toxicity
Let an agent handle toxicity by substance, dose, endpoint and route, give poison centre and emergency contacts first in exposures, and give no guidance on harming anyone.
Research draft, second pass
A second pass drafted this model: the structure a model of this thing needs, and what is known about it in the world. The line under this one says how the second half was obtained - researched against sources, or recalled without web access, in which case nothing here was read anywhere and every claim is a lead to verify. Unreviewed either way.
written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify
Researched by: Claude
Purpose and description
Let an agent handle toxicity by substance, dose, endpoint and route, give poison centre and emergency contacts first in exposures, and give no guidance on harming anyone.
The degree to which a substance can harm an organism, depending on dose, route and duration of exposure; specific forms include organ toxicity such as hepatotoxicity and nephrotoxicity.
What it is for: Assessing hazards to protect health and the environment.
It can be read safety data sheets; call a poison centre after an exposure; assess risk in regulation; monitor drug side effects with clinicians.
Distinguishing features
Dose makes the poison
Acute and chronic
Organ-specific forms
Classified under GHS
What it looks like
Not visible; expressed as dose-response data and hazard classifications.
Physical character
acute oral toxicity category 1: LD50 up to 5 mg/kg - GHS classification
How it is recognised
Hazard pictograms such as skull and crossbones
Values such as LD50 or NOAEL
Organ toxicities named by organ
Related models
is a kind of - property
is a property of - bearer
is studied by - field
is classified by - standard
In practice
Families and kinds
acute toxicity
chronic toxicity
organ toxicity: liver, kidney, nerve
ecotoxicity
drug-induced toxicity
Standards and regulation
GHS classification
EU CLP Regulation
REACH
OECD test guidelines
Failure modes and hazards
Delaying help after exposure
Accidental poisoning of children
Unmonitored drug toxicity
Also called
Where this came from
wikidata · CC0 1.0
Also registered as vr.tr.toxicity
Drafted structure
Bundle to layer to finding to question, as the second pass will find it: 4 bundles · 8 layers · 8 findings · 16 questions.
Exposure Emergency first.
Exposures need help fast.
Emergency
Poison centre.
Emergency
Emergency response.
- Has someone been exposed, and should a poison centre or emergency service be called now? boundary
- What information will they ask for? action
First aid
Safety data sheet.
First aid
First aid.
- What first aid does the safety data sheet state? provenance
- What must not be done? boundary
Hazard Classification.
Classification communicates hazard.
Class
GHS.
Class
Hazard class.
- How is the substance classified? provenance
- What pictograms and statements apply? definition
Data
Dose-response.
Data
Toxicity data.
- What toxicity values are reported? measurement
- From which study or database? provenance
Medicine Drug toxicity.
Clinicians monitor toxicity.
Monitoring
Tests.
Monitoring
Monitoring.
- Does this medicine need monitoring for organ toxicity? boundary
- Who should the patient ask? action
Reporting
Side effects.
Reporting
Adverse event reporting.
- How can a suspected side effect be reported? action
- To which regulator? provenance
Prevention Safe use.
Prevention avoids harm.
Storage
Child safety.
Storage
Safe storage.
- How should it be stored away from children? action
- Is child-resistant packaging used? boundary
Workplace
Exposure limits.
Workplace
Exposure limits.
- What occupational exposure limits apply? measurement
- What protection is required? boundary
What the second pass must settle
- Should organ toxicities be separate entries?
- How should poison centre contacts be localised?
- How should toxicity data be linked?