{ "model": { "rank": 12066, "code": "thing-q210973", "model_id": "vr.tr.cell-signaling", "name": "cell signaling", "purpose": "Let an agent explain cell signalling and signal transduction, relay receptor types and major pathways from cell biology references, describe roles in disease and drug action, and distinguish cell signalling from neural signalling and from intercellular communication in general.", "family": "Thing Registry", "category": "Activities and processes", "status": "research-draft", "kind": "thing", "plane": "ACT", "domain": "ACT.ACT", "industry": "", "version": "", "url": "/models/thing/q210973/", "tier": 2, "score": 40, "payload": { "layer": "wikidata", "aliases": [ "signal transduction", "opioid growth factor receptor signaling pathway", "granzyme-mediated programmed cell death signaling pathway", "endoplasmic reticulum unfolded protein response", "G protein-coupled receptor signaling pathway", "cell surface receptor signaling pathway", "intracellular signal transduction", "SMAD protein signal transduction", "phototransduction", "hormone-mediated signaling pathway", "hypoxia-inducible factor-1alpha signaling pathway", "dopamine receptor signaling pathway", "apoptotic signaling pathway", "intracellular receptor signaling pathway", "signal transduction involved in regulation of gene expression", "serotonin receptor signaling pathway", "bile acid signaling pathway", "necroptotic signaling pathway", "immune response-regulating signaling pathway", "carbohydrate mediated signaling", "ER-nucleus signaling pathway", "neuronal signal transduction", "mitochondria-nucleus signaling pathway", "red or far-red light signaling pathway", "signal transduction involved in positive regulation of conjugation with cellular fusion", "regulation of floral organ abscission by signal transduction", "hydrogen peroxide mediated signaling pathway", "signal transduction involved in filamentous growth", "regulation of blood pressure by chemoreceptor signaling pathway", "salicylic acid mediated signaling pathway", "signal transduction in absence of ligand", "sphingolipid mediated signaling pathway", "chloroplast-nucleus signaling pathway", "signal transduction involved in cellular response to ammonium ion", "lipoprotein particle mediated signaling", "postsynaptic signal transduction", "presynaptic signal transduction", "calmodulin dependent kinase signaling pathway", "receptor cross-talk", "ligand-gated ion channel signaling pathway" ], "aliasCount": 49, "merged": 49, "knownIn": 40, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q210973", "url": "https://www.wikidata.org/wiki/Q210973", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-13T04:49:08Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 3, "engine": "claude" }, "metaModel": { "id": "THING-Q210973", "registryId": "vr.tr.cell-signaling", "name": "cell signaling", "version": "0.2.0-wave.3", "entryKind": "thing", "family": "Thing Registry", "domain": [ "ACT.ACT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q210973/", "model": { "registry_id": "vr.tr.cell-signaling", "name": "cell signaling", "purpose": "Let an agent explain cell signalling and signal transduction, relay receptor types and major pathways from cell biology references, describe roles in disease and drug action, and distinguish cell signalling from neural signalling and from intercellular communication in general.", "definition": "The process by which cells receive, process and respond to signals from their environment and from other cells, through receptors that bind ligands such as hormones, growth factors and neurotransmitters and trigger signal transduction cascades inside the cell, including G protein-coupled receptor pathways, cell surface receptor pathways, the endoplasmic reticulum unfolded protein response, granzyme-mediated cell death signalling and opioid growth factor receptor signalling; cell signalling coordinates development, immunity, metabolism and behaviour, and its errors underlie cancer and many diseases.", "what_it_is_for": "Not applicable; a biological process.", "affordances": [ "explain receptors and pathways", "relay major pathways", "describe disease and drug relevance", "distinguish related concepts" ], "distinguishing_features": [ "Receptor-ligand binding", "Cascade amplification", "Second messengers", "Feedback control" ], "appearance": "Not a visible object; molecular cascades in cells.", "visual_identification": [ "Reception and transduction of signals by cells", "GPCR, receptor tyrosine kinase, unfolded protein response, granzyme death signalling, opioid growth factor receptor pathways", "Neural signalling is one kind; endocrine communication is the tissue-level view" ], "physical_properties": [ { "quantity": "human GPCRs", "typical_range": "about 800", "unit": "count", "note": "" }, { "quantity": "drugs targeting GPCRs", "typical_range": "about 35", "unit": "percent", "note": "of approved