lysergic acid diethylamide
Enable an agent to identify lysergic acid diethylamide, assess the identity and condition of a represented sample, and determine which handling or research actions require further evidence or authorization.
Research draft, second pass
A second pass drafted this model: the structure a model of this thing needs, and what is known about it in the world. The line under this one says how the second half was obtained - researched against sources, or recalled without web access, in which case nothing here was read anywhere and every claim is a lead to verify. Unreviewed either way.
recalled by Codex without web access - no source was read
Researched by: Codex
Purpose and description
Enable an agent to identify lysergic acid diethylamide, assess the identity and condition of a represented sample, and determine which handling or research actions require further evidence or authorization.
Lysergic acid diethylamide (LSD) is a semisynthetic ergoline compound, specifically the diethylamide of lysergic acid, whose characteristic psychedelic effects are mediated principally through serotonin 5-HT2A receptor activation.
It can be Reconcile an LSD-labelled record with verified molecular, stereochemical, and regulatory identifiers.; Assess whether analytical evidence supports identification and quantification of LSD in a represented sample.; Compare assay results after reconciling chemical form, concentration basis, and measurement uncertainty.; Flag unresolved identity, degradation, or composition issues for qualified review.; Determine which proposed analytical, storage, transfer, or disposal actions require jurisdiction-specific authorization..
Distinguishing features
Require evidence for the diethylamide molecular identity rather than accepting a name that could refer to lysergic acid or another lysergamide.
Require an explicit stereochemical assignment or an unresolved designation rather than treating every matching molecular formula as LSD.
Distinguish the represented molecule from its salt or solvate form and state which form each identifier and quantity describes.
Distinguish analytically supported LSD content from a product label, carrier appearance, or reported subjective effect.
Require methods to address plausible related compounds and degradation products before interpreting an analytical signal as confirmed LSD.
Scope
+ Molecular identity, stereochemical identity, synonyms, and verified chemical identifiers
+ Free-base or salt form, composition, purity, and quantity expressed on a stated chemical basis
+ Physical state, measured properties, storage history, and evidence of degradation
+ Analytical identification and quantification with method limitations
+ Substance-specific hazard evidence and applicable regulatory identity
- Manufacturing, synthetic routes, and precursor procurement
- Finished products, packaging, carriers, and their distribution
- Individual exposure events, intoxication assessment, and clinical care
- Dosing recommendations or instructions for consumption
- Clinical trial protocols and therapeutic efficacy assessments
- General models of psychedelics, lysergamides, or controlled substances
Characteristics
- Registry identity
- vr.tr.lysergic-acid-diethylamide; plane PHY; domain PHY.MAT Anchors samples and external records to the registered substance without creating separate entries for unverified aliases.
- Chemical and stereochemical identity
- Source-backed structure, stereochemical designation, and identifiers; confirmed, provisional, or unresolved Separates LSD from related lysergamides and stereoisomeric material.
- Material form
- Free base, specified salt, specified solvate, or unresolved; counterion and stoichiometry where applicable Determines how identifiers, formula mass, assay results, and physical properties should be interpreted.
- LSD content
- Mass fraction in %, concentration in µg/mL or mol/L, or total mass in µg or mg; chemical basis and uncertainty required Prevents confusion between preparation mass, salt mass, and the amount attributed to LSD.
- Impurity and related-compound profile
- Named analytes with mass fraction or concentration, reporting limits, and unidentified signals Makes purity claims interpretable and records substances that may interfere with identification.
- Physical state and thermal behavior
- Observed phase; temperature in °C; pressure in kPa; melting or decomposition observation tied to material form Prevents properties of one form or condition from being applied to another and allows an unavailable boiling point to remain unresolved.
- Storage and stability state
- Documented conditions and duration; stability supported, degradation detected, or unassessed Connects present sample quality to storage history and analytical evidence.
- Hazard and exposure-limit evidence
- Applicable classification or limit linked to authority, material form, route, jurisdiction, and date; unknown permitted Separates established classifications and limits from supplier statements or missing evidence.
- Regulatory status
- Jurisdiction, governing instrument, covered chemical forms, controlled activity, authorization, and effective date Supports activity-specific decisions without assuming that one jurisdiction's rules apply elsewhere.
Also called
Where this came from
wikidata · CC0 1.0
Drafted structure
Bundle to layer to finding to question, as the second pass will find it: 6 bundles · 11 layers · 19 findings · 29 questions.
LSD identity and boundaries Defines what the registry entry denotes and how evidence establishes that a material belongs to it.
An LSD label alone does not resolve molecular identity, stereochemistry, or the boundary between substance and preparation.
