{ "model": { "rank": 12903, "code": "thing-q259626", "model_id": "vr.tr.aspergillosis", "name": "aspergillosis", "purpose": "Let an agent explain aspergillosis in general terms, relay forms, risk groups, diagnosis, treatment approaches and resistance from infectious disease and veterinary sources, route coughing up blood or severe breathlessness to emergency services, describe the named forms including the bird disease, and distinguish aspergillosis from tuberculosis, other fungal infections such as mucormycosis, mould allergy in general and lung cancer, without diagnosing individuals.", "family": "Thing Registry", "category": "Cross-cutting context", "status": "research-draft", "kind": "thing", "plane": "XCT", "domain": "XCT.QLT", "industry": "", "version": "", "url": "/models/thing/q259626/", "tier": 2, "score": 38, "payload": { "layer": "wikidata", "aliases": [ "allergic bronchopulmonary aspergillosis", "pulmonary aspergilloma", "chronic pulmonary aspergillosis", "intracavitary aspergillosis", "invasive pulmonary aspergillosis", "aspergillosis in birds", "bovine aspergillosis", "avian aspergillosis", "COVID-19 Associated Pulmonary Aspergillosis", "neuroaspergillosis", "tonsillar aspergillosis", "aspergilloma", "aspergillus niger infection", "Primary cutaneous aspergillosis" ], "aliasCount": 14, "merged": 14, "knownIn": 38, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": "vr.tr.aspergillosis-state", "source": { "dataset": "wikidata", "item": "Q259626", "url": "https://www.wikidata.org/wiki/Q259626", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-13T22:45:28Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 4, "engine": "claude" }, "metaModel": { "id": "THING-Q259626", "registryId": "vr.tr.aspergillosis", "name": "aspergillosis", "version": "0.2.0-wave.4", "entryKind": "thing", "family": "Thing Registry", "domain": [ "XCT.QLT" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q259626/", "model": { "registry_id": "vr.tr.aspergillosis", "name": "aspergillosis", "purpose": "Let an agent explain aspergillosis in general terms, relay forms, risk groups, diagnosis, treatment approaches and resistance from infectious disease and veterinary sources, route coughing up blood or severe breathlessness to emergency services, describe the named forms including the bird disease, and distinguish aspergillosis from tuberculosis, other fungal infections such as mucormycosis, mould allergy in general and lung cancer, without diagnosing individuals.", "definition": "A group of infections and allergic conditions caused by moulds of the genus Aspergillus, especially Aspergillus fumigatus, whose spores are inhaled from the environment, ranging from allergic bronchopulmonary aspergillosis in people with asthma or cystic fibrosis, to pulmonary aspergilloma or fungal balls in lung cavities, also called intracavitary aspergillosis, chronic pulmonary aspergillosis, and invasive pulmonary aspergillosis, a life-threatening infection mainly in people with weakened immune systems; aspergillosis in birds is a common veterinary disease. Azole resistance linked in part to agricultural fungicide use is a growing concern, and WHO listed A. fumigatus as a critical priority fungal pathogen in 2022.", "what_it_is_for": "Not applicable; a fungal disease group.", "affordances": [ "explain forms and risk groups", "relay diagnosis and treatment approaches", "describe named forms", "relay antifungal resistance concerns" ], "distinguishing_features": [ "Inhaled spores", "Allergic to invasive spectrum", "Immunocompromised risk", "Azole resistance" ], "appearance": "Not visible externally; seen on imaging as fungal balls or lung nodules and as grey-green mould in culture.", "visual_identification": [ "Diseases caused by Aspergillus moulds", "Allergic bronchopulmonary aspergillosis, pulmonary aspergilloma, chronic pulmonary aspergillosis, intracavitary aspergillosis, invasive pulmonary aspergillosis, aspergillosis in birds", "Tuberculosis is bacterial; mucormycosis is caused by other moulds; general mould allergy differs; lung cancer is malignant" ], "physical_properties": [ { "quantity": "main species", "typical_range": "Aspergillus fumigatus", "unit": "taxon", "note": "" }, { "quantity": "WHO fungal priority pathogens list", "typical_range": "2022", "unit": "year", "note": "critical priority" }, { "quantity": "first-line invasive treatment", "typical_range": "azole antifungals such as voriconazole", "unit": "note", "note": "guidelines vary" } ], "families_and_kinds": [ "allergic aspergillosis", "aspergilloma", "chronic pulmonary aspergillosis", "invasive aspergillosis", "avian aspergillosis" ], "related_models": [ { "relation": "is a kind of", "target": "opportunistic mycosis", "why": "in registry terms" }, { "relation": "is caused by", "target": "Aspergillus fumigatus", "why": "mainly" }, { "relation": "is treated with", "target": "voriconazole", "why": "among others" }, { "relation": "is contrasted with", "target": "mucormycosis", "why": "" } ], "identifiers": [], "standards_and_regulation": [ "IDSA and ESCMID aspergillosis guidelines", "WHO fungal priority pathogens list", "Agricultural fungicide regulation" ], "failure_modes_and_hazards": [ "Missing invasive infection in immunocompromised people", "Diagnosing remotely", "Ignoring azole resistance" ], "in_scope": [], "out_of_scope": [], "characteristics": [] }, "sources": [], "structure": { "bundles": [ { "id": "understand", "name": "Understand", "description": "What aspergillosis is.", "rationale": "Science.", "layers": [ { "id": "definition", "name": "Definition", "description": "Definition.", "findings": [ { "id": "definition-finding", "name": "Definition", "description": "Definition.", "questions": [ { "text": "Is someone coughing up blood, severely breathless or an immunocompromised patient with fever, in which case seek emergency care now?", "kind": "boundary" }, { "text": "What is aspergillosis, and how does it differ from tuberculosis, mucormycosis, mould allergy and lung cancer?", "kind": "definition" } ] } ] }, { "id": "forms", "name": "Forms", "description": "Named forms.", "findings": [ { "id": "forms-finding", "name": "Forms", "description": "Forms.", "questions": [ { "text": "What are ABPA, aspergilloma, chronic, intracavitary and invasive pulmonary aspergillosis and aspergillosis in birds?", "kind": "definition" }, { "text": "Which entry fits the specific form?", "kind": "action" } ] } ] } ] }, { "id": "medical", "name": "Medical", "description": "Risk and diagnosis.", "rationale": "Science.", "layers": [ { "id": "risk", "name": "Risk groups", "description": "Risk groups.", "findings": [ { "id": "risk-finding", "name": "Risk groups", "description": "Risk groups.", "questions": [ { "text": "Who is at risk of each form, such as transplant recipients and people with asthma?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "diagnosis", "name": "Diagnosis", "description": "Diagnosis.", "findings": [ { "id": "diagnosis-finding", "name": "Diagnosis", "description": "Diagnosis.", "questions": [ { "text": "How do imaging, galactomannan tests and cultures support diagnosis, in general terms?", "kind": "provenance" }, { "text": "Which sources are cited?", "kind": "provenance" } ] } ] } ] }, { "id": "treatment", "name": "Treatment", "description": "Treatment and resistance.", "rationale": "Regulation.", "layers": [ { "id": "antifungals", "name": "Antifungals", "description": "Antifungals.", "findings": [ { "id": "antifungals-finding", "name": "Antifungals", "description": "Antifungals.", "questions": [ { "text": "What antifungal approaches do guidelines describe, in general terms?", "kind": "provenance" }, { "text": "Which entry fits antifungal?", "kind": "action" } ] } ] }, { "id": "resistance", "name": "Resistance", "description": "Azole resistance.", "findings": [ { "id": "resistance-finding", "name": "Resistance", "description": "Resistance.", "questions": [ { "text": "How is agricultural azole use linked to resistance, with positions attributed?", "kind": "provenance" }, { "text": "Is the presentation neutral and attributed?", "kind": "boundary" } ] } ] } ] }, { "id": "context", "name": "Context", "description": "Veterinary and environment.", "rationale": "Context.", "layers": [ { "id": "birds", "name": "Birds", "description": "Avian aspergillosis.", "findings": [ { "id": "birds-finding", "name": "Birds", "description": "Birds.", "questions": [ { "text": "Why is aspergillosis common in captive birds and poultry?", "kind": "provenance" }, { "text": "Which entry fits avian medicine?", "kind": "action" } ] } ] }, { "id": "environment", "name": "Environment", "description": "Environmental spores.", "findings": [ { "id": "environment-finding", "name": "Environment", "description": "Environment.", "questions": [ { "text": "Where do Aspergillus spores come from, such as compost and construction dust?", "kind": "provenance" }, { "text": "Which entry fits Aspergillus fumigatus?", "kind": "action" } ] } ] } ] } ] }, "openQuestions": [ "Should avian aspergillosis be moved to veterinary entries?", "How should infectious disease guidelines be linked?", "How should resistance surveillance be kept current?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "disease or condition", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a aspergillosis, record what state it is in, and decide what may be done with it.", "whatItIs": "Let an agent explain aspergillosis in general terms, relay forms, risk groups, diagnosis, treatment approaches and resistance from infectious disease and veterinary sources, route coughing up blood or severe breathlessness to emergency services, describe the named forms including the bird disease, and distinguish aspergillosis from tuberculosis, other fungal infections such as mucormycosis, mould allergy in general and lung cancer, without diagnosing individuals.", "characteristics": { "substance": "abstract", "origin": "conceptual", "agency": "inert" }, "whatYouCanDoWithIt": [ "observed and measured" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: allergic bronchopulmonary aspergillosis, pulmonary aspergilloma, chronic pulmonary aspergillosis, intracavitary aspergillosis, invasive pulmonary aspergillosis, aspergillosis in birds, bovine aspergillosis, avian aspergillosis, COVID-19 Associated Pulmonary Aspergillosis, neuroaspergillosis, tonsillar aspergillosis, aspergilloma.", "14 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 38 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a aspergillosis, and on what evidence are they told apart?" ], "whatItIsMadeOf": "an abstraction with no physical instance", "physicalCharacter": [ "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "observe it, measure it, record its state" ], "howItIsRecognised": [ "Recognised by criteria applied to signs and findings, not by appearance. Two conditions can look identical and be distinguished only by test." ], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "allergic bronchopulmonary aspergillosis", "pulmonary aspergilloma", "chronic pulmonary aspergillosis", "intracavitary aspergillosis", "invasive pulmonary aspergillosis", "aspergillosis in birds", "bovine aspergillosis", "avian