{ "model": { "rank": 4393, "code": "thing-q243547", "model_id": "vr.tr.rs-ketamine", "name": "(RS)-ketamine", "purpose": "Enable an AI agent to recognise (RS)-ketamine, assess the identity and condition of a material sample, and determine which handling or use decisions require further evidence or authorization.", "family": "Thing Registry", "category": "Physical world and living systems", "status": "research-draft", "kind": "thing", "plane": "PHY", "domain": "PHY.MAT", "industry": "", "version": "", "url": "/models/thing/q243547/", "tier": 2, "score": 75, "payload": { "layer": "wikidata", "aliases": [ "arketamine", "esketamine" ], "aliasCount": 2, "merged": 2, "knownIn": 75, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q243547", "url": "https://www.wikidata.org/wiki/Q243547", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-09T20:07:06Z", "providers": [ "Codex" ], "breadth": "recalled by Codex without web access - no source was read", "missingProviders": [], "pass": 2, "cost": { "grok": { "seconds": 23.6, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a087c6-fc68-71d1-a455-ceb9165ed1ee\n--------\nuser\nDescribe what is already known about one registered thing. Answer as JSON only, no prose around it.\n\nThing: (RS)-ketamine\nSense to describe: (none recorded)\nDomain code: PHY.MAT\nAlso known as: (none)\n\n\nContext for this batch of 695 things:\n# Batch 004: 1001 re", "usd": 0, "recall": true }, "codex": { "seconds": 67.2, "error": "Reading additional input from stdin...\nOpenAI Codex v0.153.4\n--------\nworkdir: R:\\02_PROJECTS\\02_Meta_Models_Platforms\\Ver.cy\\current\\thing-registry-backlog\nmodel: gpt-6-astra\nprovider: openai\napproval: never\nsandbox: read-only\nreasoning effort: none\nreasoning summaries: none\nsession id: 01a087c6-fc7b-7ad3-bd90-e89be251ba5c\n--------\nuser\nYou are drafting a Vercy meta-model for one registered thing. Answer as JSON only, no prose around it.\n\nThing: (RS)-ketamine\nRegistry id: vr.tr.rs-ketamine\nPlane / domain: PHY / PHY.MAT\nRegistry definition: (none recorded)\nNames folded into this entry: (none)\n" } } }, "metaModel": { "id": "THING-Q243547", "registryId": "vr.tr.rs-ketamine", "name": "(RS)-ketamine", "version": "0.1.0-research.1", "entryKind": "thing", "family": "Thing Registry", "domain": [ "PHY.MAT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q243547/", "model": { "registry_id": "vr.tr.rs-ketamine", "name": "(RS)-ketamine", "purpose": "Enable an AI agent to recognise (RS)-ketamine, assess the identity and condition of a material sample, and determine which handling or use decisions require further evidence or authorization.", "definition": "(RS)-Ketamine is the racemic mixture of the R and S enantiomers of ketamine, a synthetic arylcyclohexylamine whose dissociative anaesthetic effects arise primarily through noncompetitive antagonism of NMDA receptors.", "scope_statement": "This model owns vr.tr.rs-ketamine as the racemic chemical substance in PHY / PHY.MAT, including stereochemical identity, material form, composition, condition and applicable controls; it distinguishes the substance from its salts, formulated products and clinical uses.", "in_scope": [ "Racemic identity and measured proportions of the ketamine enantiomers", "Chemical identifiers with explicit free-base, salt and stereochemical scope", "Sample composition, purity, impurities and analytical evidence", "Physical state, measured properties and stability under stated conditions", "Substance hazards, storage requirements and jurisdiction-specific handling controls" ], "out_of_scope": [ "Esketamine or arketamine as independently modelled substances", "Finished medicinal products, their excipients, packaging and administration devices", "Clinical diagnosis, patient selection, dosing and treatment protocols", "Manufacturing routes and synthesis instructions", "Ketamine metabolites and biological specimens as separate things" ], "distinguishing_features": [ "Require evidence of ketamine molecular identity; a matching trade name or claimed effect does not establish identity.", "Require stereochemical evidence supporting a racemic composition; identification as ketamine alone does not distinguish it from an enantiomer-enriched material.", "Distinguish free base from a salt using counterion and material-form evidence; do not transfer identifiers or property values between them without qualification.", "Distinguish the substance from a preparation containing it by recording other constituents and the basis on which ketamine content is expressed.", "Distinguish intrinsic substance identity from sample quality: degradation or contamination changes the sample's suitability without necessarily changing the identity of its remaining ketamine." ], "characteristics": [ { "name": "Stereochemical composition", "kind": "measurement", "unit_or_values": "R:S molar ratio or enantiomer fractions, with method and uncertainty", "why_it_matters": "Tests the defining racemic identity and distinguishes enantiomer-enriched material." }, { "name": "Material