{ "model": { "rank": 2466, "code": "thing-q29496", "model_id": "vr.tr.leukemia", "name": "leukemia", "purpose": "Let an agent explain leukaemia and its types in general terms, relay information on symptoms, diagnosis and treatment from medical bodies, point to support resources, and route personal questions to clinicians.", "family": "Thing Registry", "category": "Information and virtual systems", "status": "research-draft", "kind": "thing", "plane": "INF", "domain": "INF.KNW", "industry": "", "version": "", "url": "/models/thing/q29496/", "tier": 2, "score": 105, "payload": { "layer": "wikidata", "aliases": [ "blast phase chronic myelogenous leukemia, BCR-ABL1 positive", "blastic plasmacytoid dendritic cell neoplasm", "radiation-induced leukemia", "mast cell leukemia", "childhood leukemia", "classic mast cell leukemia", "aleukemic mast cell leukemia", "splenic manifestation of leukemia", "neonatal leukemia", "childhood precursor T-lymphoblastic lymphoma/leukemia", "childhood acute myeloid leukemia", "central nervous system leukemia", "myeloid leukemia", "enzootic bovine leukosis", "feline leukemia", "lymphoblastic leukemia", "chronic erythremia", "subleukemic leukemia", "subacute leukemia", "aleukemic leukemia", "chronic leukemia", "mouse erythroid leukemia", "leukemic infiltration", "lymphoid leukemia", "Carcinocythemia", "monocytic leukemia", "subacute myeloid leukemia", "eosinophilic leukemia", "philadelphia-positive myelogenous leukemia", "bovine leukemia", "aleukemic leukemia cutis", "chronic eosinophilic leukemia", "B-cell leukemia", "subacute monocytic leukemia", "chronic eosinophilic leukemia, not otherwise specified" ], "aliasCount": 35, "merged": 35, "knownIn": 105, "facets": null, "markers": [], "lexicalClass": "", "senseRank": null, "alsoRegisteredAs": null, "source": { "dataset": "wikidata", "item": "Q29496", "url": "https://www.wikidata.org/wiki/Q29496", "license": "CC0 1.0" } }, "research": { "vercy": "1.0-draft", "publication": { "status": "research-draft", "adjudicationStatus": "unreviewed", "publishableCanonical": false, "generatedAt": "2026-09-12T01:03:13Z", "providers": [ "Claude" ], "breadth": "written by Claude from model knowledge without web access - no source was read, every claim is a lead to verify", "pass": 2, "wave": 2, "engine": "claude" }, "metaModel": { "id": "THING-Q29496", "registryId": "vr.tr.leukemia", "name": "leukemia", "version": "0.2.0-wave.2", "entryKind": "thing", "family": "Thing Registry", "domain": [ "INF.KNW" ], "status": "research-draft" }, "canonicalUrl": "https://ver.cy/models/thing/q29496/", "model": { "registry_id": "vr.tr.leukemia", "name": "leukemia", "purpose": "Let an agent explain leukaemia and its types in general terms, relay information on symptoms, diagnosis and treatment from medical bodies, point to support resources, and route personal questions to clinicians.", "definition": "A group of cancers of the blood-forming tissues in which abnormal white blood cells proliferate in the bone marrow and blood, classified into acute and chronic forms and by cell lineage as lymphoid or myeloid, including childhood leukaemias, chronic myeloid leukaemia with its phases, rare forms such as mast cell leukaemia, and leukaemia induced by radiation; leukaemia is diagnosed by blood and marrow tests and treated with chemotherapy, targeted therapy, immunotherapy and transplantation, and this entry gives general information only.", "what_it_is_for": "Cancers of blood-forming tissue.", "affordances": [ "explain types generally", "relay diagnosis and treatment information", "point to support resources", "route personal questions" ], "distinguishing_features": [ "Blood cancer", "Classified by speed and lineage", "Marrow origin", "Treatable forms" ], "appearance": "Not visible externally; identified by blood and marrow tests.", "visual_identification": [ "Abnormal white cell proliferation", "Acute or chronic, lymphoid or myeloid", "Lymphoma arises in lymph tissue; anaemia is low red cells" ], "physical_properties": [], "families_and_kinds": [ "acute lymphoblastic leukaemia", "acute myeloid leukaemia", "chronic lymphocytic leukaemia", "chronic myeloid leukaemia", "rare leukaemias such as mast cell leukaemia" ], "related_models": [ { "relation": "is a kind of", "target": "myeloproliferative disorders", "why": "category" }, { "relation": "is related to", "target": "carcinogen", "why": "radiation-induced leukaemia" }, { "relation": "is related to", "target": "histocompatibility", "why": "stem cell transplantation matching" }, { "relation": "is related to", "target": "stomach cancer", "why": "another cancer entry" } ], "identifiers": [], "standards_and_regulation": [ "Clinical guidelines from haematology and oncology bodies", "WHO classification of haematological malignancies", "Drug regulation" ], "failure_modes_and_hazards": [ "Agents giving personal medical advice", "Misinformation about causes and cures", "Delayed diagnosis from vague