated, mixed, or unassessed state", "why_it_matters": "Identity and protein quantity alone do not establish the current functional condition." }, { "name": "Physical presentation", "kind": "category", "unit_or_values": "Documented material form and matrix, with observation conditions", "why_it_matters": "Physical properties belong to a specified preparation and condition, rather than automatically to the whole group." }, { "name": "Applicable control status", "kind": "relation", "unit_or_values": "Jurisdiction-specific authoritative record with scope, effective date, and material applicability", "why_it_matters": "Supports decisions about permitted actions without assuming that rules are universal or timeless." } ], "affordances": [ "Resolve a reported name to the group, a documented member, or an unresolved identity.", "Link material records to molecular references and traceable provenance.", "Assess whether composition, integrity, and activity evidence support a stated material description.", "Compare measurements only when analytes, methods, standards, and units justify comparison.", "Identify missing hazard or authorisation evidence and route consequential decisions to qualified review." ] }, "sources": [], "structure": { "bundles": [ { "id": "group-identity-and-membership", "name": "Group identity and membership", "description": "Defines what the registry group denotes and how specific toxin identities relate to it.", "rationale": "The registry names a group, so an agent must distinguish group-wide statements from statements about individual members.", "layers": [ { "id": "registry-referent", "name": "Registry referent", "description": "Establishes the intended meaning and boundaries of the registered name.", "findings": [ { "id": "group-definition", "name": "Group definition", "description": "Record a sourced definition and the criteria used to include or exclude proposed members.", "questions": [ { "text": "Which authoritative definition establishes the intended membership of vr.tr.botulinum-toxin-group?", "kind": "definition", "id": "group-definition-q01" }, { "text": "Does the group include engineered derivatives and inactive forms, or should these be represented through explicit relationships?", "kind": "boundary", "id": "group-definition-q02" } ] } ] }, { "id": "member-nomenclature", "name": "Member nomenclature", "description": "Connects reported toxin names to supported member identities.", "findings": [ { "id": "designation-evidence", "name": "Designation evidence", "description": "Record type and variant designations together with molecular references and naming provenance.", "questions": [ { "text": "What source supports the reported type, subtype, or variant designation?", "kind": "provenance", "id": "designation-evidence-q01" }, { "text": "Which names are true synonyms, and which denote different sequences, complexes, or products?", "kind": "boundary", "id": "designation-evidence-q02" } ] } ] } ] }, { "id": "molecular-entity-and-composition", "name": "Molecular entity and composition", "description": "Separates the toxin protein from the other constituents of a material.", "rationale": "Descriptions of neurotoxin, protein complexes, and formulated preparations must not be merged into one substance identity.", "layers": [ { "id": "protein-identity", "name": "Protein identity", "description": "Identifies the molecular entity to which analytical claims refer.", "findings": [ { "id": "molecular-reference-and-form", "name": "Molecular reference and form", "description": "Record the reference sequence, documented molecular form, and limits of identity evidence.", "questions": [ { "text": "Which protein accession or other verified reference identifies the toxin component?", "kind": "provenance", "id": "molecular-reference-and-form-q01" }, { "text": "Does the evidence resolve the molecular form present, or establish only a broader toxin identity?", "kind": "measurement", "id": "molecular-reference-and-form-q02" } ] } ] }, { "id": "preparation-constituents", "name": "Preparation constituents", "description": "Describes associated proteins, matrices, and other constituents separately from the toxin.", "findings": [ { "id": "composition-and-purity-basis", "name": "Composition and purity basis", "description": "Record what the material contains and precisely what any purity claim measures.", "questions": [ { "text": "Does the material represent the neurotoxin component, an associated protein complex, or a preparation containing additional constituents?", "kind": "boundary", "id": "composition-and-purity-basis-q01" }, { "text": "What analytical basis, denominator, and uncertainty support the reported purity?", "kind": "measurement", "id": "composition-and-purity-basis-q02" } ] } ] } ] }, { "id": "activity-and-material-condition", "name": "Activity and material condition", "description": "Connects quantity, biological activity, and current material condition without conflating them.", "rationale": "A toxin identity or protein concentration does not by itself establish functional activity or the validity of an older measurement.", "layers": [ { "id": "activity-measurement", "name": "Activity measurement", "description": "Makes reported activity interpretable through its assay and reference context.", "findings": [ { "id": "activity-claim-comparability", "name": "Activity claim comparability", "description": "Record activity results with the endpoint and standard needed to judge their meaning.", "questions": [ { "text": "Which endpoint, method, reference standard, and unit definition support the activity result?", "kind": "measurement", "id": "activity-claim-comparability-q01" }, { "text": "What