drugs" } ], "families_and_kinds": [ "cell surface receptor signalling including GPCR and receptor tyrosine kinase pathways", "intracellular receptor signalling such as steroid hormone receptors", "stress pathways such as the endoplasmic reticulum unfolded protein response", "death signalling such as granzyme-mediated pathways", "specialised pathways such as opioid growth factor receptor signalling", "autocrine, paracrine, endocrine and juxtacrine modes" ], "related_models": [ { "relation": "is a kind of", "target": "signaling", "why": "in registry terms" }, { "relation": "is a kind of", "target": "biological pathway", "why": "in registry terms" }, { "relation": "uses", "target": "receptor", "why": "to bind ligands" }, { "relation": "is targeted by", "target": "drug", "why": "in pharmacology" } ], "identifiers": [ { "scheme": "GO", "value_or_pattern": "GO:0007165", "note": "signal transduction" }, { "scheme": "GO", "value_or_pattern": "GO:0023052", "note": "signaling" } ], "standards_and_regulation": [ "No regulation; Gene Ontology and Reactome pathway definitions" ], "failure_modes_and_hazards": [ "Oversimplifying pathways as linear", "Confusing cell signalling with neural transmission", "Agents giving personal medical advice" ], "in_scope": [], "out_of_scope": [], "characteristics": [] }, "sources": [], "structure": { "bundles": [ { "id": "understand", "name": "Understand", "description": "What cell signalling is.", "rationale": "Science.", "layers": [ { "id": "definition", "name": "Definition", "description": "Definition.", "findings": [ { "id": "definition-finding", "name": "Definition", "description": "Definition.", "questions": [ { "text": "What is cell signalling, and how do reception, transduction and response work?", "kind": "definition" }, { "text": "Is the question about cell signalling in general, a specific pathway or neural signalling?", "kind": "boundary" } ] } ] }, { "id": "pathways", "name": "Pathways", "description": "Major pathways.", "findings": [ { "id": "pathways-finding", "name": "Pathways", "description": "Pathways.", "questions": [ { "text": "How do GPCR, receptor tyrosine kinase, unfolded protein response and granzyme death pathways work?", "kind": "definition" }, { "text": "Which entry fits the specific pathway?", "kind": "action" } ] } ] } ] }, { "id": "mechanism", "name": "Mechanism", "description": "Mechanisms.", "rationale": "Science.", "layers": [ { "id": "messengers", "name": "Messengers", "description": "Second messengers.", "findings": [ { "id": "messengers-finding", "name": "Messengers", "description": "Messengers.", "questions": [ { "text": "How do second messengers such as cAMP, calcium and IP3 amplify signals?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "regulation", "name": "Regulation", "description": "Regulation.", "findings": [ { "id": "regulation-finding", "name": "Regulation", "description": "Regulation.", "questions": [ { "text": "How are pathways regulated by feedback, desensitisation and crosstalk?", "kind": "provenance" }, { "text": "Which sources are cited?", "kind": "provenance" } ] } ] } ] }, { "id": "medicine", "name": "Medicine", "description": "Disease and drugs.", "rationale": "Clinical.", "layers": [ { "id": "disease", "name": "Disease", "description": "Disease.", "findings": [ { "id": "disease-finding", "name": "Disease", "description": "Disease.", "questions": [ { "text": "How do signalling errors cause cancer, diabetes and other diseases, in general terms?", "kind": "provenance" }, { "text": "Is the user asking about their own condition, which needs a clinician?", "kind": "boundary" } ] } ] }, { "id": "drugs", "name": "Drugs", "description": "Drug targets.", "findings": [ { "id": "drugs-finding", "name": "Drugs", "description": "Drugs.", "questions": [ { "text": "How do drugs target receptors and kinases in signalling pathways?", "kind": "provenance" }, { "text": "Which entry fits the specific drug class?", "kind": "action" } ] } ] } ] }, { "id": "context", "name": "Context", "description": "Research and history.", "rationale": "Context.", "layers": [ { "id": "research", "name": "Research", "description": "Research tools.", "findings": [ { "id": "research-finding", "name": "Research", "description": "Research.", "questions": [ { "text": "How are pathways mapped with databases such as Reactome and KEGG?", "kind": "provenance" }, { "text": "Which entry fits Reactome?", "kind": "action" } ] } ] }, { "id": "history", "name": "History", "description": "History.", "findings": [ { "id": "history-finding", "name": "History", "description": "History.", "questions": [ { "text": "How were second messengers, GPCRs and kinases discovered?", "kind": "provenance" }, { "text": "Which entry fits the history of cell biology?", "kind": "action" } ] } ] } ] } ] }, "openQuestions": [ "Should signal transduction and GPCR signalling be separate primary entries?", "How should pathway databases be linked?", "The registry entry has merged aliases naming specific pathways; should they be split off?