symptoms" ], "in_scope": [], "out_of_scope": [], "characteristics": [] }, "sources": [], "structure": { "bundles": [ { "id": "understand", "name": "Understand", "description": "What leukaemia is.", "rationale": "General information.", "layers": [ { "id": "types", "name": "Types", "description": "Types and classification.", "findings": [ { "id": "types-finding", "name": "Types", "description": "Types.", "questions": [ { "text": "How is leukaemia classified into acute and chronic, lymphoid and myeloid forms, and what characterises each, according to medical sources?", "kind": "provenance" }, { "text": "Is the user asking about their own health, which needs a clinician?", "kind": "boundary" } ] } ] }, { "id": "causes", "name": "Causes", "description": "Causes and risk factors.", "findings": [ { "id": "causes-finding", "name": "Causes", "description": "Causes.", "questions": [ { "text": "What risk factors such as radiation, genetics and prior treatment are documented?", "kind": "provenance" }, { "text": "Which entry fits a specific type?", "kind": "action" } ] } ] } ] }, { "id": "care", "name": "Care", "description": "Diagnosis and treatment.", "rationale": "Medicine.", "layers": [ { "id": "diagnosis", "name": "Diagnosis", "description": "Symptoms and diagnosis.", "findings": [ { "id": "diagnosis-finding", "name": "Diagnosis", "description": "Diagnosis.", "questions": [ { "text": "What symptoms are associated with leukaemia, and how is it diagnosed by blood and marrow tests, according to guidelines?", "kind": "provenance" }, { "text": "Are urgent symptoms present now, requiring immediate care?", "kind": "boundary" } ] } ] }, { "id": "treatment", "name": "Treatment", "description": "Treatment.", "findings": [ { "id": "treatment-finding", "name": "Treatment", "description": "Treatment.", "questions": [ { "text": "What treatments are documented, including chemotherapy, targeted therapy, immunotherapy and stem cell transplantation, and how do they depend on type?", "kind": "provenance" }, { "text": "Which entry fits a specific treatment?", "kind": "action" } ] } ] } ] }, { "id": "support", "name": "Support", "description": "Living with leukaemia.", "rationale": "Support.", "layers": [ { "id": "support", "name": "Support", "description": "Support resources.", "findings": [ { "id": "support-finding", "name": "Support", "description": "Support.", "questions": [ { "text": "What support resources exist for patients and families, including for childhood leukaemia?", "kind": "provenance" }, { "text": "Is someone in acute distress, needing crisis support?", "kind": "boundary" } ] } ] }, { "id": "survivorship", "name": "Survivorship", "description": "Survivorship.", "findings": [ { "id": "survivorship-finding", "name": "Survivorship", "description": "Survivorship.", "questions": [ { "text": "What is documented about long-term outcomes and survivorship care?", "kind": "provenance" }, { "text": "Which entry fits cancer survivorship?", "kind": "action" } ] } ] } ] }, { "id": "learn", "name": "Learn", "description": "Research and statistics.", "rationale": "Context.", "layers": [ { "id": "statistics", "name": "Statistics", "description": "Epidemiology.", "findings": [ { "id": "statistics-finding", "name": "Statistics", "description": "Epidemiology.", "questions": [ { "text": "How common is leukaemia, and how have survival rates changed, according to cancer registries?", "kind": "provenance" }, { "text": "Which references are standard?", "kind": "provenance" } ] } ] }, { "id": "research", "name": "Research", "description": "Research.", "findings": [ { "id": "research-finding", "name": "Research", "description": "Research.", "questions": [ { "text": "What are current research directions, such as cell therapies and targeted drugs?", "kind": "provenance" }, { "text": "Which misconceptions arise?", "kind": "provenance" } ] } ] } ] } ] }, "openQuestions": [ "Should each type be a separate entry?", "How should guidelines be linked?", "How should support organisations be linked?" ], "statistics": { "bundles": 4, "layers": 8, "findings": 8, "questions": 16 } }, "draft": { "generator": "vr.draft.v3", "status": "draft-generated", "researched": false, "archetype": "discipline or field of knowledge", "method": "Written from the archetype playbook - what this kind of thing needs beyond identity and provenance - and from the structure that recurred across 6,333 models already researched by two engines. Applied to this entry by rule. No source was read for this thing and no claim here is researched. This entry carries no facets of its own, so they were inferred from its domain - a guess about a whole domain applied to one thing.", "facetsInferred": true, "nextPass": "A researcher replaces this draft with a sourced specification. Treat every sentence below as a proposal to argue with.", "purpose": "Give an agent a durable, checkable way to recognise a leukemia, record what state it is in, and decide what may be done with it.", "whatItIs": "Let