evidence permits comparison with another reported activity value, including values attached to commercial products?", "kind": "boundary", "id": "activity-claim-comparability-q02" } ] } ] }, { "id": "condition-evidence", "name": "Condition evidence", "description": "Tracks observations that constrain claims about the present material.", "findings": [ { "id": "integrity-and-evidence-validity", "name": "Integrity and evidence validity", "description": "Record observed integrity and whether existing measurements remain applicable to the material instance.", "questions": [ { "text": "What dated evidence establishes the material's molecular integrity and physical presentation?", "kind": "measurement", "id": "integrity-and-evidence-validity-q01" }, { "text": "Do documented changes or gaps in material history require qualified review before earlier activity claims can be reused?", "kind": "action", "id": "integrity-and-evidence-validity-q02" } ] } ] } ] }, { "id": "provenance-and-reference-traceability", "name": "Provenance and reference traceability", "description": "Connects identities and measurements to the particular material and evidence they describe.", "rationale": "A group name, catalogue identifier, or producer association is insufficient to establish the identity and properties of a specific material.", "layers": [ { "id": "material-lineage", "name": "Material lineage", "description": "Establishes the documented origin of the material without modelling production procedures.", "findings": [ { "id": "origin-and-instance-link", "name": "Origin and instance link", "description": "Record origin claims and the identifiers connecting supporting records to the material instance.", "questions": [ { "text": "Which provider, accession, or lot records connect this material to its documented origin?", "kind": "provenance", "id": "origin-and-instance-link-q01" }, { "text": "Is the toxin identity directly supported, or inferred only from an associated organism or provider description?", "kind": "provenance", "id": "origin-and-instance-link-q02" } ] } ] }, { "id": "identifier-and-evidence-scope", "name": "Identifier and evidence scope", "description": "Limits each identifier and source claim to its actual referent.", "findings": [ { "id": "reference-applicability", "name": "Reference applicability", "description": "Record whether a reference describes the group, one toxin member, a complex, or a particular product.", "questions": [ { "text": "For each chemical or biological database identifier, what exact entity does the source record identify?", "kind": "boundary", "id": "reference-applicability-q01" }, { "text": "Which read sources support each identity or property claim, and what limitations do those sources state?", "kind": "provenance", "id": "reference-applicability-q02" } ] } ] } ] }, { "id": "hazard-and-permitted-use", "name": "Hazard and permitted use", "description": "Records evidence governing hazard interpretation and authorised actions for the specified material.", "rationale": "The agent must distinguish documented hazard and legal applicability from assumptions based on a group name or therapeutic association.", "layers": [ { "id": "hazard-applicability", "name": "Hazard applicability", "description": "Links hazard statements to the material, exposure context, and authoritative source.", "findings": [ { "id": "material-specific-hazard-record", "name": "Material-specific hazard record", "description": "Record applicable hazard classifications and the limits of claims about reduced or absent activity.", "questions": [ { "text": "Which authoritative hazard record applies to this member, preparation, and physical form?", "kind": "provenance", "id": "material-specific-hazard-record-q01" }, { "text": "Does a claim of inactivity describe a limited assay result or a separately validated material status?", "kind": "boundary", "id": "material-specific-hazard-record-q02" } ] } ] }, { "id": "authorised-action-context", "name": "Authorised action context", "description": "Relates proposed actions to current controls and documented institutional authority.", "findings": [ { "id": "permission-and-review-evidence", "name": "Permission and review evidence", "description": "Record the evidence required to determine whether a proposed use or transfer may proceed.", "questions": [ { "text": "Which current jurisdictional and institutional requirements apply to the specific material and proposed action?", "kind": "action", "id": "permission-and-review-evidence-q01" }, { "text": "What documented authority or qualified review is needed before the agent can treat that action as permitted?", "kind": "action", "id": "permission-and-review-evidence-q02" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-confidence-notes", "name": "Check these first", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "This is recall-based information; no sources were consulted.", "The six listed serotypes are not exhaustive: classical serotype G also exists, and newer divergent toxins require careful classification.", "Confirm current regulatory wording and sequence-specific identifiers; molecular masses describe the neurotoxin itself, not larger associated protein complexes." ], "questions": [ { "id": "evidence-confidence-notes-q01", "text": "Which of these check these first hold for the sense of botulinum toxin group this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-kinds", "name": "Kinds and varieties", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Serotype A", "Serotype B", "Serotype C", "Serotype D", "Serotype E", "Serotype F" ], "questions": [ { "id": "evidence-kinds-q01", "text": "Which of these kinds and varieties hold