form", "kind": "category", "unit_or_values": "Free base; identified salt; other characterised form; unresolved", "why_it_matters": "Determines which identifiers, composition calculations and physical-property evidence apply." }, { "name": "Identifier assignment", "kind": "relation", "unit_or_values": "CAS, PubChem and EC records linked to their exact chemical and stereochemical descriptions", "why_it_matters": "Prevents records for racemate, individual enantiomers and salts from being treated as interchangeable." }, { "name": "Ketamine content", "kind": "measurement", "unit_or_values": "Mass fraction or concentration, with explicit free-base or salt basis and dry or as-received basis", "why_it_matters": "Makes assay values comparable and separates active-substance content from total sample mass." }, { "name": "Impurity profile", "kind": "measurement", "unit_or_values": "Identified and unidentified components with concentrations, detection limits and methods", "why_it_matters": "Supports quality assessment without assuming that a high overall assay proves acceptable composition." }, { "name": "Physical state and phase behaviour", "kind": "state", "unit_or_values": "Observed state at specified temperature, pressure and solvent conditions; transitions in °C", "why_it_matters": "Links appearance and measured constants to the actual material form and conditions." }, { "name": "Water and residual-solvent content", "kind": "measurement", "unit_or_values": "Mass fraction or mg/kg, with analytical method", "why_it_matters": "Can affect assay interpretation, storage behaviour and suitability." }, { "name": "Stability assessment", "kind": "state", "unit_or_values": "Supported within specified conditions; under investigation; failed assessment; unknown", "why_it_matters": "Connects storage history and analytical change to decisions about continued use." }, { "name": "Hazard evidence", "kind": "relation", "unit_or_values": "Applicable classification or safety record with material form, jurisdiction, issuer and revision date", "why_it_matters": "Keeps hazard decisions tied to evidence for the material actually present." }, { "name": "Handling authorization", "kind": "state", "unit_or_values": "Verified for stated activity; restricted; prohibited; unresolved, by jurisdiction and date", "why_it_matters": "Separates possession, transfer, storage and disposal permissions from chemical identity." } ], "affordances": [ "Reconcile a sample's analytical evidence and identifiers with the registered racemate.", "Compare assay and property results after aligning material form, conditions and reporting basis.", "Flag enantiomeric imbalance, unknown counterions, impurities or storage deviations for review.", "Select applicable handling and storage requirements from verified evidence for the material.", "Determine whether a proposed possession, transfer or disposal action has the required authorization.", "Route product-specific or patient-specific decisions to the corresponding neighbouring model." ] }, "sources": [], "structure": { "bundles": [ { "id": "racemate-identity", "name": "Racemate identity", "description": "Establish what qualifies as (RS)-ketamine and how that identity is evidenced.", "rationale": "The registered name makes stereochemical composition part of identity rather than an optional annotation.", "layers": [ { "id": "molecular-identification", "name": "Molecular identification", "description": "Separate ketamine identity from names, labels and structurally related substances.", "findings": [ { "id": "ketamine-identity-evidence", "name": "Ketamine identity evidence", "description": "Record structural identification evidence and the limitations of each method.", "questions": [ { "text": "Which analytical evidence establishes that the material contains ketamine?", "kind": "definition", "id": "ketamine-identity-evidence-q01" }, { "text": "Which reference material, method and original report support that identification?", "kind": "provenance", "id": "ketamine-identity-evidence-q02" } ] } ] }, { "id": "racemic-composition", "name": "Racemic composition", "description": "Assess whether the sample's stereochemical composition supports the registered identity.", "findings": [ { "id": "enantiomer-balance", "name": "Enantiomer balance", "description": "Represent the R:S ratio separately from total chemical purity and avoid inferring racemic composition from an achiral assay.", "questions": [ { "text": "What R:S ratio was measured, by which enantioselective method and with what uncertainty?", "kind": "measurement", "id": "enantiomer-balance-q01" }, { "text": "Which justified acceptance criterion distinguishes this racemate from an enantiomer-enriched material?", "kind": "boundary", "id": "enantiomer-balance-q02" } ] } ] } ] }, { "id": "chemical-form-and-reference-scope", "name": "Chemical form and reference scope", "description": "Connect the registered substance to material forms and correctly scoped external records.", "rationale": "A name shared across free-base, salt and product records can