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cyamemazine

vr.tr.cyamemazine · thing-q3008033

Enable an agent to recognise cyamemazine, assess the identity and condition of a material containing it, and determine which handling or use decisions require additional evidence.

Thing Registry Physical world and living systems PHY.MAT

Bundle → Layer → Finding → Questions Filled

6 bundles · 11 layers · 18 findings · 28 questions

Cyamemazine identity Establish exactly which molecular entity and material form a cyamemazine record represents.

Molecular recognition

Anchor recognition to molecular structure and traceable identifiers.

Structure and identifier agreement

Require identifiers and analytical identity evidence to refer to the same cyamemazine structure.

  1. Which verified structure, CAS number, PubChem CID and available EC identifier identify cyamemazine base, and do all records agree? definition
  2. What reference material and analytical evidence distinguish this sample from related phenothiazines? measurement

Base and salt boundary

Represent material forms without treating every cyamemazine-containing material as the free base.

Form and stereochemical specification

Keep counterion, stoichiometry, solvation and stereochemical information explicit where established.

  1. Does the record describe cyamemazine base, tartrate or another demonstrated form, and what evidence establishes its composition? boundary
  2. What stereochemical composition is specified for cyamemazine and any counterion, and what remains unspecified? definition
Content and quality Determine how much cyamemazine is present and whether the surrounding composition supports an intended use.

Quantity basis

Make cyamemazine content interpretable across base, salt and solution records.

Base-equivalent accounting

Permit conversions only from verified composition and clearly stated assay conventions.

  1. Is the reported amount cyamemazine base equivalent, total salt mass or concentration of a specified preparation? measurement
  2. Which verified stoichiometry, molecular masses, water content and assay basis justify a conversion? action

Analytical suitability

Assess cyamemazine identity, related substances and grade using batch-specific evidence.

Parent and impurity resolution

Require suitable separation and quantification before interpreting purity or accepting a batch.

  1. Which method resolves cyamemazine from relevant synthesis impurities and degradation products, with what detection and quantification limits? measurement
  2. Which certificate, specification and reference-standard traceability support the claimed analytical or pharmaceutical grade? provenance
Physical behaviour and stability Relate cyamemazine material properties to its form, environment and exposure history.

Form-dependent properties

Record physical constants with the conditions and material identity needed to use them.

Conditional property evidence

Separate measured cyamemazine properties from estimates and values belonging to salts or formulations.

  1. What phase, thermal transitions and decomposition behaviour are measured for the specified cyamemazine form? measurement
  2. What solubility, pKa and partition measurements are available, with solvent, pH, temperature and experimental or predicted status? measurement

Exposure and retest

Connect storage decisions to demonstrated stability of the actual material.

Stability-supported condition

Assess whether temperature, light, oxygen, moisture or solution preparation have changed suitability.

  1. Which stability studies establish relevant degradation pathways and storage conditions for this cyamemazine form? provenance
  2. After a recorded exposure or storage excursion, which evidence supports continued use, retesting or rejection? action
Biological activity boundaries Connect cyamemazine to pharmacological evidence without making substance identity a treatment recommendation.

Target evidence

Represent receptor interactions through comparable, source-specific experimental results.

Assay-qualified activity

Require target identity, assay context and endpoint before comparing cyamemazine activity.

  1. Which dopamine, serotonin or other receptor interactions are supported by directly inspected cyamemazine studies? provenance
  2. For each result, what species, assay, endpoint, concentration units and uncertainty distinguish binding affinity from functional activity? measurement

Parent, metabolite and product links

Keep biological transformations and clinical observations attached to their actual subjects.

Attribution of biological effects

Prevent metabolite findings or product-specific observations from being silently assigned to isolated parent cyamemazine.

  1. Which metabolites are identified by reliable evidence, and which reported activities belong to them rather than parent cyamemazine? boundary
  2. Which findings concern isolated cyamemazine, and which depend on a medicinal product, administration route or patient population? boundary
Handling and regulatory constraints Determine applicable controls for the identified cyamemazine material and intended activity.

Material exposure controls

Assess occupational and environmental handling using form-specific hazard evidence.

Supported hazard controls

Tie handling decisions to an applicable safety data sheet and documented exposure assessment.