for the sense of botulinum toxin group this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-identifiers", "name": "Identifiers and schemes", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "scheme": "UniProtKB", "value_or_pattern": "Protein accession identifying a particular toxin sequence", "note": "Sequence records distinguish toxins and variants; one accession does not identify the entire group." } ], "questions": [ { "id": "evidence-identifiers-q01", "text": "Which of these identifiers and schemes hold for the sense of botulinum toxin group this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-standards-and-regulation", "name": "Standards and regulation", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Chemical Weapons Convention, administered by the OPCW: botulinum toxins are listed in Schedule 1.", "Biological Weapons Convention: prohibits toxin weapons regardless of the toxin's origin or method of production.", "US FDA: medicinal botulinum toxin products require product-specific approval and carry boxed warnings about distant spread of toxin effect." ], "questions": [ { "id": "evidence-standards-and-regulation-q01", "text": "Which of these standards and regulation hold for the sense of botulinum toxin group this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Treatment of selected movement disorders and muscle spasticity.", "Prevention of chronic migraine using specifically approved products.", "Treatment of selected autonomic disorders, including excessive sweating.", "Temporary reduction of selected facial lines.", "Research on neurotransmitter release and SNARE protein function." ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of botulinum toxin group this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-measurements", "name": "Typical measurements", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "quantity": "Molecular mass of the neurotoxin protein", "typical_range": "Approximately 150", "unit": "kDa" }, { "quantity": "Heavy-chain molecular mass", "typical_range": "Approximately 100", "unit": "kDa" }, { "quantity": "Light-chain molecular mass", "typical_range": "Approximately 50", "unit": "kDa" } ], "questions": [ { "id": "evidence-measurements-q01", "text": "Which of these typical measurements hold for the sense of botulinum toxin group this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Intoxication causes botulism, potentially including descending flaccid paralysis and respiratory failure.", "Therapeutic exposure can cause unintended weakness, swallowing difficulty or other effects beyond the intended treatment site.", "Potency units are product- and assay-specific; treating different products' units as interchangeable can cause dosing errors.", "Neutralizing antibodies can reduce therapeutic effectiveness.", "Protein degradation or aggregation can compromise pharmaceutical potency and quality." ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of botulinum toxin group this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-regional-variation", "name": "Regional variation", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Approved products, indications and prescribing requirements differ between jurisdictions.", "Rules governing possession, transfer and handling of toxin materials differ by jurisdiction and exemption." ], "questions": [ { "id": "evidence-regional-variation-q01", "text": "Which of these regional variation hold for the sense of botulinum toxin group this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "name": "Clostridium botulinum", "difference": "The bacterium is an organism that can produce toxin; the toxin group consists of protein substances." }, { "name": "Botulism", "difference": "Botulism is the clinical disease caused by toxin action, rather than the toxin itself." }, { "name": "Botulinum toxin medicinal product", "difference": "A medicinal product has a specified active ingredient, formulation and potency assay; the group encompasses the underlying toxin family." }, { "name": "Tetanus toxin", "difference": "Tetanus toxin predominantly disrupts inhibitory neurotransmission and causes spastic paralysis, whereas botulinum toxins characteristically cause flaccid paralysis." } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of botulinum toxin group this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "What source-backed definition should be adopted for this registry entry, which currently has no recorded definition?", "Which naming authority and version should govern member inclusion, especially disputed designations and newly described variants?", "How should inactive forms and engineered derivatives relate to the group without creating unsupported additional registry entries?", "Which identifiers and physical-property records apply to the group itself, and which apply only to particular proteins, complexes, or preparations?", "Does an existing Vercy world model already own this concept, and which jurisdiction-specific sources are needed to complete its hazard and permitted-use coverage?" ], "statistics": { "bundles": 6, "layers": 11, "findings": 19, "questions": 29 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "chemical substance or material", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a botulinum toxin group, record what state it is in, and decide what may be done with it.", "whatItIs": "Enable an AI agent to recognise members of the botulinum toxin group, assess the identity and condition of a documented material, and determine which uses require further evidence or authorisation.", "characteristics": { "substance": "material", "origin": "natural", "agency": "inert", "mobility": "varies" }, "whatYouCanDoWithIt": [ "observed and measured", "consumed or used up" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: botulinum toxin type A, botA ser-430 phosphorylated, botA ser-454 phosphorylated, botA ser-454 phosphorylated [plasma membrane], botA ser-430 phosphorylated [plasma membrane], botA ser-454 phosphorylated [synaptic vesicle membrane], botA ser-430 phosphorylated [synaptic vesicle membrane], botA HC disulfide bonded [extracellular region], botA LC disulfide bonded [extracellular region], botA HC disulfide bonded [plasma membrane], botA LC disulfide bonded [plasma membrane], botA HC disulfide bonded [synaptic vesicle membrane].", "13 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 61 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a botulinum toxin group, and on what evidence are they told apart?" ], "whatItIsMadeOf": "matter you can touch", "physicalCharacter": [ "Mobility varies between examples.", "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state", "use it up, and then need more of it" ], "howItIsRecognised": [ "Not recognisable by sight in any reliable way. Appearance varies with grade, form and additives; identification is by label, by documentation, or by assay." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "botulinum toxin type A", "botA ser-430 phosphorylated", "botA ser-454 phosphorylated", "botA ser-454 phosphorylated [plasma membrane]", "botA ser-430 phosphorylated [plasma membrane]", "botA ser-454 phosphorylated [synaptic vesicle membrane]", "botA ser-430 phosphorylated [synaptic vesicle membrane]", "botA HC disulfide bonded [extracellular region]", "botA LC disulfide bonded [extracellular region]", "botA HC disulfide bonded [plasma membrane]", "botA LC disulfide bonded [plasma membrane]", "botA HC disulfide bonded [synaptic vesicle membrane]" ] } ], "standing": "Described in 61 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 13 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one botulinum toxin group from another, and a botulinum toxin group from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a botulinum toxin group, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a botulinum toxin group, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a botulinum toxin group is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a botulinum toxin group, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a botulinum toxin group, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a botulinum toxin group is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a botulinum toxin group sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a botulinum toxin group, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a botulinum toxin group, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a botulinum toxin group is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a botulinum toxin group from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a botulinum toxin group, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a botulinum toxin group, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a botulinum toxin group is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "form-and-composition", "name": "Form, composition and condition", "description": "What a botulinum toxin group is made of, what shape and size it takes, and what state it is in.", "rationale": "A physical thing can be measured, and a model that cannot record its measurements cannot support any decision that depends on them.", "layers": [ { "id": "form-and-dimensions", "name": "Form and dimensions", "description": "Shape, size, mass and the ranges these take across examples.", "findings": [ { "id": "measurable-dimensions", "name": "Measurable dimensions and their units", "description": "The quantities worth recording and the units they are recorded in.", "questions": [ { "id": "measurable-dimensions-q01", "text": "What identifies and describes the dimensions of a botulinum toxin group, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "measurable-dimensions-q02", "text": "Who or what asserted this about the dimensions of a botulinum toxin group, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "measurable-dimensions-q03", "text": "What may an agent decide or do once the dimensions of a botulinum toxin group is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "material-and-composition", "name": "Material and composition", "description": "Materials, parts and how they are put together.", "findings": [ { "id": "parts-and-materials", "name": "Parts and materials", "description": "What a botulinum toxin group is built from and which parts are replaceable.", "questions": [ { "id": "parts-and-materials-q01", "text": "What identifies and describes the composition of a botulinum toxin group, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "parts-and-materials-q02", "text": "Who or what asserted this about the composition of a botulinum toxin group, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "parts-and-materials-q03", "text": "What may an agent decide or do once the composition of a botulinum toxin group is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "condition-and-integrity", "name": "Condition and integrity", "description": "Wear, damage, health and the difference between working and broken.", "findings": [ { "id": "condition-assessment", "name": "Condition, damage and health", "description": "How the condition of a botulinum toxin group is judged and by whom.", "questions": [ { "id": "condition-assessment-q01", "text": "What identifies and describes the condition of a botulinum toxin group, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "condition-assessment-q02", "text": "Who