conceal differences that change property interpretation.", "layers": [ { "id": "free-base-and-salt-boundary", "name": "Free-base and salt boundary", "description": "Identify the actual chemical form and its relationship to this registry entry.", "findings": [ { "id": "form-assignment", "name": "Form assignment", "description": "Record whether a sample is free-base ketamine or a specified salt and make any registry linkage explicit.", "questions": [ { "text": "Is the material the free base or a salt, and what evidence identifies any counterion and stoichiometry?", "kind": "measurement", "id": "form-assignment-q01" }, { "text": "Does the registry represent this salt through a relation to (RS)-ketamine or through an existing separate entry?", "kind": "boundary", "id": "form-assignment-q02" } ] } ] }, { "id": "identifier-and-product-linkage", "name": "Identifier and product linkage", "description": "Prevent substance identifiers and preparation names from collapsing distinct entities.", "findings": [ { "id": "scoped-record-matching", "name": "Scoped record matching", "description": "Retain the exact entity described by each identifier and treat formulated preparations as containing the substance.", "questions": [ { "text": "Which CAS, PubChem and EC records explicitly match the racemate and the stated chemical form?", "kind": "provenance", "id": "scoped-record-matching-q01" }, { "text": "Does each linked record describe the substance, a salt, an individual enantiomer or a finished preparation?", "kind": "boundary", "id": "scoped-record-matching-q02" } ] } ] } ] }, { "id": "composition-and-quality", "name": "Composition and quality", "description": "Assess how much ketamine is present and what else accompanies it.", "rationale": "Racemic identity alone does not establish purity, grade or suitability for a proposed activity.", "layers": [ { "id": "assay-and-reporting-basis", "name": "Assay and reporting basis", "description": "Make ketamine content interpretable across material forms and sample conditions.", "findings": [ { "id": "comparable-ketamine-content", "name": "Comparable ketamine content", "description": "Record assay values with their denominator, chemical-form basis and supporting method.", "questions": [ { "text": "What is the measured ketamine content, and is it expressed as free base or salt on a dry or as-received basis?", "kind": "measurement", "id": "comparable-ketamine-content-q01" }, { "text": "Which assay method and reference standard support the result and any conversion between reporting bases?", "kind": "provenance", "id": "comparable-ketamine-content-q02" } ] } ] }, { "id": "impurities-and-grade", "name": "Impurities and grade", "description": "Connect measured non-ketamine components to a documented quality specification.", "findings": [ { "id": "sample-quality-evidence", "name": "Sample quality evidence", "description": "Distinguish a supplier's grade claim from demonstrated compliance with an applicable specification.", "questions": [ { "text": "Which impurities, water and residual solvents were measured, and what remains unidentified or below detection limits?", "kind": "measurement", "id": "sample-quality-evidence-q01" }, { "text": "Which documented specification supports accepting or rejecting this sample for its proposed use?", "kind": "action", "id": "sample-quality-evidence-q02" } ] } ] } ] }, { "id": "physical-state-and-stability", "name": "Physical state and stability", "description": "Represent form-specific physical behaviour and changes during storage.", "rationale": "Property values and stability conclusions are useful only when attached to the relevant ketamine form and conditions.", "layers": [ { "id": "conditional-physical-properties", "name": "Conditional physical properties", "description": "Qualify observed state and measured constants by chemical form and experimental conditions.", "findings": [ { "id": "form-specific-property-evidence", "name": "Form-specific property evidence", "description": "Keep free-base and salt measurements distinct and preserve the conditions behind reported values.", "questions": [ { "text": "What phase, melting behaviour and density are supported for this material form under stated conditions?", "kind": "measurement", "id": "form-specific-property-evidence-q01" }, { "text": "What solubility or boiling-point evidence exists, with solvent, pH, temperature, pressure and any decomposition qualification recorded as applicable?", "kind": "provenance", "id": "form-specific-property-evidence-q02" } ] } ] }, { "id": "storage-and-change", "name": "Storage and change", "description": "Relate storage history to evidence of continuing material quality.", "findings": [ { "id": "stability-supported-condition", "name": "Stability-supported condition", "description": "Track exposure history, observed changes and the evidence supporting storage or reassessment decisions.", "questions": [ { "text": "Which temperature, light, moisture and container conditions are supported by stability evidence for this