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "abstract concept", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a cell signaling, record what state it is in, and decide what may be done with it.", "whatItIs": "Let an agent explain cell signalling and signal transduction, relay receptor types and major pathways from cell biology references, describe roles in disease and drug action, and distinguish cell signalling from neural signalling and from intercellular communication in general.", "characteristics": { "substance": "activity", "origin": "conceptual", "agency": "inert" }, "whatYouCanDoWithIt": [ "observed and measured" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: signal transduction, opioid growth factor receptor signaling pathway, granzyme-mediated programmed cell death signaling pathway, endoplasmic reticulum unfolded protein response, G protein-coupled receptor signaling pathway, cell surface receptor signaling pathway, intracellular signal transduction, SMAD protein signal transduction, phototransduction, hormone-mediated signaling pathway, hypoxia-inducible factor-1alpha signaling pathway, dopamine receptor signaling pathway.", "49 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 40 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a cell signaling, and on what evidence are they told apart?" ], "whatItIsMadeOf": "something that happens over time", "physicalCharacter": [ "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state" ], "howItIsRecognised": [ "Nothing to see. What is recognised is an instance of it, and which instances count is exactly what is argued about." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "signal transduction", "opioid growth factor receptor signaling pathway", "granzyme-mediated programmed cell death signaling pathway", "endoplasmic reticulum unfolded protein response", "G protein-coupled receptor signaling pathway", "cell surface receptor signaling pathway", "intracellular signal transduction", "SMAD protein signal transduction", "phototransduction", "hormone-mediated signaling pathway", "hypoxia-inducible factor-1alpha signaling pathway", "dopamine receptor signaling pathway" ] } ], "standing": "Described in 40 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 49 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one cell signaling from another, and a cell signaling from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a cell signaling, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a cell signaling, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a cell signaling is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a cell signaling, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a cell signaling, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a cell signaling is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a cell signaling sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a cell signaling, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a cell signaling, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a cell signaling is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a cell signaling from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a cell signaling, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a cell signaling, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a cell signaling is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a cell signaling passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a cell signaling between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a cell signaling, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a cell signaling, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a cell signaling is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a cell signaling, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a cell signaling is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a cell signaling, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a cell signaling, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a cell signaling is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "process-and-outcome", "name": "Process, inputs and outcome", "description": "How a cell signaling proceeds, what it needs and what it leaves behind.", "rationale": "An activity is known by its steps and its results, and both have to be recordable while it is still running.", "layers": [ { "id": "steps-and-sequence", "name": "Steps and sequence", "description": "The steps of a cell signaling, their order and what may run in parallel.", "findings": [ { "id": "steps-and-preconditions", "name": "Steps, preconditions and completion", "description": "What has to be true before each step of a cell signaling and what marks it done.", "questions": [ { "id": "steps-and-preconditions-q01", "text": "What