or what asserted this about the condition of a botulinum toxin group, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "condition-assessment-q03", "text": "What may an agent decide or do once the condition of a botulinum toxin group is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "place-and-movement", "name": "Place and movement", "description": "Where a botulinum toxin group is, how it got there and where it may go (varies).", "rationale": "A thing that can move needs its position recorded with a time, or every later claim about it is about a place it has left.", "layers": [ { "id": "location-and-placement", "name": "Location and placement", "description": "Position, containment and the reference frame the position is given in.", "findings": [ { "id": "position-and-frame", "name": "Position, container and reference frame", "description": "Where a botulinum toxin group is, and what that position is measured against.", "questions": [ { "id": "position-and-frame-q01", "text": "What identifies and describes the location of a botulinum toxin group, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "position-and-frame-q02", "text": "Who or what asserted this about the location of a botulinum toxin group, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "position-and-frame-q03", "text": "What may an agent decide or do once the location of a botulinum toxin group is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "movement-and-transfer", "name": "Movement and transfer", "description": "How a botulinum toxin group is carried, installed or relocated.", "findings": [ { "id": "movement-events", "name": "Movement events and constraints", "description": "What counts as a movement, what records it and what limits it.", "questions": [ { "id": "movement-events-q01", "text": "What identifies and describes the movement of a botulinum toxin group, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "movement-events-q02", "text": "Who or what asserted this about the movement of a botulinum toxin group, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "movement-events-q03", "text": "What may an agent decide or do once the movement of a botulinum toxin group is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a botulinum toxin group passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a botulinum toxin group between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a botulinum toxin group, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a botulinum toxin group, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a botulinum toxin group is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a botulinum toxin group, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a botulinum toxin group is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a botulinum toxin group, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a botulinum toxin group, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a botulinum toxin group is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "use-and-operation", "name": "Use and operation", "description": "What can be done with a botulinum toxin group and what it takes to do it.", "rationale": "An agent that can recognise a thing but not act on it has only half a model.", "layers": [ { "id": "intended-use", "name": "Intended use and function", "description": "What a botulinum toxin group is for, and what it is used for anyway.", "findings": [ { "id": "function-and-purpose", "name": "Function, purpose and misuse", "description": "The function a botulinum toxin group performs and the uses that fall outside it.", "questions": [ { "id": "function-and-purpose-q01", "text": "What identifies and describes the use of a botulinum toxin group, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "function-and-purpose-q02", "text": "Who or what asserted this about the use of a botulinum toxin group, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "function-and-purpose-q03", "text": "What may an agent decide or do once the use of a botulinum toxin group is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "handling-and-procedure", "name": "Handling and procedure", "description": "The steps, skills and tools involved in using a botulinum toxin group.", "findings": [ { "id": "procedures-and-skills", "name": "Procedures, skills and required tools", "description": "What an agent needs before it can act on a botulinum toxin group at all.", "questions": [ { "id": "procedures-and-skills-q01", "text": "What identifies and describes handling a botulinum toxin group, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "procedures-and-skills-q02", "text": "Who or what asserted this about handling a botulinum toxin group, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "procedures-and-skills-q03", "text": "What may an agent decide or do once handling a botulinum toxin group is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "supply-and-consumption", "name": "Supply and consumption", "description": "Quantities, rates and what running out means.", "findings": [ { "id": "consumption-and-stock", "name": "Consumption, stock and replenishment", "description": "How much of a botulinum toxin group there is and how fast it goes.", "questions": [ { "id": "consumption-and-stock-q01", "text": "What identifies and describes the supply of a botulinum toxin group, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "consumption-and-stock-q02", "text": "Who or what asserted this about the supply of a botulinum toxin group, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "consumption-and-stock-q03", "text": "What may an agent decide or do