form?", "kind": "provenance", "id": "stability-supported-condition-q01" }, { "text": "Which storage deviation or analytical change requires quarantine, retesting or disposal review?", "kind": "action", "id": "stability-supported-condition-q02" } ] } ] } ] }, { "id": "hazards-and-permitted-handling", "name": "Hazards and permitted handling", "description": "Support evidence-based handling decisions while separating hazard assessment from legal authorization.", "rationale": "Actions involving ketamine require both material-specific safety evidence and activity-specific control checks.", "layers": [ { "id": "exposure-and-hazard-evidence", "name": "Exposure and hazard evidence", "description": "Identify applicable hazard classifications and exposure controls without borrowing unsupported product claims.", "findings": [ { "id": "applicable-safety-record", "name": "Applicable safety record", "description": "Associate safety requirements with the exact form, composition and handling activity.", "questions": [ { "text": "Which current safety data and GHS classification apply to this form and composition, and who issued them?", "kind": "provenance", "id": "applicable-safety-record-q01" }, { "text": "Which exposure limits or documented containment requirements apply to the proposed handling activity, and where is evidence absent?", "kind": "action", "id": "applicable-safety-record-q02" } ] } ] }, { "id": "jurisdiction-and-custody", "name": "Jurisdiction and custody", "description": "Evaluate proposed activities against dated legal sources and documented custody.", "findings": [ { "id": "activity-specific-authorization", "name": "Activity-specific authorization", "description": "Record applicable controls without assuming that permission for one activity authorizes another.", "questions": [ { "text": "Which authoritative rules cover racemic ketamine and the stated material form in the relevant jurisdiction on the decision date?", "kind": "provenance", "id": "activity-specific-authorization-q01" }, { "text": "What authorization, custody records and approved procedures are required for the proposed possession, transfer, storage or disposal?", "kind": "action", "id": "activity-specific-authorization-q02" } ] } ] } ] }, { "id": "evidence-and-external-alignment", "name": "Evidence and external alignment", "description": "What the world already says about this thing, gathered so the model can be checked against it.", "rationale": "A model that cannot be lined up against existing standards, identifiers and practice cannot be adopted by anyone who already uses them.", "layers": [ { "id": "reported-evidence", "name": "Reported evidence", "description": "Findings from the breadth pass, kept separate from the structural claims.", "findings": [ { "id": "evidence-confidence-notes", "name": "Check these first", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "This account is recalled knowledge; no sources were consulted.", "Verify current regulatory classifications, approved indications and pharmacopoeial editions before operational use.", "Physical constants, purity specifications and hazard classifications must be checked for the particular salt, solid form and formulation; they are not supplied here." ], "questions": [ { "id": "evidence-confidence-notes-q01", "text": "Which of these check these first hold for the sense of (RS)-ketamine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-kinds", "name": "Kinds and varieties", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Racemic ketamine free base", "Racemic ketamine hydrochloride" ], "questions": [ { "id": "evidence-kinds-q01", "text": "Which of these kinds and varieties hold for the sense of (RS)-ketamine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-identifiers", "name": "Identifiers and schemes", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "scheme": "CAS Registry Number", "value_or_pattern": "6740-88-1", "note": "Ketamine free base; salt forms have separate identifiers." }, { "scheme": "CAS Registry Number", "value_or_pattern": "1867-66-9", "note": "Ketamine hydrochloride." }, { "scheme": "Molecular formula", "value_or_pattern": "C13H16ClNO", "note": "Free-base composition; does not distinguish enantiomers." }, { "scheme": "Chemical nomenclature", "value_or_pattern": "(RS)-2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one", "note": "The RS designation specifies the racemate." } ], "questions": [ { "id": "evidence-identifiers-q01", "text": "Which of these identifiers and schemes hold for the sense of (RS)-ketamine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-standards-and-regulation", "name": "Standards and regulation", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "United States Pharmacopeia-National Formulary, issued by USP: Ketamine Hydrochloride and Ketamine Hydrochloride Injection monographs specify pharmaceutical quality requirements." ], "questions": [ { "id": "evidence-standards-and-regulation-q01", "text": "Which of these standards and regulation hold for the sense of (RS)-ketamine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-real-world-use", "name": "Real-world use", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Human anaesthesia and procedural sedation.", "Veterinary anaesthesia.", "Analgesia in clinical settings.", "Treatment of depression in some clinical settings, with authorization and off-label status depending on jurisdiction and product.", "Research on NMDA receptor function and dissociative states." ], "questions": [ { "id": "evidence-real-world-use-q01", "text": "Which of these real-world use hold for the sense of (RS)-ketamine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-measurements", "name": "Typical measurements", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "quantity": "Molar mass of ketamine free base", "typical_range": "237.73", "unit": "g/mol" }, { "quantity": "Molar mass of anhydrous ketamine hydrochloride", "typical_range": "274.19", "unit": "g/mol" }, { "quantity": "Enantiomeric composition of the racemate", "typical_range": "50 R : 50 S", "unit": "mole percent" } ], "questions": [ { "id": "evidence-measurements-q01", "text": "Which of these typical measurements hold for the sense of (RS)-ketamine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-failure-modes-and-hazards", "name": "Failure modes and hazards", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Dissociation, impaired coordination and altered perception can cause accidents and impair judgment.", "Acute effects can include agitation, hallucinations, nausea and increases in blood pressure and heart rate.", "Respiratory depression and airway complications can occur, particularly with other sedating substances.", "Repeated nonmedical use can produce dependence and serious urinary tract injury.", "Confusing free-base and hydrochloride mass, formulation strength or route of administration can cause dosing errors." ], "questions": [ { "id": "evidence-failure-modes-and-hazards-q01", "text": "Which of these failure modes and hazards hold for the sense of (RS)-ketamine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-regional-variation", "name": "Regional variation", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ "Controlled-substance classification, prescribing restrictions and storage requirements vary by jurisdiction.", "Approved indications and available formulations differ between countries and between human and veterinary practice." ], "questions": [ { "id": "evidence-regional-variation-q01", "text": "Which of these regional variation hold for the sense of (RS)-ketamine this model covers, and on what evidence?", "kind": "provenance" } ] }, { "id": "evidence-neighbours", "name": "Neighbouring kinds and how to tell them apart", "description": "Recalled without web access and unsourced; every item is a lead to verify.", "evidence": [ { "name": "Esketamine", "difference": "The isolated S enantiomer, rather than the approximately equimolar R/S mixture." }, { "name": "Arketamine", "difference": "The isolated R enantiomer, rather than the approximately equimolar R/S mixture." }, { "name": "Ketamine hydrochloride", "difference": "A salt form; salt identity is separate from whether the ketamine is racemic or enantiopure." }, { "name": "Ketamine injection", "difference": "A formulated medicinal product containing ketamine, usually as its hydrochloride, with specified concentration and excipients." }, { "name": "Norketamine", "difference": "An N-demethylated metabolite with a different chemical composition." } ], "questions": [ { "id": "evidence-neighbours-q01", "text": "Which of these neighbouring kinds and how to tell them apart hold for the sense of (RS)-ketamine this model covers, and on what evidence?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Does an existing Vercy world model already cover this concept, and how does the registry relate racemic ketamine to its salt forms?", "Which authoritative identifiers unambiguously describe the racemate, and which instead describe unspecified stereochemistry or a particular salt?", "Which specification and analytical uncertainty establish an acceptable racemic composition for the intended material grade?", "Which physical-property and stability measurements are supported specifically for the registered form, including any limitations on boiling-point evidence?", "Which current hazard classifications, exposure limits and activity-specific legal controls apply in the intended jurisdictions?" ], "statistics": { "bundles": 6, "layers": 11, "findings": 19, "questions": 29 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "chemical substance or material", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a (RS)-ketamine, record what state it is in, and decide what may be done with it.", "whatItIs": "Enable an AI agent to recognise (RS)-ketamine, assess the identity and condition of a material sample, and determine which handling or use decisions require further evidence or authorization.", "characteristics": { "substance": "material", "origin": "natural", "agency": "inert", "mobility": "varies" }, "whatYouCanDoWithIt": [ "observed and measured", "consumed or used up" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: arketamine, esketamine.", "2 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 75 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a (RS)-ketamine, and on what evidence are they told apart?" ], "whatItIsMadeOf": "matter you can touch", "physicalCharacter": [ "Mobility varies between examples.", "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state", "use it up, and then need more of it" ], "howItIsRecognised": [ "Not recognisable by sight in any reliable way. Appearance varies with grade, form and additives; identification is by label, by documentation, or by assay." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "arketamine", "esketamine" ] } ], "standing": "Described in 75 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 2 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one (RS)-ketamine from another, and a (RS)-ketamine from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a (RS)-ketamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a (RS)-ketamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a (RS)-ketamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a (RS)-ketamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a (RS)-ketamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a (RS)-ketamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a (RS)-ketamine sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a (RS)-ketamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a (RS)-ketamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a (RS)-ketamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a (RS)-ketamine from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a (RS)-ketamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a (RS)-ketamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a (RS)-ketamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "form-and-composition", "name": "Form, composition and condition", "description": "What a (RS)-ketamine is made of, what shape and size it takes, and what state it is in.", "rationale": "A physical thing can be measured, and a model that cannot record its measurements cannot support any decision that depends on them.", "layers": [ { "id": "form-and-dimensions", "name": "Form and dimensions", "description": "Shape, size, mass and the ranges these take across examples.", "findings": [ { "id": "measurable-dimensions", "name": "Measurable dimensions and their units", "description": "The quantities worth recording and the units they are recorded in.", "questions": [ { "id": "measurable-dimensions-q01", "text": "What identifies and describes the dimensions of a (RS)-ketamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "measurable-dimensions-q02", "text": "Who or what asserted this about the dimensions of a (RS)-ketamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "measurable-dimensions-q03", "text": "What may an agent decide or do once the dimensions of a (RS)-ketamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "material-and-composition", "name": "Material and composition", "description": "Materials, parts and how they are put together.", "findings": [ { "id": "parts-and-materials", "name": "Parts and materials", "description": "What a (RS)-ketamine is built from and which parts are replaceable.", "questions": [ { "id": "parts-and-materials-q01", "text": "What identifies and describes the composition of a (RS)-ketamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "parts-and-materials-q02", "text": "Who or what asserted this about the composition of a (RS)-ketamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "parts-and-materials-q03", "text": "What may an agent decide or do once the composition of a (RS)-ketamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "condition-and-integrity", "name": "Condition and integrity", "description": "Wear, damage, health and the difference between working and broken.", "findings": [ { "id": "condition-assessment", "name": "Condition, damage and health", "description": "How the condition of a (RS)-ketamine is judged and by whom.", "questions": [ { "id": "condition-assessment-q01", "text": "What identifies and describes the condition of a (RS)-ketamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "condition-assessment-q02", "text": "Who or what asserted this about the condition of a (RS)-ketamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "condition-assessment-q03", "text": "What may an agent decide or do once the condition of a (RS)-ketamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "place-and-movement", "name": "Place and movement", "description": "Where a (RS)-ketamine is, how it got there and where it may go (varies).", "rationale": "A thing that can move needs its position recorded with a time, or every later claim about it is about a place it has left.", "layers": [ { "id": "location-and-placement", "name": "Location and placement", "description": "Position, containment and the reference