  1. Which current SDS and GHS classification apply to this cyamemazine form, purity and jurisdiction? provenance
  2. What established exposure limits or documented control basis govern weighing, spill response and disposal when cyamemazine-specific limits are unavailable? action

Jurisdiction and permitted use

Connect legal and quality constraints to a specified location, date and activity.

Activity-specific permissions

Evaluate acquisition, supply and use through applicable substance and product records.

  1. Which dated jurisdictional records govern acquiring, importing, supplying or using cyamemazine for the proposed activity? action
  2. Which permissions and restrictions attach to bulk cyamemazine, and which attach only to a particular authorised medicinal product? boundary
Evidence and external alignment What the world already says about this thing, gathered so the model can be checked against it.

Reported evidence

Findings from the breadth pass, kept separate from the structural claims.

Check these first

Recalled without web access and unsourced; every item is a lead to verify.

  1. Which of these check these first hold for the sense of cyamemazine this model covers, and on what evidence? provenance

Kinds and varieties

Recalled without web access and unsourced; every item is a lead to verify.

  1. Which of these kinds and varieties hold for the sense of cyamemazine this model covers, and on what evidence? provenance

Identifiers and schemes

Recalled without web access and unsourced; every item is a lead to verify.

  1. Which of these identifiers and schemes hold for the sense of cyamemazine this model covers, and on what evidence? provenance

Real-world use

Recalled without web access and unsourced; every item is a lead to verify.

  1. Which of these real-world use hold for the sense of cyamemazine this model covers, and on what evidence? provenance

Typical measurements

Recalled without web access and unsourced; every item is a lead to verify.

  1. Which of these typical measurements hold for the sense of cyamemazine this model covers, and on what evidence? provenance

Failure modes and hazards

Recalled without web access and unsourced; every item is a lead to verify.

  1. Which of these failure modes and hazards hold for the sense of cyamemazine this model covers, and on what evidence? provenance

Regional variation

Recalled without web access and unsourced; every item is a lead to verify.

  1. Which of these regional variation hold for the sense of cyamemazine this model covers, and on what evidence? provenance

Neighbouring kinds and how to tell them apart

Recalled without web access and unsourced; every item is a lead to verify.

  1. Which of these neighbouring kinds and how to tell them apart hold for the sense of cyamemazine this model covers, and on what evidence? provenance

Classifiers Filled

Family
Thing Registry
Category
Physical world and living systems
Entry kind
thing
Plane
PHY
Domain
PHY.MAT

What it is Filled

Cyamemazine is a synthetic phenothiazine antipsychotic with sedative and anxiolytic effects, used medicinally, particularly in France.

In scope

  • Molecular identity and identifiers that distinguish cyamemazine from other phenothiazines
  • Free-base identity, salt relationships and the basis used to express cyamemazine content
  • Batch composition, purity, impurities and analytical evidence
  • Physical state, solubility, stability and storage conditions for the identified material form
  • Substance-level pharmacological evidence, hazards and jurisdiction-specific restrictions

Out of scope

  • Finished medicinal products, their excipients, packaging and administration devices
  • Patient-specific diagnosis, prescribing, dosing and treatment monitoring
  • Manufacturing routes and production equipment
  • Metabolites and other phenothiazines as independently identified substances
  • Clinical trials, marketing authorisations and safety reports as independently governed records

Why it exists Filled

Enable an agent to recognise cyamemazine, assess the identity and condition of a material containing it, and determine which handling or use decisions require additional evidence.

Distinguishing features Filled

  • Match the molecular structure associated with PubChem CID 62865 and formula C19H21N3S; phenothiazine membership alone does not identify cyamemazine. [PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/62865)
  • Require a cyamemazine-specific structure or analytical match when distinguishing it from similarly named or structurally related phenothiazines.
  • Distinguish cyamemazine base from cyamemazine tartrate and state whether a reported mass represents salt or base equivalent; French medicinal-product records explicitly make this distinction. [French public medicines database](https://base-donnees-publique.medicaments.gouv.fr/medicament/60271248/extrait)
  • Distinguish isolated cyamemazine material from a Tercian medicinal product: a product name or labelled strength does not establish the composition or purity of a bulk substance sample.
  • Require methods that separate parent cyamemazine from related substances and degradation products; a nonspecific phenothiazine signal is insufficient.

