extracellular fluid
Let an agent explain extracellular fluid and its compartments, relay composition, regulation and measurement from physiology sources, describe clinical relevance in general terms, and distinguish extracellular from intracellular fluid.
Research draft, second pass
A second pass drafted this model: the structure a model of this thing needs, and what is known about it in the world. The line under this one says how the second half was obtained - researched against sources, or recalled without web access, in which case nothing here was read anywhere and every claim is a lead to verify. Unreviewed either way.
written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify
Researched by: Claude
Purpose and description
Let an agent explain extracellular fluid and its compartments, relay composition, regulation and measurement from physiology sources, describe clinical relevance in general terms, and distinguish extracellular from intracellular fluid.
All body fluid outside the cells, comprising the interstitial fluid bathing tissues, blood plasma within vessels, lymph, and transcellular fluids in specialised compartments such as cerebrospinal, pericardial, pleural, synovial, follicular and inner ear labyrinthine fluids, together making up about a third of total body water; extracellular fluid volume and composition, especially sodium, are regulated by the kidneys and hormones, and excess fluid in lungs is measured as extravascular lung water.
What it is for: Transport and environment for cells.
It can be explain compartments and composition; relay regulation; describe clinical relevance; distinguish from intracellular fluid.
Distinguishing features
Sodium-rich
Multiple compartments
Kidney and hormone regulation
Clinical fluid balance
What it looks like
Not visible as a whole; plasma, lymph and tissue fluid.
Physical character
share of body water: about one third fraction - adults
volume: about 14 litres - 70 kg adult
main cation: sodium ion - about 140 mmol per litre
How it is recognised
Body fluid outside cells
Interstitial fluid, plasma, lymph, transcellular fluids
Intracellular fluid is inside cells; blood includes cells as well as plasma
Related models
is a kind of - in registry terms
is contrasted with - inside cells
is regulated by - and hormones such as aldosterone
includes - as its vascular part
In practice
Families and kinds
interstitial fluid
blood plasma
lymph
transcellular fluids: cerebrospinal, pericardial, pleural, peritoneal, synovial, ocular, follicular, labyrinthine
extravascular lung water as a clinical measure
Identifiers
MeSH D005110 extracellular fluid
Standards and regulation
Clinical guidelines on fluid management
No regulation of the physiological concept
Failure modes and hazards
Dehydration and fluid overload
Electrolyte disturbances
Agents giving personal medical advice
Also called
Where this came from
wikidata · CC0 1.0
Also registered as vr.tr.extracellular-fluid
Drafted structure
Bundle to layer to finding to question, as the second pass will find it: 4 bundles · 8 layers · 8 findings · 16 questions.
Understand What extracellular fluid is.
Science.
Compartments
Compartments.
Compartments
Compartments.
- What are the extracellular fluid compartments, and how do they relate? definition
- Is the question about extracellular, intracellular or total body fluid? boundary
Composition
Composition.
Composition
Composition.
- What is the composition of extracellular fluid, and how does it differ from intracellular fluid? definition
- Which entry fits the specific compartment? action
Regulate Regulation.
Science.
Volume
Volume regulation.
Volume
Volume.
- How do the kidneys, thirst and hormones regulate extracellular volume and sodium? provenance
- Which entry fits fluid balance? action
Exchange
Exchange with cells and capillaries.
Exchange
Exchange.
- How do Starling forces and membranes govern exchange between compartments? provenance
- Which references are standard? provenance
Clinical Clinical relevance.
Clinical.
Disorders
Disorders.
Disorders
Disorders.
- How do dehydration, oedema and electrolyte disorders involve extracellular fluid, in general terms? provenance
- Is the user asking about a personal condition, which needs a clinician? boundary
Measurement
Measurement.
Measurement
Measurement.
- How are extracellular volume and extravascular lung water measured? provenance
- Which sources are cited? provenance
Context Concept and history.
Context.
History
History.
History
History.
- How did Claude Bernard milieu interieur and later physiology define extracellular fluid? provenance
- Which entry fits homeostasis? action
Comparative
Comparative physiology.
Comparative
Comparative.
- How does extracellular fluid composition vary across animals? provenance
- Which entry fits comparative physiology? action
What the second pass must settle
- Should interstitial fluid and transcellular fluid be separate entries?
- How should physiology references be linked?
- The registry entry has merged aliases naming specific compartments and a clinical measure; should they be split off?