frame the position is given in.", "findings": [ { "id": "position-and-frame", "name": "Position, container and reference frame", "description": "Where a (RS)-ketamine is, and what that position is measured against.", "questions": [ { "id": "position-and-frame-q01", "text": "What identifies and describes the location of a (RS)-ketamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "position-and-frame-q02", "text": "Who or what asserted this about the location of a (RS)-ketamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "position-and-frame-q03", "text": "What may an agent decide or do once the location of a (RS)-ketamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "movement-and-transfer", "name": "Movement and transfer", "description": "How a (RS)-ketamine is carried, installed or relocated.", "findings": [ { "id": "movement-events", "name": "Movement events and constraints", "description": "What counts as a movement, what records it and what limits it.", "questions": [ { "id": "movement-events-q01", "text": "What identifies and describes the movement of a (RS)-ketamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "movement-events-q02", "text": "Who or what asserted this about the movement of a (RS)-ketamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "movement-events-q03", "text": "What may an agent decide or do once the movement of a (RS)-ketamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a (RS)-ketamine passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a (RS)-ketamine between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a (RS)-ketamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a (RS)-ketamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a (RS)-ketamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a (RS)-ketamine, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a (RS)-ketamine is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a (RS)-ketamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a (RS)-ketamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a (RS)-ketamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "use-and-operation", "name": "Use and operation", "description": "What can be done with a (RS)-ketamine and what it takes to do it.", "rationale": "An agent that can recognise a thing but not act on it has only half a model.", "layers": [ { "id": "intended-use", "name": "Intended use and function", "description": "What a (RS)-ketamine is for, and what it is used for anyway.", "findings": [ { "id": "function-and-purpose", "name": "Function, purpose and misuse", "description": "The function a (RS)-ketamine performs and the uses that fall outside it.", "questions": [ { "id": "function-and-purpose-q01", "text": "What identifies and describes the use of a (RS)-ketamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "function-and-purpose-q02", "text": "Who or what asserted this about the use of a (RS)-ketamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "function-and-purpose-q03", "text": "What may an agent decide or do once the use of a (RS)-ketamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "handling-and-procedure", "name": "Handling and procedure", "description": "The steps, skills and tools involved in using a (RS)-ketamine.", "findings": [ { "id": "procedures-and-skills", "name": "Procedures, skills and required tools", "description": "What an agent needs before it can act on a (RS)-ketamine at all.", "questions": [ { "id": "procedures-and-skills-q01", "text": "What identifies and describes handling a (RS)-ketamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "procedures-and-skills-q02", "text": "Who or what asserted this about handling a (RS)-ketamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "procedures-and-skills-q03", "text": "What may an agent decide or do once handling a (RS)-ketamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "supply-and-consumption", "name": "Supply and consumption", "description": "Quantities, rates and what running out means.", "findings": [ { "id": "consumption-and-stock", "name": "Consumption, stock and replenishment", "description": "How much of a (RS)-ketamine there is and how fast it goes.", "questions": [ { "id": "consumption-and-stock-q01", "text": "What identifies and describes the supply of a (RS)-ketamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "consumption-and-stock-q02", "text": "Who or what asserted this about the supply of a (RS)-ketamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "consumption-and-stock-q03", "text": "What may an agent decide or do once the supply of a (RS)-ketamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "composition-and-identity", "name": "Composition, grade and chemical identity", "description": "What (RS)-ketamine is made of and how pure the thing in hand is.", "rationale": "Grade decides what a substance may be used for, so a model that records only the name cannot support any decision about use.", "layers": [ { "id": "chemical-identity", "name": "Chemical