aspergillosis", "COVID-19 Associated Pulmonary Aspergillosis", "neuroaspergillosis", "tonsillar aspergillosis", "aspergilloma" ] } ], "standing": "Described in 38 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 14 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one aspergillosis from another, and a aspergillosis from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a aspergillosis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a aspergillosis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a aspergillosis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a aspergillosis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a aspergillosis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a aspergillosis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a aspergillosis sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a aspergillosis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a aspergillosis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a aspergillosis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a aspergillosis from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a aspergillosis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a aspergillosis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a aspergillosis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a aspergillosis passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a aspergillosis between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a aspergillosis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a aspergillosis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a aspergillosis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a aspergillosis, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a aspergillosis is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a aspergillosis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a aspergillosis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a aspergillosis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "diagnosis-and-criteria", "name": "Diagnosis, criteria and coding", "description": "What makes a case of aspergillosis a case, and under which revision.", "rationale": "Criteria change between revisions, so a diagnosis without its coding revision cannot be compared with a later one.", "layers": [ { "id": "criteria", "name": "Diagnostic criteria", "description": "The criteria in force and who issues them.", "findings": [ { "id": "criteria-record", "name": "Criteria, issuer and revision", "description": "What must be true for a diagnosis, according to whom.", "questions": [ { "id": "criteria-record-q01", "text": "What criteria define aspergillosis, issued by which body, in which revision?", "kind": "definition" }, { "id": "criteria-record-q02", "text": "What changed between revisions that would reclassify existing cases?", "kind": "boundary" } ] } ] }, { "id": "coding", "name": "Coding and terminology", "description": "The codes used to record it and their mapping.", "findings": [ { "id": "coding-record", "name": "Codes and mappings", "description": "Which classification codes apply and how they map.", "questions": [ { "id": "coding-record-q01", "text": "Which classification and terminology codes cover aspergillosis, and how do they map to each other?", "kind": "definition" }, { "id": "coding-record-q02", "text": "What is lost when a case is mapped from one scheme to another?", "kind": "boundary" } ] } ] } ] }, { "id": "course-and-population", "name": "Course, population and care", "description": "How aspergillosis develops, whom it affects, and what is done about it.", "rationale": "The condition, the diagnosis and the episode of care are three different things, and an agent must not merge them.", "layers": [ { "id": "course", "name": "Course and stages", "description": "Onset, progression, remission and outcome.", "findings": [ { "id": "course-record", "name": "Stages and transitions", "description": "The stages recorded and what moves a case between them.", "questions": [ { "id": "course-record-q01", "text": "What course does aspergillosis typically take, and what marks each stage?", "kind": "definition" }, { "id": "course-record-q02", "text": "What separates the condition itself from an episode of care for it?", "kind": "boundary" } ] } ] }, { "id": "population", "name": "Affected populations", "description": "Who is affected, how often, and on what evidence.", "findings": [ { "id": "epidemiology", "name": "Prevalence and its basis", "description": "Rates with their population, period and source.", "questions": [ { "id": "epidemiology-q01", "text": "What prevalence or incidence is reported for aspergillosis, in which population and period?", "kind": "measurement" }, { "id": "epidemiology-q02", "text": "What may an agent not conclude about an individual from a population rate?", "kind": "action" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a aspergillosis came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a aspergillosis and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a aspergillosis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a aspergillosis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a aspergillosis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a aspergillosis is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a aspergillosis, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a aspergillosis, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a aspergillosis is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 5, "layers": 10, "findings": 12, "questions": 32 } } } }