Molecular and stereochemical identity
Records the structure and stereochemical meaning attached to the substance name.
Identity evidence
Require a sourced identity assignment with explicit treatment of stereochemistry and related lysergamides.
- Which molecular structure and stereochemical designation does lysergic acid diethylamide denote in this registry entry? definition
- Which evidence distinguishes the assigned substance from other lysergamides and relevant stereoisomers? boundary
Identifiers and forms
Reconciles external identifiers with the exact substance form they describe.
Form-specific identifier mapping
Attach identifiers to their documented structures and forms rather than treating all LSD-associated records as interchangeable.
- Which CAS number, PubChem CID, and EC number, if assigned, have been verified for the exact structure and form represented? provenance
- Does each external record describe the parent compound, a specified salt or solvate, or a preparation containing LSD? boundary
LSD composition and quantity Makes the amount and composition of represented material interpretable across forms and preparations.
LSD content cannot be inferred from total preparation mass or compared reliably when assay bases differ.
Chemical form and assay basis
Records the chemical form and the basis used to express quantity.
Comparable LSD amount
Keep measured quantities attached to their denominator, chemical basis, and uncertainty.
- Is the reported amount expressed as parent-compound equivalent, specified salt mass, or total preparation mass? measurement
- What counterion, stoichiometry, solvent content, and uncertainty must be known before converting this result to another basis? measurement
Purity and sample representation
Separates LSD assay from impurity assessment and the representativeness of the tested portion.
Interpretable purity
Treat purity as a method-dependent result rather than a complete description of everything present.
- Which related compounds, residual constituents, and unidentified signals were assessed, and which were outside the method's scope? measurement
- How does the tested portion represent the material or carrier from which it was sampled? provenance
LSD condition and stability Connects physical properties and present condition to chemical form and documented environmental history.
A reference property or past assay does not by itself establish the current condition of an LSD sample.
Form-dependent properties
Records physical observations and constants with the conditions needed to interpret them.
Qualified physical properties
Accept physical-property values only with identified material form, conditions, and source quality.
- What phase, solubility, and melting or decomposition behavior are supported for this specific LSD form and under which conditions? measurement
- Is a reported boiling point experimentally supported, estimated, or unsuitable for representing material that decomposes under the stated conditions? provenance
Storage history and change
Records environmental history and evidence of changes in composition.
Evidence-based stability state
Assign a stability state from relevant studies or sample measurements while retaining gaps in the exposure history.
- What temperature, light, moisture, solvent, and elapsed-time history is documented for this material? provenance
- What measurements support unchanged LSD content, stereochemical change, or degradation, and how do they compare with the initial assay? measurement
LSD analytical confidence Defines how identification and quantification claims are supported and bounded.
Screening responses, labels, and confirmatory measurements provide different levels of evidence for LSD identity and content.
Identification selectivity
Evaluates whether the method distinguishes LSD from plausible alternatives in the sample matrix.
Confirmed versus presumptive identity
Record the strength of an identification claim and the alternatives the method can or cannot exclude.
- Is the LSD assignment based on a label, a presumptive screen, or a validated confirmatory method? provenance
- Which related compounds, stereoisomers, or matrix interferences can the method distinguish, and which remain unresolved? boundary
Quantification and traceability
Connects concentration results to reference materials, calibration, and reporting limits.
Defensible assay result
Retain enough measurement context to compare results and avoid interpreting non-detection as demonstrated absence.
- Which reference material, calibration basis, recovery assessment, and uncertainty support the reported LSD quantity? provenance
- What detection and quantification limits apply in this matrix, and what can a result below either limit establish? measurement
LSD hazards and permitted actions Links material-specific hazard evidence and current legal coverage to proposed activities.
An agent needs separate evidence for handling requirements and legal authorization, each tied to the actual material and activity.
Hazard evidence and handling
Distinguishes documented hazard classifications from unverified assumptions and missing limits.
Applicable hazard record
Record the authority, applicability, and uncertainty of hazard and occupational-exposure information.
- Which authoritative or supplier hazard classifications apply to this LSD form and concentration, and are any classifications inconsistent? provenance
- Are substance-specific occupational exposure limits established by the relevant authority, and what approved handling procedure applies if none is identified? action
Jurisdiction and authorization
Associates each proposed activity with the governing rules and evidence of permission.
Activity-specific permission
Determine legal coverage and authorization for the exact substance form, location, and activity.
- Which current legal instruments cover LSD and any relevant salts, stereoisomers, or preparations in the jurisdictions involved? provenance
- What documented authorization and institutional procedure are required for the proposed possession, analysis, storage, transfer, or disposal? action
Evidence and external alignment What the world already says about this thing, gathered so the model can be checked against it.