identity", "description": "Formula, structure and the registry numbers that name it unambiguously.", "findings": [ { "id": "identity-record", "name": "Identity and registry numbers", "description": "What identifies this substance across suppliers and regulators.", "questions": [ { "id": "identity-record-q01", "text": "What formula, structure and registry identifiers name (RS)-ketamine unambiguously?", "kind": "definition" }, { "id": "identity-record-q02", "text": "Which related substances share a name in common use but not an identifier?", "kind": "boundary" } ] } ] }, { "id": "grade-and-impurities", "name": "Grade, purity and impurities", "description": "The specification a batch meets and what else is in it.", "findings": [ { "id": "specification", "name": "Specification and assay", "description": "How purity is stated and measured, and which impurities matter.", "questions": [ { "id": "specification-q01", "text": "What grades of (RS)-ketamine exist, how is purity assayed, and which impurities are limited?", "kind": "measurement" }, { "id": "specification-q02", "text": "Which use requires which grade, and what happens when a lower grade is substituted?", "kind": "action" } ] } ] } ] }, { "id": "properties-and-behaviour", "name": "Properties and behaviour", "description": "How (RS)-ketamine behaves under conditions an agent can measure or change.", "rationale": "Physical constants are the part of a substance model that transfers between contexts, and each needs its unit and its conditions.", "layers": [ { "id": "physical-constants", "name": "Physical constants", "description": "Values that hold for the pure substance, with their conditions.", "findings": [ { "id": "constants-record", "name": "Constants and conditions", "description": "The quantities worth recording and the state they apply in.", "questions": [ { "id": "constants-record-q01", "text": "What are the defining physical constants of (RS)-ketamine, in what units and under what conditions?", "kind": "measurement" }, { "id": "constants-record-q02", "text": "Which of these values change with grade or form rather than being fixed?", "kind": "boundary" } ] } ] }, { "id": "stability-and-reactivity", "name": "Stability and reactivity", "description": "What it reacts with, degrades into, and how it is stored.", "findings": [ { "id": "incompatibilities", "name": "Incompatibilities and degradation", "description": "What must not meet it, and what it becomes over time.", "questions": [ { "id": "incompatibilities-q01", "text": "What is (RS)-ketamine incompatible with, and what does it degrade into under storage?", "kind": "definition" }, { "id": "incompatibilities-q02", "text": "What storage and handling does that require, and who is competent to do it?", "kind": "action" } ] } ] } ] }, { "id": "hazard-and-regulation", "name": "Hazard classification and regulation", "description": "How (RS)-ketamine can harm, and what the law says about holding and moving it.", "rationale": "A substance model without its hazard class and its regulatory identity is unusable in exactly the situations that matter.", "layers": [ { "id": "hazard-class", "name": "Hazard classification", "description": "Classified hazards, exposure limits and protective measures.", "findings": [ { "id": "classified-hazards", "name": "Classified hazards and limits", "description": "The classification, the scheme it belongs to, and the limits set.", "questions": [ { "id": "classified-hazards-q01", "text": "How is (RS)-ketamine classified for hazard, under which scheme, and what exposure limits apply?", "kind": "definition" }, { "id": "classified-hazards-q02", "text": "What protection does handling require, and what must an agent refuse to do without it?", "kind": "action" } ] } ] }, { "id": "regulatory-identity", "name": "Regulatory identity and control", "description": "Registration, restriction and transport rules by jurisdiction.", "findings": [ { "id": "controls", "name": "Controls and jurisdiction", "description": "Where it is restricted and what the restriction attaches to.", "questions": [ { "id": "controls-q01", "text": "Which registrations, restrictions or transport rules cover (RS)-ketamine, and where?", "kind": "provenance" }, { "id": "controls-q02", "text": "Does the control attach to the substance, its concentration, or its intended use?", "kind": "boundary" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a (RS)-ketamine came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a (RS)-ketamine and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a (RS)-ketamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a (RS)-ketamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a (RS)-ketamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a (RS)-ketamine is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a (RS)-ketamine, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a (RS)-ketamine, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a (RS)-ketamine is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 9, "layers": 20, "findings": 22, "questions": 60 } } } }