identifies and describes a step of a cell signaling, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "steps-and-preconditions-q02", "text": "Who or what asserted this about a step of a cell signaling, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "steps-and-preconditions-q03", "text": "What may an agent decide or do once a step of a cell signaling is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "inputs-and-results", "name": "Inputs, resources and results", "description": "What a cell signaling consumes and what it produces.", "findings": [ { "id": "inputs-and-outputs", "name": "Inputs, outputs and side effects", "description": "The resources a cell signaling takes and the results it leaves, wanted or not.", "questions": [ { "id": "inputs-and-outputs-q01", "text": "What identifies and describes the inputs and results of a cell signaling, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "inputs-and-outputs-q02", "text": "Who or what asserted this about the inputs and results of a cell signaling, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "inputs-and-outputs-q03", "text": "What may an agent decide or do once the inputs and results of a cell signaling is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "definitions-in-contest", "name": "Definitions and who holds them", "description": "What cell signaling is taken to mean, and by whom.", "rationale": "When a field disagrees about a concept, the disagreement is the content. A model that picks one definition silently destroys the information.", "layers": [ { "id": "competing-definitions", "name": "Competing definitions", "description": "The main readings and the traditions behind them.", "findings": [ { "id": "definition-map", "name": "Definitions and their holders", "description": "Each definition with the school or body that holds it.", "questions": [ { "id": "definition-map-q01", "text": "Which definitions of cell signaling are in use, and which tradition or body holds each?", "kind": "definition" }, { "id": "definition-map-q02", "text": "What turns on the difference between them in practice?", "kind": "boundary" } ] } ] }, { "id": "operationalisation", "name": "Operationalisation", "description": "How it is measured or applied when it has to be.", "findings": [ { "id": "operational-record", "name": "Measures and proxies", "description": "Instruments and indicators used to stand in for it.", "questions": [ { "id": "operational-record-q01", "text": "How is cell signaling operationalised or measured in practice, and by what instrument?", "kind": "measurement" }, { "id": "operational-record-q02", "text": "What does that operationalisation leave out, and when does that matter?", "kind": "boundary" } ] } ] } ] }, { "id": "instances-and-use", "name": "Instances, use and consequence", "description": "What counts as an instance of cell signaling and what follows from calling something that.", "rationale": "Applying a concept is an act with consequences, so a model must say what the label licenses and what it does not.", "layers": [ { "id": "instances", "name": "What counts as an instance", "description": "Clear cases, borderline cases and non-cases.", "findings": [ { "id": "instance-tests", "name": "Tests for an instance", "description": "What would settle whether something falls under it.", "questions": [ { "id": "instance-tests-q01", "text": "What would settle whether something is an instance of cell signaling?", "kind": "boundary" }, { "id": "instance-tests-q02", "text": "Which borderline cases are argued about, and on what grounds?", "kind": "definition" } ] } ] }, { "id": "consequence", "name": "Consequence of application", "description": "Rights, duties or decisions that follow from the label.", "findings": [ { "id": "consequence-record", "name": "What the label licenses", "description": "What an agent may do once something is classified this way.", "questions": [ { "id": "consequence-record-q01", "text": "What follows practically once something is treated as cell signaling?", "kind": "action" }, { "id": "consequence-record-q02", "text": "What must an agent not infer from the label alone?", "kind": "action" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a cell signaling came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a cell signaling and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a cell signaling, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a cell signaling, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a cell signaling is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a cell signaling is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a cell signaling, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a cell signaling, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a cell signaling is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 6, "layers": 12, "findings": 14, "questions": 38 } } } }