an agent explain leukaemia and its types in general terms, relay information on symptoms, diagnosis and treatment from medical bodies, point to support resources, and route personal questions to clinicians.", "characteristics": { "substance": "information", "origin": "conceptual", "agency": "inert" }, "whatYouCanDoWithIt": [ "read and interpreted" ], "distinguishingFeatures": [ "Names folded into this entry, which a task may need to split apart again: blast phase chronic myelogenous leukemia, BCR-ABL1 positive, blastic plasmacytoid dendritic cell neoplasm, radiation-induced leukemia, mast cell leukemia, childhood leukemia, classic mast cell leukemia, aleukemic mast cell leukemia, splenic manifestation of leukemia, neonatal leukemia, childhood precursor T-lymphoblastic lymphoma/leukemia, childhood acute myeloid leukemia, central nervous system leukemia.", "35 finer distinctions are held as aliases rather than separate entries, because telling them apart needs a task that asks for it.", "Described in 105 Wikipedia languages, which is a measure of how widely the thing is known, not of how important it is." ], "openQuestionsForResearch": [ "Which of the bundles below does a real task actually need, and which are ceremony?", "What does this thing have that the facets do not capture at all?", "Which neighbouring kind is most often confused with a leukemia, and on what evidence are they told apart?" ], "whatItIsMadeOf": "content that has to be carried by something else", "physicalCharacter": [ "Does nothing on its own; everything it does, something else did to it.", "These come from the domain this entry sits in rather than from the entry itself, so treat them as a first guess about the whole domain applied to one thing." ], "whatCanBeDoneWithIt": [ "read it and act on what it says" ], "howItIsRecognised": [], "relatedModels": [ { "relation": "covers", "note": "Finer kinds folded into this entry because telling them apart needs a task that asks for it. Each is a model waiting to be split out when one does.", "targets": [ "blast phase chronic myelogenous leukemia, BCR-ABL1 positive", "blastic plasmacytoid dendritic cell neoplasm", "radiation-induced leukemia", "mast cell leukemia", "childhood leukemia", "classic mast cell leukemia", "aleukemic mast cell leukemia", "splenic manifestation of leukemia", "neonatal leukemia", "childhood precursor T-lymphoblastic lymphoma/leukemia", "childhood acute myeloid leukemia", "central nervous system leukemia" ] } ], "standing": "Described in 105 Wikipedia languages, which measures how widely it is written about rather than how important or how common it is. 35 finer distinctions are held inside this entry as names rather than as separate models.", "structure": { "bundles": [ { "id": "identity-and-classification", "name": "Identity, naming and classification", "description": "How an agent tells one leukemia from another, and a leukemia from things that resemble it.", "rationale": "Recognition comes before every other claim. Without stable identity nothing else in the model can be trusted to be about the same thing twice.", "layers": [ { "id": "naming-and-identifiers", "name": "Names and identifiers", "description": "The names this thing goes by and the identifiers that survive translation and time.", "findings": [ { "id": "preferred-name-and-aliases", "name": "Preferred name, aliases and local names", "description": "Which name to use, which names mean the same thing, and which merely sound similar.", "questions": [ { "id": "preferred-name-and-aliases-q01", "text": "What identifies and describes the name of a leukemia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "preferred-name-and-aliases-q02", "text": "Who or what asserted this about the name of a leukemia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "preferred-name-and-aliases-q03", "text": "What may an agent decide or do once the name of a leukemia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "stable-identifiers", "name": "Stable identifiers and external keys", "description": "Identifiers that keep pointing at this kind of thing across systems and languages.", "questions": [ { "id": "stable-identifiers-q01", "text": "What identifies and describes an identifier for a leukemia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stable-identifiers-q02", "text": "Who or what asserted this about an identifier for a leukemia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stable-identifiers-q03", "text": "What may an agent decide or do once an identifier for a leukemia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "classification-and-granularity", "name": "Classification and granularity", "description": "Where a leukemia sits among kinds, and how finely a task needs to cut it.", "findings": [ { "id": "kind-and-parents", "name": "Kind, parents and neighbouring kinds", "description": "The classes this thing belongs to and the ones it is next to.", "questions": [ { "id": "kind-and-parents-q01", "text": "What identifies and describes the kind of a leukemia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "kind-and-parents-q02", "text": "Who or what asserted this about the kind of a leukemia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "kind-and-parents-q03", "text": "What may an agent decide or do once the kind of a leukemia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] }, { "id": "distinguishing-features", "name": "Distinguishing features", "description": "What separates a leukemia from the things most often confused with it.", "questions": [ { "id": "distinguishing-features-q01", "text": "What identifies and describes what distinguishes a leukemia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "distinguishing-features-q02", "text": "Who or what asserted this about what distinguishes a leukemia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "distinguishing-features-q03", "text": "What may an agent decide or do once what distinguishes a leukemia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "state-and-lifecycle", "name": "State and lifecycle", "description": "The states a leukemia passes through and the events that move it between them.", "rationale": "Most decisions about a thing depend on what state it is in now, which is a claim with a time on it, not a property.", "layers": [ { "id": "lifecycle-stages", "name": "Lifecycle stages", "description": "From coming into existence to ceasing to be one of these.", "findings": [ { "id": "stages-and-transitions", "name": "Stages and transitions", "description": "The stages worth naming and what moves a leukemia between them.", "questions": [ { "id": "stages-and-transitions-q01", "text": "What identifies and describes the lifecycle of a leukemia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "stages-and-transitions-q02", "text": "Who or what asserted this about the lifecycle of a leukemia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "stages-and-transitions-q03", "text": "What may an agent decide or do once the lifecycle of a leukemia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "observations-and-status", "name": "Observations and current status", "description": "What is observed about a leukemia, how often and by whom.", "findings": [ { "id": "observation-record", "name": "Observation record", "description": "How an observation of a leukemia is recorded so that it can be superseded rather than overwritten.", "questions": [ { "id": "observation-record-q01", "text": "What identifies and describes an observation of a leukemia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "observation-record-q02", "text": "Who or what asserted this about an observation of a leukemia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "observation-record-q03", "text": "What may an agent decide or do once an observation of a leukemia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "content-and-access", "name": "Content, encoding and access", "description": "What a leukemia says, how it is encoded and who may read it.", "rationale": "An informational thing carries content that can be copied, versioned and withheld, none of which its physical carrier explains.", "layers": [ { "id": "content-and-encoding", "name": "Content and encoding", "description": "The content itself, its format and its language.", "findings": [ { "id": "content-and-format", "name": "Content, format and language", "description": "What a leukemia contains and in what form it is held.", "questions": [ { "id": "content-and-format-q01", "text": "What identifies and describes the content of a leukemia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "content-and-format-q02", "text": "Who or what asserted this about the content of a leukemia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "content-and-format-q03", "text": "What may an agent decide or do once the content of a leukemia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "access-and-rights", "name": "Access, rights and retention", "description": "Who may read, copy or change it, and for how long it is kept.", "findings": [ { "id": "access-rules", "name": "Access rules and retention", "description": "The permissions attached to a leukemia and the period it survives.", "questions": [ { "id": "access-rules-q01", "text": "What identifies and describes access to a leukemia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "access-rules-q02", "text": "Who or what asserted this about access to a leukemia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "access-rules-q03", "text": "What may an agent decide or do once access to a leukemia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] }, { "id": "subject-and-method", "name": "Subject matter and method", "description": "What leukemia studies and how it establishes anything.", "rationale": "A field is identified by its questions and its methods, and those are what distinguish it from