once the supply of a botulinum toxin group is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "composition-and-identity", "name": "Composition, grade and chemical identity", "description": "What botulinum toxin group is made of and how pure the thing in hand is.", "rationale": "Grade decides what a substance may be used for, so a model that records only the name cannot support any decision about use.", "layers": [ { "id": "chemical-identity", "name": "Chemical identity", "description": "Formula, structure and the registry numbers that name it unambiguously.", "findings": [ { "id": "identity-record", "name": "Identity and registry numbers", "description": "What identifies this substance across suppliers and regulators.", "questions": [ { "id": "identity-record-q01", "text": "What formula, structure and registry identifiers name botulinum toxin group unambiguously?", "kind": "definition" }, { "id": "identity-record-q02", "text": "Which related substances share a name in common use but not an identifier?", "kind": "boundary" } ] } ] }, { "id": "grade-and-impurities", "name": "Grade, purity and impurities", "description": "The specification a batch meets and what else is in it.", "findings": [ { "id": "specification", "name": "Specification and assay", "description": "How purity is stated and measured, and which impurities matter.", "questions": [ { "id": "specification-q01", "text": "What grades of botulinum toxin group exist, how is purity assayed, and which impurities are limited?", "kind": "measurement" }, { "id": "specification-q02", "text": "Which use requires which grade, and what happens when a lower grade is substituted?", "kind": "action" } ] } ] } ] }, { "id": "properties-and-behaviour", "name": "Properties and behaviour", "description": "How botulinum toxin group behaves under conditions an agent can measure or change.", "rationale": "Physical constants are the part of a substance model that transfers between contexts, and each needs its unit and its conditions.", "layers": [ { "id": "physical-constants", "name": "Physical constants", "description": "Values that hold for the pure substance, with their conditions.", "findings": [ { "id": "constants-record", "name": "Constants and conditions", "description": "The quantities worth recording and the state they apply in.", "questions": [ { "id": "constants-record-q01", "text": "What are the defining physical constants of botulinum toxin group, in what units and under what conditions?", "kind": "measurement" }, { "id": "constants-record-q02", "text": "Which of these values change with grade or form rather than being fixed?", "kind": "boundary" } ] } ] }, { "id": "stability-and-reactivity", "name": "Stability and reactivity", "description": "What it reacts with, degrades into, and how it is stored.", "findings": [ { "id": "incompatibilities", "name": "Incompatibilities and degradation", "description": "What must not meet it, and what it becomes over time.", "questions": [ { "id": "incompatibilities-q01", "text": "What is botulinum toxin group incompatible with, and what does it degrade into under storage?", "kind": "definition" }, { "id": "incompatibilities-q02", "text": "What storage and handling does that require, and who is competent to do it?", "kind": "action" } ] } ] } ] }, { "id": "hazard-and-regulation", "name": "Hazard classification and regulation", "description": "How botulinum toxin group can harm, and what the law says about holding and moving it.", "rationale": "A substance model without its hazard class and its regulatory identity is unusable in exactly the situations that matter.", "layers": [ { "id": "hazard-class", "name": "Hazard classification", "description": "Classified hazards, exposure limits and protective measures.", "findings": [ { "id": "classified-hazards", "name": "Classified hazards and limits", "description": "The classification, the scheme it belongs to, and the limits set.", "questions": [ { "id": "classified-hazards-q01", "text": "How is botulinum toxin group classified for hazard, under which scheme, and what exposure limits apply?", "kind": "definition" }, { "id": "classified-hazards-q02", "text": "What protection does handling require, and what must an agent refuse to do without it?", "kind": "action" } ] } ] }, { "id": "regulatory-identity", "name": "Regulatory identity and control", "description": "Registration, restriction and transport rules by jurisdiction.", "findings": [ { "id": "controls", "name": "Controls and jurisdiction", "description": "Where it is restricted and what the restriction attaches to.", "questions": [ { "id": "controls-q01", "text": "Which registrations, restrictions or transport rules cover botulinum toxin group, and where?", "kind": "provenance" }, { "id": "controls-q02", "text": "Does the control attach to the substance, its concentration, or its intended use?", "kind": "boundary" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a botulinum toxin group came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a botulinum toxin group and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a botulinum toxin group, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a botulinum toxin group, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a botulinum toxin group is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a botulinum toxin group is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a botulinum toxin group, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a botulinum toxin group, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a botulinum toxin group is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 9, "layers": 20, "findings": 22, "questions": 60 } } } }