What robots and AI may and may not do Filled

Must not

  • Recommend, dose or adjust cyamemazine for a specific person.
  • Suggest giving it to someone without their knowledge or consent.
  • Advise stopping antipsychotic treatment without a clinician.
  • Present it as a non-sedating or risk-free anxiety treatment.

Only with a human decision

  • Starting, stopping or changing psychiatric treatment for a patient.

May

  • Explain cyamemazine as a phenothiazine antipsychotic with anxiolytic use and where it is authorized, from official sources.
  • Report warnings and side effects from official labelling.

Moral aspects Filled

  • Sedating psychiatric drugs touch autonomy and the risk of coercion.
  • People with mental illness face stigma that careless language worsens.

Who is affected

  • Patients
  • Families and carers
  • Prescribers

Owners Filled

Steward

The prescriber and the pharmacist for each patient; medicines regulators authorize products.

Master systems

  • National medicines registers

Links to other meta-models Filled

parent

  • Q11173 - registry parent class

What else AI and robots need to interact with it Filled

Identity and identifiers required Filled

  • Vercy registry: vr.tr.cyamemazine
  • Wikidata: Q3008033 (https://www.wikidata.org/wiki/Q3008033)

Direct properties required Filled

  • Molecular identity: Verified structure, molecular formula, stereochemical specification and structure-linked identifiers
  • Material form: Free base; specified salt; hydrate or solvate where demonstrated; unresolved
  • Cyamemazine content: % mass fraction, mg/g or mg/mL, with salt/base basis and as-is/dried basis
  • Impurity profile: Individual and total impurities in %, ppm or method-specific units, with detection limits
  • Physical and solid-state condition: Observed phase and appearance; characterised crystalline or amorphous form; temperature and pressure
  • Solubility and ionisation: Solubility in mg/mL or mol/L; pKa dimensionless; solvent, pH, temperature and material form required
  • Thermal behaviour: Melting, transition or decomposition temperature in °C, with method; boiling point only when experimentally applicable
  • Storage and retest status: Within supported conditions; excursion under review; retest due; rejected; evidence unavailable
  • Biological evidence: Links to target assays, pharmacological studies and product safety information with species, method and exposure context
  • Hazard and regulatory identity: Form-specific SDS, applicable GHS classification, exposure limits and jurisdiction-dated regulatory records

Recognition required Filled

  • Identified by product label, active ingredient name and pack details rather than by appearance alone.

Capabilities and actions required Filled

  • Resolve a supplier or catalogue record to cyamemazine using structure-linked identifiers.
  • Reconcile cyamemazine quantities expressed as free base, salt mass or solution concentration when composition is verified.
  • Assess whether analytical evidence supports the identity, purity and intended grade of a batch.
  • Select evidence-supported conditions for storage, sampling and analytical preparation.
  • Flag unresolved exposure controls, stability excursions or regulatory restrictions before material use.
  • Link cyamemazine to medicinal products and biological studies while preserving their separate decision contexts.

Hazards and failure modes required Filled

  • Sedation and impaired driving.
  • Heart rhythm effects.
  • Movement disorders.

Standards and interfaces required Filled

  • The World Health Organization Collaborating Centre for Drug Statistics Methodology classifies cyamemazine under ATC code N05AA06 among phenothiazine antipsychotics with an aliphatic side chain.

Context of use required Filled

  • Cyamemazine is encountered as an active pharmaceutical ingredient and in prescription medicines used in psychiatric care, particularly in France.
  • It is also encountered in pharmaceutical analysis and research concerned with substance identity, formulation and stability.

Sources Filled

  1. Wikidata item Q3008033: cyamemazine - identity and sense of the item
  2. Wikipedia: Cyamemazine - general description of the item

Open questions

  • What authoritative identifier set, stereochemical specification and salt stoichiometry should govern cyamemazine base and each linked material form?
  • Which experimentally supported physical constants and stability conditions exist for the free base versus tartrate, including whether reported thermal values describe melting or decomposition?
  • Which validated analytical methods, impurity limits and grade specifications are available for assessing cyamemazine batches?
  • Which directly inspected studies establish parent and metabolite pharmacology, and how comparable are their assays?
  • What current form-specific GHS classifications, occupational exposure limits and jurisdictional restrictions apply, and where is evidence absent?

Machine files

Provenance

thing registry research (pass 2) · unreviewed

Built from: models/things/publications/thing-q3008033/spec.json