the fields next to it.", "layers": [ { "id": "subject", "name": "Subject matter", "description": "The questions it takes as its own.", "findings": [ { "id": "subject-record", "name": "Questions and objects of study", "description": "What it is about, stated so a neighbouring field can be told apart.", "questions": [ { "id": "subject-record-q01", "text": "What questions and objects does leukemia take as its own?", "kind": "definition" }, { "id": "subject-record-q02", "text": "Which questions does it share with a neighbouring field, and who claims them?", "kind": "boundary" } ] } ] }, { "id": "method", "name": "Method and evidence", "description": "How claims are established and what counts as evidence.", "findings": [ { "id": "method-record", "name": "Methods and standards of evidence", "description": "The methods used and what they are taken to establish.", "questions": [ { "id": "method-record-q01", "text": "By what methods does leukemia establish claims, and what counts as sufficient evidence?", "kind": "provenance" }, { "id": "method-record-q02", "text": "What kind of claim can this field not settle, and where should an agent look instead?", "kind": "action" } ] } ] } ] }, { "id": "institutions-and-classification", "name": "Institutions and classification", "description": "Where leukemia is practised and how catalogues place it.", "rationale": "The institutional footprint is the evidence that a field exists as a field rather than as a topic.", "layers": [ { "id": "institutions", "name": "Institutional markers", "description": "Societies, journals, degrees and departments.", "findings": [ { "id": "institution-record", "name": "Bodies and venues", "description": "Where the field organises itself.", "questions": [ { "id": "institution-record-q01", "text": "Which societies, journals or degrees mark leukemia as an established field?", "kind": "provenance" }, { "id": "institution-record-q02", "text": "What would show that it is emerging or dissolving rather than established?", "kind": "boundary" } ] } ] }, { "id": "classification", "name": "Classification schemes", "description": "Where library and research classifications put it.", "findings": [ { "id": "classification-record", "name": "Codes and their disagreements", "description": "The classification codes that place it, and where they differ.", "questions": [ { "id": "classification-record-q01", "text": "Which classification schemes place leukemia, under what codes?", "kind": "definition" }, { "id": "classification-record-q02", "text": "Where do those schemes disagree about its scope?", "kind": "boundary" } ] } ] } ] }, { "id": "provenance-and-evidence", "name": "Provenance, evidence and time", "description": "Where every claim about a leukemia came from and when it held.", "rationale": "A claim without a source and a time cannot be superseded, only overwritten, and an agent that overwrites loses the ability to explain itself.", "layers": [ { "id": "source-and-authority", "name": "Source and authority", "description": "Who said it, on what evidence, and how strongly.", "findings": [ { "id": "claim-provenance", "name": "Claim provenance and confidence", "description": "The authority behind each claim about a leukemia and how confident it is.", "questions": [ { "id": "claim-provenance-q01", "text": "What identifies and describes a claim about a leukemia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "claim-provenance-q02", "text": "Who or what asserted this about a claim about a leukemia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "claim-provenance-q03", "text": "What may an agent decide or do once a claim about a leukemia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] }, { "id": "time-and-versions", "name": "Time, versions and supersession", "description": "When a claim was true, when it was learnt, and what replaced it.", "findings": [ { "id": "validity-and-supersession", "name": "Validity period and supersession", "description": "How an old claim about a leukemia is retired without being erased.", "questions": [ { "id": "validity-and-supersession-q01", "text": "What identifies and describes the validity of a claim about a leukemia, and in what units or vocabulary?", "kind": "definition", "answer_data": [ "identifiers", "types and classes", "values with units", "explicit unknowns" ] }, { "id": "validity-and-supersession-q02", "text": "Who or what asserted this about the validity of a claim about a leukemia, by which method, and when was it true?", "kind": "provenance", "answer_data": [ "authority", "method", "evidence", "event time", "knowledge time" ] }, { "id": "validity-and-supersession-q03", "text": "What may an agent decide or do once the validity of a claim about a leukemia is known, and what must it refuse?", "kind": "action", "answer_data": [ "permitted actions", "preconditions", "refusals", "escalation" ] } ] } ] } ] } ] }, "statistics": { "bundles": 6, "layers": 12, "findings": 14, "questions": 38 } } } }