A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.
Reported evidence
Findings from the breadth pass, kept separate from the structural claims.
Check these first
Recalled without web access and unsourced; every item is a lead to verify.
- This is a recall-based description; no sources were consulted.
- Verify salt-specific identifiers, stereochemistry, purity, physical constants and hazard classifications before building a material specification.
- Verify current domestic legal status and clinical evidence; effect duration varies with exposure and individual circumstances.
- Which of these check these first hold for the sense of lysergic acid diethylamide this model covers, and on what evidence? provenance
Kinds and varieties
Recalled without web access and unsourced; every item is a lead to verify.
- LSD free base
- LSD tartrate salt
- Which of these kinds and varieties hold for the sense of lysergic acid diethylamide this model covers, and on what evidence? provenance
Identifiers and schemes
Recalled without web access and unsourced; every item is a lead to verify.
- CAS Registry Number - 50-37-3 - Identifies LSD free base; salts and stereoisomers require separate identity checks.
- PubChem CID - 5761 - Compound record for lysergic acid diethylamide.
- Molecular formula - C20H25N3O - Free-base composition; the formula alone does not distinguish stereoisomers.
- Which of these identifiers and schemes hold for the sense of lysergic acid diethylamide this model covers, and on what evidence? provenance
Standards and regulation
Recalled without web access and unsourced; every item is a lead to verify.
- United Nations Convention on Psychotropic Substances of 1971: lysergide is listed in Schedule I; domestic implementation varies.
- Which of these standards and regulation hold for the sense of lysergic acid diethylamide this model covers, and on what evidence? provenance
Real-world use
Recalled without web access and unsourced; every item is a lead to verify.
- Research on perception, consciousness and serotonin receptor pharmacology.
- Investigational psychotherapy and psychiatric research.
- Nonmedical use for psychedelic experiences.
- Analytical reference material in forensic toxicology.
- Which of these real-world use hold for the sense of lysergic acid diethylamide this model covers, and on what evidence? provenance
Typical measurements
Recalled without web access and unsourced; every item is a lead to verify.
- Molar mass of the free base - 323.43 - g/mol
- Approximate duration of acute subjective effects after oral administration - 8-12 - hours
- Which of these typical measurements hold for the sense of lysergic acid diethylamide this model covers, and on what evidence? provenance
Failure modes and hazards
Recalled without web access and unsourced; every item is a lead to verify.
- Acute anxiety, panic, paranoia or severe confusion can occur.
- Altered perception and judgment can contribute to accidents and unsafe behavior.
- Psychiatric destabilization can occur, particularly in susceptible individuals; persistent perceptual disturbances have also been reported.
- Unregulated products may have uncertain identity, concentration or contaminants.
- Light, heat and unfavorable chemical conditions can degrade material and compromise analytical accuracy.
- Which of these failure modes and hazards hold for the sense of lysergic acid diethylamide this model covers, and on what evidence? provenance
Regional variation
Recalled without web access and unsourced; every item is a lead to verify.
- Domestic laws differ in their treatment of possession, research authorization and penalties.
- Access to authorized clinical research varies by jurisdiction and institution.
- Which of these regional variation hold for the sense of lysergic acid diethylamide this model covers, and on what evidence? provenance
Neighbouring kinds and how to tell them apart
Recalled without web access and unsourced; every item is a lead to verify.
- Lysergic acid - The parent carboxylic acid; LSD has a diethylamide group in place of its carboxylic acid hydroxyl.
- Lysergic acid amide - Has a primary amide group rather than LSD's N,N-diethylamide group.
- iso-LSD - A stereoisomer differing at the carbon bearing the carboxamide substituent; it is not interchangeable with LSD.
- LSD-containing blotter - A formulated delivery material containing a claimed or measured amount of LSD, rather than the chemical substance itself.
- Which of these neighbouring kinds and how to tell them apart hold for the sense of lysergic acid diethylamide this model covers, and on what evidence? provenance
What the second pass must settle
- Which authoritative structure and identifier records establish the registry entry's exact stereochemical scope and its relationship to separately identified salt forms?
- Which form-specific physical constants are experimentally supported, and which commonly reported values are estimates or decomposition observations?
- Which stability studies apply to the represented material forms and matrices, and what evidence supports any proposed reassessment interval?
- Which analytical methods adequately resolve relevant related compounds and stereoisomers at the concentrations and in the matrices of interest?
- Which current hazard classifications, occupational exposure limits, and legal requirements apply in the intended jurisdictions, and where does authoritative guidance remain unavailable?